CS226352B1 - Method of preparing l-tronine - Google Patents
Method of preparing l-tronine Download PDFInfo
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- CS226352B1 CS226352B1 CS80477A CS47780A CS226352B1 CS 226352 B1 CS226352 B1 CS 226352B1 CS 80477 A CS80477 A CS 80477A CS 47780 A CS47780 A CS 47780A CS 226352 B1 CS226352 B1 CS 226352B1
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- tpeohhha
- escherichia coli
- nutrient solution
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- C—CHEMISTRY; METALLURGY
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
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- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/185—Escherichia
- C12R2001/19—Escherichia coli
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/848—Escherichia
- Y10S435/849—Escherichia coli
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- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Biophysics (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
Description
-V-
OmiCAHMS K30EPETEHK3 K JiBTOPCKOMy CBHflETEJIÍCTBy 3aflBjreHO 13.07.79 3aaBKa N? 2781356/28-13
Abtopn H3o6peTeHna: Β.Γ. HeÓaĎoB, H.M. S^aHOBa, A.K. Οοκολοβ, B.A. JlMBniMIÍ, Ώ.Μ. ΚΟ3ΛΟΒ, E.M. Xyprec, H.K. Hhkobckhíí , M.M. rycaTHHep, Α.Φ. ΠΙολμη, B.H._ Αητηποβ, „ T.M. Πθ3£ΗΗΚΟΒΘ 3aaBHTejib: BcecojosHNS HayHHo-HccjieflOBaTejibCKHH HHCTHTyT reae- ΤΗΧΜ Η ΟβΛβΚφϊΗ ΠρΟΜΝΠΝΙβΗΗΝΧ ΜΗΚρΟΟρΓβΗΗΒΜΟΒ \ HA3BAHKE Χ30ΒΡΕΤΕΗΗΉ
Cnocoó nojiyqeHMa h - TpeoHHHa ίΙβοόρβτβΗκθ othocmtch k ΜΗκροδΗΟΛΟΓΗΗβοκοβ npoMNnweHHOCTM,a ημθηηο - κ cnocoóy nojiyqeHMa - TpeoHHHa.
TpeoHMH HBJíHeTcs ne38MeHMMoíí aMKHOKHCJiOTOíí, KOTopaa mwpoKOΠρΜΜβΗΛΘΤΟΗ K8K ΚΟΜΠΟΗβΗΤ paSJIHHHNX ΠΗΤβΤβΛΒΗΝΧ CMeceH MeflH—φϊΗΟΚΟΓΟ ΗΘ3Η ΘΗβΗΗΗ. ΚρΟΜβ ΨΟΓΟ, L —ΤρβΟΗΜΗ ΜΟΧβΤ ČNTb Η3-ΠΟΛΒ3ΟΒΘΗ Β ΚΘΗβΟΤΒβ £OÓaBKH Β niony ΗβΛΟΒβΚΘ Η Β ΚΟρΜ ΚΗΒΟΤ-ηνχ, a τβκχβ xax ρββκτΜΒ λλη $apMan;eBTMXíecKow η χΗΜΗΗβοκο&ΠρΟΜΝΙΠΛβΗΗΟ CTH . Β HacToamee ΒρβΜΗ -τρβΟΗΗΗ nojiyqasoT nyTeM npaMoči φβρΜθπτθ-π;ηη 6es npeípnecTBeHHHKOB c KenonbsoBaHHeM πργθμμοβ npojiyueHTOBTaKHX BHHOB KaK Brevibacterium flavum, Escherichia c»B. , Ce-rinebacterium. aceteacidophilum, Preteus rettgeri, Serratia marcescens, Aerebacter aer©genens, C®rynebacteriusi glutamicum
Ha πητaTejibHux cpe^ax, coflepacanpíx b KanecTBe hctohhhkob yraepo^a rjWK03y, ($pyKTO3y,βρβτβτ, STaHOJi πρκ jjočaBJíeHHM βητθμηηοβ h 3μηηοκηοηοτ hjihhx co^epscamnx cyócTpaTOB, a τθκχθ coAepxamnx hctohhhkh a30TaΗ ΗβΟόΧΟβΗΜΝβ MHHepaJIbHHe COJIH.
MsBecTen cnocoĎ nonyneHMa h -TpeoHHHa c Hcnoab3OBaHHeM MyraH-thhx nrraMMOB Escherichia c©li πρκ rxyÓHHHOM
KyjIbTItBMpOB8HWI4 Ηθ ΠΜΤδΤβΛΒΗΗΧ CpeASX, COflepxamHX γΓΛβΒΟΛΗ,xctohhxkm aaoTa, κ MXHepajtbHue cojim πρκ ΛΟόθΒΛβΗκκ β cpe^yqWCTHX aMMHOKHCJIOT Η ΒΗΤΘΜΗΗΟΒ ΜΛΜ COflepsaqMX WX rHflpOXX3a-. ΤΟΒ όβΛΚΟΒΟΐί MaCCH. ΠρΜ 9T0M ΛΟΟΤΗΓΗγΤ MaKCHMaJIbHHÍÍ ΒΗΧΟΛ 10,4 γ/jx J^-TpeoHHHa β φβρΜθΗΤθπκοΗΗοΙί cpe^e aa 96 nacoB φβρ-ΜβΗΤθρΜΜ /1/. ΠρΗΜβΗΗβΜΗΘ ΜγΤΘΗΤΗΗβ ΙϋΤΘΜΜΗ Escherichia C®li ΧθρβΚ-
