CR20150469A - Sistemas de espectroscopía de fluorescencia inducida por láser resuelta en el tiempo y usos de los mismos - Google Patents

Sistemas de espectroscopía de fluorescencia inducida por láser resuelta en el tiempo y usos de los mismos

Info

Publication number
CR20150469A
CR20150469A CR20150469A CR20150469A CR20150469A CR 20150469 A CR20150469 A CR 20150469A CR 20150469 A CR20150469 A CR 20150469A CR 20150469 A CR20150469 A CR 20150469A CR 20150469 A CR20150469 A CR 20150469A
Authority
CR
Costa Rica
Prior art keywords
laser
resolved
same
time
fluorescence spectroscopy
Prior art date
Application number
CR20150469A
Other languages
English (en)
Inventor
Pramod Butte
Dengjin Wang
David Scott Kittle
Original Assignee
Cedars Sinai Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cedars Sinai Medical Center filed Critical Cedars Sinai Medical Center
Publication of CR20150469A publication Critical patent/CR20150469A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
    • G01J3/0218—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows using optical fibers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/2889—Rapid scan spectrometers; Time resolved spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G01J3/4406—Fluorescence spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6402—Atomic fluorescence; Laser induced fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14556—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases by fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/1459—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4866—Evaluating metabolism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G01N2021/6421—Measuring at two or more wavelengths
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6484—Optical fibres
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/061—Sources
    • G01N2201/06113—Coherent sources; lasers

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Lasers (AREA)

Abstract

La invención proporciona sistemas para caracterizar una muestra biológica mediante el análisis de la emisión de luz fluorescente de la muestra biológica luego de su excitación y métodos para el uso de la misma. El sistema incluye una fuente láser, fibras de recolección, un demultiplexor y un dispositivo de retardo óptico. Todas las referencias citadas en la presente memoria se incorporan por referencia en su totalidad como si se expusieran por completo. A menos que se defina lo contrario, los términos técnicos y científicos utilizados en la presente memoria tienen el mismo significado como los entiende comúnmente alguien con experiencia ordinaria en la técnica a la que pertenece esta invención.
CR20150469A 2013-03-15 2015-09-08 Sistemas de espectroscopía de fluorescencia inducida por láser resuelta en el tiempo y usos de los mismos CR20150469A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361794741P 2013-03-15 2013-03-15
PCT/US2014/030610 WO2014145786A1 (en) 2013-03-15 2014-03-17 Time-resolved laser-induced fluorescence spectroscopy systems and uses thereof

Publications (1)

Publication Number Publication Date
CR20150469A true CR20150469A (es) 2016-02-24

Family

ID=51538097

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20150469A CR20150469A (es) 2013-03-15 2015-09-08 Sistemas de espectroscopía de fluorescencia inducida por láser resuelta en el tiempo y usos de los mismos

Country Status (12)

