CR20150481A - Composición farmacéutica de clorhidrato de s-ketamina - Google Patents

Composición farmacéutica de clorhidrato de s-ketamina

Info

Publication number
CR20150481A
CR20150481A CR20150481A CR20150481A CR20150481A CR 20150481 A CR20150481 A CR 20150481A CR 20150481 A CR20150481 A CR 20150481A CR 20150481 A CR20150481 A CR 20150481A CR 20150481 A CR20150481 A CR 20150481A
Authority
CR
Costa Rica
Prior art keywords
pharmaceutical composition
ketamine
ketamine chlorhydrate
chlorhydrate
formulation
Prior art date
Application number
CR20150481A
Other languages
English (en)
Inventor
Esther D G Basstanie
Johanna Bentz
Roger C A Embrechts
Nico Rudolph Niemeiijer
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50687638&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR20150481(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of CR20150481A publication Critical patent/CR20150481A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Otolaryngology (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Emergency Medicine (AREA)

Abstract

La presente invención está dirigida a una formulación acuosa de clorhidrato de S-ketamina, preferentemente, para la administración nasal, en donde la formulación no contiene un conservante antimicrobiano.
CR20150481A 2013-03-15 2015-09-11 Composición farmacéutica de clorhidrato de s-ketamina CR20150481A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361791237P 2013-03-15 2013-03-15
PCT/US2014/027059 WO2014152196A1 (en) 2013-03-15 2014-03-14 Pharmaceutical composition of s-ketamine hydrochloride

Publications (1)

Publication Number Publication Date
CR20150481A true CR20150481A (es) 2015-10-26

Family

ID=50687638

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20150481A CR20150481A (es) 2013-03-15 2015-09-11 Composición farmacéutica de clorhidrato de s-ketamina

Country Status (16)

Country Link
US (5) US20140274981A1 (es)
EP (2) EP3636251B1 (es)
KR (1) KR102217616B1 (es)
CN (2) CN105073096A (es)
AU (2) AU2014240102A1 (es)
BR (1) BR112015022972B1 (es)
CL (1) CL2015002736A1 (es)
CR (1) CR20150481A (es)
ES (2) ES2755809T3 (es)
MX (1) MX371392B (es)
MY (1) MY180526A (es)
NI (1) NI201500135A (es)
PE (1) PE20200404A1 (es)
PH (1) PH12015502013B1 (es)
SG (2) SG10201802104QA (es)
WO (1) WO2014152196A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3043785T (pt) 2013-09-13 2021-11-05 Univ Chiba Nat Univ Corp Aplicação de r-cetamina e seu sal como medicamentos
US20160332962A1 (en) 2015-05-13 2016-11-17 Janssen Pharmaceutica Nv (s)-csa salt of s-ketamine, (r)-csa salt of s-ketamine and processes for the preparation of s-ketamine
CA2987909C (en) 2015-06-27 2022-04-26 Shenox Pharmaceuticals, Llc Ketamine transdermal delivery system
CN106562952B (zh) * 2015-10-09 2020-06-09 江阴安博生物医药有限公司 氯胺酮在治疗重性抑郁障碍中的应用
WO2017139382A1 (en) * 2016-02-08 2017-08-17 The Texas A&M University System Combination of adjuvant drugs esketamine and brimonidine for medical treatments
US20180177744A1 (en) * 2016-12-22 2018-06-28 Gary Jay Method of treating pain and depression using a hybrid mixture of s-ketamine and r-ketamine
US20200009081A1 (en) 2017-09-13 2020-01-09 Janssen Pharmaceutica N.V. Delivery Of Esketamine For The Treatment Of Depression
EP3505157B1 (en) 2017-12-29 2021-12-08 Celon Pharma S.A. Dry powder ketamine composition for pulmonary administration in treatment-resistant depression
EP3753557A4 (en) 2018-02-15 2021-12-01 National University Corporation Chiba University PREVENTIVE OR THERAPEUTIC AGENT AND PHARMACEUTICAL COMPOSITION FOR INFLAMMATORY DISEASES OR BONE DISEASES
CN118121577A (zh) 2018-05-04 2024-06-04 感知神经科学公司 治疗物质滥用的方法
US11154537B2 (en) 2018-08-10 2021-10-26 Eleusis Therapeutics Us, Inc. Method of treatment for ketamine infusion
EP3628313A1 (en) 2018-09-28 2020-04-01 Celon Pharma S.A. Ketamine composition for use in a method of treatment of depression by pulmonary administration
US20230117657A1 (en) 2019-03-05 2023-04-20 Janssen Pharmaceuticals, Inc. Esketamine for the treatment of depression
WO2020239243A1 (en) 2019-05-31 2020-12-03 Celon Pharma S.A. Electronically supervised administration of a pharmaceutical composition
BR112021024141A2 (pt) 2019-05-31 2022-01-11 Celon Pharma Sa Inalador para administração parenteral supervisionada eletronicamente de uma composição farmacêutica
FI3976012T3 (fi) 2019-05-31 2024-04-05 Afyx Therapeutics As Ketamiinin intranasalinen annostus klusteripäänsärkypotilaille
TW202135787A (zh) 2019-12-12 2021-10-01 比利時商健生藥品公司 艾氯胺酮調配物及製備與儲存的方法
CN114306218B (zh) * 2020-09-30 2023-11-10 四川普锐特药业有限公司 满足药学抑菌要求的经粘膜给药r-氯胺酮药物组合物
CN113813250B (zh) * 2021-07-21 2023-05-05 广州新济药业科技有限公司 含氯胺酮的药物组合物及其制备方法和应用
WO2023207729A1 (zh) * 2022-04-26 2023-11-02 宜昌人福药业有限责任公司 艾司氯胺酮液体制剂及其用途

