CR20180564A - Nuevos derivados piperidinilo, un proceso para su preparación y composiciones farmacéuticas que lo contienen - Google Patents

Nuevos derivados piperidinilo, un proceso para su preparación y composiciones farmacéuticas que lo contienen

Info

Publication number
CR20180564A
CR20180564A CR20180564A CR20180564A CR20180564A CR 20180564 A CR20180564 A CR 20180564A CR 20180564 A CR20180564 A CR 20180564A CR 20180564 A CR20180564 A CR 20180564A CR 20180564 A CR20180564 A CR 20180564A
Authority
CR
Costa Rica
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
piperidinyl derivatives
new piperidinyl
Prior art date
Application number
CR20180564A
Other languages
English (en)
Spanish (es)
Inventor
Maïa Chanrion
Elodie Lewkowicz
András Kotschy
Csaba; Wéber
Árpád; Kiss
Balázs Molnár
Attila Vasas
Didier; Demarles
Olivier; Geneste
James Brooke; Murray
Alba; Macias
Original Assignee
Vernalis R&D Ltd
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vernalis R&D Ltd, Servier Lab filed Critical Vernalis R&D Ltd
Publication of CR20180564A publication Critical patent/CR20180564A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CR20180564A 2016-06-10 2017-06-09 Nuevos derivados piperidinilo, un proceso para su preparación y composiciones farmacéuticas que lo contienen CR20180564A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1655392A FR3052452B1 (fr) 2016-06-10 2016-06-10 Nouveaux derives de piperidinyle, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
PCT/EP2017/064067 WO2017212012A1 (fr) 2016-06-10 2017-06-09 Nouveaux dérivés de pipéridinyle, procédé de préparation de ceux-ci et compositions pharmaceutiques les contenant

Publications (1)

Publication Number Publication Date
CR20180564A true CR20180564A (es) 2019-03-04

Family

ID=56943687

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20180564A CR20180564A (es) 2016-06-10 2017-06-09 Nuevos derivados piperidinilo, un proceso para su preparación y composiciones farmacéuticas que lo contienen

Country Status (45)

Country Link
US (1) US11046681B2 (fr)
EP (1) EP3468974B1 (fr)
JP (1) JP6928005B2 (fr)
KR (1) KR20190016106A (fr)
CN (1) CN109311888B (fr)
AR (1) AR108706A1 (fr)
AU (1) AU2017277734B2 (fr)
BR (1) BR112018075433A2 (fr)
CA (1) CA3027014C (fr)
CL (1) CL2018003474A1 (fr)
CO (1) CO2018013210A2 (fr)
CR (1) CR20180564A (fr)
CU (1) CU20180145A7 (fr)
CY (1) CY1122870T1 (fr)
DK (1) DK3468974T3 (fr)
DO (1) DOP2018000270A (fr)
EA (1) EA037211B1 (fr)
EC (1) ECSP18090144A (fr)
ES (1) ES2775789T3 (fr)
FR (1) FR3052452B1 (fr)
GE (1) GEP20207160B (fr)
HR (1) HRP20200361T1 (fr)
HU (1) HUE049507T2 (fr)
IL (1) IL263463B (fr)
LT (1) LT3468974T (fr)
MA (1) MA45222B1 (fr)
MD (1) MD3468974T2 (fr)
ME (1) ME03670B (fr)
MX (1) MX2018015216A (fr)
MY (1) MY196562A (fr)
NI (1) NI201800132A (fr)
PE (1) PE20220567A1 (fr)
PH (1) PH12018502515B1 (fr)
PL (1) PL3468974T3 (fr)
PT (1) PT3468974T (fr)
RS (1) RS60029B1 (fr)
RU (1) RU2743163C2 (fr)
SG (1) SG11201810629QA (fr)
SI (1) SI3468974T1 (fr)
SV (1) SV2018005791A (fr)
TN (1) TN2018000410A1 (fr)
TW (1) TWI620750B (fr)
UA (1) UA123794C2 (fr)
UY (1) UY37288A (fr)
WO (1) WO2017212012A1 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2017229007B2 (en) 2016-03-07 2021-04-01 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
US11672800B2 (en) 2017-04-21 2023-06-13 Epizyme, Inc. Combination therapies with EHMT2 inhibitors
KR102556744B1 (ko) 2017-08-28 2023-07-18 이난타 파마슈티칼스, 인코포레이티드 B형 간염 항바이러스제
AU2018377976A1 (en) * 2017-11-29 2020-06-04 Les Laboratoires Servier New piperidinyl derivatives as inhibitors of ubiquitin specific protease 7
GB201801562D0 (en) * 2018-01-31 2018-03-14 Almac Diagnostics Ltd Pharmaceutical compounds
UY38291A (es) * 2018-07-05 2020-06-30 Servier Lab Nuevos derivados de amino-pirimidonilo un proceso para su preparación y composiciones farmacéuticas
CA3113235A1 (fr) 2018-09-21 2020-03-26 Enanta Pharmaceuticals, Inc. Heterocycles fonctionnalises utiles en tant qu'agents antiviraux
UY38423A (es) * 2018-10-19 2021-02-26 Servier Lab Nuevos derivados amino-pirimidonil-piperidinilo, un proceso para su preparación y composiciones farmacéuticas que los contienen
AU2019385477A1 (en) 2018-11-21 2021-06-10 Enanta Pharmaceuticals, Inc. Functionalized heterocycles as antiviral agents
CA3121376A1 (fr) * 2018-12-06 2020-06-11 Almac Discovery Limited Composes pharmaceutiques et leur utilisation en tant qu'inhibiteurs de la protease 19 specifique de l'ubiquitine (usp19)
WO2020247444A1 (fr) 2019-06-03 2020-12-10 Enanta Pharmaceuticals, Inc, Agents antiviraux de l'hépatite b
US11760755B2 (en) 2019-06-04 2023-09-19 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
US11472808B2 (en) 2019-06-04 2022-10-18 Enanta Pharmaceuticals, Inc. Substituted pyrrolo[1,2-c]pyrimidines as hepatitis B antiviral agents
US11738019B2 (en) 2019-07-11 2023-08-29 Enanta Pharmaceuticals, Inc. Substituted heterocycles as antiviral agents
WO2021055425A2 (fr) 2019-09-17 2021-03-25 Enanta Pharmaceuticals, Inc. Hétérocycles fonctionnalisés utiles en tant qu'agents antiviraux
CN113087718B (zh) * 2020-01-09 2024-02-09 四川科伦博泰生物医药股份有限公司 噻吩并嘧啶酮类化合物及其医药应用
CN112608320B (zh) * 2020-01-16 2023-03-17 中国药科大学 哌啶类化合物及其制备方法和医药用途
GB202001980D0 (en) 2020-02-13 2020-04-01 Almac Discovery Ltd Therapeutic mentods
WO2021188414A1 (fr) 2020-03-16 2021-09-23 Enanta Pharmaceuticals, Inc. Composés hétérocycliques fonctionnalisés utiles en tant qu'agents antiviraux

