CS249455B1 - N-substituted 2-chloro-7-fluoro-10-piperazino-10,11-dihydrodibenzo(b,f)thiepines and their salts and method of their preparation - Google Patents

N-substituted 2-chloro-7-fluoro-10-piperazino-10,11-dihydrodibenzo(b,f)thiepines and their salts and method of their preparation Download PDF

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Publication number
CS249455B1
CS249455B1 CS85516A CS51685A CS249455B1 CS 249455 B1 CS249455 B1 CS 249455B1 CS 85516 A CS85516 A CS 85516A CS 51685 A CS51685 A CS 51685A CS 249455 B1 CS249455 B1 CS 249455B1
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CS
Czechoslovakia
Prior art keywords
fluoro
chloro
enzo
piperazino
formula
Prior art date
Application number
CS85516A
Other languages
Czech (cs)
English (en)
Inventor
Miroslav Protiva
Jiri Jilek
Irena Cervena
Antonin Dlabac
Martin Valchar
Josef Pomykacek
Original Assignee
Miroslav Protiva
Jiri Jilek
Irena Cervena
Antonin Dlabac
Martin Valchar
Josef Pomykacek
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miroslav Protiva, Jiri Jilek, Irena Cervena, Antonin Dlabac, Martin Valchar, Josef Pomykacek filed Critical Miroslav Protiva
Priority to CS85516A priority Critical patent/CS249455B1/cs
Priority to CA000498881A priority patent/CA1238047A/en
Priority to DK30586A priority patent/DK30586A/da
Priority to EP86300389A priority patent/EP0189310A3/en
Priority to FI860329A priority patent/FI860329A/fi
Priority to JP61011194A priority patent/JPS61204181A/ja
Priority to US06/821,992 priority patent/US4678788A/en
Publication of CS249455B1 publication Critical patent/CS249455B1/cs

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D337/14—[b,f]-condensed

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Anesthesiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
CS85516A 1985-01-24 1985-01-24 N-substituted 2-chloro-7-fluoro-10-piperazino-10,11-dihydrodibenzo(b,f)thiepines and their salts and method of their preparation CS249455B1 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CS85516A CS249455B1 (en) 1985-01-24 1985-01-24 N-substituted 2-chloro-7-fluoro-10-piperazino-10,11-dihydrodibenzo(b,f)thiepines and their salts and method of their preparation
CA000498881A CA1238047A (en) 1985-01-24 1986-01-02 N-substituted 2-chloro-7-fluoro-10-piperazino-10,11- dihydrodibenzo (b,f)thiepins, their acid addition salts and processes for the preparation thereof
DK30586A DK30586A (da) 1985-01-24 1986-01-21 N-substituerede 2-chlor-7-fluor-10-piperzino-10,11-dihydrodibenzo(b,f)thiepiner, deres syreadditionssalte og fremgangsmaader til deres fremstilling
EP86300389A EP0189310A3 (en) 1985-01-24 1986-01-21 N-substituted 2-chloro-7-fluoro-10-piperazino-10,11-dihydrodibenzo (b,f) thiepins, their acid addition salts and processes for the preparation thereof
FI860329A FI860329A (fi) 1985-01-24 1986-01-23 N-substituerade 2-klor-7-fluor-10 -piperazino-10,11-dihydrodibenzo(b,f)tiepiner, deras syraadditionssalter och foerfaranden foer framstaellning av dem.
JP61011194A JPS61204181A (ja) 1985-01-24 1986-01-23 Ｎ−置換された２−クロロ−７−フルオロ−１０−ピペラジノ−１０，１１−ジヒドロジベンゾ〔ｂ，ｆ〕チエピン，酸付加塩類及びそれらの調製法
US06/821,992 US4678788A (en) 1985-01-24 1986-01-24 N-substituted 2-chloro-7-fluoro-10-piperazino-10,11-dihydrodibenzo (B,F) thiepins and acid addition salts thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CS85516A CS249455B1 (en) 1985-01-24 1985-01-24 N-substituted 2-chloro-7-fluoro-10-piperazino-10,11-dihydrodibenzo(b,f)thiepines and their salts and method of their preparation

Publications (1)

Publication Number Publication Date
CS249455B1 true CS249455B1 (en) 1987-03-12

Family

ID=5337371

Family Applications (1)

Application Number Title Priority Date Filing Date
CS85516A CS249455B1 (en) 1985-01-24 1985-01-24 N-substituted 2-chloro-7-fluoro-10-piperazino-10,11-dihydrodibenzo(b,f)thiepines and their salts and method of their preparation

Country Status (7)

Country Link
US (1) US4678788A (ja)
EP (1) EP0189310A3 (ja)
JP (1) JPS61204181A (ja)
CA (1) CA1238047A (ja)
CS (1) CS249455B1 (ja)
DK (1) DK30586A (ja)
FI (1) FI860329A (ja)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992012133A2 (en) * 1991-01-08 1992-07-23 E.I. Du Pont De Nemours And Company Arthropodicidal carboxanilides
US5538965A (en) * 1993-12-23 1996-07-23 Allelix Biopharmaceuticals Inc. Dopamine receptor ligands
AR043880A1 (es) * 2003-04-22 2005-08-17 Solvay Pharm Gmbh Mesilato acido de 4-(4.trans-hidroxiciclohexil) amino-2-fenil-7h-pirrolo (2,3-d) pirimidina y sus formas polimorfas

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE757868A (fr) * 1969-10-25 1971-04-01 Spofa Usines Pharma Reunies Procede de preparation de nouvelles 10-piperazino-10,11-dihydrodibenzo/b,f,/thiepines et de leurs sels, ainsi que les produits obtenus
BE757926A (fr) * 1969-10-25 1971-04-01 Spofa Usines Pharma Reunies Procede de preparation de nouvelles amidoximes de la serie des 10-piperazino-10,11-dihydrodibenzo/b,f/thiepines et leurs sels, ainsique les produits obtenus
DD113545A5 (ja) * 1973-03-30 1975-06-12
DE2704934A1 (de) * 1976-02-17 1977-08-18 Sandoz Ag Organische verbindungen, ihre herstellung und verwendung
CS196893B1 (en) * 1977-12-22 1980-04-30 Miroslav Protiva 3-fluor-10-piperazino-8-substituted 10,11-dihydro-dibenzothiepines

Also Published As

Publication number Publication date
DK30586A (da) 1986-07-25
CA1238047A (en) 1988-06-14
US4678788A (en) 1987-07-07
FI860329A (fi) 1986-07-25
JPS61204181A (ja) 1986-09-10
DK30586D0 (da) 1986-01-21
EP0189310A3 (en) 1987-05-20
EP0189310A2 (en) 1986-07-30
FI860329A0 (fi) 1986-01-23

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