CS225106B2 - The production of new tetrahyro-and hexahydro-aza-tetra cyclic compounds - Google Patents
The production of new tetrahyro-and hexahydro-aza-tetra cyclic compounds Download PDFInfo
- Publication number
- CS225106B2 CS225106B2 CS782988A CS298877A CS225106B2 CS 225106 B2 CS225106 B2 CS 225106B2 CS 782988 A CS782988 A CS 782988A CS 298877 A CS298877 A CS 298877A CS 225106 B2 CS225106 B2 CS 225106B2
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- CS
- Czechoslovakia
- Prior art keywords
- radical
- formula
- group
- alkyl
- carbon atoms
- Prior art date
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- 238000004519 manufacturing process Methods 0.000 title claims description 3
- 150000001923 cyclic compounds Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 65
- -1 hydroxy, methoxy, methylthio Chemical group 0.000 claims description 74
- 125000004432 carbon atom Chemical group C* 0.000 claims description 41
- 150000003839 salts Chemical class 0.000 claims description 30
- 239000002253 acid Substances 0.000 claims description 29
- 239000000203 mixture Substances 0.000 claims description 28
- 229910052739 hydrogen Inorganic materials 0.000 claims description 24
- 239000001257 hydrogen Substances 0.000 claims description 22
- 238000000034 method Methods 0.000 claims description 22
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 18
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 12
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 10
- XYOVOXDWRFGKEX-UHFFFAOYSA-N azepine Chemical compound N1C=CC=CC=C1 XYOVOXDWRFGKEX-UHFFFAOYSA-N 0.000 claims description 10
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 10
- 230000002829 reductive effect Effects 0.000 claims description 10
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- 239000000460 chlorine Substances 0.000 claims description 8
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- 238000002360 preparation method Methods 0.000 claims description 8
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 7
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims description 6
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 5
- 229910052736 halogen Inorganic materials 0.000 claims description 5
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- 125000003884 phenylalkyl group Chemical group 0.000 claims description 5
- 125000003342 alkenyl group Chemical group 0.000 claims description 4
- 125000003700 epoxy group Chemical group 0.000 claims description 4
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 4
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims description 3
- 125000003545 alkoxy group Chemical group 0.000 claims description 3
- 125000006350 alkyl thio alkyl group Chemical group 0.000 claims description 3
- 125000000304 alkynyl group Chemical group 0.000 claims description 3
- 125000004429 atom Chemical group 0.000 claims description 3
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 3
- 125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 claims description 3
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 2
- 125000004414 alkyl thio group Chemical group 0.000 claims description 2
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- 229910052794 bromium Inorganic materials 0.000 claims description 2
- 229910052740 iodine Inorganic materials 0.000 claims description 2
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- 238000002844 melting Methods 0.000 description 11
- 230000008018 melting Effects 0.000 description 11
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- 125000000217 alkyl group Chemical group 0.000 description 8
- 239000003054 catalyst Substances 0.000 description 8
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- 235000011152 sodium sulphate Nutrition 0.000 description 8
- 125000004851 cyclopentylmethyl group Chemical group C1(CCCC1)C* 0.000 description 7
- 239000012280 lithium aluminium hydride Substances 0.000 description 7
- 125000004433 nitrogen atom Chemical group N* 0.000 description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/32—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D313/14—[b,f]-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/74—Naphthothiophenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
- C07D337/02—Seven-membered rings
- C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D337/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D337/14—[b,f]-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
