CS202545B2 - Method of preparing living vaccine from influenza virus for nasal application - Google Patents
Method of preparing living vaccine from influenza virus for nasal application Download PDFInfo
- Publication number
- CS202545B2 CS202545B2 CS75669A CS66975A CS202545B2 CS 202545 B2 CS202545 B2 CS 202545B2 CS 75669 A CS75669 A CS 75669A CS 66975 A CS66975 A CS 66975A CS 202545 B2 CS202545 B2 CS 202545B2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- strain
- virus
- influenza
- atcc
- attenuated
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title claims abstract description 40
- 241000712461 unidentified influenza virus Species 0.000 title claims description 23
- 238000000034 method Methods 0.000 title claims description 17
- 241000700605 Viruses Species 0.000 claims abstract description 41
- 241000287828 Gallus gallus Species 0.000 claims abstract description 31
- 230000002238 attenuated effect Effects 0.000 claims abstract description 30
- 239000000203 mixture Substances 0.000 claims abstract description 20
- 239000001888 Peptone Substances 0.000 claims abstract description 19
- 108010080698 Peptones Proteins 0.000 claims abstract description 19
- 235000019319 peptone Nutrition 0.000 claims abstract description 19
- 206010022000 influenza Diseases 0.000 claims abstract description 14
- 239000003381 stabilizer Substances 0.000 claims abstract description 9
- 230000000890 antigenic effect Effects 0.000 claims abstract description 6
- 239000004480 active ingredient Substances 0.000 claims abstract description 5
- 241000713196 Influenza B virus Species 0.000 claims description 20
- 238000002360 preparation method Methods 0.000 claims description 19
- 241000712431 Influenza A virus Species 0.000 claims description 7
- 238000005215 recombination Methods 0.000 claims description 7
- 230000006798 recombination Effects 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 5
- 241000283690 Bos taurus Species 0.000 claims description 3
- 239000000758 substrate Substances 0.000 claims description 3
- 210000003837 chick embryo Anatomy 0.000 claims description 2
- 208000037797 influenza A Diseases 0.000 claims description 2
- 230000008569 process Effects 0.000 claims description 2
- 210000005084 renal tissue Anatomy 0.000 claims description 2
- 235000013330 chicken meat Nutrition 0.000 claims 3
- 229940031567 attenuated vaccine Drugs 0.000 claims 1
- 210000003754 fetus Anatomy 0.000 claims 1
- 235000013601 eggs Nutrition 0.000 abstract description 29
- 229940124873 Influenza virus vaccine Drugs 0.000 abstract description 6
- 241000701076 Macacine alphaherpesvirus 1 Species 0.000 abstract description 4
- 229960003971 influenza vaccine Drugs 0.000 abstract description 2
- 239000003550 marker Substances 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 description 33
- 239000012530 fluid Substances 0.000 description 20
- 210000002257 embryonic structure Anatomy 0.000 description 19
- 239000002054 inoculum Substances 0.000 description 13
- 239000000725 suspension Substances 0.000 description 10
- 238000010790 dilution Methods 0.000 description 9
- 239000012895 dilution Substances 0.000 description 9
- 238000002255 vaccination Methods 0.000 description 9
- 230000003612 virological effect Effects 0.000 description 9
- 239000011521 glass Substances 0.000 description 8
- 239000003112 inhibitor Substances 0.000 description 8
- 210000003928 nasal cavity Anatomy 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 241001494479 Pecora Species 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 238000011534 incubation Methods 0.000 description 6
- 238000011081 inoculation Methods 0.000 description 6
- 239000011780 sodium chloride Substances 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 241000831652 Salinivibrio sharmensis Species 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 210000003743 erythrocyte Anatomy 0.000 description 5
- 230000035931 haemagglutination Effects 0.000 description 5
- 230000036512 infertility Effects 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 4
- 244000052616 bacterial pathogen Species 0.000 description 4
- 230000001717 pathogenic effect Effects 0.000 description 4
- 241000282339 Mustela Species 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000009021 pre-vaccination Methods 0.000 description 3
- 241000271566 Aves Species 0.000 description 2
- 101710154606 Hemagglutinin Proteins 0.000 description 2
- 101710093908 Outer capsid protein VP4 Proteins 0.000 description 2
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 description 2
- 101710176177 Protein A56 Proteins 0.000 description 2
- 210000001643 allantois Anatomy 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000001747 exhibiting effect Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000000185 hemagglutinin Substances 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000000405 serological effect Effects 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 241000353621 Eilat virus Species 0.000 description 1
- 241001500351 Influenzavirus A Species 0.000 description 1
- 241001500350 Influenzavirus B Species 0.000 description 1
- 241000282341 Mustela putorius furo Species 0.000 description 1
- 206010028735 Nasal congestion Diseases 0.000 description 1
- 206010062106 Respiratory tract infection viral Diseases 0.000 description 1
