CR20160303A - Moduladores ror gamma (rory) - Google Patents
Moduladores ror gamma (rory)Info
- Publication number
- CR20160303A CR20160303A CR20160303A CR20160303A CR20160303A CR 20160303 A CR20160303 A CR 20160303A CR 20160303 A CR20160303 A CR 20160303A CR 20160303 A CR20160303 A CR 20160303A CR 20160303 A CR20160303 A CR 20160303A
- Authority
- CR
- Costa Rica
- Prior art keywords
- rory
- ror gamma
- gamma modulators
- modulators
- ror
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/20—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/46—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
La presente invecion se refiere a compuestos de acuerdo con la formula I: Meta o para (Fórmula I) donde A11-A14 son N o Cr11 CR12 CR13 CR 14, respectivamente, con la condición de que no más de dos de las cuatro posiciones A puedan ser simultáneamente N;
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13195813 | 2013-12-05 | ||
EP14183274 | 2014-09-02 | ||
PCT/EP2014/076390 WO2015082533A1 (en) | 2013-12-05 | 2014-12-03 | Ror gamma (rory) modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
CR20160303A true CR20160303A (es) | 2016-11-10 |
Family
ID=52021176
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR20160303A CR20160303A (es) | 2013-12-05 | 2014-12-03 | Moduladores ror gamma (rory) |
Country Status (29)
Country | Link |
---|---|
US (1) | US9738600B2 (es) |
EP (1) | EP3077372B8 (es) |
JP (1) | JP6461960B2 (es) |
KR (1) | KR102251128B1 (es) |
CN (1) | CN105980353B (es) |
AU (1) | AU2014359324B2 (es) |
CA (1) | CA2932483C (es) |
CL (1) | CL2016001364A1 (es) |
CR (1) | CR20160303A (es) |
DK (1) | DK3077372T3 (es) |
DO (1) | DOP2016000125A (es) |
EA (1) | EA030393B1 (es) |
ES (1) | ES2722409T3 (es) |
HR (1) | HRP20190483T1 (es) |
HU (1) | HUE043258T2 (es) |
IL (1) | IL246018B (es) |
LT (1) | LT3077372T (es) |
MX (1) | MX368721B (es) |
MY (1) | MY179106A (es) |
PE (1) | PE20160891A1 (es) |
PH (1) | PH12016501066A1 (es) |
PL (1) | PL3077372T3 (es) |
PT (1) | PT3077372T (es) |
RS (1) | RS58650B1 (es) |
SI (1) | SI3077372T1 (es) |
TN (1) | TN2016000224A1 (es) |
UA (1) | UA117941C2 (es) |
WO (1) | WO2015082533A1 (es) |
ZA (1) | ZA201604043B (es) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015145371A1 (en) * | 2014-03-27 | 2015-10-01 | Piramal Enterprises Limited | Ror-gamma modulators and uses thereof |
EA201691491A1 (ru) * | 2014-04-16 | 2017-02-28 | Гленмарк Фармасьютикалс С.А. | Арильные и гетероарильные эфиры в качестве модуляторов ror-гамма |
CA2965518A1 (en) | 2014-10-30 | 2016-05-06 | Janssen Pharmaceutica Nv | Amide substituted thiazoles as modulators of ror.gamma.t |
JOP20200117A1 (ar) | 2014-10-30 | 2017-06-16 | Janssen Pharmaceutica Nv | كحولات ثلاثي فلوروميثيل كمُعدلات للمستقبل النووي جاما تي المرتبط بحمض الريتيونَويك ROR?t |
WO2016069976A1 (en) | 2014-10-30 | 2016-05-06 | Janssen Pharmaceutica Nv | THIAZOLES AS MODULATORS OF RORyt |
JP2018513123A (ja) | 2015-03-12 | 2018-05-24 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | Rorガンマ阻害剤を用いてがんを治療するための方法 |
EP3294713B1 (en) | 2015-05-15 | 2021-02-17 | Aurigene Discovery Technologies Limited | Substituted tetrahydroquinolinone compounds as ror gamma modulators |
WO2016193894A1 (en) * | 2015-05-29 | 2016-12-08 | Glenmark Pharmaceuticals S.A. | Treatment of respiratory disorders using ror- gamma inhibitors |
