CS247089B2 - Production method of the 2-bromine-8-ergolinyl compounds - Google Patents

Production method of the 2-bromine-8-ergolinyl compounds Download PDF

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Publication number
CS247089B2
CS247089B2 CS848310A CS831084A CS247089B2 CS 247089 B2 CS247089 B2 CS 247089B2 CS 848310 A CS848310 A CS 848310A CS 831084 A CS831084 A CS 831084A CS 247089 B2 CS247089 B2 CS 247089B2
Authority
CS
Czechoslovakia
Prior art keywords
ergolinyl
bromo
compounds
bromination
methyl
Prior art date
Application number
CS848310A
Other languages
Czech (cs)
English (en)
Inventor
Helmut Boerner
Gregor Haffner
Gerhard Sauer
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of CS247089B2 publication Critical patent/CS247089B2/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06—Lysergic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
    • C07D457/12—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/02—Ergot alkaloids of the cyclic peptide type

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CS848310A 1983-11-03 1984-11-01 Production method of the 2-bromine-8-ergolinyl compounds CS247089B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3340025A DE3340025C2 (de) 1983-11-03 1983-11-03 Verfahren zur Herstellung von 2-Brom-8-ergolinyl-Verbindungen

Publications (1)

Publication Number Publication Date
CS247089B2 true CS247089B2 (en) 1986-11-13

Family

ID=6213531

Family Applications (1)

Application Number Title Priority Date Filing Date
CS848310A CS247089B2 (en) 1983-11-03 1984-11-01 Production method of the 2-bromine-8-ergolinyl compounds

Country Status (10)

Country Link
US (1) US4970314A (da)
EP (1) EP0141387B1 (da)
JP (1) JPS60115580A (da)
AT (1) ATE42103T1 (da)
CA (1) CA1253489A (da)
CS (1) CS247089B2 (da)
DE (2) DE3340025C2 (da)
DK (1) DK163583C (da)
HU (1) HU198714B (da)
IE (1) IE57909B1 (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3101535A1 (de) * 1981-01-14 1982-08-12 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue (2-halogen-ergolinyl)-n'.n'-diethyl-harnstoffderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel
DE3303616A1 (de) * 1982-02-12 1983-08-25 Sandoz-Patent-GmbH, 7850 Lörrach Mutterkornalkaloide, verfahren zu deren herstellung sowie diese verbindungen enthaltende pharmazeutische zubereitungen
DD238051A1 (de) * 1985-06-10 1986-08-06 Dresden Arzneimittel Verfahren zur herstellung neuer lysergsaeureamide
HU193317B (en) * 1985-06-12 1987-09-28 Richter Gedeon Vegyeszet Process for producing 2-bromo-alpha-ergochristin
US5441961A (en) * 1992-08-27 1995-08-15 Eli Lilly And Company Substituted cyclo or bicycloalkylamides of (8β)-6-(substituted) ergolines
CA2895829A1 (en) * 2012-12-21 2014-06-26 Map Pharmaceuticals, Inc. Novel methysergide derivatives
US9676776B2 (en) 2015-01-20 2017-06-13 Xoc Pharmaceuticals, Inc. Isoergoline compounds and uses thereof
CN107428745A (zh) 2015-01-20 2017-12-01 Xoc制药股份有限公司 麦角灵化合物及其用途
AU2018275873A1 (en) 2017-06-01 2019-12-19 Xoc Pharmaceuticals, Inc. Ergoline derivatives for use in medicine

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH507249A (de) * 1968-05-31 1971-05-15 Sandoz Ag Verfahren zur Herstellung von 2-Brom-a-ergokryptin
DE2330912C3 (de) * 1972-06-22 1979-01-11 Societa Farmaceutici Italia S.P.A., Mailand (Italien) Verfahren zur Herstellung von Bromergolinverbindungen
YU216177A (en) * 1977-09-09 1984-02-29 Rudolf Rucman Process for preparing 2-bromo ergosine
US4166182A (en) * 1978-02-08 1979-08-28 Eli Lilly And Company 6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds
YU40046B (en) * 1978-09-04 1985-06-30 Lek Tovarna Farmacevtskih Process for preparing 2-bromo-9,10-dihydroergosine
HU180929B (en) * 1979-08-13 1983-05-30 Richter Gedeon Vegyeszet Process for producing new bromo-vincamone derivatives
US4609731A (en) * 1979-10-10 1986-09-02 Sandoz Ltd. Process for brominating ergot alkaloids
US4352909A (en) * 1980-08-20 1982-10-05 Ferro Corporation Process for the bromination of polystyrenes

Also Published As

Publication number Publication date
DE3340025C2 (de) 1986-01-09
DK163583C (da) 1992-08-24
IE842743L (en) 1985-05-03
IE57909B1 (en) 1993-05-05
US4970314A (en) 1990-11-13
EP0141387A1 (de) 1985-05-15
DK163583B (da) 1992-03-16
DK515184A (da) 1985-05-04
DK515184D0 (da) 1984-10-29
HUT35672A (en) 1985-07-29
HU198714B (en) 1989-11-28
CA1253489A (en) 1989-05-02
DE3340025A1 (de) 1985-05-23
DE3477666D1 (en) 1989-05-18
JPH0556349B2 (da) 1993-08-19
EP0141387B1 (de) 1989-04-12
JPS60115580A (ja) 1985-06-22
ATE42103T1 (de) 1989-04-15

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