CS226153B2 - Method of preparing new stable neutral water-soluble complexes of tetracyclin series antibiotics - Google Patents

Method of preparing new stable neutral water-soluble complexes of tetracyclin series antibiotics Download PDF

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Publication number
CS226153B2
CS226153B2 CS726077A CS607772A CS226153B2 CS 226153 B2 CS226153 B2 CS 226153B2 CS 726077 A CS726077 A CS 726077A CS 607772 A CS607772 A CS 607772A CS 226153 B2 CS226153 B2 CS 226153B2
Authority
CS
Czechoslovakia
Prior art keywords
complexes
tetracycline
solution
series
antibiotics
Prior art date
Application number
CS726077A
Other languages
Czech (cs)
English (en)
Inventor
Ilona Dr Kahan
Helga Dr Hammer
Ilona Dr Beladi
Original Assignee
Kahan Ilona
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kahan Ilona filed Critical Kahan Ilona
Publication of CS226153B2 publication Critical patent/CS226153B2/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CS726077A 1971-09-06 1972-09-05 Method of preparing new stable neutral water-soluble complexes of tetracyclin series antibiotics CS226153B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4153371A GB1401178A (en) 1971-09-06 1971-09-06 Complexes of tetracyclines

Publications (1)

Publication Number Publication Date
CS226153B2 true CS226153B2 (en) 1984-03-19

Family

ID=10420133

Family Applications (1)

Application Number Title Priority Date Filing Date
CS726077A CS226153B2 (en) 1971-09-06 1972-09-05 Method of preparing new stable neutral water-soluble complexes of tetracyclin series antibiotics

Country Status (10)

Country Link
US (1) US4418060A (pl)
JP (1) JPS587610B2 (pl)
BE (1) BE788479A (pl)
CS (1) CS226153B2 (pl)
DE (1) DE2243776C2 (pl)
FR (1) FR2154464B1 (pl)
GB (1) GB1401178A (pl)
HK (1) HK58877A (pl)
PL (1) PL83459B1 (pl)
YU (1) YU225972A (pl)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE788479A (fr) 1971-09-06 1973-01-02 Medimpex Gyogyszerkulkereskede Complexes du tris(hydroxymethyl)aminomethane avec les tetracyclines formant des solutions neutres, stables, tres actives etnon toxiques
US6455583B1 (en) * 1998-05-08 2002-09-24 The University Of Miami Method for treating meibomian gland disease
US6346547B1 (en) 1999-02-08 2002-02-12 Checkpoint, Genetics, Inc. N-substituted amino acids, antioxidant pharmaceutical compositions containing n-substituted amino acids and methods for preventing cardiovascular diseases and/or preventing and/or treating antioxidant responsive diseases therewith
CA2533150C (en) * 2003-07-25 2013-03-12 Warner Chilcott Company, Inc. A doxycycline metal complex in a solid dosage form
PL1753713T3 (pl) 2004-05-21 2017-02-28 President And Fellows Of Harvard College Synteza tetracyklin oraz ich analogów
ES2588584T3 (es) * 2005-01-21 2016-11-03 Warner Chilcott Company, Llc Un complejo metálico de tetraciclina en una forma de dosificación sólida
CA2648668C (en) * 2006-04-07 2015-06-23 The President And Fellows Of Harvard College Synthesis of tetracyclines and analogues thereof
EP2076133B1 (en) 2006-10-11 2012-12-12 President and Fellows of Harvard College Synthesis of enone intermediate
EP2424834B1 (en) 2009-04-30 2018-07-11 President and Fellows of Harvard College Synthesis of tetracyclines and intermediates thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE754346A (fr) * 1969-08-06 1971-01-18 Bru Jean Composition pharmaceutique a base de tetracycline presentee sous une forme effervescente
BE788479A (fr) 1971-09-06 1973-01-02 Medimpex Gyogyszerkulkereskede Complexes du tris(hydroxymethyl)aminomethane avec les tetracyclines formant des solutions neutres, stables, tres actives etnon toxiques

Also Published As

Publication number Publication date
GB1401178A (en) 1975-07-16
BE788479A (fr) 1973-01-02
HK58877A (en) 1977-12-02
JPS4861610A (pl) 1973-08-29
YU225972A (en) 1982-02-28
FR2154464B1 (pl) 1975-10-31
PL83459B1 (pl) 1975-12-31
FR2154464A1 (pl) 1973-05-11
DE2243776C2 (de) 1983-01-27
DE2243776A1 (de) 1973-03-22
US4418060A (en) 1983-11-29
JPS587610B2 (ja) 1983-02-10

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