CR11866A - Derivados de piridino-piridinonas, su preparacion y su aplicacion en terapeutica - Google Patents

Derivados de piridino-piridinonas, su preparacion y su aplicacion en terapeutica

Info

Publication number
CR11866A
CR11866A CR11866A CR11866A CR11866A CR 11866 A CR11866 A CR 11866A CR 11866 A CR11866 A CR 11866A CR 11866 A CR11866 A CR 11866A CR 11866 A CR11866 A CR 11866A
Authority
CR
Costa Rica
Prior art keywords
derivatives
preparation
piridinonas
piridino
therapeutics
Prior art date
Application number
CR11866A
Other languages
English (en)
Inventor
Bellevergue Patrice
Lassalle Gilbert
Mccort Gary
Martin Valerie
Savi Pierre
Volle-Challier Cecile
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of CR11866A publication Critical patent/CR11866A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Transplantation (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La invención se refiere a los derivados de piridino-piridinonas, de fórmula general (I): en la que R1, R2, R3, R4, R5, R6, R7, V, W, Y, Z son tales como se han definido en la descripcion. Procedimiento de preparació h aplicación en terapéutica.
CR11866A 2008-07-08 2010-12-22 Derivados de piridino-piridinonas, su preparacion y su aplicacion en terapeutica CR11866A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0803862A FR2933700B1 (fr) 2008-07-08 2008-07-08 Derives de pyridino-pyridinones, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
CR11866A true CR11866A (es) 2011-03-14

Family

ID=40219672

Family Applications (1)

Application Number Title Priority Date Filing Date
CR11866A CR11866A (es) 2008-07-08 2010-12-22 Derivados de piridino-piridinonas, su preparacion y su aplicacion en terapeutica

Country Status (32)

Country Link
US (1) US8436011B2 (es)
EP (1) EP2315767B1 (es)
JP (1) JP5606434B2 (es)
KR (1) KR20110031372A (es)
CN (1) CN102149713B (es)
AR (1) AR072798A1 (es)
AU (1) AU2009267827B2 (es)
BR (1) BRPI0915438A2 (es)
CA (1) CA2729833A1 (es)
CL (1) CL2011000048A1 (es)
CO (1) CO6341476A2 (es)
CR (1) CR11866A (es)
DO (1) DOP2011000008A (es)
EA (1) EA019362B1 (es)
EC (1) ECSP11010742A (es)
ES (1) ES2438540T3 (es)
FR (1) FR2933700B1 (es)
HK (1) HK1159108A1 (es)
HN (1) HN2011000076A (es)
IL (1) IL210514A (es)
MA (1) MA32544B1 (es)
MX (1) MX2011000330A (es)
MY (1) MY149705A (es)
NI (1) NI201100011A (es)
NZ (1) NZ590862A (es)
PE (1) PE20110405A1 (es)
SV (1) SV2011003800A (es)
TW (1) TW201004955A (es)
UA (1) UA102858C2 (es)
UY (1) UY31971A (es)
WO (1) WO2010004197A2 (es)
ZA (1) ZA201100210B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0205455D0 (en) 2002-03-07 2002-04-24 Molecular Sensing Plc Nucleic acid probes, their synthesis and use
FR2933700B1 (fr) 2008-07-08 2010-07-30 Sanofi Aventis Derives de pyridino-pyridinones, leur preparation et leur application en therapeutique
FR2952934B1 (fr) 2009-11-23 2012-06-22 Sanofi Aventis Derives de pyridino-pyridinones, leur preparation et leur application en therapeutique
FR2954943B1 (fr) * 2010-01-07 2013-03-01 Sanofi Aventis Derives de pyridino-pyridinones arylsulfonamides, leur preparation et leur application en therapeutique
FR2955109B1 (fr) * 2010-01-08 2012-09-07 Sanofi Aventis Derives de 5-oxo-5,8-dihydro-pyrido[2, 3-d]pyrimidine, leur preparation et leur application en therapeutique
US10420665B2 (en) 2010-06-13 2019-09-24 W. L. Gore & Associates, Inc. Intragastric device for treating obesity
US8628554B2 (en) 2010-06-13 2014-01-14 Virender K. Sharma Intragastric device for treating obesity
US9526648B2 (en) 2010-06-13 2016-12-27 Synerz Medical, Inc. Intragastric device for treating obesity
US10010439B2 (en) 2010-06-13 2018-07-03 Synerz Medical, Inc. Intragastric device for treating obesity
EP2524915A1 (en) * 2011-05-20 2012-11-21 Sanofi 2-Amino-3-(imidazol-2-yl)-pyridin-4-one derivatives and their use as VEGF receptor kinase inhibitors
EP2874625B1 (en) * 2012-07-17 2017-05-17 Sanofi Use of vegfr-3 inhibitors for treating hepatocellular carcinoma
UA110688C2 (uk) * 2012-09-21 2016-01-25 Пфайзер Інк. Біциклічні піридинони
US10779980B2 (en) 2016-04-27 2020-09-22 Synerz Medical, Inc. Intragastric device for treating obesity
JP2018052878A (ja) * 2016-09-29 2018-04-05 第一三共株式会社 ピリジン化合物
US11498904B2 (en) 2017-11-14 2022-11-15 Merck Sharp & Dohme Llc Substituted biaryl compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors
US10647705B2 (en) 2017-11-14 2020-05-12 Merck Sharp & Dohme Corp. Substituted biaryl compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors
AU2018380132B2 (en) * 2017-12-06 2023-11-09 Lin Bioscience, Inc. Tubulin inhibitors

