CO7151503A2 - Composiciones que comprenden benzodiazepinas de acción corta - Google Patents

Composiciones que comprenden benzodiazepinas de acción corta

Info

Publication number
CO7151503A2
CO7151503A2 CO14258220A CO14258220A CO7151503A2 CO 7151503 A2 CO7151503 A2 CO 7151503A2 CO 14258220 A CO14258220 A CO 14258220A CO 14258220 A CO14258220 A CO 14258220A CO 7151503 A2 CO7151503 A2 CO 7151503A2
Authority
CO
Colombia
Prior art keywords
compositions
short
acting benzodiazepines
benzodiazepines
acting
Prior art date
Application number
CO14258220A
Other languages
English (en)
Spanish (es)
Inventor
John Aitken Graham
Alan James Baillie
Kevin Richard Ward
Original Assignee
Paion Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48669863&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO7151503(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Paion Uk Ltd filed Critical Paion Uk Ltd
Publication of CO7151503A2 publication Critical patent/CO7151503A2/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/55131,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/55171,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/55131,4-Benzodiazepines, e.g. diazepam or clozapine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/161,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/161,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/181,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40Cyclodextrins; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
CO14258220A 2012-05-22 2014-11-24 Composiciones que comprenden benzodiazepinas de acción corta CO7151503A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP12168968 2012-05-22

Publications (1)

Publication Number Publication Date
CO7151503A2 true CO7151503A2 (es) 2014-12-29

Family

ID=48669863

Family Applications (1)

Application Number Title Priority Date Filing Date
CO14258220A CO7151503A2 (es) 2012-05-22 2014-11-24 Composiciones que comprenden benzodiazepinas de acción corta

Country Status (41)