Country Link
US (5) US9404870B2 (es)
EP (3) EP3301435B1 (es)
JP (4) JP6581566B2 (es)
KR (4) KR102154547B1 (es)
CN (1) CN105143855B (es)
AU (2) AU2014232480B2 (es)
BR (1) BR112015022766A2 (es)
CA (1) CA2906890A1 (es)
CR (1) CR20150469A (es)
ES (2) ES2925022T3 (es)
MX (1) MX349624B (es)
WO (2) WO2014168734A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9095414B2 (en) * 2011-06-24 2015-08-04 The Regents Of The University Of California Nonlinear optical photodynamic therapy (NLO-PDT) of the cornea
WO2014168734A1 (en) 2013-03-15 2014-10-16 Cedars-Sinai Medical Center Time-resolved laser-induced fluorescence spectroscopy systems and uses thereof
US9814037B2 (en) * 2013-06-28 2017-11-07 Intel Corporation Method for efficient channel estimation and beamforming in FDD system by exploiting uplink-downlink correspondence
EP3265785A4 (en) * 2015-10-30 2018-04-04 Cedars-Sinai Medical Center Methods and systems for performing tissue classification using multi-channel tr-lifs and multivariate analysis
JP7266519B2 (ja) * 2016-04-01 2023-04-28 ブラック ライト サージカル， インコーポレイテッド 時間分解蛍光分光法のためのシステム、デバイス、および方法
CN109313119B (zh) * 2016-06-20 2021-11-02 普莱尔股份公司 用于检测和/或表征流体携带的颗粒的装置和方法
CN110050183A (zh) 2016-10-11 2019-07-23 科克理工学院 荧光感测系统
US11523738B2 (en) 2017-03-22 2022-12-13 Adiuvo Diagnostics Pvt Ltd Device and method for detection and classification of pathogens
CN107677654B (zh) * 2017-09-15 2020-05-05 哈尔滨工业大学 一种基于lif的氧原子绝对浓度时域/空域分辨的测试方法及装置
DE102018129807A1 (de) 2017-11-24 2019-06-27 Deutsches Zentrum für Luft- und Raumfahrt e.V. Verfahren und System zur Klassifizierung chemischer und biologischer Stoffe
CN108801987B (zh) * 2018-03-17 2021-03-23 杨佳苗 共焦分立荧光光谱及荧光寿命探测方法与装置
CN108507986A (zh) * 2018-03-17 2018-09-07 杨佳苗 差动共焦分立荧光光谱及荧光寿命探测方法与装置
CN108844929B (zh) * 2018-05-14 2020-10-30 杨佳苗 分光瞳差动共焦分立荧光光谱及荧光寿命探测方法与装置
CN108844930B (zh) * 2018-05-14 2020-10-30 杨佳苗 分光瞳共焦分立荧光光谱及荧光寿命探测方法与装置
CN110487756A (zh) * 2018-05-14 2019-11-22 杨佳苗 分光瞳分立荧光光谱及荧光寿命探测方法与装置
JP2020071152A (ja) * 2018-10-31 2020-05-07 ソニー株式会社 免疫染色方法、免疫染色システム、および免疫染色キット
WO2021076972A1 (en) 2019-10-17 2021-04-22 C2Sense, Inc. Luminescence imaging for sensing
US11726037B2 (en) * 2019-10-17 2023-08-15 C2Sense, Inc. Luminescence imaging for sensing and/or authentication
CN111504978B (zh) * 2020-05-13 2021-03-30 华中科技大学 脉冲型延时色散光谱测量方法和装置及光谱成像方法和装置
CN112557362B (zh) * 2020-12-04 2022-08-23 厦门大学 Led光源作为连续波激发光源的同步荧光光谱检测方法
US20230026893A1 (en) * 2021-07-22 2023-01-26 Cilag Gmbh International Intercommunication and cooperative operation of surgical devices

