CA2119057A1 - An aqueous liposome system and a method for the preparation of such a liposome system - Google Patents

An aqueous liposome system and a method for the preparation of such a liposome system

Info

Publication number
CA2119057A1
CA2119057A1 CA002119057A CA2119057A CA2119057A1 CA 2119057 A1 CA2119057 A1 CA 2119057A1 CA 002119057 A CA002119057 A CA 002119057A CA 2119057 A CA2119057 A CA 2119057A CA 2119057 A1 CA2119057 A1 CA 2119057A1
Authority
CA
Canada
Prior art keywords
liposome system
phospholipidic
bile acid
substance
aqueous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002119057A
Other languages
French (fr)
Other versions
CA2119057C (en
Inventor
Jorg-Christian Hager
Josef-Peter Lohr
Manfred Durr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2119057A1 publication Critical patent/CA2119057A1/en
Application granted granted Critical
Publication of CA2119057C publication Critical patent/CA2119057C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/14—Liposomes; Vesicles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/26—Optical properties
    • A61K2800/262—Transparent; Translucent

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Birds (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

An aqueous liposome system is descibed, which comprises optionally besides a non-toxic organic solvent a further non-phospholipidic substance , said non-phospholipidic subsance being a bile acid, a salt of a bile acid, a bile acid derivative and/or a salt of a bile acid derivative. The mass ratio of the phospholipid to the further non-phospholipidic substance varies between 0.001 and 0.1.

According to a method for the production of the liposome system initially the phospholipid is dissolved or dispersed in an organic solvent together with the at least one non-phospholipidic substance at a mass ratio of 1:0.001 to 1:0.1, thereafter the.
solvent is evaporated partially or completely from the solution or the dispersion and hereafter water is added to foam the liposome system.
CA002119057A 1993-03-15 1994-03-14 An aqueous liposome system and a method for the preparation of such a liposome system Expired - Lifetime CA2119057C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP4308121.5 1993-03-15
DE4308121A DE4308121A1 (en) 1993-03-15 1993-03-15 Aqueous liposome system and method for producing such a liposome system

Publications (2)

Publication Number Publication Date
CA2119057A1 true CA2119057A1 (en) 1994-09-16
CA2119057C CA2119057C (en) 2004-01-20

Family

ID=6482793

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002119057A Expired - Lifetime CA2119057C (en) 1993-03-15 1994-03-14 An aqueous liposome system and a method for the preparation of such a liposome system

Country Status (8)

Country Link
EP (1) EP0615746B1 (en)
JP (1) JPH06321772A (en)
AT (1) ATE181826T1 (en)
CA (1) CA2119057C (en)
DE (2) DE4308121A1 (en)
DK (1) DK0615746T3 (en)
ES (1) ES2133150T3 (en)
GR (1) GR3030726T3 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19522694A1 (en) * 1995-06-22 1997-01-02 Vinas Jose Maria De Moragas Tar-containing composition and pharmaceutical and cosmetic preparation containing the same
ES2196978B1 (en) * 2001-10-26 2005-03-16 Universitat Autonoma De Barcelona PHARMACEUTICAL COMPOSITION
DE10349979B4 (en) * 2003-10-24 2006-05-18 Sanofi-Aventis Deutschland Gmbh Drug targeted local lipolysis
WO2006042751A2 (en) * 2004-10-19 2006-04-27 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Formulations containing alkylphosphocholines using novel negative charge carriers
DE102007015701A1 (en) 2007-03-19 2008-09-25 Maria Clementine Martin Klosterfrau Vertriebsgesellschaft Mbh New pharmaceutical compositions for lipolysis and process for their preparation
DE102010028365A1 (en) 2010-04-29 2011-11-03 Lichtblick Gmbh Use of a phospholipid-containing composition for the removal of subcutaneous fat accumulations
AU2013268379B2 (en) * 2012-05-31 2017-05-25 Terumo Kabushiki Kaisha pH-sensitive carrier and method for production thereof, pH-sensitive medicine and pH-sensitive pharmaceutical composition each containing said carrier, and culture method using said pH-sensitive medicine or said pH-sensitive pharmaceutical composition
RU2725622C1 (en) * 2019-10-30 2020-07-03 Открытое акционерное общество "Фармстандарт-Лексредства" (ОАО "Фармстандарт-Лексредства") Pharmaceutical composition for treating and/or preventing liver diseases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE464743B (en) * 1989-06-21 1991-06-10 Ytkemiska Inst PROCEDURE FOR PREPARATION OF MEDICINAL PARTICLES
CA2067754C (en) * 1990-08-24 2002-06-04 Gregor Cevc Preparation for the application of agents in mini-droplets
JPH08509202A (en) * 1992-07-08 1996-10-01 ディアノルム―ゲレーテ・ゲー・マイエルホファー・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Liposomes, methods of preparing them and their use in drug preparation

Also Published As

Publication number Publication date
EP0615746B1 (en) 1999-07-07
DE4308121A1 (en) 1994-09-22
EP0615746A1 (en) 1994-09-21
CA2119057C (en) 2004-01-20
GR3030726T3 (en) 1999-11-30
DE59408450D1 (en) 1999-08-12
DK0615746T3 (en) 1999-11-22
JPH06321772A (en) 1994-11-22
ATE181826T1 (en) 1999-07-15
ES2133150T3 (en) 1999-09-01

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Legal Events

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MKEX Expiry

Effective date: 20140314