Tepwayswcji ποτρβδΗοοτΒ© β xaojreJíííHHe χλχ β Η30ΛβϋπκΗβ κ Μβτκ-0Η0Η6. ' ΜβΒβοτβΗ TaKse cnocoó noxyHeHXH 1/ -TpeoHMHa nyTeM KyjibTX-BHpoBaHMH npoflyijHpyxxiníx ero μηκροοργθηηβμοβ BM^a Escfceri-chia celi Ήβ ΠΜτβτβΛΒΗοϋ cpe^e, co^epxameň hctohhhkh yrjiepofla, aaoTa κ ΗβοδχοβΗΜίιβ MHHepajn>Hne cojih b npxcyTCTBHHβΗτκδκοτκκβ c nocxe^yronniM ΒΗΑβκβΗκβΜ πβκοΓο npcmyKTa /2/. OčmfiM ΗβΑΟοτβτκοΜ οπηοθηηηχ cnocodoB ΗβΒΗοοχκζ ypOBeHh Haxon-ΛβΗΗΗ (,-TpeoHHHa Ha yrjieBo.xax, b hscthocth, Ha rjiBKoae, ko-TOpas ΗΒΛΗΘΤΟΗ ΠρβΛΠΟΠΤΗΤβΛΒΗΗΜ CHpbeM ΠρΗ ΠρΟΗΘΒΟβΟΤΒβ t -Τρβοημηθ λτιη ΜθΑΗΐίΗΗοκκχ nejieft, HeflOCTaTKOM TaKse ηβληθτοη cjihui-ΚΟΜ δΟΛΒΙΠΟβ ΒρβΜΗ φβρΜβΗΤβΙξΗΗ /96-120 HaCOB/ Ha 3ΤΟΜ ΟϊφΒβ .UeJIbD npeftnaraeMOrO Η3θ6ρθΤβΗΗΗ ΗΒΛΗβΤΟΗ ΠΟΒΒΠΠθΗκβ BHXO^anpojtyKTa κ coKpameHwe ΒρβΜβΗκ φβρΜβΗτβρκκ. Ποοτθβλθηηθη πθλβflOCTHraeTGH τθμ, ητο β xanecTBe MXKpoopraHM3MOB, npojjynHpyia-iqHX k-τρβΟΗΜΗ, H3 BHfla Escherichia celi Mcnojib3y- -®t uiTaMM Escherichia celi ΒΗΜΜτβΗβτκκκ M-l, a b KanecT-Be aHTHóHOTHKa - πθηηπηλλμη. Πρκ stom neHHijHjijiHH bhocht b HcxoflHy® nxTaTejibHyio cpejiy bκοΛΜΗβοτΒβ 0,1 - 0,5 γ/λ, a KyxbTHBHpoBaHxe BeflyT Ha πητθτθλβ-Ηοϋ cpe/ζβ, co^epacaqež nxTaTe^bHy© .qoÓaBicy β βη^θ Γκ,ςροκκθβτβSejiKOBoS Maccia, HanpxMep, κηολοτηογο rxflpcxziHaaTa, φβρΜβπτο -xxaaTa κκκ aBTOjrxaaTa ^poatxeS.
KpoMe toto, b npopecce KyjibTHBHpoBaHHH pejiecoo6pa3HO ββοαητβcda^aHcHpoBaHHyr no^nxTKy, co^epacamyio rx©KO3y κ pacTBop hmmjj _axa.
HfraMM BHIBíreHeTXKa M-l οτοδρβΗ b pacceBe nrraMMa VL 334 p YN 7. Ot Hcxo^Horo nrraMMa oh οτληηθθτοη θθμθτηημ Myxo-HflHHM xapaKTepoM ποΒβρχΗοοτκ κολοηηζ, no b ume h ho Jí cnocoÓHOCTbio κ προΛγκφΐΗ TpeoHHHa, Óojiee bucokoS cTaÓMjibHOCTbffi πρκ poc-τβ Ha cpe^ax c nHTaTejrbHHMH .qoóaBKaMH, T.e. cnocoóHocTb®IIOnyjIHUHH KJieTOK COXpaHHTb OCHOBHHe CBOÍÍCTBa /npOAyKpMH Tpeo-HHHa H yCTOÍÍHHBOCTb K neHHIíHJIJIMHy/ nOCJie KyjIbTHBHpOBaHMH Bgthx ycmoBwax. ΠΙτθμμ ^enoHwpoBsh b HeHTpajibHOM My3ee npoMura-JieHHHX MHKp00praHM3M0B ΠρΗ MHCTHTyTe ΒΗΜΠγΘΗΘΤΜΚΘ Η ΜΜββΤperacTpaiíHOHHEtií HOMep ΠΜΠΜΒ - 1856.
ΠΙΤ8ΜΜ BHWMreHeTHKa Μ - 1 coxpaHneT πολθθηηθ ΓβΗβτκΗβοκκβ cBofíCTBa acxojíHoró nrraMMa BHIÍKreHeTWHa VL 334 p YN 7/ CnOCOÓHOCTb K OBepXCHHTeSy TpeoHHHa H yCTOÍÍHMBOCTb Κ ΠΘΗΜ—ijHJíJiHHy, ητο οπρβ£βΛίϊβτοίϊ co^epscaHMeM b KjieTKax βΜΠΛΗμκφιιρο-BSHHOS ΓΜδρΜΛΗΟδ ΠΛ a3MH£H pYK 7 7, HG OTJlMHaeTCíI OT ΗβΓΟ PH£OM ΜΟρφΟΛΟΓΜΉβCKHX ΠρΜ3ΗΒΚ0Β, ĎOJiee BHCOKOÍÍ CTaÓHJIb-HOCTbE COXpaHeHHS ΟΒΟβΜ nOnyjIfllíHH KJieTOK B ΧΟΑβ φβρΜβΗΤΘΙξΗΗHa cpejsax C ΠΗΤΘΤΘΛΒΗΗΜΜ ΛΟδβΒΚΘΜΜ H CnOCOÓHOCTbK) K ÓOJieeBHCOKOMy ypOBHKJ HaKOEUieHHfl Z/“TpeoHHHa. Ββθβθηηθ b Hcxo^Hy© nMTaTeJibHyro cpe^y neHHUHjnrHHa β xojiHHecT—Be 0,1 -0,5 γ/ji πο3βοληθτ ncnojib3OB8Tb oóorameHHyio iiHTaTeJib-HHMH cpeflCTBaMH cpe^y Óea ποτβρκ ochobhhx cbOzSctb πγγημμθ hT6M CaMHM pe3KO HOBHCHTb CKOpOCTb HapamHBaHHfl ÓHOMaCCH B Ha-ηθλβηοη cTajíHH φθρΜθΗτβφϊκ, sa κοτοροίί cjie^yeT npoiíecc ηητθη-οηβηογο ÓHOcKHTeaa ζ -TpeoHHHa. IIpeAaaraeMHS cnocoó npeAycwaTpHBaeT βθλθηηθ nponecca φβρΜθΗ-TaiJHH B OnTHMSJIbHHX yCJIOBHSX 3δ CHeT ΠΟΑίβρΚΘΗΗΗ B XO£e ΠρΟ-Hecca onTHManbHoro οοοτηοςπθηηη yrjiepo.ua h aeoTa η