- C07C2603/26—Phenanthrenes; Hydrogenated phenanthrenes
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH665076A CH624105A5 (en) | 1976-05-26 | 1976-05-26 | Process for the preparation of novel azatetracyclic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CS225106B2 true CS225106B2 (en) | 1984-02-13 |
Family
ID=4312888
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS782988A CS225106B2 (en) | 1976-05-26 | 1977-05-26 | The production of new tetrahyro-and hexahydro-aza-tetra cyclic compounds |
| CS773475A CS225103B2 (en) | 1976-05-26 | 1977-05-26 | The production of new tetrahydro-and hexahydro-aza-tetracyclic compounds |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS773475A CS225103B2 (en) | 1976-05-26 | 1977-05-26 | The production of new tetrahydro-and hexahydro-aza-tetracyclic compounds |
Country Status (30)
| Country | Link |
|---|---|
| JP (1) | JPS52144687A (en)) |
| AR (2) | AR227608A1 (en)) |
| AT (1) | AT356114B (en)) |
| AU (1) | AU510471B2 (en)) |
| BE (1) | BE855009A (en)) |
| CA (1) | CA1104566A (en)) |
| CH (2) | CH624105A5 (en)) |
| CS (2) | CS225106B2 (en)) |
| CY (1) | CY1211A (en)) |
| DD (1) | DD131169A5 (en)) |
| DE (1) | DE2723105C2 (en)) |
| DK (1) | DK150301C (en)) |
| ES (1) | ES459070A1 (en)) |
| FI (1) | FI64582C (en)) |
| FR (1) | FR2352816A1 (en)) |
| GB (1) | GB1578266A (en)) |
| GR (1) | GR72092B (en)) |
| HK (1) | HK8784A (en)) |
| HU (1) | HU177417B (en)) |
| IE (1) | IE45204B1 (en)) |
| IL (1) | IL52168A (en)) |
| KE (1) | KE3339A (en)) |
| MY (1) | MY8500099A (en)) |
| NL (1) | NL7705707A (en)) |
| NO (1) | NO148489C (en)) |
| NZ (1) | NZ184191A (en)) |
| PT (1) | PT66588B (en)) |
| SE (1) | SE427354B (en)) |
| SG (1) | SG63683G (en)) |
| ZA (1) | ZA773161B (en)) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0030916B1 (de) * | 1979-12-10 | 1984-08-29 | Ciba-Geigy Ag | Azatetracyclische Carbonitrile |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL178593C (nl) * | 1974-01-31 | 1986-04-16 | Akzo Nv | Werkwijze ter bereiding van een farmaceutisch preparaat op basis van een tetracyclische verbinding en werkwijze voor de bereiding van de daarbij te gebruiken tetracyclische verbindingen. |
| CH592095A5 (en)) * | 1974-02-22 | 1977-10-14 | Ciba Geigy Ag |
-
1976
- 1976-05-26 CH CH665076A patent/CH624105A5/de not_active IP Right Cessation
-
1977
- 1977-05-20 CY CY1211A patent/CY1211A/xx unknown
- 1977-05-20 GB GB21304/77A patent/GB1578266A/en not_active Expired
- 1977-05-21 DE DE2723105A patent/DE2723105C2/de not_active Expired
- 1977-05-23 FR FR7715703A patent/FR2352816A1/fr active Granted
- 1977-05-24 GR GR53547A patent/GR72092B/el unknown
- 1977-05-24 CA CA278,990A patent/CA1104566A/en not_active Expired
- 1977-05-24 ES ES459070A patent/ES459070A1/es not_active Expired
- 1977-05-24 PT PT66588A patent/PT66588B/pt unknown
- 1977-05-24 DD DD7700199101A patent/DD131169A5/xx unknown
- 1977-05-24 NL NL7705707A patent/NL7705707A/xx not_active Application Discontinuation
- 1977-05-24 NZ NZ184191A patent/NZ184191A/xx unknown
- 1977-05-24 FI FI771651A patent/FI64582C/fi not_active IP Right Cessation
- 1977-05-25 IE IE1074/77A patent/IE45204B1/en not_active IP Right Cessation
- 1977-05-25 IL IL52168A patent/IL52168A/xx unknown
- 1977-05-25 SE SE7706120A patent/SE427354B/xx not_active IP Right Cessation
- 1977-05-25 HU HU77CI1744A patent/HU177417B/hu not_active IP Right Cessation
- 1977-05-25 NO NO771830A patent/NO148489C/no unknown
- 1977-05-25 AT AT372577A patent/AT356114B/de not_active IP Right Cessation
- 1977-05-25 ZA ZA00773161A patent/ZA773161B/xx unknown
- 1977-05-25 AU AU25473/77A patent/AU510471B2/en not_active Expired
- 1977-05-25 BE BE177877A patent/BE855009A/xx not_active IP Right Cessation
- 1977-05-25 DK DK229977A patent/DK150301C/da not_active IP Right Cessation
- 1977-05-26 AR AR267787A patent/AR227608A1/es active
- 1977-05-26 CS CS782988A patent/CS225106B2/cs unknown
- 1977-05-26 JP JP6057877A patent/JPS52144687A/ja active Granted
- 1977-05-26 CS CS773475A patent/CS225103B2/cs unknown
-
1978
- 1978-06-18 AR AR272606A patent/AR228124A1/es active
-
1980
- 1980-02-01 CH CH83380A patent/CH624106A5/de not_active IP Right Cessation
-
1983
- 1983-10-19 SG SG63683A patent/SG63683G/en unknown
- 1983-10-24 KE KE3339A patent/KE3339A/xx unknown
-
1984
- 1984-02-01 HK HK87/84A patent/HK8784A/xx unknown
-
1985
- 1985-12-30 MY MY99/85A patent/MY8500099A/xx unknown
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