EP3101008A1 (en) * | 2015-06-05 | 2016-12-07 | Lead Pharma Cel Models IP B.V. | Ror gamma (rory) modulators |
EP3101005A1 (en) * | 2015-06-05 | 2016-12-07 | Lead Pharma Cel Models IP B.V. | Ror gamma (rory) modulators |
WO2017010399A1 (ja) * | 2015-07-10 | 2017-01-19 | 塩野義製薬株式会社 | RORγt阻害作用を有する化合物およびそれらを含有する医薬組成物 |
EP3390396B1 (en) | 2015-12-15 | 2022-07-06 | Astrazeneca AB | Isoindole compounds |
TW201803869A (zh) | 2016-04-27 | 2018-02-01 | 健生藥品公司 | 作為RORγT調節劑之6-胺基吡啶-3-基噻唑 |
TW201811760A (zh) | 2016-07-14 | 2018-04-01 | 印度商卡迪拉保健有限公司 | 新穎的環丙基衍生物 |
WO2018011747A1 (en) * | 2016-07-14 | 2018-01-18 | Cadila Healthcare Limited | Polycyclic compounds as ror-gamma modulators |
UY37507A (es) * | 2016-12-05 | 2018-06-29 | Lead Pharma Holding Bv | Moduladores de ror gamma (ror¿) |
WO2018116285A1 (en) * | 2016-12-23 | 2018-06-28 | Glenmark Pharmaceuticals S.A. | Substituted morpholine derivatives as ror gamma modulators |
WO2018229155A1 (en) | 2017-06-14 | 2018-12-20 | Astrazeneca Ab | 2,3-dihydroisoindole-1-carboxamides useful as ror-gamma modulators |
WO2019244002A1 (en) | 2018-06-18 | 2019-12-26 | Janssen Pharmaceutica Nv | Pyridinyl pyrazoles as modulators of roryt |
JP2021528405A (ja) | 2018-06-18 | 2021-10-21 | ヤンセン ファーマシューティカ エヌ.ベー. | RORγtのモジュレータとしてのアミド置換チアゾール |
CA3103770A1 (en) | 2018-06-18 | 2019-12-26 | Janssen Pharmaceutica Nv | Phenyl and pyridinyl substituted imidazoles as modulators of roryt |
CA3103771A1 (en) | 2018-06-18 | 2019-12-26 | Janssen Pharmaceutica Nv | 6-aminopyridin-3-yl pyrazoles as modulators of roryt |
AU2020348685A1 (en) * | 2019-09-16 | 2022-04-14 | Dice Alpha, Inc. | IL-17A modulators and uses thereof |
CN112759541B (zh) * | 2019-10-21 | 2023-03-17 | 复旦大学 | 类吲哚衍生物及其用途 |
TW202136238A (zh) * | 2020-01-06 | 2021-10-01 | 大陸商廣東東陽光藥業有限公司 | RORγt抑制劑及其製備方法和用途 |
CN113072521B (zh) * | 2020-01-06 | 2024-04-05 | 广东东阳光药业股份有限公司 | RORγt抑制剂及其在药物中的应用 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011115892A1 (en) * | 2010-03-15 | 2011-09-22 | Griffin Patrick R | Modulators of the retinoic acid receptor-related orphan receptors |
WO2012027965A1 (en) * | 2010-09-01 | 2012-03-08 | Glaxo Group Limited | Novel compounds |
WO2013029338A1 (en) * | 2011-09-01 | 2013-03-07 | Glaxo Group Limited | Novel compounds |
KR20150070348A (ko) * | 2012-10-16 | 2015-06-24 | 얀센 파마슈티카 엔.브이. | RoRγt의 헤테로아릴 결합 퀴놀리닐 조절제 |
WO2013171729A2 (en) | 2013-01-08 | 2013-11-21 | Glenmark Pharmaceuticals S.A. | Aryl and heteroaryl amide compounds as rorgamat modulator |
KR20150128863A (ko) * | 2013-03-15 | 2015-11-18 | 에프. 호프만-라 로슈 아게 | RORc 조절제로서 아릴 설파미드 및 설파메이트 유도체 |
EP2781217A1 (en) * | 2013-03-18 | 2014-09-24 | ETH Zurich | ROR gamma modulators |
-
2014
- 2014-12-03 LT LTEP14809794.2T patent/LT3077372T/lt unknown
- 2014-12-03 PL PL14809794T patent/PL3077372T3/pl unknown
- 2014-12-03 MY MYPI2016702008A patent/MY179106A/en unknown
- 2014-12-03 CA CA2932483A patent/CA2932483C/en active Active
- 2014-12-03 CN CN201480074695.6A patent/CN105980353B/zh active Active
- 2014-12-03 UA UAA201607189A patent/UA117941C2/uk unknown
- 2014-12-03 DK DK14809794.2T patent/DK3077372T3/en active
- 2014-12-03 MX MX2016007275A patent/MX368721B/es active IP Right Grant
- 2014-12-03 CR CR20160303A patent/CR20160303A/es unknown
- 2014-12-03 ES ES14809794T patent/ES2722409T3/es active Active
