CR20130056A - Derivados heterocíclicos fusionados como moduladores s1p - Google Patents
Derivados heterocíclicos fusionados como moduladores s1pInfo
- Publication number
- CR20130056A CR20130056A CR20130056A CR20130056A CR20130056A CR 20130056 A CR20130056 A CR 20130056A CR 20130056 A CR20130056 A CR 20130056A CR 20130056 A CR20130056 A CR 20130056A CR 20130056 A CR20130056 A CR 20130056A
- Authority
- CR
- Costa Rica
- Prior art keywords
- heterocyclic derivatives
- fusioned
- modulators
- receptor
- involved
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Abstract
Esta invención se relaciona con nuevos derivados heterocíclicos fusionados que tienen afinidad con los receptores S1P, con una composición farmacéutica que contiene dichos compuestos, así como también con el uso de dichos compuestos para la preparación de un medicamento para tratar, aliviar o evitar enfermedades y afecciones en las que está involucrado cualquier receptor S1P o en las que está involucrada la modulación del sistema de señalización S1P endógeno a través de cualquier receptor S1P.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36278410P | 2010-07-09 | 2010-07-09 | |
EP10169107 | 2010-07-09 | ||
EP11156007 | 2011-02-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
CR20130056A true CR20130056A (es) | 2013-06-12 |
Family
ID=44358260
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR20130056A CR20130056A (es) | 2010-07-09 | 2013-02-08 | Derivados heterocíclicos fusionados como moduladores s1p |
Country Status (27)
Country | Link |
---|---|
US (3) | US8796262B2 (es) |
EP (1) | EP2590980B1 (es) |
JP (1) | JP5973429B2 (es) |
KR (1) | KR101889694B1 (es) |
CN (1) | CN103068827B (es) |
AR (1) | AR082136A1 (es) |
AU (1) | AU2011275755B2 (es) |
BR (1) | BR112013000627B1 (es) |
CA (1) | CA2804137C (es) |
CL (1) | CL2013000069A1 (es) |
CO (1) | CO6670577A2 (es) |
CR (1) | CR20130056A (es) |
DO (1) | DOP2013000009A (es) |
EC (1) | ECSP13012416A (es) |
ES (1) | ES2653682T3 (es) |
HK (1) | HK1179956A1 (es) |
IL (1) | IL224054A (es) |
MX (1) | MX2013000360A (es) |
MY (1) | MY161229A (es) |
NZ (1) | NZ605491A (es) |
PE (1) | PE20130592A1 (es) |
RU (1) | RU2576660C2 (es) |
SG (1) | SG186952A1 (es) |
TW (1) | TWI522361B (es) |
UY (1) | UY33496A (es) |
WO (1) | WO2012004373A1 (es) |
ZA (1) | ZA201300157B (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE48301E1 (en) | 2010-07-09 | 2020-11-10 | Abbvie B.V. | Fused heterocyclic derivatives as S1P modulators |
TWI543984B (zh) | 2010-07-09 | 2016-08-01 | 艾伯維公司 | 作為s1p調節劑的螺-哌啶衍生物 |
JP2016011257A (ja) * | 2012-10-23 | 2016-01-21 | 大日本住友製薬株式会社 | テトラヒドロオキサゾロピリジン誘導体 |
US10556907B2 (en) | 2015-08-28 | 2020-02-11 | AbbVie Deutschland GmbH & Co. KG | Fused heterocyclic compounds as S1P modulators |
WO2018083171A1 (en) | 2016-11-02 | 2018-05-11 | AbbVie Deutschland GmbH & Co. KG | Spiro-compounds as s1p modulators |
WO2021087299A1 (en) | 2019-10-31 | 2021-05-06 | E-Scape Bio, Inc. | Solid forms of an s1p-receptor modulator |
CN114650996A (zh) * | 2019-10-31 | 2022-06-21 | 逃逸生物有限公司 | 用于制备s1p受体调节剂的方法 |
US11760751B2 (en) | 2020-03-04 | 2023-09-19 | Helioeast Science & Technology Co., Ltd. | Benzo 2-azaspiro[4.4]nonane compound and use thereof |
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SU1069387A1 (ru) * | 1982-07-01 | 1985-11-30 | Институт физико-органической химии и углехимии АН УССР | Дигидрохлорид 5-/ @ -( @ -анизил)- @ -оксиэтил/ 2-(3,4-диметоксифенил)-1-метил-4,5,6,7-тетрагидроимидазо(4,5- @ )пиридина,обладающий спазмолитическим действием |
GB2228432A (en) | 1989-01-13 | 1990-08-29 | Grayston Central Services | Multi-role machine for heating and coating pipe welds. |
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JP2681589B2 (ja) | 1992-12-28 | 1997-11-26 | 日揮株式会社 | 配管溶接継手の熱処理方法 |