Family Cites Families (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US612459A (en) * 1898-10-18 Oscar l
US570190A (en) * 1896-10-27 sunderland
US1065608A (en) 1911-10-24 1913-06-24 Patrick A Hennessy Concrete mixer and conveyer.
NL7500951A (nl) * 1975-01-28 1976-07-30 Akzo Nv Fluorimetrisch aantonen en bepalen van een gereduceerd co-enzym of derivaat in een waterig systeem.
US5464013A (en) 1984-05-25 1995-11-07 Lemelson; Jerome H. Medical scanning and treatment system and method
ATE133545T1 (de) * 1988-12-21 1996-02-15 Massachusetts Inst Technology Verfahren für laserinduzierte fluoreszenz von gewebe
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US4937457A (en) 1989-02-10 1990-06-26 Slm Instruments, Inc. Picosecond multi-harmonic fourier fluorometer
WO1990009637A1 (en) 1989-02-13 1990-08-23 Research Corporation Technologies, Inc. Method and means for parallel frequency acquisition in frequency domain fluorometry
US5151869A (en) 1990-02-16 1992-09-29 The Boc Group, Inc. Frequency domain fluorometry using coherent sampling
US5196709A (en) 1991-05-03 1993-03-23 University Of Maryland Systems Fluorometry method and apparatus using a semiconductor laser diode as a light source
US5762609A (en) 1992-09-14 1998-06-09 Sextant Medical Corporation Device and method for analysis of surgical tissue interventions
US5462879A (en) 1993-10-14 1995-10-31 Minnesota Mining And Manufacturing Company Method of sensing with emission quenching sensors
JPH07222712A (ja) 1994-02-10 1995-08-22 Olympus Optical Co Ltd 蛍光内視鏡装置
US5749830A (en) 1993-12-03 1998-05-12 Olympus Optical Co., Ltd. Fluorescent endoscope apparatus
JP3448090B2 (ja) * 1994-02-16 2003-09-16 浜松ホトニクス株式会社 エネルギー移動検出法およびその装置
US5701902A (en) * 1994-09-14 1997-12-30 Cedars-Sinai Medical Center Spectroscopic burn injury evaluation apparatus and method
US5697373A (en) 1995-03-14 1997-12-16 Board Of Regents, The University Of Texas System Optical method and apparatus for the diagnosis of cervical precancers using raman and fluorescence spectroscopies
US6258576B1 (en) 1996-06-19 2001-07-10 Board Of Regents, The University Of Texas System Diagnostic method and apparatus for cervical squamous intraepithelial lesions in vitro and in vivo using fluorescence spectroscopy
US5991653A (en) 1995-03-14 1999-11-23 Board Of Regents, The University Of Texas System Near-infrared raman spectroscopy for in vitro and in vivo detection of cervical precancers
JP3980683B2 (ja) * 1995-08-29 2007-09-26 仁 岩崎 還元型ニコチンアミド補酵素の測定用試薬および測定方法
US5769081A (en) 1996-03-18 1998-06-23 The Research Foundation Of City College Of New York Method for detecting cancerous tissue using optical spectroscopy and fourier analysis
US5829448A (en) 1996-10-30 1998-11-03 Photogen, Inc. Method for improved selectivity in photo-activation of molecular agents
US6124597A (en) 1997-07-07 2000-09-26 Cedars-Sinai Medical Center Method and devices for laser induced fluorescence attenuation spectroscopy
WO2000015101A1 (en) 1998-09-11 2000-03-23 Spectrx, Inc. Multi-modal optical tissue diagnostic system
US6051437A (en) 1998-05-04 2000-04-18 American Research Corporation Of Virginia Optical chemical sensor based on multilayer self-assembled thin film sensors for aquaculture process control
WO1999057529A1 (en) 1998-05-04 1999-11-11 The Board Of Regents Combined fluorescence and reflectance spectroscopy
