CS221283B2 - Method of making the n-substituted thiazole derivatives of oxyimino-substituted cephalosporine - Google Patents

Method of making the n-substituted thiazole derivatives of oxyimino-substituted cephalosporine Download PDF

Info

Publication number
CS221283B2
CS221283B2 CS808518A CS851880A CS221283B2 CS 221283 B2 CS221283 B2 CS 221283B2 CS 808518 A CS808518 A CS 808518A CS 851880 A CS851880 A CS 851880A CS 221283 B2 CS221283 B2 CS 221283B2
Authority
CS
Czechoslovakia
Prior art keywords
group
compound
formula
imino
acid
Prior art date
Application number
CS808518A
Other languages
Czech (cs)
English (en)
Inventor
Ettore Perrone
Giuliano Nannini
Marco Alpegiani
Franco Giudici
Giuseppe Meinardi
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of CS221283B2 publication Critical patent/CS221283B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
CS808518A 1979-12-07 1980-12-04 Method of making the n-substituted thiazole derivatives of oxyimino-substituted cephalosporine CS221283B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7942269 1979-12-07

Publications (1)

Publication Number Publication Date
CS221283B2 true CS221283B2 (en) 1983-04-29

Family

ID=10509695

Family Applications (1)

Application Number Title Priority Date Filing Date
CS808518A CS221283B2 (en) 1979-12-07 1980-12-04 Method of making the n-substituted thiazole derivatives of oxyimino-substituted cephalosporine

Country Status (24)

Country Link
US (1) US4358448A (sv)
JP (1) JPS5692291A (sv)
AT (1) AT369747B (sv)
AU (1) AU532251B2 (sv)
BE (1) BE886534A (sv)
CA (1) CA1177481A (sv)
CS (1) CS221283B2 (sv)
DE (1) DE3043865A1 (sv)
DK (1) DK522580A (sv)
ES (1) ES497531A0 (sv)
FI (1) FI803627L (sv)
FR (1) FR2475046A1 (sv)
GR (1) GR72925B (sv)
IE (1) IE50582B1 (sv)
IL (1) IL61458A0 (sv)
IT (1) IT1193392B (sv)
LU (1) LU82979A1 (sv)
NL (1) NL8006337A (sv)
NO (1) NO803695L (sv)
NZ (1) NZ195675A (sv)
PH (1) PH17385A (sv)
PT (1) PT72173B (sv)
SE (1) SE8008540L (sv)
ZA (1) ZA807281B (sv)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL58717A (en) * 1978-11-15 1983-05-15 Glaxo Group Ltd Derivatives of(6r,7r)-7-((z)-2-(2-aminothiazol-4-yl)-2-(carboxy-(lower alkyl or cycloalkyl)oxyimino)acetamido)-3-(2-alkyl-pyrazolium-1-ylmethyl)ceph-3-em-4-carboxylate,process for their preparation and pharmaceutical compositions comprising them
IL74822A (en) * 1984-04-17 1989-06-30 Daiichi Seiyaku Co Cephalosporin derivatives and salts thereof and their preparation
GB8410993D0 (en) * 1984-04-30 1984-06-06 Glaxo Group Ltd Process
GB8410991D0 (en) * 1984-04-30 1984-06-06 Glaxo Group Ltd Process
EP0225634B1 (en) * 1985-12-13 1994-04-06 Takeda Chemical Industries, Ltd. Antibacterial compounds, their production and use

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2345153A1 (fr) * 1976-03-25 1977-10-21 Roussel Uclaf Nouvelles alcoyloximes derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
JPS5946237B2 (ja) * 1976-04-02 1984-11-10 武田薬品工業株式会社 セフアロスポリン誘導体およびその製造法
GB1576625A (en) * 1976-04-12 1980-10-08 Fujisawa Pharmaceutical Co Syn isomer 3,7 disubstituted 3 cephem 4 carboxylic acid compounds and processes for the preparation thereof
DK162391C (da) * 1976-04-12 1992-03-09 Fujisawa Pharmaceutical Co Analogifremgangsmaade til fremstilling af syn-isomerer af 3,7-disubstituerede 3-cephem-4-carboxylsyreforbindelser
FR2361895A1 (fr) * 1976-08-20 1978-03-17 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-carbamoyloxymethyl 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
FR2384779A1 (fr) * 1977-03-25 1978-10-20 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-chloro ou 3-methoxy 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
DE2715495A1 (de) * 1977-04-06 1978-10-19 Cusi Lab Neue cephalosporinverbindungen, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
JPS609719B2 (ja) * 1977-08-06 1985-03-12 武田薬品工業株式会社 セフアロスポリン誘導体およびその製造法
FR2387235A1 (fr) 1978-01-23 1978-11-10 Fujisawa Pharmaceutical Co Procede de preparation de composes d'acide 3,7-disubstitue-3-cephem-4-carboxylique et nouveaux produits ainsi obtenus, ayant une forte activite antibacterienne
FR2432521A1 (fr) * 1978-03-31 1980-02-29 Roussel Uclaf Nouvelles oximes o-substituees derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments