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3845008A (en) * 1973-03-02 1974-10-29 Du Pont Brake lining composition comprising particulate tar residue
US4959363A (en) * 1989-06-23 1990-09-25 Sterling Drug Inc. Quinolonecarboxamide compounds, their preparation and use as antivirals.
US5476632A (en) * 1992-09-09 1995-12-19 Stackpole Limited Powder metal alloy process
US5332422A (en) * 1993-07-06 1994-07-26 Ford Motor Company Solid lubricant and hardenable steel coating system
AU7811194A (en) * 1993-10-02 1995-05-01 Cerasiv Gmbh Molded article
US5518639A (en) * 1994-08-12 1996-05-21 Hoeganaes Corp. Powder metallurgy lubricant composition and methods for using same
US5641580A (en) * 1995-10-03 1997-06-24 Osram Sylvania Inc. Advanced Mo-based composite powders for thermal spray applications
JP3537286B2 (ja) * 1997-03-13 2004-06-14 株式会社三協精機製作所 焼結含油軸受およびそれを用いたモータ
CA2207579A1 (fr) * 1997-05-28 1998-11-28 Paul Caron Piece frittee a surface anti-abrasive et procede pour sa realisation
US6689424B1 (en) * 1999-05-28 2004-02-10 Inframat Corporation Solid lubricant coatings produced by thermal spray methods
MXPA02006983A (es) * 2000-11-16 2002-12-13 Honda Motor Co Ltd Miembro metalico deslizable, piston para un motor de combustion interna, metodo para tratamiento de superficie de este, y aparato para esto.
JP2004124130A (ja) * 2002-09-30 2004-04-22 Fujimi Inc 溶射用粉末及びその製造方法並びに該溶射用粉末を用いた溶射方法
US7300488B2 (en) * 2003-03-27 2007-11-27 Höganäs Ab Powder metal composition and method for producing components thereof
TW200502236A (en) * 2003-03-28 2005-01-16 Hoffmann La Roche Novel pyrido[2,3-d]pyrimidin-7-carboxylic acid derivatives, their manufacture and use as pharmaceutical agents
DE10326769B3 (de) * 2003-06-13 2004-11-11 Esk Ceramics Gmbh & Co. Kg Dauerhafte BN-Formtrennschichten für das Druckgießen von Nichteisenmetallen
US7563748B2 (en) 2003-06-23 2009-07-21 Cognis Ip Management Gmbh Alcohol alkoxylate carriers for pesticide active ingredients
WO2005026156A1 (en) * 2003-09-16 2005-03-24 Astrazeneca Ab Quinazoline derivatives
US7553564B2 (en) * 2004-05-26 2009-06-30 Honeywell International Inc. Ternary carbide and nitride materials having tribological applications and methods of making same
US7968503B2 (en) * 2004-06-07 2011-06-28 Ppg Industries Ohio, Inc. Molybdenum comprising nanomaterials and related nanotechnology
US7687112B2 (en) * 2004-07-14 2010-03-30 Kinetitec Corporation Surface for reduced friction and wear and method of making the same
GB0423554D0 (en) * 2004-10-22 2004-11-24 Cancer Rec Tech Ltd Therapeutic compounds
DE102005001198A1 (de) * 2005-01-10 2006-07-20 H.C. Starck Gmbh Metallische Pulvermischungen
US7575619B2 (en) * 2005-03-29 2009-08-18 Hitachi Powdered Metals Co., Ltd. Wear resistant sintered member
US7470307B2 (en) * 2005-03-29 2008-12-30 Climax Engineered Materials, Llc Metal powders and methods for producing the same
TW200801513A (en) 2006-06-29 2008-01-01 Fermiscan Australia Pty Ltd Improved process
ES2393326T3 (es) * 2006-12-18 2012-12-20 Amgen, Inc Compuestos basados en azaquinolona que presentan actividad inhibidora de prolil hidroxilasas, composiciones y usos de los mismos
FR2917412B1 (fr) 2007-06-13 2009-08-21 Sanofi Aventis Sa Derives de 7-alkynyl, 1,8-naphthyridones, leur preparation et leur application en therapeutique
FR2917413B1 (fr) 2007-06-13 2009-08-21 Sanofi Aventis Sa Derives de 7-alkynyl-1,8-naphthyridones, leur preparation et leur application en therapeutique
WO2010000020A1 (en) 2008-06-30 2010-01-07 Cathrx Ltd A catheter
FR2933700B1 (fr) 2008-07-08 2010-07-30 Sanofi Aventis Derives de pyridino-pyridinones, leur preparation et leur application en therapeutique
FR2933701A1 (fr) * 2008-07-08 2010-01-15 Sanofi Aventis Derives anticancereux, leur preparation et leur application en therapeutique
US8038760B1 (en) * 2010-07-09 2011-10-18 Climax Engineered Materials, Llc Molybdenum/molybdenum disulfide metal articles and methods for producing same

