CO6761397A2 - Métodos para preparar glicoesfingolípidos y usos de los mismos - Google Patents
Métodos para preparar glicoesfingolípidos y usos de los mismosInfo
- Publication number
- CO6761397A2 CO6761397A2 CO13159964A CO13159964A CO6761397A2 CO 6761397 A2 CO6761397 A2 CO 6761397A2 CO 13159964 A CO13159964 A CO 13159964A CO 13159964 A CO13159964 A CO 13159964A CO 6761397 A2 CO6761397 A2 CO 6761397A2
- Authority
- CO
- Colombia
- Prior art keywords
- glycosphingolipids
- methods
- heteroaryl
- aryl
- formula
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 150000002339 glycosphingolipids Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 5
- 125000001072 heteroaryl group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 125000003107 substituted aryl group Chemical group 0.000 abstract 2
- 238000003786 synthesis reaction Methods 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 239000003814 drug Chemical class 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 210000000581 natural killer T-cell Anatomy 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- C07H15/06—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical being a hydroxyalkyl group esterified by a fatty acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/18—Acyclic radicals, substituted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Crystallography & Structural Chemistry (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pyridine Compounds (AREA)
- Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161430117P | 2011-01-05 | 2011-01-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6761397A2 true CO6761397A2 (es) | 2013-09-30 |
Family
ID=45688966
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO13159964A CO6761397A2 (es) | 2011-01-05 | 2013-07-05 | Métodos para preparar glicoesfingolípidos y usos de los mismos |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US9181292B2 (OSRAM) |
| EP (1) | EP2661440B1 (OSRAM) |
| JP (2) | JP6057300B2 (OSRAM) |
| KR (1) | KR102005003B1 (OSRAM) |
| CN (1) | CN103748103A (OSRAM) |
| AU (2) | AU2012204336C1 (OSRAM) |
| BR (1) | BR112013017382B1 (OSRAM) |
| CA (1) | CA2854725C (OSRAM) |
| CO (1) | CO6761397A2 (OSRAM) |
| ES (1) | ES2654382T3 (OSRAM) |
| HK (1) | HK1197068A1 (OSRAM) |
| IL (1) | IL227333B (OSRAM) |
| MX (1) | MX345764B (OSRAM) |
| RU (1) | RU2636587C2 (OSRAM) |
| WO (1) | WO2012094540A2 (OSRAM) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7960139B2 (en) | 2007-03-23 | 2011-06-14 | Academia Sinica | Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells |
| DK2318832T3 (da) | 2008-07-15 | 2014-01-20 | Academia Sinica | Glycan-arrays på PTFE-lignende aluminiumcoatede objektglas og relaterede fremgangsmåder |
| US10087236B2 (en) | 2009-12-02 | 2018-10-02 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| US11377485B2 (en) | 2009-12-02 | 2022-07-05 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| WO2011130332A1 (en) | 2010-04-12 | 2011-10-20 | Academia Sinica | Glycan arrays for high throughput screening of viruses |
| EP2568976B1 (en) | 2010-05-10 | 2015-09-30 | Academia Sinica | Zanamivir phosphonate congeners with anti-influenza activity and determining oseltamivir susceptibility of influenza viruses |
| HK1197068A1 (en) | 2011-01-05 | 2015-01-02 | 台湾大学 | Methods for preparation of glycosphingolipids and uses thereof |
| EP2811831B1 (en) * | 2012-02-07 | 2018-04-11 | The Regents Of The University Of California | Glycosphingolipids for use in modulating immune responses |
| US10130714B2 (en) | 2012-04-14 | 2018-11-20 | Academia Sinica | Enhanced anti-influenza agents conjugated with anti-inflammatory activity |
| US9914956B2 (en) | 2012-08-18 | 2018-03-13 | Academia Sinica | Cell-permeable probes for identification and imaging of sialidases |
| WO2014031762A1 (en) | 2012-08-21 | 2014-02-27 | Academia Sinica | Benzocyclooctyne compounds and uses thereof |