Country Link
US (2) US20150148338A1 (enExample)
EP (1) EP2852389B1 (enExample)
JP (1) JP6313286B2 (enExample)
KR (1) KR102116737B1 (enExample)
CN (2) CN108578413A (enExample)
AP (1) AP2014008084A0 (enExample)
AR (1) AR092008A1 (enExample)
AU (1) AU2013265295B2 (enExample)
BR (1) BR112014029108B1 (enExample)
CA (1) CA2874247C (enExample)
CL (1) CL2014003171A1 (enExample)
CO (1) CO7151503A2 (enExample)
DK (1) DK2852389T3 (enExample)
EA (1) EA032119B1 (enExample)
EC (1) ECSP14032553A (enExample)
ES (1) ES2651389T3 (enExample)
FR (1) FR21C1043I2 (enExample)
GE (1) GEP20186852B (enExample)
HR (1) HRP20171872T1 (enExample)
HU (2) HUE037734T2 (enExample)
IL (1) IL235789B (enExample)
LT (2) LT2852389T (enExample)
LU (1) LUC00230I2 (enExample)
MA (1) MA37581B1 (enExample)
MX (1) MX368854B (enExample)
MY (1) MY185117A (enExample)
NL (1) NL301130I2 (enExample)
NO (2) NO2852389T3 (enExample)
NZ (1) NZ702063A (enExample)
PE (1) PE20150683A1 (enExample)
PH (1) PH12014502608B1 (enExample)
PL (1) PL2852389T4 (enExample)
PT (1) PT2852389T (enExample)
RS (1) RS56660B1 (enExample)
SG (1) SG11201407710VA (enExample)
SI (1) SI2852389T1 (enExample)
TN (1) TN2014000479A1 (enExample)
TW (1) TWI590826B (enExample)
UA (1) UA115063C2 (enExample)
WO (1) WO2013174883A1 (enExample)
ZA (1) ZA201408412B (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2081921T1 (sl) 2006-07-10 2011-01-31 Paion Uk Ltd Soli benzodiazepina s kratkotrajnim učinkom ter njihove polimorfne oblike
EP2305647A1 (en) 2009-09-18 2011-04-06 PAION UK Limited Process for preparing 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4 H-imidazo[1,2-a][1,4]benzodiazepine-4-yl] propionic acid methyl ester or the benzene sulfonate salt thereof, and compounds useful in that process
EP2450039A1 (en) 2010-11-08 2012-05-09 PAION UK Ltd. Dosing regimen for sedation with CNS 7056 (Remimazolam)
AR094963A1 (es) 2013-03-04 2015-09-09 Ono Pharmaceutical Co Reacción de oxidación excelente en el índice de conversión
WO2015076340A1 (ja) * 2013-11-21 2015-05-28 小野薬品工業株式会社 全身麻酔および/または鎮静のための注射用組成物
JP6767881B2 (ja) 2014-02-10 2020-10-14 バイオルミック リミテッド 光合成生物の特徴の改善、及びそれに関する制御
MX380722B (es) 2014-03-14 2025-03-12 Biolumic Ltd Metodo para mejorar rendimiento y/o calidad de cultivos.
US9994578B2 (en) 2014-07-23 2018-06-12 Jiangsu Nhwaluokang Pharmceutical Research And Development Co., Ltd Benzodiazepine derivative and use thereof
AU2015318730B2 (en) 2014-09-17 2021-03-25 Biolumic Limited Method of seed treatments and resulting products
CN105726495B (zh) * 2014-12-12 2019-03-29 宜昌人福药业有限责任公司 一种注射用短效苯并二氮杂卓盐药物组合物及其制备方法
CN107198691A (zh) * 2016-03-17 2017-09-26 江苏恒瑞医药股份有限公司 一种瑞马唑仑的药物组合物
KR20180131617A (ko) * 2016-04-14 2018-12-10 파이온 유케이 리미티드 경구 흡입 및 비 벤조디아제핀
WO2017198224A1 (zh) * 2016-05-20 2017-11-23 江苏恒瑞医药股份有限公司 一种瑞马唑仑的药物组合物
WO2018037281A1 (en) 2016-08-22 2018-03-01 Biolumic Limited System, device and methods of seed treatment
CN108503644B (zh) 2016-12-09 2019-06-14 成都倍特药业有限公司 一种苯并二氮杂*衍生物的氢溴酸盐及其制备方法和用途
WO2019002946A1 (en) 2017-06-29 2019-01-03 Biolumic Limited METHOD OF ENHANCING YIELD AND / OR CULTURE QUALITY
EP3714884A1 (en) 2019-03-27 2020-09-30 Paion UK Limited Medical uses for benzodiazepines with a particular eeg pattern
CN112209932B (zh) * 2019-07-12 2023-03-24 成都倍特药业股份有限公司 一种化合物氢溴酸盐的新固体形态及其制备方法和用途
ES2803099B2 (es) 2019-07-22 2021-11-08 Moehs Iberica Sl Procedimiento de obtención de besilato de remimazolam amorfo
CN114478535B (zh) * 2020-10-23 2024-02-09 成都苑东生物制药股份有限公司 一种苯磺酸瑞马唑仑ii晶型的制备方法
CN112462015B (zh) * 2020-11-18 2022-07-12 海南倍特药业有限公司 一种氢溴酸瑞马唑仑细菌内毒素的检测方法
CN114624351B (zh) * 2020-12-14 2024-04-09 宜昌人福药业有限责任公司 苯磺酸瑞马唑仑原料药中(r)-(-)-1-氨基-2-丙醇残留的分析方法
AU2023394304A1 (en) * 2022-12-16 2025-05-22 Lts Lohmann Therapie-Systeme Ag Oromucosal delivery system containing remimazolam
CN119101054A (zh) * 2023-06-09 2024-12-10 成都麻沸散医药科技有限公司 一种氮杂䓬类化合物及其组合物和应用
WO2025052259A1 (en) 2023-09-05 2025-03-13 Reena Patel Ready to use compositions of remimazolam