- 208000036071 Rhinorrhea Diseases 0.000 description 1
- 206010039101 Rhinorrhoea Diseases 0.000 description 1
- 230000027645 antigenic variation Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 229940031416 bivalent vaccine Drugs 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- AIUDWMLXCFRVDR-UHFFFAOYSA-N dimethyl 2-(3-ethyl-3-methylpentyl)propanedioate Chemical class CCC(C)(CC)CCC(C(=O)OC)C(=O)OC AIUDWMLXCFRVDR-UHFFFAOYSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000032050 esterification Effects 0.000 description 1
- 238000005886 esterification reaction Methods 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 229940031551 inactivated vaccine Drugs 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 208000037798 influenza B Diseases 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 229960001226 live attenuated influenza Drugs 0.000 description 1
- 210000001161 mammalian embryo Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229940037525 nasal preparations Drugs 0.000 description 1
- 210000001989 nasopharynx Anatomy 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- XULSCZPZVQIMFM-IPZQJPLYSA-N odevixibat Chemical compound C12=CC(SC)=C(OCC(=O)N[C@@H](C(=O)N[C@@H](CC)C(O)=O)C=3C=CC(O)=CC=3)C=C2S(=O)(=O)NC(CCCC)(CCCC)CN1C1=CC=CC=C1 XULSCZPZVQIMFM-IPZQJPLYSA-N 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 229940066779 peptones Drugs 0.000 description 1
- 239000008063 pharmaceutical solvent Substances 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 210000001533 respiratory mucosa Anatomy 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43917674A | 1974-02-04 | 1974-02-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CS202545B2 true CS202545B2 (en) | 1981-01-30 |
Family
ID=23743623
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS75669A CS202545B2 (en) | 1974-02-04 | 1975-02-03 | Method of preparing living vaccine from influenza virus for nasal application |
Country Status (21)
| Country | Link |
|---|---|
| JP (1) | JPS50107122A (en。) |
| AT (1) | AT338416B (en。) |
| BE (1) | BE824970A (en。) |
| CA (1) | CA1047922A (en。) |
| CH (1) | CH596316A5 (en。) |
| CS (1) | CS202545B2 (en。) |
| DD (1) | DD116474A5 (en。) |
| DE (1) | DE2504373A1 (en。) |
| DK (1) | DK141926B (en。) |
| ES (1) | ES434384A1 (en。) |
| FI (1) | FI750260A7 (en。) |
| FR (1) | FR2259616B1 (en。) |
| GB (1) | GB1439742A (en。) |
| HU (1) | HU170522B (en。) |
| IE (1) | IE42043B1 (en。) |
| IL (1) | IL46446A (en。) |
| LU (1) | LU71784A1 (en。) |
| NL (1) | NL7501028A (en。) |
| NO (1) | NO750295L (en。) |
| SE (1) | SE424503B (en。) |
| ZA (1) | ZA75248B (en。) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2588918A (en) * | 1947-11-07 | 1952-03-11 | William T Graham | Mechanism for raising and lowering plow frames relative to the ground wheels |
| JPS6042209B2 (ja) * | 1974-05-31 | 1985-09-20 | 北里研究所（社団法人） | インフルエンザウイルスの新鮮分離株を発育鶏卵へ短期間で順化させる方法 |
-
1975
- 1975-01-14 ZA ZA00750248A patent/ZA75248B/xx unknown
- 1975-01-16 IL IL46446A patent/IL46446A/xx unknown
- 1975-01-16 DK DK9775AA patent/DK141926B/da not_active IP Right Cessation
- 1975-01-20 SE SE7500549A patent/SE424503B/xx unknown
- 1975-01-23 CA CA218,508A patent/CA1047922A/en not_active Expired
- 1975-01-24 FR FR7502331A patent/FR2259616B1/fr not_active Expired
- 1975-01-27 IE IE160/75A patent/IE42043B1/en unknown
- 1975-01-29 NL NL7501028A patent/NL7501028A/xx not_active Application Discontinuation
- 1975-01-30 BE BE152864A patent/BE824970A/xx not_active IP Right Cessation
- 1975-01-30 NO NO750295A patent/NO750295L/no unknown
- 1975-01-31 FI FI750260A patent/FI750260A7/fi not_active Application Discontinuation
- 1975-02-01 ES ES434384A patent/ES434384A1/es not_active Expired
- 1975-02-03 GB GB453575A patent/GB1439742A/en not_active Expired
- 1975-02-03 AT AT76675A patent/AT338416B/de not_active IP Right Cessation
- 1975-02-03 DD DD183973A patent/DD116474A5/xx unknown
- 1975-02-03 CH CH124275A patent/CH596316A5/xx not_active IP Right Cessation
- 1975-02-03 JP JP50014790A patent/JPS50107122A/ja active Pending
- 1975-02-03 HU HUTE805A patent/HU170522B/hu unknown
- 1975-02-03 DE DE19752504373 patent/DE2504373A1/de not_active Withdrawn
- 1975-02-03 CS CS75669A patent/CS202545B2/cs unknown
- 1975-02-03 LU LU71784A patent/LU71784A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SE424503B (sv) | 1982-07-26 |
| ATA76675A (de) | 1976-12-15 |
| LU71784A1 (en。) | 1975-06-24 |
| DK9775A (en。) | 1975-09-29 |
| HU170522B (en。) | 1977-06-28 |
| NL7501028A (nl) | 1975-08-06 |
| CA1047922A (en) | 1979-02-06 |
| NO750295L (en。) | 1975-09-01 |
| DD116474A5 (en。) | 1975-11-20 |
| CH596316A5 (en。) | 1978-03-15 |
| FR2259616B1 (en。) | 1980-01-04 |
| FR2259616A1 (en。) | 1975-08-29 |
| GB1439742A (en) | 1976-06-16 |
| ES434384A1 (es) | 1976-12-01 |
| ZA75248B (en) | 1976-01-28 |
| AT338416B (de) | 1977-08-25 |
| IE42043B1 (en) | 1980-05-21 |
| DE2504373A1 (de) | 1975-08-07 |
| JPS50107122A (en。) | 1975-08-23 |
| BE824970A (fr) | 1975-07-30 |
| DK141926B (da) | 1980-07-21 |
| SE7500549L (en。) | 1975-08-05 |
| FI750260A7 (en。) | 1975-08-05 |
| AU7734675A (en) | 1976-07-15 |
| DK141926C (en。) | 1981-01-19 |
| IL46446A (en) | 1978-01-31 |
| IL46446A0 (en) | 1975-04-25 |
| IE42043L (en) | 1975-08-04 |
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