| EP2727929A1 (en) * | 2012-10-30 | 2014-05-07 | Wittycell | Method of preparation of alpha galactosyl ceramides compounds |
| EP3013365B1 (en) | 2013-06-26 | 2019-06-05 | Academia Sinica | Rm2 antigens and use thereof |
| WO2014210564A1 (en) | 2013-06-27 | 2014-12-31 | Academia Sinica | Glycan conjugates and use thereof |
| KR102298172B1 (ko) * | 2013-09-06 | 2021-09-06 | 아카데미아 시니카 | 변화된 글리코실 그룹을 갖는 당지질을 사용한 인간 iNKT 세포 활성화 |
| US10150818B2 (en) | 2014-01-16 | 2018-12-11 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| KR20160104727A (ko) | 2014-01-16 | 2016-09-05 | 아카데미아 시니카 | 암의 치료 및 검출을 위한 조성물 및 방법 |
| JP6562942B2 (ja) | 2014-03-27 | 2019-08-28 | アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ | 反応性標識化合物およびその使用 |
| CN107074945B (zh) | 2014-05-27 | 2021-08-24 | 中央研究院 | 增进抗体功效的通用糖型的组合物及方法 |
| US10118969B2 (en) | 2014-05-27 | 2018-11-06 | Academia Sinica | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
| CA2950415A1 (en) | 2014-05-27 | 2015-12-03 | Academia Sinica | Anti-cd20 glycoantibodies and uses thereof |
| CA2950440A1 (en) | 2014-05-27 | 2015-12-03 | Academia Sinica | Anti-her2 glycoantibodies and uses thereof |
| KR102494193B1 (ko) | 2014-05-28 | 2023-01-31 | 아카데미아 시니카 | 항-ｔｎｆ-알파 글리코항체 및 이의 용도 |
| KR102422375B1 (ko) * | 2014-09-08 | 2022-07-18 | 아카데미아 시니카 | 당지질을 사용한 인간 iNKT 세포 활성화 |
| US9975965B2 (en) | 2015-01-16 | 2018-05-22 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| US10495645B2 (en) | 2015-01-16 | 2019-12-03 | Academia Sinica | Cancer markers and methods of use thereof |
| EP3248005B1 (en) | 2015-01-24 | 2020-12-09 | Academia Sinica | Novel glycan conjugates and methods of use thereof |
| EP3374028B1 (en) * | 2015-11-13 | 2021-05-26 | La Jolla Institute for Allergy and Immunology | Sphingamide compounds and methods for binding inkt cells |
| WO2017100457A1 (en) | 2015-12-11 | 2017-06-15 | Opko Diagnostics, Llc | Fluidic systems involving incubation samples and/or reagents |
| CA3006882C (en) | 2015-12-29 | 2023-11-28 | Opko Diagnostics, Llc | Fluid collection device and related methods |
| WO2017156192A1 (en) | 2016-03-08 | 2017-09-14 | Academia Sinica | Methods for modular synthesis of n-glycans and arrays thereof |
| AU2017316663B2 (en) | 2016-08-22 | 2024-02-22 | CHO Pharma Inc. | Antibodies, binding fragments, and methods of use |
| AU2018332046B2 (en) * | 2017-09-13 | 2024-06-13 | Abivax | ABX196 for use in the treatment of bladder cancer |
| CN110835361A (zh) * | 2019-10-21 | 2020-02-25 | 山东大学 | 一类唾液酸糖基给体及其制备方法和应用 |
| WO2021142581A1 (zh) * | 2020-01-13 | 2021-07-22 | 郑州市御合源生物科技有限公司 | 一种糖苷化合物及其制备方法和应用 |
| JP7788458B2 (ja) * | 2021-01-06 | 2025-12-18 | エボニック オペレーションズ ゲーエムベーハー | ヒドロキシ置換スフィンゴ脂質 |
| CN114805454B (zh) * | 2021-01-21 | 2023-07-18 | 中国科学院生态环境研究中心 | α-半乳糖神经酰胺类化合物及其制备方法和用途 |
| IL305579A (en) | 2021-03-01 | 2023-10-01 | Deciduous Therapeutics Inc | Compounds for activating invariant natural killer T cells and methods for use in eliminating inflammatory senescent cells |
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| JPH0676429B2 (ja) * | 1987-03-09 | 1994-09-28 | 理化学研究所 | ラクト系列スフィンゴ糖脂質の合成法 |
| JP2588729B2 (ja) * | 1987-10-05 | 1997-03-12 | 塩野義製薬株式会社 | スフィンゴシン誘導体 |
| CA2147629C (en) | 1992-10-22 | 2005-03-22 | Koji Akimoto | Novel sphingoglycolipids and the use thereof |
| CA2142153A1 (en) * | 1994-03-04 | 1995-09-05 | Jacques Banville | Sulfated .beta.-glycolipid derivatives as cell adhesion inhibitors |
| JPH11269189A (ja) * | 1998-03-19 | 1999-10-05 | Nissin Food Prod Co Ltd | 免疫調節作用を有する化合物 |
| CN1405172A (zh) * | 2001-08-13 | 2003-03-26 | 青岛海洋大学 | 一种乳糖胺脂及其制备方法和应用 |
| DE10258007B4 (de) * | 2002-12-12 | 2006-02-09 | Sanofi-Aventis Deutschland Gmbh | Aromatische Fluorglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel |
| JP2008516194A (ja) | 2004-10-04 | 2008-05-15 | アルケミア リミティッド | 選択的阻害剤 |