JPH072848A (ja) | 1993-04-23 | 1995-01-06 | Sankyo Co Ltd | モルホリンおよびチオモルホリン誘導体 |
GB9522845D0 (en) | 1995-11-08 | 1996-01-10 | Smithkline Beecham Plc | Novel compounds |
JP3822680B2 (ja) | 1996-08-30 | 2006-09-20 | 新日本製鐵株式会社 | 誘導加熱された接合部の冷却方法および冷却装置 |
AU2001246916B2 (en) | 2000-04-21 | 2004-10-07 | Shionogi & Co., Ltd. | Oxadiazole derivatives having anticancer effects |
FR2822727A1 (fr) | 2001-04-03 | 2002-10-04 | Gesal Ind | Procede d'application d'un revetement resistant aux hautes temperatures, dispositif pour la mise en oeuvre de ce procede et objet pourvu dudit revetement |
JP3649223B2 (ja) | 2003-01-08 | 2005-05-18 | 株式会社日立製作所 | 配管系の熱処理方法および熱処理装置 |
US7265128B2 (en) * | 2003-01-17 | 2007-09-04 | Merck & Co., Inc. | 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
EP1631557B1 (en) | 2003-06-12 | 2006-12-20 | Btg International Limited | Cyclic hydroxylamine as psychoactive compounds |
US7550485B2 (en) | 2003-10-14 | 2009-06-23 | Wyeth | Substituted N-heterocycle derivatives and methods of their use |
GB0329498D0 (en) | 2003-12-19 | 2004-01-28 | Novartis Ag | Organic compounds |
GB0401332D0 (en) | 2004-01-21 | 2004-02-25 | Novartis Ag | Organic compounds |
JP4185154B2 (ja) | 2004-04-30 | 2008-11-26 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | 中枢神経系障害治療用の置換モルホリン化合物 |
GB0409744D0 (en) | 2004-04-30 | 2004-06-09 | Pfizer Ltd | Novel compounds |
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EP1804793A4 (en) | 2004-10-22 | 2010-03-31 | Merck Sharp & Dohme | 2- (ARYL) AZACYCLYLMETHYL-CARBOXYLATE, SULPHONATE, PHOSPHONATE, PHOSPHINATE AND HETEROCYCLES AS S1P RECEPTOR AGONISTS |
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2011
- 2011-07-07 TW TW100124107A patent/TWI522361B/zh active
- 2011-07-08 JP JP2013517399A patent/JP5973429B2/ja active Active
- 2011-07-08 CN CN201180033957.0A patent/CN103068827B/zh active Active
- 2011-07-08 PE PE2013000026A patent/PE20130592A1/es active IP Right Grant
- 2011-07-08 SG SG2013000997A patent/SG186952A1/en unknown
- 2011-07-08 KR KR1020137003333A patent/KR101889694B1/ko active IP Right Grant
- 2011-07-08 AR ARP110102455A patent/AR082136A1/es active IP Right Grant
- 2011-07-08 AU AU2011275755A patent/AU2011275755B2/en active Active
- 2011-07-08 WO PCT/EP2011/061586 patent/WO2012004373A1/en active Application Filing
- 2011-07-08 MX MX2013000360A patent/MX2013000360A/es active IP Right Grant
- 2011-07-08 BR BR112013000627-7A patent/BR112013000627B1/pt active IP Right Grant
- 2011-07-08 US US13/808,908 patent/US8796262B2/en not_active Ceased
- 2011-07-08 NZ NZ605491A patent/NZ605491A/en unknown
- 2011-07-08 RU RU2013105444/04A patent/RU2576660C2/ru active
- 2011-07-08 EP EP11733645.3A patent/EP2590980B1/en active Active
- 2011-07-08 UY UY0001033496A patent/UY33496A/es unknown
- 2011-07-08 MY MYPI2013000055A patent/MY161229A/en unknown
- 2011-07-08 ES ES11733645.3T patent/ES2653682T3/es active Active
- 2011-07-08 CA CA2804137A patent/CA2804137C/en active Active
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2012
- 2012-12-31 IL IL224054A patent/IL224054A/en active IP Right Grant
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2013
- 2013-01-07 ZA ZA2013/00157A patent/ZA201300157B/en unknown
- 2013-01-08 CL CL2013000069A patent/CL2013000069A1/es unknown
- 2013-01-09 DO DO2013000009A patent/DOP2013000009A/es unknown
- 2013-01-25 CO CO13014079A patent/CO6670577A2/es active IP Right Grant
- 2013-02-04 EC ECSP13012416 patent/ECSP13012416A/es unknown
- 2013-02-08 CR CR20130056A patent/CR20130056A/es unknown
- 2013-06-19 HK HK13107150.6A patent/HK1179956A1/zh unknown
- 2013-09-05 US US14/019,236 patent/US9096612B2/en active Active
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2015
- 2015-06-18 US US14/743,234 patent/US9670220B2/en active Active
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