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1965862A2 (fr) * 2005-12-21 2008-09-10 Schering Corporation Combinaison d'un antagoniste/agoniste inverse de h3 et d'un moderateur de l'appetit
CL2008000594A1 (es) * 2007-03-02 2008-09-05 Schering Corp Uso de compuestos derivados de heterociclos; composicion farmaceutica que comprende a dichos compuestos y otros agentes activos; y su uso para tratar diabetes, enfermedad arterial coronaria entre otras enfermedades.
EP2565186A1 (fr) * 2011-09-02 2013-03-06 Hybrigenics S.A. Inhibiteurs sélectifs et réversibles de la protéase 7 spécifique de l'ubiquitine
TWI770525B (zh) * 2014-12-30 2022-07-11 美商瓦洛健康公司 作為泛素特異性蛋白酶７抑制劑之吡咯并及吡唑并嘧啶
UA123793C2 (uk) * 2016-06-10 2021-06-02 Ле Лаборатуар Сервьє Нові (гетеро)арил-заміщені похідні піперидинілу, спосіб їхнього одержання та фармацевтичні композиції, що їх містять

Also Published As

Publication number Publication date
PL3468974T3 (pl) 2020-07-13
PH12018502515A1 (en) 2019-09-30
RU2018147430A3 (fr) 2020-07-10
EP3468974A1 (fr) 2019-04-17
KR20190016106A (ko) 2019-02-15
US20190144448A1 (en) 2019-05-16
WO2017212012A1 (fr) 2017-12-14
MX2018015216A (es) 2019-04-25
CL2018003474A1 (es) 2019-05-24
RU2743163C2 (ru) 2021-02-15
TW201802092A (zh) 2018-01-16
MD3468974T2 (ro) 2020-05-31
RS60029B1 (sr) 2020-04-30
FR3052452B1 (fr) 2018-06-22
CN109311888A (zh) 2019-02-05
AR108706A1 (es) 2018-09-19
AU2017277734B2 (en) 2021-07-01
EA037211B1 (ru) 2021-02-19
CA3027014C (fr) 2021-01-05
ECSP18090144A (es) 2019-01-31
UY37288A (es) 2018-01-02
NI201800132A (es) 2019-04-08
PE20220567A1 (es) 2022-04-13
CA3027014A1 (fr) 2017-12-14
TN2018000410A1 (en) 2020-06-15
CO2018013210A2 (es) 2018-12-28
MA45222A (fr) 2019-04-17
CN109311888B (zh) 2021-09-14
DOP2018000270A (es) 2019-05-15
EA201892838A1 (ru) 2019-06-28
SV2018005791A (es) 2019-01-16
MY196562A (en) 2023-04-19
PT3468974T (pt) 2020-03-25
AU2017277734A1 (en) 2018-12-20
IL263463B (en) 2021-01-31
IL263463A (en) 2019-01-31
HRP20200361T1 (hr) 2020-06-12
SI3468974T1 (sl) 2020-07-31
FR3052452A1 (fr) 2017-12-15
ME03670B (fr) 2020-10-20
UA123794C2 (uk) 2021-06-02
TWI620750B (zh) 2018-04-11
RU2018147430A (ru) 2020-07-10
CY1122870T1 (el) 2021-05-05
HUE049507T2 (hu) 2020-09-28
CU20180145A7 (es) 2019-07-04
MA45222B1 (fr) 2020-04-30
GEP20207160B (en) 2020-10-12
BR112018075433A2 (pt) 2019-03-19
JP6928005B2 (ja) 2021-09-01
DK3468974T3 (da) 2020-05-11
US11046681B2 (en) 2021-06-29
PH12018502515B1 (en) 2019-09-30
LT3468974T (lt) 2020-04-10
JP2019517556A (ja) 2019-06-24
SG11201810629QA (en) 2018-12-28
ES2775789T3 (es) 2020-07-28
EP3468974B1 (fr) 2020-02-12

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