Also Published As

Publication number Publication date
SE8008540L (sv) 1981-06-08
NO803695L (no) 1981-06-09
JPS5692291A (en) 1981-07-25
ATA596380A (de) 1982-06-15
AU6434380A (en) 1981-06-11
AU532251B2 (en) 1983-09-22
IL61458A0 (en) 1980-12-31
ES8200371A1 (es) 1981-10-16
PT72173B (en) 1983-01-10
ZA807281B (en) 1981-11-25
FR2475046A1 (fr) 1981-08-07
NZ195675A (en) 1983-05-31
IE50582B1 (en) 1986-05-14
IT8026400A0 (it) 1980-12-03
NL8006337A (nl) 1981-07-01
LU82979A1 (fr) 1981-03-26
AT369747B (de) 1983-01-25
PH17385A (en) 1984-08-08
ES497531A0 (es) 1981-10-16
IE802552L (en) 1981-06-07
BE886534A (fr) 1981-06-05
DK522580A (da) 1981-06-08
FI803627L (fi) 1981-06-08
IT1193392B (it) 1988-06-15
CA1177481A (en) 1984-11-06
DE3043865A1 (de) 1981-09-03
US4358448A (en) 1982-11-09
PT72173A (en) 1981-01-01
GR72925B (sv) 1984-01-11
FR2475046B1 (sv) 1984-07-13

Similar Documents

Publication Publication Date Title
US4080498A (en) 7-Alpha-(2-aminothiazole)-acetamido-cephalosporins
SE447384B (sv) Forfarande for framstellning av cefalosporinderivat
DE3688477T2 (de) Antibakterielle verbindungen, ihre herstellung und verwendung.
KR910000035B1 (ko) 세팔로스포린 화합물, 이의 제법 및 이를 함유하는 약학적 조성물
CS199714B2 (en) Process for preparing heteromonocyclic and heterobicyclic derivatives of unsaturated 7-acylamido-3-cephem-4-carboxylic acids
KR920008953B1 (ko) 항균 화합물의 제조방법
US4331666A (en) 3-[(8-Carboxy-6-tetrazolo[1,5-b]pyridazinyl)-thiomethyl]-7-[2-(2-amino-4-thiazolyl)-2-methoxyimino-acetamido]-3-cephem-4-carboxylic acid
NO852294L (no) Fremgangsmaate for fremstilling av antibakterielt virksomme cefemforbindelser.
GB2071654A (en) Hydroxamic acid derivatives of 7-(2-amino-4-thiazolyl)oximino cephalosporins
CS221283B2 (en) Method of making the n-substituted thiazole derivatives of oxyimino-substituted cephalosporine
US4145418A (en) Thienopyridine substituted cephalosporins
DE2620094A1 (de) Cephalosporinverbindungen und verfahren zu ihrer herstellung
US4092480A (en) Intermediates for preparing substituted phenylglycylcephalosporins
US4379924A (en) Cephalosporin derivatives
US5484928A (en) 2-(2-aminothiazol-4-yl)-2-oxoacetic acid derivatives
US4044047A (en) Intermediates for preparing substituted phenylglycylcephalosporins
SE454512B (sv) 7beta-isotiazolyltioacetamido-7alfa-metoxicefalosporansyraderivat
US4022895A (en) Substituted phenylglycylcephalosporins
US4013764A (en) Pharmaceutical compositions comprising substituted phenylglycylcephalosporins and methods of treating bacterial infections
NL8000815A (nl) Nieuwe oximen, die aan het zuurstofatoom gesubstitueerd zijn door een quaternair ammonium- -bevattende groep en afgeleid zijn van 7-aminothia- zolylaceetamidocefalosporaanzuur, werkwijze voor hun bereiding, hun toepassing als geneesmiddelen en farmacologische samenstellingen, die deze verbindingen bevatten.
WO1985005106A1 (en) Cephem compounds
DE2651386A1 (de) Cephemderivate und verfahren zu ihrer herstellung
EP0257275A2 (en) Cephalosporin and penicillin derivatives
IE51464B1 (en) New cephalosporin derivatives,their production and their use
WO1985004879A1 (fr) Nouveaux composes de cephem