CS227348B2 - Method of preparing 3-(4-aminoethoxybenzoyl)-benzo (b) thiophene - Google Patents

Method of preparing 3-(4-aminoethoxybenzoyl)-benzo (b) thiophene Download PDF

Info

Publication number
CS227348B2
CS227348B2 CS822357A CS235782A CS227348B2 CS 227348 B2 CS227348 B2 CS 227348B2 CS 822357 A CS822357 A CS 822357A CS 235782 A CS235782 A CS 235782A CS 227348 B2 CS227348 B2 CS 227348B2
Authority
CS
Czechoslovakia
Prior art keywords
group
acid
formula
benzo
product
Prior art date
Application number
CS822357A
Other languages
Czech (cs)
English (en)
Inventor
Charles D Jones
Mary E Goettel
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/246,334 external-priority patent/US4358593A/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CS227348B2 publication Critical patent/CS227348B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Extrusion Moulding Of Plastics Or The Like (AREA)
CS822357A 1981-04-03 1982-04-01 Method of preparing 3-(4-aminoethoxybenzoyl)-benzo (b) thiophene CS227348B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24633581A 1981-04-03 1981-04-03
US06/246,334 US4358593A (en) 1981-04-03 1981-04-03 Process for preparing 3-(4-aminoethoxybenzoyl)benzo[b]thiophenes
US33104581A 1981-12-16 1981-12-16

Publications (1)

Publication Number Publication Date
CS227348B2 true CS227348B2 (en) 1984-04-16

Family

ID=27399920

Family Applications (1)

Application Number Title Priority Date Filing Date
CS822357A CS227348B2 (en) 1981-04-03 1982-04-01 Method of preparing 3-(4-aminoethoxybenzoyl)-benzo (b) thiophene

Country Status (17)

Country Link
EP (1) EP0062504B1 (el)
KR (1) KR850001882B1 (el)
CS (1) CS227348B2 (el)
DD (1) DD201793A5 (el)
DE (1) DE3268227D1 (el)
DK (1) DK151282A (el)
EG (1) EG15610A (el)
ES (1) ES511124A0 (el)
FI (1) FI821160L (el)
GB (1) GB2097392B (el)
GR (1) GR76468B (el)
HU (1) HU191353B (el)
IE (1) IE53187B1 (el)
IL (1) IL65378A (el)
PL (1) PL130867B1 (el)
PT (1) PT74692B (el)
SU (1) SU1155157A3 (el)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4117512A1 (de) * 1991-05-25 1992-11-26 Schering Ag 2-phenylbenzo(b)furane und -thiophene, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
CA2145614A1 (en) * 1994-03-31 1995-10-01 Jeffrey A. Dodge Intermediates and processes for preparing benzothiophene compounds
US5523416A (en) * 1994-07-22 1996-06-04 Eli Lilly And Company Process for preparing 3-(4-aminoethoxy-benzoyl) benzo (B)-thiophenes
CO4410190A1 (es) 1994-09-19 1997-01-09 Lilly Co Eli 3-[4-(2-AMINOETOXI)-BENZOIL]-2-ARIL-6-HIDROXIBENZO [b] TIOFENO CRISTALINO
US5629425A (en) * 1994-09-19 1997-05-13 Eli Lilly And Company Haloalkyl hemisolvates of 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-piperidinoethoxy)-benzoyl]benzo[b]thiophene
US5589482A (en) * 1994-12-14 1996-12-31 Pfizer Inc. Benzo-thiophene estrogen agonists to treat prostatic hyperplasia
US6391892B1 (en) * 1995-03-10 2002-05-21 Eli Lilly And Company Naphthyl pharmaceutical compounds
US5728724A (en) * 1995-08-17 1998-03-17 Eli Lilly And Company Benzothiophene compounds
US6008377A (en) * 1996-03-19 1999-12-28 Eli Lilly And Company Synthesis of 3-[4-(2-aminoethoxy)-benzoyl]-2-aryl-6-hydroxy-benzo[B]thiophenes
IN183239B (el) * 1996-09-25 1999-10-09 Lilly Co Eli
US5916916A (en) * 1996-10-10 1999-06-29 Eli Lilly And Company 1-aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods
ZA9710262B (en) * 1996-11-19 1999-05-13 Lilly Co Eli Process for the synthesis of benzothiophenes
CA2287920A1 (en) * 1997-04-30 1998-11-05 Eli Lilly And Company Intermediates and a process for preparing benzo¬b|thiophenes
CN1254280A (zh) * 1997-04-30 2000-05-24 伊莱利利公司 用于制备取代的苯并[b]噻吩的区域选择性烷基化方法
WO1998049156A1 (en) * 1997-04-30 1998-11-05 Eli Lilly And Company Processes for preparing benzothiophenes
CA2231013A1 (en) * 1997-04-30 1998-10-30 Eli Lilly And Company Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceuticals
CA2287922A1 (en) * 1997-04-30 1998-11-05 Eli Lilly And Company Intermediates and processes for preparing benzo[b]thiophenes
CA2236254A1 (en) * 1997-04-30 1998-10-30 David Warren Hoard Process for preparing benzo¬b|thiophenes
EP1832583A1 (en) 2002-09-30 2007-09-12 A/S GEA Farmaceutisk Fabrik Novel raloxifene sulphuric acid addition salts and/or solvates thereof, and pharmaceutical compositions comprising these
EP2322519A1 (en) * 2009-10-23 2011-05-18 Hexal AG A process for preparing benzo[b]thiophene derivatives
WO2011099942A1 (en) 2010-02-09 2011-08-18 Silverstone Pharma New addition salts of raloxifene, process for the preparation thereof and use thereof in therapy