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CA2143246C (en) 1994-03-16 2000-08-22 Thierry Godel Imidazodiazepines
FI972865L (fi) 1995-01-06 1997-09-03 Hoffmann La Roche Hydroksimetyyli-imidatsodiatseptiinejä ja niiden esterit
AU4382896A (en) 1995-02-02 1996-08-21 F. Hoffmann-La Roche Ag Acetylimidazobenzodiazepines
JPH0971533A (ja) * 1995-06-30 1997-03-18 Takeda Chem Ind Ltd 凍結乾燥製剤
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TWI233805B (en) * 1999-07-01 2005-06-11 Fujisawa Pharmaceutical Co Stabilized pharmaceutical composition in lyophilized form as antifungal agent
EP1161949A1 (en) * 2000-06-09 2001-12-12 Warner-Lambert Company Use od diazepinoindoles for the treatment of chronic obstructive pulmonary disease
WO2006088894A2 (en) * 2005-02-15 2006-08-24 Elan Pharma International Limited Aerosol and injectable formulations of nanoparticulate benzodiazepine
GB0613693D0 (en) 2006-07-10 2006-08-16 Cenes Ltd Benzodiazepine salts (3)
GB0613692D0 (en) * 2006-07-10 2006-08-16 Cenes Ltd Benzodiazepine salts
SI2081921T1 (sl) * 2006-07-10 2011-01-31 Paion Uk Ltd Soli benzodiazepina s kratkotrajnim učinkom ter njihove polimorfne oblike
CN101352422B (zh) * 2008-09-17 2011-04-20 厦门朝阳生物工程有限公司 河豚毒素冻干粉针制剂及其制备方法
EP3050885B1 (en) * 2009-11-05 2017-10-18 GlaxoSmithKline LLC Benzodiazepine bromodomain inhibitor
EP2450039A1 (en) * 2010-11-08 2012-05-09 PAION UK Ltd. Dosing regimen for sedation with CNS 7056 (Remimazolam)
CN102964349A (zh) * 2011-08-31 2013-03-13 江苏恒瑞医药股份有限公司 苯并二氮杂*衍生物的托西酸盐及其多晶型、它们的制备方法和用途

Also Published As

Publication number Publication date
MA37581B1 (fr) 2016-07-29
HUE037734T2 (hu) 2018-09-28
ECSP14032553A (es) 2018-11-30
EA201492160A1 (ru) 2015-10-30
TW201400119A (zh) 2014-01-01
DK2852389T3 (en) 2017-12-18
GEP20186852B (en) 2018-05-25
WO2013174883A1 (en) 2013-11-28
PE20150683A1 (es) 2015-06-03
AR092008A1 (es) 2015-03-18
CL2014003171A1 (es) 2015-06-19
JP6313286B2 (ja) 2018-04-18
CN108578413A (zh) 2018-09-28
NO2021041I1 (no) 2021-09-20
LT2852389T (lt) 2017-12-27
NO2852389T3 (enExample) 2018-03-17
KR102116737B1 (ko) 2020-05-29
AU2013265295A1 (en) 2015-01-22
CA2874247C (en) 2020-07-28
US20220040198A1 (en) 2022-02-10
NL301130I2 (nl) 2021-10-25
US20150148338A1 (en) 2015-05-28
BR112014029108A2 (pt) 2017-06-27
HUS2100040I1 (hu) 2021-10-28
JP2015517552A (ja) 2015-06-22
KR20150009601A (ko) 2015-01-26
MA20150233A1 (fr) 2015-07-31
BR112014029108B1 (pt) 2022-02-08
AP2014008084A0 (en) 2014-11-30
EP2852389A1 (en) 2015-04-01
HK1208164A1 (en) 2016-02-26
UA115063C2 (uk) 2017-09-11
FR21C1043I1 (enExample) 2021-11-19
PL2852389T4 (pl) 2022-02-21
ES2651389T3 (es) 2018-01-26
NL301130I1 (enExample) 2021-09-22
PL2852389T3 (pl) 2018-02-28
CN104968348A (zh) 2015-10-07
HRP20171872T1 (hr) 2018-02-23
LTC2852389I2 (enExample) 2024-11-25
EA032119B1 (ru) 2019-04-30
CA2874247A1 (en) 2013-11-28
EP2852389B1 (en) 2017-10-18
MY185117A (en) 2021-04-30
SI2852389T1 (en) 2018-02-28
SG11201407710VA (en) 2015-01-29
MX2014014225A (es) 2015-06-17
IL235789B (en) 2019-07-31
IL235789A0 (en) 2015-01-29
PT2852389T (pt) 2017-12-13
TWI590826B (zh) 2017-07-11
PH12014502608A1 (en) 2015-01-21
MX368854B (es) 2019-10-18
LUC00230I2 (enExample) 2022-10-07
AU2013265295B2 (en) 2017-08-31
NZ702063A (en) 2016-11-25
LTPA2021521I1 (enExample) 2021-10-11
RS56660B1 (sr) 2018-03-30
FR21C1043I2 (fr) 2022-10-07
CN104968348B (zh) 2018-04-17
TN2014000479A1 (en) 2016-03-30
PH12014502608B1 (en) 2019-11-27
ZA201408412B (en) 2016-09-28

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