AU5429199A (en) 1998-08-08 2000-02-28 Imperial Cancer Research Technology Limited Modified green fluorescent protein
JP2002525587A (ja) * 1998-08-28 2002-08-13 フェビット フェラリウス バイオテクノロジー ゲゼルシャフト ミット ベシュレンクテル ハフツング 試料中の分析物を測定するための方法および装置
US6246817B1 (en) 1998-09-01 2001-06-12 Innova Quartz Inc. Optical fiber with numerical aperture compression
JP2002532181A (ja) 1998-12-23 2002-10-02 メディスペクトラ， インコーポレイテッド 頚部のスクリーニングのための光学的方法およびシステム
US6272376B1 (en) 1999-01-22 2001-08-07 Cedars-Sinai Medical Center Time-resolved, laser-induced fluorescence for the characterization of organic material
US6097485A (en) * 1999-03-08 2000-08-01 Integrated Waveguides, Inc. Microchip optical transport technology for use in a personal flow cytometer
US6697666B1 (en) 1999-06-22 2004-02-24 Board Of Regents, The University Of Texas System Apparatus for the characterization of tissue of epithelial lined viscus
WO2001008552A1 (en) 1999-08-03 2001-02-08 Biophysica, Llc Spectroscopic systems and methods for detecting tissue properties
US7904139B2 (en) 1999-08-26 2011-03-08 Non-Invasive Technology Inc. Optical examination of biological tissue using non-contact irradiation and detection
US7260248B2 (en) 1999-12-15 2007-08-21 Medispectra, Inc. Image processing using measures of similarity
GR1004180B (el) 2000-03-28 2003-03-11 ����������� ����� ��������� (����) Μεθοδος και συστημα χαρακτηρισμου και χαρτογραφησης αλλοιωσεων των ιστων
WO2001082786A2 (en) 2000-05-03 2001-11-08 Flock Stephen T Optical imaging of subsurface anatomical structures and biomolecules
JP5507780B2 (ja) 2000-06-08 2014-05-28 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 視覚的サーボ制御光学顕微鏡
US7546210B2 (en) 2000-06-08 2009-06-09 The Regents Of The University Of California Visual-servoing optical microscopy
ATE417543T1 (de) 2000-07-13 2009-01-15 Univ Virginia Commonwealth Verwendung von ultraviolett, nahultraviolett und nahinfrarot-resonanzrmanspektroskopie und fluoresenzspektoskopie zur gewebeuntersuchung auf schockzustand, kritische krankheiten oder andere krankheitszustände
US6826424B1 (en) 2000-12-19 2004-11-30 Haishan Zeng Methods and apparatus for fluorescence and reflectance imaging and spectroscopy and for contemporaneous measurements of electromagnetic radiation with multiple measuring devices
US6697652B2 (en) 2001-01-19 2004-02-24 Massachusetts Institute Of Technology Fluorescence, reflectance and light scattering spectroscopy for measuring tissue
US7015484B2 (en) * 2001-04-16 2006-03-21 Dakota Technologies, Inc. Multi-dimensional fluorescence apparatus and method for rapid and highly sensitive quantitative analysis of mixtures
US6929779B2 (en) 2001-06-22 2005-08-16 Biocal Technology, Inc. Optical detection in bio-separation device using axial radiation output
GB2382648B (en) * 2001-12-11 2003-11-12 Amersham Pharm Biotech Uk Ltd System and method for time correlated multi-photon counting measurements
US20030136921A1 (en) 2002-01-23 2003-07-24 Reel Richard T Methods for fluorescence detection that minimizes undesirable background fluorescence
US7647092B2 (en) 2002-04-05 2010-01-12 Massachusetts Institute Of Technology Systems and methods for spectroscopy of biological tissue
US20060193905A1 (en) * 2002-05-14 2006-08-31 University Of Louisville Research Foundation, Inc. Direct cellular energy delivery system
US6933154B2 (en) 2002-07-09 2005-08-23 Medispectra, Inc. Optimal windows for obtaining optical data for characterization of tissue samples