- 2014-12-03 PE PE2016000733A patent/PE20160891A1/es unknown
- 2014-12-03 US US15/102,098 patent/US9738600B2/en active Active
- 2014-12-03 EP EP14809794.2A patent/EP3077372B8/en active Active
- 2014-12-03 EA EA201691173A patent/EA030393B1/ru not_active IP Right Cessation
- 2014-12-03 AU AU2014359324A patent/AU2014359324B2/en active Active
- 2014-12-03 WO PCT/EP2014/076390 patent/WO2015082533A1/en active Application Filing
- 2014-12-03 HU HUE14809794A patent/HUE043258T2/hu unknown
- 2014-12-03 RS RS20190494A patent/RS58650B1/sr unknown
- 2014-12-03 PT PT14809794T patent/PT3077372T/pt unknown
- 2014-12-03 TN TN2016000224A patent/TN2016000224A1/en unknown
- 2014-12-03 KR KR1020167017849A patent/KR102251128B1/ko active IP Right Grant
- 2014-12-03 SI SI201431174T patent/SI3077372T1/sl unknown
- 2014-12-03 JP JP2016536162A patent/JP6461960B2/ja active Active
-
2016
- 2016-06-03 PH PH12016501066A patent/PH12016501066A1/en unknown
- 2016-06-03 CL CL2016001364A patent/CL2016001364A1/es unknown
- 2016-06-03 DO DO2016000125A patent/DOP2016000125A/es unknown
- 2016-06-05 IL IL246018A patent/IL246018B/en active IP Right Grant
- 2016-06-14 ZA ZA2016/04043A patent/ZA201604043B/en unknown
-
2019
- 2019-03-11 HR HRP20190483TT patent/HRP20190483T1/hr unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CR20160303A (es) | Moduladores ror gamma (rory) | |
CO2017013229A2 (es) | Agonistas de receptor de apelina (apj) de 4-hidroxi-3-(heteroaril)piridin-2-ona como para uso en el tratamiento de trastornos cardiovasculares | |
DOP2017000298A (es) | Reguladores de nrf2 | |
BR112018006471A2 (pt) | compostos úteis como moduladores de trpm8 | |
BR112018007395A2 (pt) | 2,4-di-hidróxi-nicotinamidas como agonistas de apj | |
CR20160272A (es) | REGULADORES DE Nrf2 | |
BR112016014020A8 (pt) | moduladores de tetra-hidropiridopirazinas de gpr6. | |
BR112018012112A2 (pt) | heteroaril-hidroxipirimidinonas como agonistas do receptor apj | |
CL2015000944A1 (es) | Compuestos de benceno sustituido | |
CR20150541A (es) | Compuestos y composiciones nuevos para la inhibición de fasn | |
BR112018003343A2 (pt) | compostos heteroarila como inibidores de irak e usos dos mesmos | |
CL2016000221A1 (es) | Anticuerpos anti-fgfr2iiib afucosilados. | |
BR112016001977A2 (pt) | septo acústico de vários segmentos | |
CO7111287A2 (es) | Composiciones plaguicidas y procesos relacionados | |
BR112018003812A2 (pt) | compostos de heteroarila como inibidores de irak e usos dos mesmos | |
BR112016029333A2 (pt) | síntese de compostos de carbamoilpiridona policíclico | |
CU20140081A7 (es) | Nuevos derivados de pirrol, su procedimiento de preparación y las composiciones farmacéuticas que los contienen | |
BR112016028476A2 (pt) | compostos, composição, utilização de um composto, método para o combate dos fungos nocivos e sementes | |
MY165124A (en) | Semifluorinated alkane compositions | |
CU20140095A7 (es) | Nuevos derivados fosfatos, su procedimiento de preparación y las composiciones farmacéuticas que los contienen | |
EA201590951A1 (ru) | Дигидропиразольные модуляторы gpr40 | |
EA201590949A1 (ru) | Дигидропиразольные модуляторы gpr40 | |
EA201590954A1 (ru) | Дигидропиразольные модуляторы gpr40 | |
BR112016007757A8 (pt) | Derivados antibacterianos de 2h-indazol | |
BR112015028213A2 (pt) | componentes catalisadores para polimerização de olefinas |