ποοτοηηηογοypoBHH ρΗ, ητο flocTHraeTcs nyTeM Bse^eHMs b xojie φβρΜβΗτβπ,ΗΗcČaJcaHCHpoBaHHoíí πολπμτκη, co^epsameM rjiKKO3y h pacTBop ημμμ-axa. npejyiaraeMEix cnocoó nosBOJineT nojiyHHTb β φβρΜβπτθχ θμκ. 0,5 jiΛ0 30 γ/ji i, -TpeoHHHa aa 40 nacoB φβρΜβΗτβΐίΗΜ Ha nnTaTejib-hoh cpe#e, cojiepxaineH rjuoK03y, MKHepanbHHe cojih h nHTaTejibHHe^OÓaBKM B BH^e rMflpOJIMSaTa, φepMΘH’Γ0JIH3aτa HJIH aBTOJIH3aTaóHOMaccii ^posacež npn jioÓaBJíeHMH b ncxo^Hya nHTao\eJibHyx> epe^yneHMn;HJiJiHHa b KOJinnecTBe 0,1 - 0,5 r/ji. 4 XAPAKTEPMCTMKA ώτθμμθ Escherichia c®li ΒΗΜΜγθηθτηκθ M-l ΠΙτθμμ E. celí ΒΗΗΗγθηθτηκθ M-l, npoflynHpyiomHií L -TpeoHMH,xpaHKTCfl b neHTpajiijHOM My3ee προμβππλθηηηχ MHKpoopraHH3MOBHHCTHTyTa ΒΗΜΡίΓβΗΘΤΜΚΜ Η ΗΜββΤ perMGTpaiíMOHHHíi HOMep B-1856.ΜορφΟ^ΟΓΜΗ, ΓρΘΜΟΤρΜΙξθΤβΛΒΗΚβ CJiaÓO ΠΟΛΒΜΚΗΗβ ΤΟΗΚΜβ ΠΘΛΟΗΚΗc saKpyrjieHHHMM kohiísmm, ρβ3ΜβροΜ 1,5 - 2 mm b jyiHHy.
KyjibTyp ajibHO—žHSHOJiorHHe CKMe πρηβηβκη MHco-neirroHHHií arap. ^epes 24 naca pocra πρκ 37°C oópa3yeTKpyrjiHe, ÓejiOBaTHe, nojiynpo3paHHue Ha οβθτ kojiohhm ^ΗβΜβτροΜ 2-3 MM, nOBepXHOCTB KOJIOHHM ΓΛΘΛΚΘΗ, KpajI ρΟΒΗΗβ HJIH CJieTKaBOJlHKCThie , ςβΗΤρ KOJIOHHM ΠρΗΠΟΛΗΗΤ, CTpyKTypa OJXHOpOAHaa,KOHcMCTeHuHH nacTooCpasHas, jierKO SMyjihrMpyeTCJi.
ArapH3OBaHHag MHHHMajiBHaa cpeja /AjaMca/ c rjiPKoaoii ^íepes 2-e cyTOK pocra npw 37°C oĎpasyeT kojiohhm ΛΗβΜβτροΜ 1-1,5 mm cepoBSTO-ČeJiHe, Kpyrjme, c pobhhmm KpasMH, cjieráaBunyKJiHe, BHyTpeHHHH CTpyKTypa o^HopoflHaa, noBepxHocTb ĎJiec-TsmaH, nepea 4-5 cyroK kojiohmh npnoópeTaroT CHH3HCTyro /MyKo-HflHyK)/ KOHCHCTeHUHlO.
Poct b mhco—πβπτοΗΗΟΜ ĎyjibOHe - nocjie 24 mbcob pocra πρκ 37°CCHjibHoe paBHOMepHoe noMyTHeHHe, HeÓOJibraolS ocaflOK, aanax xa-paKTepHHÍi.
Poct b hhjko^ MMHHMajibHoit cpeae AaaKca - nepe3 jjBoe cyTOKpocra πρκ 37°C aapanHeii cHJibHoe paBHOMepnoe noMyTHeHHe, sa-nax oTcyTCTByeT.
Pocr .no yKOJiy β μηοο-πθπτοηηομ arape - χοροπίΗϋ no BceMy ynojiy.JKejiaTHHy - He pasacnacaeT.
Ha MQjioKe -χοροπικδ ροοτ c KoaryjrHn;Heíí MOJioKa.
Hhjioji - oópaeyeT.
Poct Ha pa3JiMHHHX yrjieBOjiaxi xopoino pacTeT Ha rjiBKoae, JiaKTO-se, MaHHOse, ranaKToae, KCHJioae, $pyKToae, rjiHijepojie η msh—HHTOjie c o6pa3OBaHHeM khcjioth h rasa. yCTQŽHHBO CTb K aHTHgHOTHKaM, ΥΟΤΟΗΗΗΒΟΟΤΒ K neHHIíHJIJIHHy. ΙΠτ8μμ He naToreHBH.
CojepacaHHe iuia3MHjíH. Β τιοΓθρκφΜΗΗβοκοκ cTa^HH pocra κλθτκη coaepsaT okojio 50 κοπηχ πλθθμηαη p YN 7 /moji. Bec 5,7 Mera- ΛΘΛΒτοη/, očecne^MBaromeií ycTOĚ^MBOCTb πιτθμμθ κ nemmujuíMHy η necymefi γθηη τρθοηηηοβογο onepoHa. ΠοτρβδΗοοτΒ b φΒΚτορβχ pocTa. PacTeT Ha MHHHMajihHoií γλεκο3ο-οοΛβΒΟΜ cpe^e /ερθΜΗ reHepanxx 240 mhh./. Poct CTHMyjiHpyeTCHH3.0JieMIíMH0M /βρΘΜΗ ΓβΗθρβΙξΜΗ 60 «ΜΗ/. -Cnocoó ocymecTBJífleTCíí cjiejíyHmKM oópa3OM. IIocéBHoií MaTepnaa KyjrbTypu MHKpoopraHH3Ma Escherichia celiBHJOlreHeTHKa Μ - 1 BHpamHBaBT b τβηβΗΗβ 48 nacoB Ha arapnao-BaHHOÍÍ ΜΗΗΗΜΘΛΒΗΟϋ Ορβ^ξβ, ΟΟΛθρΚβΠίθίί ΠΘΗΗΙίΗΛΛΗΗ /500ΜΚΓ/ίθ/, Η SaTeM CMHBOM $H3H0JI0rH*ieCKMM paCTBOpOM ΚΛβΤΟΚ C ΠΟΒβρΧΗΟΟΤΧKocsKa γοτοβητ KJieTOHHyro cycneH3iw, KOTopyro Mcnojib3yx)T’'λπηsaceBa φβρΜβΗΤθρΗΟΗΗοίί cpejiH.
