CS195707B2 - Method of producing novel n up 4-substituted derivatives of 1,3,4,5-tetrahydro-2h-1,4-benzodiazepine-2-one - Google Patents

Method of producing novel n up 4-substituted derivatives of 1,3,4,5-tetrahydro-2h-1,4-benzodiazepine-2-one Download PDF

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Publication number
CS195707B2
CS195707B2 CS754443A CS444375A CS195707B2 CS 195707 B2 CS195707 B2 CS 195707B2 CS 754443 A CS754443 A CS 754443A CS 444375 A CS444375 A CS 444375A CS 195707 B2 CS195707 B2 CS 195707B2
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CS
Czechoslovakia
Prior art keywords
formula
compound
defined above
tetrahydro
reaction
Prior art date
Application number
CS754443A
Other languages
Czech (cs)
English (en)
Inventor
Lajos Kisfaludy
Julianna Roehricht
Laszlo Ueroegdi
Szabolcs Szeberenyi
Eva Palosi
Laszlo Szporny
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of CS195707B2 publication Critical patent/CS195707B2/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/26—Preparation from compounds already containing the benzodiazepine skeleton

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CS754443A 1974-06-25 1975-06-23 Method of producing novel n up 4-substituted derivatives of 1,3,4,5-tetrahydro-2h-1,4-benzodiazepine-2-one CS195707B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HURI540A HU170623B (nl) 1974-06-25 1974-06-25

Publications (1)

Publication Number Publication Date
CS195707B2 true CS195707B2 (en) 1980-02-29

Family

ID=11000952

Family Applications (1)

Application Number Title Priority Date Filing Date
CS754443A CS195707B2 (en) 1974-06-25 1975-06-23 Method of producing novel n up 4-substituted derivatives of 1,3,4,5-tetrahydro-2h-1,4-benzodiazepine-2-one

Country Status (21)

Country Link
US (1) US4021421A (nl)
JP (2) JPS541716B2 (nl)
AT (1) AT344698B (nl)
AU (1) AU499054B2 (nl)
BE (1) BE830582A (nl)
BG (2) BG32570A3 (nl)
CA (1) CA1047493A (nl)
CH (2) CH632254A5 (nl)
CS (1) CS195707B2 (nl)
DD (1) DD123887A5 (nl)
DE (1) DE2527901A1 (nl)
DK (1) DK284675A (nl)
FR (1) FR2276054A1 (nl)
GB (1) GB1509445A (nl)
HU (1) HU170623B (nl)
IL (1) IL47495A (nl)
NL (1) NL7507556A (nl)
PL (1) PL101952B1 (nl)
SE (1) SE423711B (nl)
SU (1) SU1080744A3 (nl)
YU (1) YU161075A (nl)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU187262B (en) * 1979-08-16 1985-12-28 Richter Gedeon Vegyeszet Process for preparing new tetrahydro-1,4-benzodiazepin-2-ones
WO2000073284A2 (en) * 1999-05-26 2000-12-07 Du Pont Pharmaceuticals Company 1,4-benzodiazepin-2-ones useful as hiv reverse transcriptase inhibitors
CN105716725B (zh) * 2016-03-10 2019-02-12 中国科学院光电技术研究所 一种基于叠层扫描的相位差波前探测和图像复原方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3236838A (en) * 1964-06-09 1966-02-22 Hoffmann La Roche Certain 1-substituted-benzodiazepin-2-one compounds

Also Published As

Publication number Publication date
FR2276054A1 (fr) 1976-01-23
AU8223875A (en) 1976-12-23
JPS6026113B2 (ja) 1985-06-21
US4021421A (en) 1977-05-03
DK284675A (da) 1975-12-26
BG32569A3 (en) 1982-08-16
YU161075A (en) 1983-01-21
PL101952B1 (pl) 1979-02-28
CH634835A5 (de) 1983-02-28
JPS5377079A (en) 1978-07-08
IL47495A0 (en) 1975-08-31
CH632254A5 (de) 1982-09-30
BG32570A3 (en) 1982-08-16
BE830582A (fr) 1975-10-16
SE7507039L (sv) 1975-12-29
HU170623B (nl) 1977-07-28
SE423711B (sv) 1982-05-24
CA1047493A (en) 1979-01-30
ATA481975A (de) 1977-12-15
JPS541716B2 (nl) 1979-01-27
AT344698B (de) 1978-08-10
FR2276054B1 (nl) 1979-08-10
GB1509445A (en) 1978-05-04
DD123887A5 (nl) 1977-01-19
SU1080744A3 (ru) 1984-03-15
IL47495A (en) 1979-03-12
AU499054B2 (en) 1979-04-05
NL7507556A (nl) 1975-12-30
DE2527901A1 (de) 1976-01-15
JPS5119783A (nl) 1976-02-17

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