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH535201A (de) 1969-12-19 1973-03-31 Bristol Myers Co Verfahren zur Spaltung von racemischen 2-(o-Chlorphenyl)-2-methylaminocyclohexanon in die optisch-aktiven Isomeren
JPS632932A (ja) * 1986-06-23 1988-01-07 Teijin Ltd 経鼻投与用粉末状組成物
US5002935A (en) 1987-12-30 1991-03-26 University Of Florida Improvements in redox systems for brain-targeted drug delivery
US4994467A (en) 1989-05-31 1991-02-19 Zimmerman Andrew W Treating autism and other developmental disorders in children with NMDA receptor antagonists
DE4312016A1 (de) * 1993-04-13 1994-10-20 Goedecke Ag Stabile Ketamin-Lösungen
US5543434A (en) 1994-02-25 1996-08-06 Weg; Stuart L. Nasal administration of ketamine to manage pain
JP4173538B2 (ja) 1995-02-24 2008-10-29 スチュアート エル ウェグ 痛みの管理及び解毒のためのケタミンの点鼻及び点眼投与
WO1997007750A1 (en) 1995-08-30 1997-03-06 Weg Stuart L Administration of ketamine to manage pain and to reduce drug dependency
FR2739294B1 (fr) 1995-09-29 1998-01-16 Lhd Lab Hygiene Dietetique Embout nasal de securite
DE19619665C2 (de) 1996-05-15 2001-03-08 Goedecke Ag Racemattrennung von Ketamin
DE19723133A1 (de) 1997-06-03 1998-12-10 Caideil M P Teoranta Tourmakea Austragvorrichtung für Medien
FR2764807B1 (fr) 1997-06-18 1999-08-20 Valois Sa Dispositif de distribution nasale d'un produit fluide ou pulverulent
US6251428B1 (en) * 1998-07-24 2001-06-26 Seo Hong Yoo Preparation of aqueous clear solution dosage forms with bile acids
US6599883B1 (en) 1998-10-30 2003-07-29 Nastech Pharmaceutical Company, Inc. Nasal delivery of xylitol
US6176242B1 (en) 1999-04-30 2001-01-23 Medtronic Inc Method of treating manic depression by brain infusion
US6017961A (en) 1999-07-08 2000-01-25 Flores; John Anthony Ketamine and n-butyl-p-aminobezoate in PLO
EP1103256A1 (de) 1999-11-26 2001-05-30 Claudius Dr. med. Böck Verwendung von Ketamin zur Behandlung von neuroendokriner Immundysfunktion und algogenem Psychosyndrom
US6572849B2 (en) 2000-09-20 2003-06-03 Lee Shahinian, Jr. Self-preserved antibacterial nasal, inhalable, and topical ophthalmic preparations and medications
US6881731B1 (en) 2000-10-23 2005-04-19 Shanbrom Technologies, Llc Enhancers for microbiological disinfection
MXPA05000294A (es) 2002-07-30 2005-08-19 Peter Migaly Terapia combinada para la depresion, prevencion de suicidios y varias condiciones medicas y psiquiatricas.
US7273889B2 (en) 2002-09-25 2007-09-25 Innovative Drug Delivery Systems, Inc. NMDA receptor antagonist formulation with reduced neurotoxicity
WO2004045601A1 (en) 2002-11-18 2004-06-03 Yaupon Therapeutics, Inc. Analgesic uses of norketamine and ketamine/norketamine prodrugs
US7687080B2 (en) 2002-11-25 2010-03-30 Taraxos Inc. Treatment of neuropathy
US20040214215A1 (en) * 2003-03-07 2004-10-28 Yu Ruey J. Bioavailability and improved delivery of alkaline pharmaceutical drugs