US7136518B2 (en) 2003-04-18 2006-11-14 Medispectra, Inc. Methods and apparatus for displaying diagnostic data
US7103401B2 (en) 2002-07-10 2006-09-05 Medispectra, Inc. Colonic polyp discrimination by tissue fluorescence and fiberoptic probe
US6768918B2 (en) 2002-07-10 2004-07-27 Medispectra, Inc. Fluorescent fiberoptic probe for tissue health discrimination and method of use thereof
US7285424B2 (en) * 2002-08-27 2007-10-23 Kimberly-Clark Worldwide, Inc. Membrane-based assay devices
US6897954B2 (en) * 2002-12-20 2005-05-24 Becton, Dickinson And Company Instrument setup system for a fluorescence analyzer
US7192783B2 (en) 2003-02-05 2007-03-20 Research Foundation Of The City University Of New York Stokes shift emission spectroscopy for detection of disease and physiological state of specimen
JP2004305382A (ja) 2003-04-04 2004-11-04 Olympus Corp 特殊光観察システム
US20040225222A1 (en) 2003-05-08 2004-11-11 Haishan Zeng Real-time contemporaneous multimodal imaging and spectroscopy uses thereof
WO2005019800A2 (en) 2003-08-19 2005-03-03 Cedars-Sinai Medical Center Method for fluorescence lifetime imaging microscopy and spectroscopy
US20050105791A1 (en) 2003-10-29 2005-05-19 Lee Ken K. Surface inspection method
WO2006015251A2 (en) 2004-07-29 2006-02-09 The Research Foundation Of State University Of New York System and method for cross-talk cancellation in a multilane fluorescence detector
JP5318413B2 (ja) * 2004-09-01 2013-10-16 パーキンエルマー・シンガポール・プライベート・リミテッド サンプルを分析する方法およびその装置
US20060229515A1 (en) 2004-11-17 2006-10-12 The Regents Of The University Of California Fiber optic evaluation of tissue modification
US7554663B2 (en) * 2005-02-08 2009-06-30 Northrop Grumman Corporation Systems and methods for use in detecting harmful aerosol particles
CN101156059B (zh) * 2005-04-01 2011-06-08 3M创新有限公司 具有将多个光学模块连接到公共检测器的纤维束的多重荧光检测装置
US7709249B2 (en) * 2005-04-01 2010-05-04 3M Innovative Properties Company Multiplex fluorescence detection device having fiber bundle coupling multiple optical modules to a common detector
KR101281855B1 (ko) 2005-07-18 2013-07-15 안드레아스 만델리스 적외선 광열 복사 측정(피티아르) 및 변조 레이저냉광(엘유엠)을 이용한 치아 내의 결함 진단을 위한 방법및 장치
GB2429521A (en) 2005-08-18 2007-02-28 E2V Tech CCD device for time resolved spectroscopy
US8057408B2 (en) * 2005-09-22 2011-11-15 The Regents Of The University Of Michigan Pulsed cavitational ultrasound therapy
WO2008034070A2 (en) 2006-09-15 2008-03-20 Pathologics Associates, Inc. Improved method for biomolecular detection and system thereof
US7824902B2 (en) 2006-11-03 2010-11-02 Mark Selker Optical interface for disposable bioreactors
US8405827B2 (en) 2006-11-21 2013-03-26 Ricardo Claps Time-resolved spectroscopy system and methods for multiple-species analysis in fluorescence and cavity-ringdown applications
WO2008127434A2 (en) * 2006-11-28 2008-10-23 The Regents Of The University Of California Time-resolved and wavelength-resolved spectroscopy for characterizing biological materials
US20100069720A1 (en) 2006-11-30 2010-03-18 Newton Laboratories, Inc. Spectroscopically enhanced imaging
EP2174118A4 (en) 2007-02-01 2015-06-24 Ls Biopath Inc OPTICAL SYSTEM FOR THE IDENTIFICATION AND CHARACTERIZATION OF FABRICS AND ABNORMAL CELLS
WO2008144760A1 (en) 2007-05-21 2008-11-27 Board Of Regents, The University Of Texas System Optical methods to intraoperatively detect positive prostate and kidney cancer margins