HananbHas KOHneHTpanHH κπβτοκ b paÓoneM φβρΜβτβρβ Μοχβτ co-3 CTaBJTHTB okojio 2-5.10 kji/μλ. Mcxo^Haa nHTeTejibHaa cpe,qa co-aepacHT rjiBKoey, MHHepajibHHS aaoT, cojiíí, neHaipajiaH a nitTaTejib- t ΗΗβ βΟδβΒΚΜ B BHfle THApOJaMSaTOB ÓeJSKOBOÍÍ MaCCH, HanpHMep, KHC—XOTHHX rHXpOJIH3aTOB, SBT0JIH3βΤΟΒ HJIH φβρΜβΗΤ0^Η33T0B ,ΣζρΟΧΧβϋ.Ha^íanbHííá pH cpe^H ycTaHaBjiHBáx)T Ha ypoBHe 7,0-7,2 η 3βτβΜaBTOMaTHtiecKH noAJíepaciiBaffiT b bthx npejxejiax b xo#e φβρΜβΗτβίξΗΗc noMombK ^aTHHKa pH nyTeM ΒΒβ^βΗΗΗ cČaziaHCHpoBaHHOH πο,ζιπητκη,coflepsaujeS aMMwaK /βοληη3 pacTBop/ h rjiBKOsy. Ββη^γ τογο, titoCHKaceHwe pH cpe^s b xone xyxbTMBHpoBaHHH npo,nyneHTa TpeoHHHaoóycjiOBJíeHO yMeHbmeHHeM KOHneHTpanHH θμμοηηη /asoTa/ b cpe-ae BCjre,a;cTBHe yTOHsapuM ero npo^ypeHTOM, a οοοτηοιπθηηθ Meac^yCKOpOCTHMM yTHJJH3 aiJHK a3OTa H rJIíDKOSH OCTaeTCH ΠρΗΜβρΗΟ noc-TOflHHHM,-το cooTHoraeHHe Meawy KOJixnecTBOM j^aHHHX'κομποηθητοβb nHTaTejibHoS cMecin flOJiacHo οοοτβθτοτβοββτβ cooTHomeHMD weamyCKOpOCTHMH yTMJIXSaHXÍÍ 3THX ΚΟΜΠΟΗβΗΤΟΒ KyjIbTypO# npOflyiieHTQM,hto h flOCTHraeTCfl nyTeM BsefleHus b χο,ςβ φβρΜβΗτβπΗΗ BHmeyxa-saHHoft ΠΟΛΠΗΤΚΚ. TeMnepaTypy nojmepxxBaET Ha ypoBHe 35-37°C.Πβρββ 40-43 naca φβρΜβκτβηΗΗ o6pa3OBaHHHH b nuTaTejibHož cpe^e
Lt -TpeOHHH ΒΗΑβΠΗΒΤ CJieAyXiníIlM ΜβΤΟβΟΜ. BHOMaCCy ΚΛβΤΟΚ npo-syneHTa OT^ejiHiDT hm6o cenapupoBaHneii, λη6ο φΟΒτροΒβΗΗβΜ nO-CHe npe^BapMTeJIbHOÍl OÓpaÓOTKW OKHCblQ K8JIbU;MH /Η3ΒβΟΤΚΟΒΗΜmojiokom/ η ορτοφοοφορΗοϋ khcjiotoíí. C yqeTOM co^epxaHHH τρβο- HJtHa Μ ΚΘΤΜΟΗΟΒ Β ΗΘΤΜΒΗΟΜ paCTBOpe, a ΤΘΚΧβ ΠΜΓΜβΗΤΗΗΧοοβΑΜΗβΗΜδ ηθτμβηηΚ pacTBop nponycKasOT nepes psiA ποολθαοβθ-ΤβΛΒΗΟ ΟΟβΛΜΗβΗΗΗΧ ΚΟΛΟΗΗ C Ο ΟΒβΤΑΑΚ)ΠίΜΜ COpĎeHTOM ΑΛΑ ΠΟΓΛΟ-πιθημα OKpameHHHX coe^HHeHA^ μ ουλβΦοκθτηοηοβ, HanpnMep KY-2-8,JíwaSoH SK-1B sum αρυγμμ θηθλογμζηογο τμπθ β Η-φορωβ jua cop-ČIÍMM ΚΘΤΜΟΗΟΒ Μ ΤρβΟΗΜΗΘ.
CopÓMpOBaHHHÍi ΤρβΟΗΜΗ 9AS0HpyK)T C ΚΟΛΟΗΗΗ C Cyj^OKaTMOHMTOMpacTBopoM aMMHaKa. Φρθκαημ ajiioaTa, coAepaamHe ocHOBHoe koam-ηθοτβο TpeaHMHa, ynapHBamT ποα BaicyyMOM, oxnaxAaroT m κρμοτθλ-JIHSyBT TpeaHMH. ÍUa yCKOpeHHA KpMCTaJIAMSaiíMM ΜΟΧβΤ ÓHTb HCHOJIb30B8H0 flOÓaBJíeHMe CHMpTa. HojryMeHHHii ΤρβΟΗΜΗ ΧρΟΜβΤΟΓρβφΗΠβ c—kh ΟΛΗορο,ζζβΗ m coa©P®ht 97-99 % οοηοβηογο BeiqecTBa. Ληα nojry-ΗβΗΗΑ npenapaTOB ΑΛΑ MeAMAHHCKHX ΙξβΛβδ A0CT8T0HH0 npOBeCTMAOHOAHMTeAbHyX) nepeKpMCTSUAMB aííHSO.