US8082173B2 (en) 2003-05-22 2011-12-20 Cecil Kost Drug sample fulfillment architecture
US20040265364A1 (en) 2003-06-25 2004-12-30 Binnur Ozturk Neuropathy cream
US20050095277A1 (en) 2003-06-25 2005-05-05 Binnur Ozturk Neuropathy cream
US20060223788A1 (en) 2005-03-29 2006-10-05 Cathcart Clifton H Analgesic composition for topical use
DK1885414T3 (da) 2005-06-01 2013-02-11 Shl Group Ab Indretning til afgivelse af et lægemiddel
US20060276550A1 (en) 2005-06-03 2006-12-07 Dileep Bhagwat Topical compositions of ketamine and butamben and methods of their use
KR20090029690A (ko) * 2006-03-22 2009-03-23 마운트 시나이 스쿨 오브 메디신 오브 뉴욕 유니버시티 우울증을 치료하기 위한 케타민의 투여 방법
WO2007123945A2 (en) 2006-04-21 2007-11-01 Aradigm Corporation Mechanical single dose intrapulmonary drug delivery devices
AU2007253684A1 (en) 2006-05-22 2007-11-29 Vanda Pharmaceuticals, Inc. Treatment for depressive disorders
DE102007009888A1 (de) * 2007-02-28 2008-09-04 Hermann, Holger Lars, Dr. Verwendung von S-(+)-Ketamin zur Behandlung von Depressionen
US7745665B2 (en) 2007-06-04 2010-06-29 Auspex Pharmaceuticals, Inc. Substituted phenethylamines
US8710070B2 (en) 2008-03-27 2014-04-29 University Of Kentucky Research Foundation Opioid-ketamine and norketamine codrug combinations for pain management
BRPI0911945A2 (pt) * 2008-05-13 2015-10-13 Clarassance Inc cc10 humana recombinante e suas composições para uso no tratamento de rinite nasal
US20120225949A1 (en) 2009-08-14 2012-09-06 Demitri Papalos Compositions and methods for treating bipolar disorder
US20110038807A1 (en) 2009-08-14 2011-02-17 Demitri Papolos Compositions and methods for treating bipolar disorder
WO2011157391A1 (en) 2010-06-15 2011-12-22 Grünenthal GmbH Pharmaceutical combination for the treatment of pain
WO2013003669A2 (en) 2011-06-30 2013-01-03 University Of South Florida Compositions, methods of use, and methods of treatment
CA2851619C (en) 2011-10-14 2021-12-07 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services The use of hydroxynorketamine, dehydronorketamine and other ketamine metabolites in the treatment of depression and neuropathic pain
EP2780467B1 (en) 2011-11-14 2018-10-17 Alfasigma S.p.A. Assays and methods for selecting a treatment regimen for a subject with depression and methods for treatment
US20130209585A1 (en) 2012-02-13 2013-08-15 Stanley Kim Topical NMDA Antagonist Formulations for the Treatment of Peripheral Neuropathy
US20130236573A1 (en) 2012-03-12 2013-09-12 Janssen Pharmaceutica Nv Esketamine for the treatment of treatment-refractory or treatment-resistant depression
AU2016203771A1 (en) 2012-03-13 2016-06-23 Janssen Pharmaceutica Nv Esketamine for the treatment of treatment-refractory or treatment-resistant depression
JP2015512418A (ja) 2012-03-30 2015-04-27 ザ ジェネラル ホスピタル コーポレイション うつ病の治療におけるスコポラミンおよびケタミンを含む組成物