| US7923013B2 (en) * | 2004-12-28 | 2011-04-12 | The Rockefeller University | Glycolipids and analogues thereof as antigens for NKT cells |
| JP5090928B2 (ja) | 2004-12-28 | 2012-12-05 | ザ ロックフェラー ユニバーシティ | Ｎｋｔ細胞に対する抗原としての糖脂質及びその類似体 |
| EP2390255B1 (en) | 2006-04-03 | 2016-07-13 | Technion Research & Development Foundation Ltd. | Novel aminoglycosides and uses thereof in the treatment of genetic disorders |
| US8420607B2 (en) | 2006-06-30 | 2013-04-16 | University Of Georgia Research Foundation, Inc. | Anthrax carbohydrates, synthesis and uses thereof |
| CN101012254A (zh) * | 2006-08-29 | 2007-08-08 | 中国海洋大学 | 一种α－半乳糖鞘糖脂的2’－OH衍生物及其制备方法 |
| KR100868959B1 (ko) * | 2006-12-30 | 2008-11-17 | 재단법인서울대학교산학협력재단 | 알파-갈락토실세라마이드 유도체, 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는면역보조용 약학적 조성물 |
| JP2010523724A (ja) | 2007-04-13 | 2010-07-15 | アカデミア シニカ | α−ガラクトシルセラミド類似体およびそれらの免疫療法剤としての使用 |
| US20090137793A1 (en) | 2007-11-19 | 2009-05-28 | Academia Sinica | Disaccharide compounds |
| ES2611206T3 (es) | 2008-05-16 | 2017-05-05 | Galecto Biotech Ab | Derivados de di-(3-deoxi-3-1H-1,2,3-triazol-1-il)-beta-D-galacto-iranosil)sulfano como inhibidores de galectina-3 |
| US7928077B2 (en) * | 2008-07-11 | 2011-04-19 | Academia Sinica | Alpha-galactosyl ceramide analogs and their use as immunotherapies |
| HK1197068A1 (en) | 2011-01-05 | 2015-01-02 | 台湾大学 | Methods for preparation of glycosphingolipids and uses thereof |
-
2012
- 2012-01-05 HK HK14110574.7A patent/HK1197068A1/xx unknown
- 2012-01-05 RU RU2013136531A patent/RU2636587C2/ru active
- 2012-01-05 BR BR112013017382-3A patent/BR112013017382B1/pt active IP Right Grant
- 2012-01-05 KR KR1020137020635A patent/KR102005003B1/ko active Active
- 2012-01-05 AU AU2012204336A patent/AU2012204336C1/en active Active
- 2012-01-05 WO PCT/US2012/020388 patent/WO2012094540A2/en not_active Ceased
- 2012-01-05 CN CN201280011839.4A patent/CN103748103A/zh active Pending
- 2012-01-05 EP EP12704939.3A patent/EP2661440B1/en active Active
- 2012-01-05 CA CA2854725A patent/CA2854725C/en active Active
- 2012-01-05 ES ES12704939.3T patent/ES2654382T3/es active Active
- 2012-01-05 MX MX2013007888A patent/MX345764B/es active IP Right Grant
- 2012-01-05 JP JP2013548554A patent/JP6057300B2/ja active Active
- 2012-01-05 US US13/344,557 patent/US9181292B2/en active Active
-
2013
- 2013-07-04 IL IL227333A patent/IL227333B/en active IP Right Grant
- 2013-07-05 CO CO13159964A patent/CO6761397A2/es unknown
-
2015
- 2015-10-07 US US14/877,897 patent/US10654880B2/en active Active
-
2016
- 2016-10-25 JP JP2016209071A patent/JP6259887B2/ja active Active
-
2017
- 2017-07-21 AU AU2017206277A patent/AU2017206277B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| HK1197068A1 (en) | 2015-01-02 |
| MX345764B (es) | 2017-02-15 |
| CA2854725A1 (en) | 2013-07-12 |
| AU2012204336A1 (en) | 2013-08-22 |
| BR112013017382A2 (pt) | 2016-10-04 |
| JP6057300B2 (ja) | 2017-01-11 |
| EP2661440B1 (en) | 2017-09-27 |
| KR102005003B1 (ko) | 2019-07-29 |
| IL227333B (en) | 2018-01-31 |
| US20160229881A1 (en) | 2016-08-11 |
| IL227333A0 (en) | 2013-09-30 |
| MX2013007888A (es) | 2014-09-11 |
| RU2636587C2 (ru) | 2017-11-24 |
| WO2012094540A3 (en) | 2012-08-30 |
| US20120178705A1 (en) | 2012-07-12 |
| AU2012204336B2 (en) | 2017-05-04 |
| CN103748103A (zh) | 2014-04-23 |
| AU2017206277A1 (en) | 2017-08-10 |
| JP2017061481A (ja) | 2017-03-30 |
| AU2017206277B2 (en) | 2019-05-02 |
| AU2012204336C1 (en) | 2017-08-03 |
| EP2661440A2 (en) | 2013-11-13 |
| US9181292B2 (en) | 2015-11-10 |
| JP2014504593A (ja) | 2014-02-24 |
| BR112013017382B1 (pt) | 2021-03-16 |
| ES2654382T3 (es) | 2018-02-13 |
| WO2012094540A2 (en) | 2012-07-12 |
| US10654880B2 (en) | 2020-05-19 |
| CA2854725C (en) | 2019-10-22 |
| KR20140036147A (ko) | 2014-03-25 |
| RU2013136531A (ru) | 2015-02-10 |
| JP6259887B2 (ja) | 2018-01-10 |
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