Also Published As

Publication number Publication date
US20110124643A1 (en) 2011-05-26
DOP2011000008A (es) 2011-02-15
IL210514A0 (en) 2011-03-31
AR072798A1 (es) 2010-09-22
MY149705A (en) 2013-09-30
SV2011003800A (es) 2011-04-29
AU2009267827A1 (en) 2010-01-14
WO2010004197A3 (fr) 2010-03-11
KR20110031372A (ko) 2011-03-25
PE20110405A1 (es) 2011-07-04
CL2011000048A1 (es) 2011-07-15
ECSP11010742A (es) 2011-02-28
WO2010004197A2 (fr) 2010-01-14
HN2011000076A (es) 2013-07-22
ZA201100210B (en) 2012-03-28
BRPI0915438A2 (pt) 2015-11-10
MA32544B1 (fr) 2011-08-01
CN102149713B (zh) 2013-12-11
EP2315767A2 (fr) 2011-05-04
HK1159108A1 (en) 2012-07-27
JP5606434B2 (ja) 2014-10-15
NI201100011A (es) 2011-08-05
CO6341476A2 (es) 2011-11-21
UY31971A (es) 2010-02-26
FR2933700A1 (fr) 2010-01-15
CN102149713A (zh) 2011-08-10
EP2315767B1 (fr) 2013-09-04
ES2438540T3 (es) 2014-01-17
EA201170154A1 (ru) 2011-08-30
FR2933700B1 (fr) 2010-07-30
UA102858C2 (ru) 2013-08-27
TW201004955A (en) 2010-02-01
IL210514A (en) 2013-11-28
MX2011000330A (es) 2011-04-05
US8436011B2 (en) 2013-05-07
CA2729833A1 (fr) 2010-01-14
EA019362B1 (ru) 2014-03-31
JP2011527320A (ja) 2011-10-27
NZ590862A (en) 2012-06-29
AU2009267827B2 (en) 2014-01-09

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