TaKMe npenapaTH MoryT Chtb μοπολβ3οβ8Ηη b cpeflax αλα KyAbTH-BHpOBaHMA ΚΛβΤΟΚ ΤΚΘΗβδ. ΒηΧΟΑ ΠΟ OHHCaHHOMy Bbnne MeTOflyοοοτθβλαθτ 80-95 %. Πρα bhcokoíí κοΗΑβΗτρβίξΗΗ TpeoHMHa b xyjib-TypHoS xHflKOCTM /BHme 18 γ/ji / η οτηοομτθλβηο hm3koh coflep-aaHHM ΠρΜΜβΟΜ ΤρβΟΗΜΗ ΜΟΚβΤ ÍJHTb ΒΗΑβΛβΗ 6es Μ0Π0ΛΒ30ΒΘΗΗΑCTSAHM COpSlíHH Ha ΗΟΗΗΤΘΧ. JUa 3ΤΟΓΟ ΟΟΒβΤΛβΗΗΗδ ρβΟΤΒΟρ KOH—ueHTpHpyroT ynapHBaHHeM b BaxyyMe πρκ ηθβηοοκηχ Te«napa<rypaxm KpMCTajuMSHpyiOT τρβοΗΗΗ íipw ποΗΜΚθΗΗοδ TeMnepaType c AOÓaB—Κθδ HJIM -δβ3 AOÓaBKH 3ΤΗΛΟΒΟΓΟ ΟΠΗρτ'θ. ΠθΟΛβ ΠβρβΚρΗΟΤ8ΚΛΗ3Θ-HMz ncuyzaioT Li -τρβΟΗΜΗ c coAepaaHzeM ochobhoto BenjecTBa 99%i
Cnocoó noACHAeTCA CAeAymíHMH npHMepaiíM. ΠρΜΜβρ 1 ΠοοβΒΗοδ ΜθτβρΗβΛ KyAbTypu npoAypeHTa Escherichia coliBHHHreHeTHKa M-l BHpamHBamr β τβηβΗΜβ 48 nacoB Ha arapzso-BSHHOM ΜΜΗΜΜΘΛΒΗΟδ ΓΛΒΚ03Ο-ΟΟΛβΒΟΗ Cpefle ΟΛβΑΥ^θΓΟ COCTSBa/γ/λ/, ΓΛ»Κ038 - 5,0; KH^CI - 1,0; KH2PO4-1,5j Na2HPO4-3,5;
MgSO4 . 7H20 - 0,1; - . neHMiíiujiHH -500 μκγ/μλ; arap-arap - 20,0; boas αμοτηλληροβθη-HSA, pH 7,0-7,2. ΓλϊΟΚ038 Η ,ΠβΗ MASUJI MH CTepiUM3yK)TCA ΟΤΑβΛΒΗΟm AOÓaBjíAETCA b paeruaBJíeHHyio cpe^y nepeA ee οχλθααθημθμ h no-ceBOM. Bapocray© xyjibTypy ομηβθετ cTepsubHoft ΒΟΑοηροΒΟΑΗοδ — 7 —
BoaoS h nojiyneHHyx) KJieTOHHyro cycneasMK ncnojib3y©T kjix sa-CeBa φβρΜβΗΤβρΟΒ. ΦβρΜδΗΤβρίϊΚΙ ΠρΟΒΟ,ΣζίϊΤ Ha JiaĎOpaTOpHOM φθρΜβΗΤβρθ eMKOCTb® 0,5 ji .
CocTaB hcxo^hoíí mt^TaTejibHoií cpe^n % /no oSbeMy/ 1. /NH4/2SO4 -1,8% 2. K2HPO4 - 0,2% 3. MgSO4 - 0,04% 4. Khcjiothhíí rnflpojiHsaT BBK /b pacneTe na cyxoíí Bec/-0,3% . ... " k 5. ΠβΗΟΓβΟΗΤβΛΒ - 0,1 %
IlHTaTeJibHyK) cpeay CTepiumsyrT coBMecTHo c annapaTOM, nocjienero BBO^flT b cpe^y cTepmiBHym rjiEKO3y - 2 % h neHMipwmH-0,5 γ/ji. 4>epMeHTanjiio Be#yT npw TeMnepaType 35-37° C c ββθγΑβΗΜβΜ cÓajiaHcupoBaHHOM πολπητκη, coflepxame® snímají b kojih-^ecTBe 2,5-2,7 h rjwicoay b KOHneHTpanHM 35 %. IIoAnHTKy bbo^jitno cHtrHa&y aaTninea pH. YpoBeHb pH ycTaHaBJíHBaBT b npe^ejiax7,0-7,2, ο^ΗΒφΗΤΗΟβ hhcjio φβρΜβΗτβρθ 3,5-4,0 r Og/ ji. nac.^Tepea 40 tiaeOB φβρΜβΗτβςιικ b xyjibTypajibHOH shjixocth HaKanjrn-BaeTCH L» -τρβΟΗΗΗ b KOJuraecTBe 30 γ/λ. 3aTpaTH γλ®κο8η Ha0ΜΗτβ3 TpeoHHHa 6 r/r. 5ajiee jJ-TpeoHHH Ba^ejnsOT na xyjrbTypaiibHOÍi acn/ncocTH.
