CS134492A3 - Piperazine derivatives, process of their preparation and pharmaceuticalscontaining thereof - Google Patents
Piperazine derivatives, process of their preparation and pharmaceuticalscontaining thereofInfo
- Publication number
- CS134492A3 CS134492A3 CS921344A CS134492A CS134492A3 CS 134492 A3 CS134492 A3 CS 134492A3 CS 921344 A CS921344 A CS 921344A CS 134492 A CS134492 A CS 134492A CS 134492 A3 CS134492 A3 CS 134492A3
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- aryl
- lower alkyl
- cycloalkyl
- opt
- heteroaryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB919109475A GB9109475D0 (en) | 1991-05-02 | 1991-05-02 | Piperazine derivatives |
GB919127189A GB9127189D0 (en) | 1991-12-21 | 1991-12-21 | Piperazine derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
CS134492A3 true CS134492A3 (en) | 1992-10-14 |
CZ286778B6 CZ286778B6 (cs) | 2000-07-12 |
Family
ID=26298819
Country Status (24)
Country | Link |
---|---|
US (1) | US6127357A (cs) |
EP (1) | EP0512755B1 (cs) |
JP (1) | JP3095521B2 (cs) |
KR (1) | KR100203254B1 (cs) |
CN (2) | CN1040106C (cs) |
AT (1) | ATE115566T1 (cs) |
AU (1) | AU645681B2 (cs) |
BR (1) | BR9201624A (cs) |
CA (1) | CA2067929C (cs) |
CZ (1) | CZ286778B6 (cs) |
DE (1) | DE69200893T2 (cs) |
DK (1) | DK0512755T3 (cs) |
ES (1) | ES2065133T3 (cs) |
FI (1) | FI108720B (cs) |
GB (1) | GB2255337B (cs) |
HK (1) | HK1003001A1 (cs) |
HU (2) | HU223527B1 (cs) |
IE (1) | IE64634B1 (cs) |
IL (1) | IL101722A (cs) |
MX (1) | MX9201991A (cs) |
MY (1) | MY107756A (cs) |
RU (1) | RU2193561C2 (cs) |
SK (1) | SK280133B6 (cs) |
UA (1) | UA39917C2 (cs) |
Families Citing this family (100)
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AU645681B2 (en) * | 1991-05-02 | 1994-01-20 | John Wyeth & Brother Limited | Piperazine derivatives |
GB9223153D0 (en) * | 1992-11-05 | 1992-12-16 | Wyeth John & Brother Ltd | Piperazine derivatives |
GB9300195D0 (en) * | 1993-01-06 | 1993-03-03 | Wyeth John & Brother Ltd | Piperazine derivatives |
GB9302622D0 (en) * | 1993-02-10 | 1993-03-24 | Wellcome Found | Heteroaromatic compounds |
GB9303968D0 (en) * | 1993-02-26 | 1993-04-14 | Wyeth John & Brother Ltd | 5-ht1a ligands |
GB9305672D0 (en) * | 1993-03-19 | 1993-05-05 | Wyeth John & Brother Ltd | Amide derivatives |
GB9306103D0 (en) * | 1993-03-24 | 1993-05-12 | Wyeth John & Brother Ltd | Piperazine derivatives |
FR2707294B1 (fr) * | 1993-07-06 | 1995-09-29 | Pf Medicament | Nouveaux dérivés de la 3,5-dioxo-(2H,4H)-1,2,4-triazine, leur préparation et leur application en thérapeutique humaine. |
GB9314758D0 (en) * | 1993-07-16 | 1993-08-25 | Wyeth John & Brother Ltd | Heterocyclic derivatives |
US5609849A (en) * | 1994-03-11 | 1997-03-11 | The Trustees Of The University Of Pennsylvania | Serotonin (5-HT1A) receptor ligands and imaging agents |
GB9411099D0 (en) * | 1994-06-03 | 1994-07-27 | Wyeth John & Brother Ltd | Piperazine derivatives |
DK0763024T3 (da) * | 1994-06-03 | 2002-12-02 | Wyeth John & Brother Ltd | Fremgangmåde og mellemprodukter til fremstilling af piperazinderivater |
DE4425146A1 (de) * | 1994-07-15 | 1996-01-18 | Basf Ag | Verwendung heterocyclischer Verbindungen |
US6231833B1 (en) | 1999-08-05 | 2001-05-15 | Pfizer Inc | 2,7-substituted octahydro-1H-pyrido[1,2-A]pyrazine derivatives as ligands for serotonin receptors |
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US5541179A (en) * | 1995-05-02 | 1996-07-30 | American Home Products Corporation | Tropon-2-one piperazine carboxamides as serotonergic agents |
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DE69607904T2 (de) * | 1995-08-16 | 2000-10-05 | Lilly Co Eli | Potenzierung von Serotonin-Wirkstoffresponz |