US9226731B2 (en) 2007-05-21 2016-01-05 The Board Of Regents Of The University Of Texas System Optically guided needle biopsy system using multi-modal spectroscopy in combination with a transrectal ultrasound probe
KR100885927B1 (ko) * 2007-10-16 2009-02-26 광주과학기술원 형광수명 측정 방법 및 장치
US20090099460A1 (en) 2007-10-16 2009-04-16 Remicalm Llc Method and device for the optical spectroscopic identification of cervical cancer
WO2009061832A1 (en) * 2007-11-05 2009-05-14 Kci Licensing Inc. Identification of tissue for debridement
US8509879B2 (en) * 2007-11-06 2013-08-13 The Regents Of The University Of California Apparatus and method for widefield functional imaging (WiFI) using integrated structured illumination and laser speckle imaging
US8694266B2 (en) 2008-06-05 2014-04-08 The Regents Of The University Of Michigan Multimodal spectroscopic systems and methods for classifying biological tissue
US20100234684A1 (en) 2009-03-13 2010-09-16 Blume Jurgen Multifunctional endoscopic device and methods employing said device
US8264694B2 (en) 2009-03-16 2012-09-11 Ut-Battelle, Llc Quantitative phase-contrast and excitation-emission systems
JP2011062348A (ja) 2009-09-17 2011-03-31 Fujifilm Corp 内視鏡システム
CN102770071B (zh) 2009-12-15 2015-03-25 爱默蕾大学 用于在诊断或治疗程序中提供实时解剖学指导的系统和方法
US20130076861A1 (en) * 2010-01-21 2013-03-28 Shmuel Sternklar Method and apparatus for probing an object, medium or optical path using noisy light
JP5704827B2 (ja) 2010-03-19 2015-04-22 オリンパス株式会社 蛍光観察装置
US20130087718A1 (en) 2010-06-28 2013-04-11 Ge Healthcare Bio-Sciences Corp. Confocal fluorescence lifetime imaging system
US9662047B2 (en) 2010-08-05 2017-05-30 Massachusetts Institute Of Technology Portable raman diagnostic system
US20120088262A1 (en) * 2010-10-06 2012-04-12 Millipore Corporation Cyanine compounds, conjugates and method of use
US20130015370A1 (en) * 2011-07-15 2013-01-17 Huron Technologies International In Confocal fluorescence slide scanner with parallel detection
CN102525481B (zh) 2011-12-14 2014-03-19 山东大学 一种基于近红外光谱的人体内酒精含量检测方法及系统
EP2820398B1 (en) 2012-03-02 2018-10-24 The Regents of The University of California Apparatus for time-resolved fluorescence imaging and pulse shaping
US10376147B2 (en) 2012-12-05 2019-08-13 AccuVeiw, Inc. System and method for multi-color laser imaging and ablation of cancer cells using fluorescence
US20140273181A1 (en) 2013-03-15 2014-09-18 Biofire Diagnostics, Inc. Compact optical system for substantially simultaneous monitoring of samples in a sample array
US20170238807A9 (en) 2013-03-15 2017-08-24 LX Medical, Inc. Tissue imaging and image guidance in luminal anatomic structures and body cavities
WO2014168734A1 (en) 2013-03-15 2014-10-16 Cedars-Sinai Medical Center Time-resolved laser-induced fluorescence spectroscopy systems and uses thereof
US10362983B2 (en) 2014-05-12 2019-07-30 Robert R. Alfano Near infrared photonic prostatoscopy analyzer
EP3265785A4 (en) 2015-10-30 2018-04-04 Cedars-Sinai Medical Center Methods and systems for performing tissue classification using multi-channel tr-lifs and multivariate analysis
JP7266519B2 (ja) 2016-04-01 2023-04-28 ブラック ライト サージカル， インコーポレイテッド 時間分解蛍光分光法のためのシステム、デバイス、および方法
US20170290515A1 (en) 2016-04-08 2017-10-12 Cedars-Sinai Medical Center Tissue classification method using time-resolved fluorescence spectroscopy and combination of monopolar and bipolar cortical and subcortical stimulator with time-resolved fluorescence spectroscopy