θτογο κ 300 mji KyjrbTypaMbHoíi kh^kocth c KOHneHTpanneS
TpeoHHHa 30 γ/ji irpMóaBjuiBT npn nepeMeniHBaHHH 3 r okhch xajib-IJHa Η 3&ΤΘΜ SOÓaBJIHST θρΤθφθθφθρΗ7® KHCJIOTy AO JXOCTHSeHHHΒβΛΜΗΗΗΗ pH 5,6, pacTBop HarpeBaBT #o 60 °, BH^epsHBaroT 10MHHyT a OTKejisno? ĎHOMaccy Ha φιυΐΒτρβ πολ BaxyyMOM. nojiynen-HKM ΗΗΤΗΒΗΗΗ paCTBOp /οΠΤΗΠβΟΧΘΗ ,ΠΛΟΤΗΟCTb 0,4 ΠρΗ 525 HM B1 cm KraeTe/ nponycxaroT nepea KOJiOHKy c 50 mji οοΒβτΛΗκπξβΜcmojih KA-lp h ocBeTJieHHHH pacTBop /onTHnecxaji anoTHOCTb 0,08/nponycKamT nepea xojioHKy co 150 jo ογΛΒφοκβτκοΗΗΤθ KY-2-8 bΗ - φορΜβ, KOJioHicy npoMHBaxjT 300 mji bo^ee. CopóHpoBaHHíí τρβ-ΟΗΗΗ 9Ji30HpyiDT pacTBopoM 3%—ηογο aMMHaxa, 9JiK>aT ynapHBaxiT no#BaxyyMOM #0 co^epsaHHH cyxnx BemecTB 25%, ^oóaBjíHxiT θτηλοβηζιοππρτ B COOTHOmeHHH 1:1 H OCTaBJIHSOT KpHCTajIJIH3HpOBaTb B ΤβΗβ-ΗΗβ 10 nacoB πρκ TeMnepaType 0° - + 6° C. Κρηοτθλλν b -τρβο- hmhs οτφΗΛίϊΤροΒΗΒευοτ, πρθΜΗΒ3ΐοτ η cymaT. IIojiy^íaiOT 8,1 r /j -TpeoHiraa /βηχολ 90%/. Αηθλμβ μθτοαομ TCX /10 μκγ/noKaaHBaeT OTcyTCTBwe jipyriíx ημηηοκμολοτ· ΠρΗΜβρ 2
HocěBHoň MaTepwajr KyjibTypia npojiyiíeHTa BHMMreHeTHKa M-l πρκ-γοτοβληβτ no npwMepy 1. ΦβρΜθΗτβςη© BeflyT Ha φβρΜβΗΤβρβ eMKOCTbro 0,5 ji. CoeraB hc-χοληο3 nwraTejibHoft cpe^H no npnMepy 1, aa HCKJuoneHHeM toto,hto b KanecTBe πκτβτθΛΒΗοϋ λο6θβκη Hcnojib3yBT φβρΜβΗτοΛΗθβτ BBK b KoasraecTBe 0,5% βμθοτο κηοκοτηογο ΓΟΛρΟΛίίββτβ BBK.YCJIOBHfl φβρΜβΗΤβΙζΗΗ ΚβΚ B ΠρΗΜβρβ 1. %ρθ3 41 ΗβΟ φβρΜβΗΤΗΓζΗΗβ KyjiBTypHoii χηλκοοτη HaKanjiHBaeTCH 1—τρβΟΗΜΗ β KOJinnecTBe29 γ/ji. 4anee 1-τρβθΗΗΗ βηλθληβτ sis KyjibTypHoii khakocth. 4λη 9Τ0Γ0 300 mji ηθτηβηογο pacTBopa Ι-τρβοΗΗΗβ nocjre οτ^β-jieHHH KjieTOK npojxyiieHTa iíeHTpH$yrHpoBaHHeM KyjibTypajibHoSshjikocth /cyxHx BeiqecTB s ηθτηβηομ pacTBope 7,5%, onTwnec-ksh wroTHOCTb 0,6 /525 hm/ ynapuBaroT no# BaxyyMOM πρπ τβΜΠβ-paType 50°C #0 ofitewa 50 mji, aofíaBjííímT TaKoit xe oÓbeM sthjio-βογο cnMjpTa κ KpzcTajumayKT Ι-τρβοΗΖΗ β τβηβκκβ 5 nacoB npwTeMnepaType 0°C. nojiyneHHHe KpHCTajuiBi OT^ejunoT φιωΒτροΒβΗΗθΜ,npOMUBaioT 15 mji stiuioboto οπκρτβ η cymaT. IIojiynamT 6,1 r1-TpeoHHHa, He co^epacaniero no aHaJizsy Μβτο,ςοΜ TCX /10 μκγ/npMMecez .npyrwx aMMHOKMcjioT.
HpKMep 3 IIoceBHoií MaTepzaji KyjibTypu npojiyiieHTa E· coli BHMMreHeTHKa M-l npzroTOBJíJWT no npuMepy 1. 3 ΦβρΜβΗΤβΙξΗΧ) BeAyT Ha φβρΜβΗΤβρβ eMKOCTBJO 2 M . CoCTaB ^CXOJI-hoS nHTaTejibHOíi cpeflH no npzMepy 1, aa McKJUDneHHeM τογο, htob KanecTBe nHTaTejibHoíi \no6aBKH b nHTaTejibHoií cpejie Hcnojib3y-iot aBTOjmeaT jipoacsež b KOJiHnecTBe 0,4%, a co^epsaHMe ηβΗΜίμω-jiHHa 0,2 γ/ji.
Hepea 43 xtaca φβρΜβΗτθΐίΜΗ b KyjibTypajibHOH sch^kocth HaKaruiH-BaeTCJi 18 γ/ji TpeoHHHa. Pacxoji rjiroKOSH no npuMepy 1.