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3947470A (en) * 1974-06-20 1976-03-30 Smithkline Corporation Substituted benzofurans and benzothiophenes
US4001426A (en) * 1974-10-17 1977-01-04 Smithkline Corporation Substituted benzofurans and benzothiophenes
FR2279395A1 (fr) * 1975-06-02 1976-02-20 Labaz Nouveaux derives de benzthiophene, leurs precedes de preparation ainsi que les compositions pharmaceutiques les contenant
US4133814A (en) 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents

Also Published As

Publication number Publication date
HU191353B (en) 1987-02-27
PL130867B1 (en) 1984-09-29
DD201793A5 (de) 1983-08-10
PT74692A (en) 1982-05-01
ES8307240A1 (es) 1983-06-16
IL65378A0 (en) 1982-05-31
EP0062504A1 (en) 1982-10-13
DE3268227D1 (en) 1986-02-13
IE53187B1 (en) 1988-08-17
ES511124A0 (es) 1983-06-16
KR850001882B1 (ko) 1985-12-28
EP0062504B1 (en) 1986-01-02
KR830010100A (ko) 1983-12-26
IL65378A (en) 1986-02-28
EG15610A (en) 1986-06-30
IE820786L (en) 1982-10-03
DK151282A (da) 1982-10-04
GR76468B (el) 1984-08-10
PT74692B (en) 1985-01-08
SU1155157A3 (ru) 1985-05-07
FI821160A0 (fi) 1982-04-02
FI821160L (fi) 1982-10-04
GB2097392B (en) 1985-04-24
GB2097392A (en) 1982-11-03
PL235752A1 (el) 1982-11-22

Similar Documents

Publication Publication Date Title
CS227348B2 (en) Method of preparing 3-(4-aminoethoxybenzoyl)-benzo (b) thiophene
US4358593A (en) Process for preparing 3-(4-aminoethoxybenzoyl)benzo[b]thiophenes
US4380635A (en) Synthesis of acylated benzothiophenes
Thompson et al. Synthesis and pharmacological evaluation of a series of dibenzo [a, d] cycloalkenimines as N-methyl-D-aspartate antagonists
EP0062505B1 (en) A process for preparing acylated benzothiophenes
GB2097788A (en) Benzothiophene compounds and process for preparing them
DE69520738T2 (de) 2-amino-3-aroyl-benzo beta thiophene und verfahren zu deren herstellung
AU694212B2 (en) Benzofuran derivatives as d4 receptor antagonists
IE53186B1 (en) Tree resistant power cable
CZ138592A3 (en) Acetic acid derivative, process of its preparation and a pharmaceutical composition in which said derivative is comprised
JPH07278138A (ja) ベンゾチオフェン化合物の新規中間体及び製造法
AU684181B2 (en) An improved process for preparing 3-(4-aminoethoxy-benzoyl) benzo {B} - thiophenes
EP1362854B1 (en) Benzo[b[thiophene derivatives and process for producing the same
NZ250580A (en) 3-(hetero)aryloxymorphinan derivatives and their use in the manufacture of medicaments
HUT73136A (en) Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents
JPH115789A (ja) ベンゾ［ｂ］チオフェン類の製造法
DE69513022T2 (de) Verfahren zur herstellung von hydroxythioacetamiden und deren verwendung zur synthese von benzothiophenen
WO2001014385A1 (fr) Derives de dihydrobenzofuran, leur procede de preparation et agents
WO2015156428A1 (ko) 비결정성 랄록시펜 염산염의 신규 제조방법 및이에 사용되는 신규 중간체