US20140079740A1 (en) 2012-08-02 2014-03-20 ClinPharm Support GmbH Oral transmucosal adminstration forms of s-ketamine
WO2014031975A1 (en) 2012-08-23 2014-02-27 Weg Stuart L Anxiolytic composition, formulation and method of use
FR2994844B1 (fr) 2012-08-31 2015-01-02 Assist Publ Hopitaux De Paris Formulation gelifiante a base de ketamine
NZ619257A (en) 2012-10-08 2015-07-31 Auckland Uniservices Ltd Ketamine derivatives
ES2484068B1 (es) 2013-02-08 2015-04-16 Ana MÍNGUEZ MARTÍ Una composición farmacéutica que contiene ketamina y amitriptilina
PL2983787T3 (pl) 2013-04-12 2020-04-30 Icahn School Of Medicine At Mount Sinai Sposób leczenia zespołu stresu pourazowego
JP2016531913A (ja) 2013-08-26 2016-10-13 アモーサ セラピューティックス， インコーポレイテッドＡｍｏｒｓａ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． 神経抑制性ケタミンの単層による経口投与
PT3043785T (pt) 2013-09-13 2021-11-05 Univ Chiba Nat Univ Corp Aplicação de r-cetamina e seu sal como medicamentos
US9569220B2 (en) 2013-10-06 2017-02-14 Synopsys, Inc. Processor branch cache with secondary branches
CN103705909A (zh) 2013-12-16 2014-04-09 陈镜伊 一种无痛人流用药
WO2015101693A1 (es) 2013-12-31 2015-07-09 Servicio Andaluz De Salud Composiciones y preparaciones combinadas para el tratamiento de las algias orofaríngeas
ES2726223T3 (es) 2014-01-14 2019-10-02 Childrens Hospital Med Ct Composiciones que comprenden ketamina para el tratamiento de un trastorno del espectro autista
HUE060851T2 (hu) 2014-04-17 2023-04-28 Ketabon Gmbh Ketamin orális dózisformája
PE20211759A1 (es) 2014-05-04 2021-09-07 Firmenich & Cie Formulacion edulcorante con naringenina
FR3023188B1 (fr) 2014-07-04 2016-08-19 Aptar France Sas Dispositif de distribution de produit fluide.
CA2957926A1 (en) 2014-08-13 2016-02-18 Janssen Pharmaceutica Nv Method for the treatment of depression
MX2017003366A (es) 2014-09-15 2018-02-01 Janssen Pharmaceutica Nv Regimenes de dosificacion y métodos especificos para el tratamiento de la depresión con el genotipo val66met (snp rs6265).
US20180015054A1 (en) 2014-12-31 2018-01-18 Icahn School Of Medicine At Mount Sinai Method of Maintaining the Anti-Depressant Effect of Ketamine With Lithium
CN104798728A (zh) 2015-05-08 2015-07-29 南京中医药大学 产后抑郁动物模型的建立方法及其应用
US20160332962A1 (en) 2015-05-13 2016-11-17 Janssen Pharmaceutica Nv (s)-csa salt of s-ketamine, (r)-csa salt of s-ketamine and processes for the preparation of s-ketamine
US20160338977A1 (en) 2015-05-20 2016-11-24 Janssen Pharmaceutica Nv Methods and kits for treating depression
CA2987909C (en) 2015-06-27 2022-04-26 Shenox Pharmaceuticals, Llc Ketamine transdermal delivery system
US20180296478A1 (en) 2016-02-12 2018-10-18 Synergistic Therapeutics, Llc Sublingual antidepressant and antianxiety tablet
US20180042936A1 (en) 2016-03-18 2018-02-15 Genomind, Inc. Maintenance therapy using tianeptine
RU2020123893A (ru) 2017-12-22 2022-01-24 Янссен Фармасьютикалз, Инк. Эскетамин для лечения депрессии