Also Published As

Publication number Publication date
WO2014168734A1 (en) 2014-10-16
US20160003742A1 (en) 2016-01-07
JP6850843B2 (ja) 2021-03-31
AU2018204489A1 (en) 2018-07-12
EP2972224A1 (en) 2016-01-20
EP4083611A1 (en) 2022-11-02
US11428636B2 (en) 2022-08-30
CN105143855A (zh) 2015-12-09
ES2639750T3 (es) 2017-10-30
JP2021105609A (ja) 2021-07-26
AU2014232480B2 (en) 2018-03-15
EP3301435A1 (en) 2018-04-04
ES2925022T3 (es) 2022-10-13
MX349624B (es) 2017-08-07
WO2014145786A1 (en) 2014-09-18
EP3301435B1 (en) 2022-08-03
US9404870B2 (en) 2016-08-02
US10288567B2 (en) 2019-05-14
AU2014232480A1 (en) 2015-09-24
KR20150131085A (ko) 2015-11-24
JP7268072B2 (ja) 2023-05-02
JP2019215373A (ja) 2019-12-19
KR20210122864A (ko) 2021-10-12
JP2023106381A (ja) 2023-08-01
CN105143855B (zh) 2018-04-20
EP2972224A4 (en) 2017-01-11
JP6581566B2 (ja) 2019-09-25
JP2016512891A (ja) 2016-05-09
US20210255107A1 (en) 2021-08-19
KR20200106229A (ko) 2020-09-11
US20200096447A1 (en) 2020-03-26
KR102391386B1 (ko) 2022-04-27
MX2015012157A (es) 2016-04-25
KR20220057644A (ko) 2022-05-09
KR102306192B1 (ko) 2021-09-29
AU2018204489B2 (en) 2020-08-27
US20230228683A1 (en) 2023-07-20
US20160377547A1 (en) 2016-12-29
EP2972224B1 (en) 2017-08-23
CA2906890A1 (en) 2014-09-18
BR112015022766A2 (pt) 2017-07-18
KR102154547B1 (ko) 2020-09-10
US10983060B2 (en) 2021-04-20

Similar Documents

Publication Publication Date Title
CR20150469A (es) Sistemas de espectroscopía de fluorescencia inducida por láser resuelta en el tiempo y usos de los mismos
WO2013049702A3 (en) Systems and methods for biological analysis
CU20180024A7 (es) Moléculas de unión a linfopoyetina estromal tímica (tslp), composiciones farmacéuticas que las contienen y método de producción de las mismas
BR112015020980A2 (pt) armadilha para inseto, cartucho de armadilha para inseto removível, método e aparelho de acoplamento
AR068848A1 (es) Espectrometro con conjunto ordenado de leds
CL2017001461A1 (es) Composiciones y métodos para anticuerpos que se marcan bmp6
DE102013226181A8 (de) Optisches Element, sowie Anordnung zur Lichtabgabe
BR112014005273A2 (pt) aparelho e aparelho para formar um feixe óptico a partir de uma fonte de luz estendida
CR20110544A (es) Anticuerpo antagonista específico para el heterodímero de alfa-4-beta-7
BR112017006964A2 (pt) ?componente óptico de um aparelho de iluminação e aparelho de iluminação?
AR086646A1 (es) Inspeccion de radiaciones multiples de lentes oftalmicas
DK3505885T3 (da) Lysenergi-fluoroscens-excitering
CO2019014432A2 (es) Dispositivos de detección de luz con dos filtros y métodos relacionados con los mismos
BR112012000156A8 (pt) Dispositivo de fototerapia
GB2545850A (en) System and method using a combined modality optical probe
BR112015007216A2 (pt) conjunto emissor de luz e método de readaptação de um dispositivo de iluminação fluorescente
GB201305226D0 (en) Transmitted light detection type measurement apparatus for skin autofluorescence
BR112015014361A2 (pt) conjunto de amostragem para amostragem de um espécime, módulo de microscópio aplicado para proporcionar uma imagem de uma amostra, e aparelho de microscópio
JP2017502341A5 (es)
CY1121506T1 (el) Συστημα φωτεινου πλαισιου
EP3479444A4 (en) FIBER LASER SYSTEM WITH MECHANISM FOR INDUCTION OF PARASITICAL LIGHT LOSS
GB201617381D0 (en) Metamaterial optical member, light detection device, laser excitation light source, and measuring device
BR112017024936A2 (pt) método implantado por computador e sistema para criar uma imagem de um espécime
CL2014001967A1 (es) Método de detección de objetivo de luz incidente redirigida, para la ayuda del control de redirección de luz desde fuentes hacia objetivos, para heliostatos, comprende el uso de un elemento re-direccionador de luz incidente, proveer un conjunto de poxies ópticos asociado con el re-direccionador, observación de la información óptica obtenida de los poxies y el uso de la información; sistema.
PL396830A1 (pl) Sposób walidacji próbek w analizatorze biochemicznym i analizator biochemiczny realizujacy ten sposób