CR9937A - Composiciones farmaceuticas de galio y metodos - Google Patents

Composiciones farmaceuticas de galio y metodos

Info

Publication number
CR9937A
CR9937A CR9937A CR9937A CR9937A CR 9937 A CR9937 A CR 9937A CR 9937 A CR9937 A CR 9937A CR 9937 A CR9937 A CR 9937A CR 9937 A CR9937 A CR 9937A
Authority
CR
Costa Rica
Prior art keywords
pharmaceutical compositions
gallium
galio
methods
complexes
Prior art date
Application number
CR9937A
Other languages
English (en)
Inventor
N Julian Thomas
Original Assignee
Genta Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genta Inc filed Critical Genta Inc
Publication of CR9937A publication Critical patent/CR9937A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/76—Metal complexes of amino carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/06—Chelate

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invencion se refiere a nuevas composiciones farmaceuticas de galio, que incluyen complejos de galio que tienen biodisponibilidad oral incrementada, con relacion a sales de galio no formadas en complejos. Tales composiciones son empleadas en el tratamiento de condiciones y enfermedades en las cuales, la inhibicion de la resorpcion anormalmente incrementada de calcio se desea, que incluye cancer, hipercalcemia, osteoporosis, osteopenia y enfermedad de Paget. Tambien se proporcionan metodos de preparacion.
CR9937A 2005-11-04 2008-04-28 Composiciones farmaceuticas de galio y metodos CR9937A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73338805P 2005-11-04 2005-11-04

Publications (1)

Publication Number Publication Date
CR9937A true CR9937A (es) 2008-06-26

Family

ID=38023756

Family Applications (1)

Application Number Title Priority Date Filing Date
CR9937A CR9937A (es) 2005-11-04 2008-04-28 Composiciones farmaceuticas de galio y metodos

Country Status (13)

Country Link
US (3) US7354952B2 (es)
EP (1) EP1948159A4 (es)
JP (1) JP2009514856A (es)
KR (1) KR20080072830A (es)
CN (1) CN101296694A (es)
AU (1) AU2006312117A1 (es)
BR (1) BRPI0618096A2 (es)
CA (1) CA2626029A1 (es)
CR (1) CR9937A (es)
EA (1) EA200801261A1 (es)
IL (1) IL190239A0 (es)
WO (1) WO2007055885A2 (es)
ZA (1) ZA200803283B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2535311T3 (es) * 2004-12-29 2015-05-08 Emisphere Technologies, Inc. Formulaciones farmacéuticas de sales de galio
US7354952B2 (en) * 2005-11-04 2008-04-08 Genta Incorporated Pharmaceutical gallium compositions and methods
MX2010004716A (es) 2007-11-02 2010-12-17 Emisphere Tech Inc Metodo para tratar la deficiencia de vitamina b12.
US20090275654A1 (en) * 2008-04-30 2009-11-05 Genta Incorporated Pharmaceutical Gallium Compositions and Methods
WO2010114861A1 (en) * 2009-03-30 2010-10-07 Niiki Pharma Inc. Method of treating osteoporosis
US20110318265A1 (en) * 2009-04-07 2011-12-29 Bernstein Lawrence R Coupled identification and treatment of cancer
WO2010129031A1 (en) * 2009-05-05 2010-11-11 Map Pharmaceuticals, Inc. Gallium complexes with polyalcohols and methods of use
KR20130026429A (ko) * 2010-02-24 2013-03-13 에미스페어 테크놀로지스, 인코포레이티드 경구 ｂ12 치료요법
US20120245135A1 (en) * 2011-03-24 2012-09-27 Genta Incorporated Gallium Complexes, Pharmaceutical Compositions And Methods Of Use
US9205108B2 (en) 2012-08-13 2015-12-08 Jan M. Troup Treatment of traumatic brain injury by using gallium compounds to reduce oxidative stress levels
BR112015003761B1 (pt) * 2012-08-23 2022-02-15 Emisphere Technologies, Inc Composto, composição farmacêutica, forma unitária de dosageme método para preparar uma composição
RU2019128191A (ru) * 2017-02-10 2021-03-10 Альтум Фармасьютикалз Инк. Композиции комплексов галлия (iii) для перорального введения
US10507218B2 (en) 2018-02-22 2019-12-17 Lipidrisk, Llc Treatment of cardiovascular disease by using gallium compounds to bind calcified lesions

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5574027A (en) 1989-11-22 1996-11-12 Bernstein; Lawrence R. Pharmaceutical compositions of gallium complexes of 3-hydroxy-4-pyrones
US6004951A (en) 1989-11-22 1999-12-21 Bernstein; Lawrence Richard Administration of gallium complexes of 3-hydroxy-4-pyrones to provide physiologically active gallium levels in a mammalian individual
US5258376A (en) 1989-11-22 1993-11-02 Bernstein Lawrence R Pharmaceutical compositions of gallium complexes of 3-hydroxy-4-pyrones
WO1991017751A1 (en) 1990-05-24 1991-11-28 Fujisawa, Inc. Orally administrable gallium compositions and methods of treatment therewith
US5196412A (en) 1991-03-06 1993-03-23 Johnson Matthey, Inc. Gallium compounds
GB9111689D0 (en) * 1991-05-31 1991-07-24 Johnson Matthey Plc Gallium compounds
US5525598A (en) 1991-07-25 1996-06-11 Phillippe Collery Gallium (III) complexes in pharmaceutical compositions
US5866536A (en) 1995-03-31 1999-02-02 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5650386A (en) 1995-03-31 1997-07-22 Emisphere Technologies, Inc. Compositions for oral delivery of active agents
DE60133555T2 (de) 2000-06-29 2008-09-18 Emisphere Technologies, Inc. Verbindungen und gemische zur verabreichung eines aktiven agens
MXPA04004567A (es) 2001-11-13 2004-09-10 Emisphere Tech Inc Compuestos y composiciones de fenoxi amina para adminstrar agentes activos.
US20050147662A1 (en) 2003-12-19 2005-07-07 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
ES2535311T3 (es) 2004-12-29 2015-05-08 Emisphere Technologies, Inc. Formulaciones farmacéuticas de sales de galio
US7354952B2 (en) * 2005-11-04 2008-04-08 Genta Incorporated Pharmaceutical gallium compositions and methods

Also Published As

Publication number Publication date
US7842724B2 (en) 2010-11-30
AU2006312117A1 (en) 2007-05-18
CN101296694A (zh) 2008-10-29
EP1948159A4 (en) 2011-10-12
CA2626029A1 (en) 2007-05-18
JP2009514856A (ja) 2009-04-09
EA200801261A1 (ru) 2008-08-29
US20080166296A1 (en) 2008-07-10
US7354952B2 (en) 2008-04-08
US20070105953A1 (en) 2007-05-10
WO2007055885A3 (en) 2007-07-12
WO2007055885A2 (en) 2007-05-18
BRPI0618096A2 (pt) 2011-08-16
KR20080072830A (ko) 2008-08-07
US7456215B2 (en) 2008-11-25
ZA200803283B (en) 2009-11-25
IL190239A0 (en) 2008-11-03
US20080160103A1 (en) 2008-07-03
EP1948159A2 (en) 2008-07-30

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