Also Published As

Publication number Publication date
EP2968122A1 (en) 2016-01-20
CL2015002736A1 (es) 2016-03-28
CN105073096A (zh) 2015-11-18
US20140274981A1 (en) 2014-09-18
KR20150132381A (ko) 2015-11-25
PH12015502013A1 (en) 2016-01-11
WO2014152196A1 (en) 2014-09-25
US20230241009A1 (en) 2023-08-03
US20140275278A1 (en) 2014-09-18
AU2019200424A1 (en) 2019-02-14
US11446260B2 (en) 2022-09-20
MX371392B (es) 2020-01-28
MX2015012617A (es) 2016-06-21
PE20200404A1 (es) 2020-02-26
BR112015022972B1 (pt) 2023-02-14
EP3636251B1 (en) 2022-01-19
ES2911466T3 (es) 2022-05-19
AU2014240102A1 (en) 2015-09-17
US20190117591A1 (en) 2019-04-25
PH12015502013B1 (en) 2016-01-11
AU2019200424A8 (en) 2019-02-21
SG11201507347QA (en) 2015-10-29
AU2019200424B2 (en) 2020-05-14
EP2968122B1 (en) 2019-08-28
US20200069612A1 (en) 2020-03-05
CN111643449A (zh) 2020-09-11
EP3636251A1 (en) 2020-04-15
KR102217616B1 (ko) 2021-02-19
SG10201802104QA (en) 2018-05-30
BR112015022972A2 (pt) 2017-07-18
NI201500135A (es) 2016-03-16
ES2755809T3 (es) 2020-04-23
MY180526A (en) 2020-12-01

Similar Documents

Publication Publication Date Title
CR20150481A (es) Composición farmacéutica de clorhidrato de s-ketamina
CR20150480A (es) Composición farmacéutica de clorhidrato de s-cetamina
EA201692301A1 (ru) Производные бороновой кислоты и их терапевтическое применение
CU20160006A7 (es) Derivados de piperidinil-indol como inhibidores de factor de complemento b
JO3452B1 (ar) بنزاميدات أمينو اريل مغاير كمثبطات كيناز
EA201591004A1 (ru) Производные бороновой кислоты и их терапевтическое применение
PH12015501993B1 (en) Pyrazole-amide compound and medicinal uses therefor
MX2016005395A (es) Formulacion estable de insulina glulisina.
BR112016024235A2 (pt) composições farmacêuticas compreendendo agentes antibacterianos
DK3103453T3 (da) Medicinsk sammensætning omfattende heterocyklisk diamino-carboxamidforbindelse som aktiv bestanddel
MX2016001422A (es) Composicion farmaceutica de fingolimod.
BR112014030720A8 (pt) composto, composição farmacêutica e usos de inibidores de fbx03
PE20150167A1 (es) (r)-nifuratel, su uso para el tratamiento de las infecciones y sintesis de (r) y (s)-nifuratel
PH12016500577A1 (en) Piperazine derivatives and the use thereof as medicament
EA201890477A1 (ru) Инкапсулированная композиция финголимода
CL2015003460A1 (es) Composiciones oftálmicas acuosas tópicas que contienen un derivado de 1h-indol-1-carboxamida y uso de estas para el tratamiento de una enfermedad oftálmica
EA201501130A1 (ru) Офтальмологическая фармацевтическая композиция
BR112016008704A8 (pt) derivados de indol-urea glucopiranosil-substituídos, composições farmacêuticas, e seus usos
NZ719215A (en) Pharmaceutical compositions comprising antibacterial agents
MX2016005160A (es) Composiciones farmaceuticas que comprenden agentes antibacterianos.
MX2016005539A (es) Composiciones farmaceuticas que comprenden agentes antibacterianos.
EA201891848A1 (ru) Фармацевтическая композиция для применения в лечении фиброза
BR112016024236A2 (pt) composições farmacêuticas compreendendo agentes antibacterianos
MX2013003022A (es) Composiciones farmaceuticas de montelukast y levocetirizina.
UA90602U (uk) Фармацевтична композиція комбінованої дії