TaKHM oópaaoM κβκ noKa3aHO b θκοπθρμμθητθλβηηχ jsaHHHx,npeflJiaraeMHM cnocoó npeBQcxo^HT no θφφβκτηΒΗοοτη BceHBBecTHNe cnocoČH nojiyneHHH L) -TpeoHHHa Ha yrjiepoflHOMcpe^e. 3a 40-43 naca φβρΜβΗτβηΐίΐί c ηοπολβ3οβ3ημθμHOBoro nrraMMa E. celi BHMWreHeTMKa M-l Ha oóora- ΐηβΗΗΟδ ΠΜΤβΤβΛΒΗΟΐϊ Ορβ,Ζξθ C βθ6 ΘΒΛΘΗΗβΜ neHHIíHJIJIIÍHa B HC“xojíHys) nuTaTeJibHyio cpe^y, cnocoó ποββοληθτ nojjynHTb b xy-jibTypajibHoS 2ch#kocth βθ 30 γ/λ í/-TpeoHHHa óes npHMeceňaMHHOKJÍCJIOT . 10 ΦΟΡΜΖΑΑ Η30ΒΡΞΤΞΗΜΗ 1. CnocoÓ nojiyqeHMa L· -TpeoHXHa πγτβΜ rnyówHHoro Kyjib- TMBWpOBaHHíI npO^yUMpyjOIUMX ero MMKp00praHM3M0B BH£aEscherichia celi Ha πΗτβτβΛΒΗοίί cpene, conepacameii KCToqHHKH yrviepoAa, aeoTa κ HeoÓxoflUMHe MMHepajibHHe cojih B npMCyrCTBHH aHTHÓHOTHKa C ΠΟCJiejíyKmMM ΒΗΑβΛβΗΗβΜ ΙξβΛβΒΟΓΟπρο,π^κτβ, OTjriraammMiícs τθμ, hto, c nejibiD noBtaneHMs Buxona L) -TpeOHHHa H COKpameHMH ΒρβΜβΗΗ φβρΜβΗΤaiJHH B KaneCTBeuHKpoopraHHSMOB, npoíyniípy©mHX I4-τρβοκκΗ, H3 BK^a HCnOJb3yiDT ΠΓΓΒΜΜ BHMWreHeTHKa M-l, a b xanecTBe aHTHÓHOTHKa - πβΗΗίμυυιΚΗ. í 2. Cnocoó ΠΟ Π. 1, ΟΤΛΗΗβΧΗφΙΗΟΗ ΤβΜ, ΗΤΟ ΠβΗΜΗΗΛΛΗΗ BHOCHTb HcxoflHy© nHTaTejjbHyx) cpe^y b κοΛκγβοτεβ 0,1-0,5 γ/ji. 3. CnocoÓ no npwMepy 1, OTjuraa©nfHScH τθμ, 'ήτο KyjibTHBiípoBa-HHe BeayT Ha πκτθτβΛΒΗοίί cpe^e, co,a;epxameži πητ aTejibHy© .noóaBKy B BÍIfle ΓΗΛΡΟΛΗββΤΘ ÓeJtKOBO^ MSCCH, ΗΘΠρΗΜβρ, ΚΗΟΛΟΤΗΟΓΟrn.upo.HMaaTa, φβρΜβΗτοΛΗΒθτβ min θΒτοΛΜββτβ Aposaceft. 4. CnocoÓ no π. 1, OTJiMHasHmíSca τβΜ, ητο b nponecce KyjibTn-ΒΗροΒθΗΗΗ bbqrsv cěajraHCHpoBaHHy© no^nitTKy, co^epsamyx» γλ©-Kosy n pacTBOp aMMHaxa·
HcTOHHHKH ΗΗφΟρΜΒΗΗΗ, πρΗΗΗΤΗβ BO ΒΗΗΜΘΗΗβ ΠρΗ 9Κ0ΠβρΤΗ3β: 1. Πητθητ Αηγληη - 1223470 κλ. C 2 C onyójunc. 1971 r. 2. 3aaBKa ΦΡΓ IE 1792495 κλ. C 12 4 13/06, onyóji. 1972 r. -V' AHHOTAffllfl
UpejmaraeTCH cnocoó nojiyneHMa b-TpeoHKHa c πρΗΜβΗβΗΜθΜηοβογο nrraMMa E. c®Ii BHMHreHeTHxa M-l, κλθτκη κοτοροτο co^epxaT θΜΠΛΗφκηκροΒβΗΗ^το níópHaHyro rmasMH.ny, jíOTJureaicauerocíi οτ κσχο,ζξΗΟΓΟ πιτθμμθ BHHííreHeTMKa VL 334 pYN7pa^OM ΜΟρφΟΛΟrM^eCKMX Jí φΗ3Μ0Λ0ΓΜΗβ0ΚΙίΧ ΠρΗ3Η3Κ0Β μ óojieebhcokoíÍ cnocoóHocTBE nonyasnjuí κ,πβτοκ coxpaHaTB cboh cbojí-cTBa npx KyabTHBHpoBaHHH na oÓorameHHoS πητητθλβηοη cpe^e.3a 40-43 qaca φβρΜβΗΤθηΜκ Ha oÓorameHHOíí ππτβτβΛΒΗοδ cpe^eC ΛΟδβΒΛβΗΜβΜ ΠβΗΜςΐίΛΛΜΗβ B HCXO^Hy© HHTeTeJIbHyX) Cpe^ycnocoó nosBOJiaeT nojrynHTb b KyjibTypaabHoií xh^koctm λο30 τ/χ L> -TpeoHHHa Óee npraíeceS flpyrjrx ημμηοκηοηοτ.
Claims (4)
- - ,Ά " PŘEDMĚT VYNÁLEZU1. Způsob přípravy L-treoninu submerzní kultivací mikroorganismůrodu Escherichia coli v živném roztoku, který obsahuje uhlík,dusík a potřebné minerální soli v přítomnosti antibiotik a ná-sledujícím oddělením konečného produktu, vyznačující se tím, že - se jako mikroorganismu rodu Escherichia coli,-který produkujeL-treonin, používá kmen Escherichia coli. VNII genetiky M-ICMPMV--1856 a jako antibiotika penicilín.
- 2. Způsob podle bodu 1, vyznačující se tím, že se penicilín přivádído výchozího živného roztoku v množství 0,1 až 0,5 g/1.
- 3. Způsob podle bodu 1, vyznačující se tím, že se kultivace pro-vádí v živném roztoku, obsahující další část živin ve forměhydrolyzátu bílkovinných látek, například kyselého hydrolyzátu,fermentolyzátu nebo autolyzátu kvasinek.