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FR2753968B1 (fr) * | 1996-09-27 | 1998-11-27 | Sod Conseils Rech Applic | Nouvelles heteroaryloxyethylamines, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
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EP3718536A1 (en) | 2012-09-19 | 2020-10-07 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions having improved storage stability |
CN103864761B (zh) * | 2014-03-12 | 2016-01-20 | 天津药物研究院有限公司 | 一种含吡啶的哌嗪类衍生物及其制备方法和用途 |
MA39495A (fr) | 2014-03-20 | 2015-09-24 | Alkermes Pharma Ireland Ltd | Formulations d'aripiprazole présentant des vitesses d'injection plus élevées |
KR101556571B1 (ko) | 2014-03-31 | 2015-10-01 | (주)월드트렌드 | 장식용 보석을 체결할 수 있는 안경 |
UY36390A (es) | 2014-11-05 | 2016-06-01 | Flexus Biosciences Inc | Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen |
MX2017005462A (es) | 2014-11-05 | 2017-07-28 | Flexus Biosciences Inc | Agentes inmunorreguladores. |
MA41168A (fr) * | 2014-12-17 | 2017-10-24 | Acraf | Nouveaux composés antibactériens |
HUE049547T2 (hu) * | 2016-06-08 | 2020-10-28 | Acraf | Új baktériumellenes szerek |
EP3761983A1 (en) | 2018-03-05 | 2021-01-13 | Alkermes Pharma Ireland Limited | Aripiprazole dosing strategy |
KR20210076226A (ko) | 2019-12-13 | 2021-06-24 | 주식회사 에피바이오텍 | 피페라진 유도체를 포함하는 탈모의 예방 또는 치료용 조성물 |
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GB9411099D0 (en) * | 1994-06-03 | 1994-07-27 | Wyeth John & Brother Ltd | Piperazine derivatives |
-
1992
- 1992-04-29 AU AU15241/92A patent/AU645681B2/en not_active Ceased
- 1992-04-29 IL IL10172292A patent/IL101722A/en active IP Right Grant
- 1992-04-29 MX MX9201991A patent/MX9201991A/es active IP Right Grant
- 1992-04-30 RU SU5011552/04A patent/RU2193561C2/ru active
- 1992-04-30 GB GB9209340A patent/GB2255337B/en not_active Expired - Fee Related
- 1992-04-30 FI FI921942A patent/FI108720B/fi active
- 1992-04-30 AT AT92303918T patent/ATE115566T1/de not_active IP Right Cessation
- 1992-04-30 EP EP92303918A patent/EP0512755B1/en not_active Expired - Lifetime
- 1992-04-30 HU HU9201462A patent/HU223527B1/hu not_active IP Right Cessation
- 1992-04-30 DK DK92303918.4T patent/DK0512755T3/da active
- 1992-04-30 DE DE69200893T patent/DE69200893T2/de not_active Expired - Lifetime
- 1992-04-30 ES ES92303918T patent/ES2065133T3/es not_active Expired - Lifetime
- 1992-04-30 BR BR929201624A patent/BR9201624A/pt not_active Application Discontinuation
- 1992-04-30 MY MYPI92000746A patent/MY107756A/en unknown
- 1992-05-01 CA CA002067929A patent/CA2067929C/en not_active Expired - Lifetime
- 1992-05-01 JP JP04112527A patent/JP3095521B2/ja not_active Expired - Fee Related
- 1992-05-02 CN CN92103153A patent/CN1040106C/zh not_active Expired - Fee Related
- 1992-05-02 KR KR1019920007528A patent/KR100203254B1/ko not_active IP Right Cessation
- 1992-05-04 CZ CS19921344A patent/CZ286778B6/cs not_active IP Right Cessation
- 1992-05-04 SK SK1344-92A patent/SK280133B6/sk not_active IP Right Cessation
- 1992-07-01 IE IE921409A patent/IE64634B1/en not_active IP Right Cessation
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1993
- 1993-06-15 UA UA93002895A patent/UA39917C2/uk unknown
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1995
- 1995-05-11 US US08/438,812 patent/US6127357A/en not_active Expired - Fee Related
- 1995-06-22 HU HU95P/P00338P patent/HU211148A9/hu unknown
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1996
- 1996-12-06 CN CN96118586A patent/CN1084619C/zh not_active Expired - Fee Related
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1998
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
IF00 | In force as of 2000-06-30 in czech republic | ||
MM4A | Patent lapsed due to non-payment of fee |
Effective date: 20090504 |