- 4. Způsob podle bodu 1, vyznačující se tím, že se, během kultivacepřidává rovnovážná doplňková směs, obsahující glukózu a amoniak. Uznáno vynálezem na základě výsledků expertizy provedené Státnímvýborem pro vynálezy a objevy SSSR, Moskva, SU
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU792781356A SU943282A1 (ru) | 1979-07-13 | 1979-07-13 | Способ получени L-треонина |
Publications (1)
Publication Number | Publication Date |
---|---|
CS226352B1 true CS226352B1 (en) | 1984-03-19 |
Family
ID=20834297
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CS80477A CS226352B1 (en) | 1979-07-13 | 1980-01-22 | Method of preparing l-tronine |
Country Status (8)
Country | Link |
---|---|
US (1) | US4321325A (cs) |
JP (1) | JPS5615696A (cs) |
CS (1) | CS226352B1 (cs) |
DD (1) | DD148464A3 (cs) |
FR (1) | FR2461006A1 (cs) |
HU (1) | HU180566B (cs) |
SU (1) | SU943282A1 (cs) |
YU (1) | YU42330B (cs) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS55156591A (en) * | 1979-05-23 | 1980-12-05 | Ajinomoto Co Inc | Method for stabilizing property of bacteria containing plasmid |
NL8401255A (nl) * | 1983-08-05 | 1985-03-01 | Grace W R & Co | Werkwijze voor de biologische bereiding van l-aminozuren. |
EP0219808B1 (en) * | 1985-10-18 | 1993-12-22 | Toray Industries, Inc. | Plasmid with wide host range |
DE3844959B4 (de) * | 1988-10-25 | 2006-04-27 | Ajinomoto Co., Inc. | Stamm der Bakterien Escherichia coli BKIIM B-3996, Produzent von L-Threonin |
DE3891417T1 (de) * | 1988-10-25 | 1991-01-10 | Vnii Genetiki Selektsii Promy | Stamm der bakterien escherichia coli bkiim b-3996, produziert von l-threonin |
US5976843A (en) | 1992-04-22 | 1999-11-02 | Ajinomoto Co., Inc. | Bacterial strain of Escherichia coli BKIIM B-3996 as the producer of L-threonine |
WO1994011517A1 (en) | 1992-11-10 | 1994-05-26 | Ajinomoto Co., Inc. | Process for producing l-threonine by fermentation |
US5939307A (en) * | 1996-07-30 | 1999-08-17 | The Archer-Daniels-Midland Company | Strains of Escherichia coli, methods of preparing the same and use thereof in fermentation processes for l-threonine production |
RU2148642C1 (ru) * | 1998-12-23 | 2000-05-10 | ЗАО "Научно-исследовательский институт АДЖИНОМОТО-Генетика" (ЗАО "АГРИ") | Фрагмент днк rhtc, кодирующий синтез белка rhtc, придающего повышенную устойчивость к l-треонину бактериям escherichia coli, и способ получения l-аминокислоты |
US7220571B2 (en) * | 2000-09-28 | 2007-05-22 | Archer-Daniels-Midland Company | Escherichia coli strains which over-produce L-threonine and processes for the production of L-threonine by fermentation |
US7368266B2 (en) * | 2001-02-13 | 2008-05-06 | Cj Corporation | Method for L-threonine production |
JP4380305B2 (ja) * | 2003-11-21 | 2009-12-09 | 味の素株式会社 | 発酵法によるl−アミノ酸の製造法 |
US7723097B2 (en) * | 2005-03-11 | 2010-05-25 | Archer-Daniels-Midland Company | Escherichia coli strains that over-produce L-threonine and processes for their production |
CN103497979B (zh) * | 2005-06-20 | 2018-09-11 | 阿彻-丹尼尔斯-米德兰公司 | 用于改良生产天冬氨酸衍生的氨基酸及化学品的改变的乙醛酸支路 |
US20070004014A1 (en) * | 2005-06-29 | 2007-01-04 | Yuichiro Tsuji | Method for producing l-threonine |
JP2009153382A (ja) | 2006-03-30 | 2009-07-16 | Ajinomoto Co Inc | メタノール資化性細菌を用いたカルボン酸の製造法 |
EP2046949B1 (en) * | 2006-07-19 | 2014-01-15 | Ajinomoto Co., Inc. | A method for producing an l-amino acid using a bacterium of the enterobacteriaceae family |
DE102007051024A1 (de) | 2007-03-05 | 2008-09-11 | Evonik Degussa Gmbh | Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von Stämmen der Familie Enterobacteriaceae |
EP1975241A1 (de) | 2007-03-29 | 2008-10-01 | Evonik Degussa GmbH | Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae |
DE102007044134A1 (de) | 2007-09-15 | 2009-03-19 | Evonik Degussa Gmbh | Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae |
DE102007052270A1 (de) | 2007-11-02 | 2009-05-07 | Evonik Degussa Gmbh | Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae |
EP2060636A1 (de) | 2007-11-14 | 2009-05-20 | Evonik Degussa GmbH | Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae |
DE102008002309A1 (de) | 2008-06-09 | 2009-12-10 | Evonik Degussa Gmbh | Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae |
DE102008044768A1 (de) | 2008-08-28 | 2010-03-04 | Evonik Degussa Gmbh | Verfahren zur Herstellung von organisch-chemischen Verbindungen unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae |
EP2267145A1 (de) | 2009-06-24 | 2010-12-29 | Evonik Degussa GmbH | Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae |
EP2762571A1 (de) | 2013-01-30 | 2014-08-06 | Evonik Industries AG | Mikroorganismus und Verfahren zur fermentativen Herstellung von Aminosäuren |
US11053526B2 (en) | 2018-08-09 | 2021-07-06 | Evonik Operations Gmbh | Process for preparing L amino acids using improved strains of the enterobacteriaceae family |
EP3608409A1 (en) | 2018-08-09 | 2020-02-12 | Evonik Operations GmbH | Process for preparing l amino acids using improved strains of the enterobacteriaceae family |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1176125A (en) * | 1967-01-21 | 1970-01-01 | Kyowa Hakko Kogyo Kk | Process for Producing L-Threonine. |
GB1521032A (en) * | 1974-08-08 | 1978-08-09 | Ici Ltd | Biological treatment |
US4237224A (en) * | 1974-11-04 | 1980-12-02 | Board Of Trustees Of The Leland Stanford Jr. University | Process for producing biologically functional molecular chimeras |
FR2464299A1 (fr) * | 1979-08-28 | 1981-03-06 | Inst Genetiki Selektsii | Procede de preparation de souches productrices d'acides amines |
-
1979
- 1979-07-13 SU SU792781356A patent/SU943282A1/ru active
-
1980
- 1980-01-22 CS CS80477A patent/CS226352B1/cs unknown
- 1980-01-29 DD DD80218718A patent/DD148464A3/xx not_active IP Right Cessation
- 1980-03-13 HU HU8080597A patent/HU180566B/hu not_active IP Right Cessation
- 1980-03-20 YU YU773/80A patent/YU42330B/xx unknown
- 1980-03-24 US US06/133,284 patent/US4321325A/en not_active Expired - Lifetime
- 1980-03-31 FR FR8007209A patent/FR2461006A1/fr active Granted
- 1980-04-30 JP JP5773380A patent/JPS5615696A/ja active Granted
Also Published As
Publication number | Publication date |
---|---|
FR2461006B1 (cs) | 1984-03-09 |
HU180566B (en) | 1983-03-28 |
JPH0120871B2 (cs) | 1989-04-18 |
SU943282A1 (ru) | 1982-07-15 |
JPS5615696A (en) | 1981-02-14 |
FR2461006A1 (fr) | 1981-01-30 |
US4321325A (en) | 1982-03-23 |
YU42330B (en) | 1988-08-31 |
DD148464A3 (de) | 1981-05-27 |
YU77380A (en) | 1984-02-29 |
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