CO6612268A2 - Heterobiaril-ciclohexil-tetraazabenzo[e]azulenos - Google Patents

Heterobiaril-ciclohexil-tetraazabenzo[e]azulenos

Info

Publication number
CO6612268A2
CO6612268A2 CO12170756A CO12170756A CO6612268A2 CO 6612268 A2 CO6612268 A2 CO 6612268A2 CO 12170756 A CO12170756 A CO 12170756A CO 12170756 A CO12170756 A CO 12170756A CO 6612268 A2 CO6612268 A2 CO 6612268A2
Authority
CO
Colombia
Prior art keywords
tetraazabenzo
receptor
relates
present
act
Prior art date
Application number
CO12170756A
Other languages
English (en)
Inventor
Cosimo Dolente
Patrick Schnider
Martin Schnider
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CO6612268A2 publication Critical patent/CO6612268A2/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

La presente invención se refiere a heterobiaril-ciclo-hexil5 tetraazabenzo[e]azulenos de la fórmula Ien la queRy Rtienen los significados aquí descritos.Los compuestos según la invención actúan como moduladores del receptor de la Vía y en particular como antagonistas del receptor de la Vía, la invención se refiere además a su obtención, a las composiciones farmacéuticas que los contienen y a su utilización como medicamentos. Los compuestos activos de la presente invención son útiles como agentes terapéuticos que actúan a nivel periférico y central en estados patológicos tales como la dismenorrea, disfunción sexual masculina o femenina, hipertensión, fallo cardíaco crónico, secreción in15 apropiada de vasopresina, cirrosis hepática, síndrome nefrótico, ansiedad, trastornos depresivos, trastorno obsesivo-compulsivo, trastornos del espectro autista, esquizofrenia y conducta agresiva.
CO12170756A 2010-04-26 2012-09-28 Heterobiaril-ciclohexil-tetraazabenzo[e]azulenos CO6612268A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP10161043 2010-04-26

Publications (1)

Publication Number Publication Date
CO6612268A2 true CO6612268A2 (es) 2013-02-01

Family

ID=43991411

Family Applications (1)

Application Number Title Priority Date Filing Date
CO12170756A CO6612268A2 (es) 2010-04-26 2012-09-28 Heterobiaril-ciclohexil-tetraazabenzo[e]azulenos

Country Status (35)

Country Link
US (1) US8481528B2 (es)
EP (1) EP2571879B1 (es)
JP (1) JP5579925B2 (es)
KR (1) KR101506778B1 (es)
CN (1) CN102858778B (es)
AR (1) AR081182A1 (es)
AU (1) AU2011246553B2 (es)
BR (1) BR112012027392A2 (es)
CA (1) CA2794824A1 (es)
CL (1) CL2012002954A1 (es)
CO (1) CO6612268A2 (es)
CR (1) CR20120515A (es)
CY (1) CY1117145T1 (es)
DK (1) DK2571879T3 (es)
EA (1) EA021495B1 (es)
EC (1) ECSP12012209A (es)
ES (1) ES2553246T3 (es)
HK (1) HK1176933A1 (es)
HR (1) HRP20160051T1 (es)
HU (1) HUE028018T2 (es)
IL (1) IL222408A (es)
MA (1) MA34173B1 (es)
MX (1) MX2012012517A (es)
MY (1) MY160977A (es)
NZ (1) NZ602663A (es)
PE (1) PE20130189A1 (es)
PL (1) PL2571879T3 (es)
PT (1) PT2571879E (es)
RS (1) RS54418B1 (es)
SG (1) SG184533A1 (es)
SI (1) SI2571879T1 (es)
TW (1) TWI419891B (es)
UA (1) UA110031C2 (es)
WO (1) WO2011134877A1 (es)
ZA (1) ZA201207693B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0921110A2 (pt) * 2008-11-13 2016-02-16 Hoffmann La Roche espiro-5,6-di-hidro-4h-2,3,5,10b-tetraaza-benzo[e]azulenos
WO2010057795A1 (en) * 2008-11-18 2010-05-27 F. Hoffmann-La Roche Ag Alkylcyclohexylethers of dihydrotetraazabenzoazulenes
ES2431279T3 (es) 2008-11-28 2013-11-25 F. Hoffmann-La Roche Ag Arilciclohexiléteres de dihidro-tetraazabenzoazulenos para uso como antagonistas del receptor V1A de la vasopresina
US8420633B2 (en) 2010-03-31 2013-04-16 Hoffmann-La Roche Inc. Aryl-cyclohexyl-tetraazabenzo[e]azulenes
US8461151B2 (en) 2010-04-13 2013-06-11 Hoffmann-La Roche Inc. Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes
US8481528B2 (en) 2010-04-26 2013-07-09 Hoffmann-La Roche Inc. Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes
US8513238B2 (en) * 2010-05-10 2013-08-20 Hoffmann-La Roche Inc. Heteroaryl-cyclohexyl-tetraazabenzo[E]azulenes
CN115246781B (zh) * 2021-04-28 2024-03-29 南京正大天晴制药有限公司 一种沙芬酰胺的制备方法

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US5516774A (en) * 1993-07-29 1996-05-14 American Cyanamid Company Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
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NZ502449A (en) * 1997-07-30 2002-08-28 Wyeth Corp Tricyclic vasopressin agonists and their pharmaceutical use
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GB0400700D0 (en) * 2004-01-13 2004-02-18 Pfizer Ltd Compounds useful in therapy
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WO2010057795A1 (en) 2008-11-18 2010-05-27 F. Hoffmann-La Roche Ag Alkylcyclohexylethers of dihydrotetraazabenzoazulenes
US8420633B2 (en) 2010-03-31 2013-04-16 Hoffmann-La Roche Inc. Aryl-cyclohexyl-tetraazabenzo[e]azulenes
US8461151B2 (en) 2010-04-13 2013-06-11 Hoffmann-La Roche Inc. Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes
US8481528B2 (en) 2010-04-26 2013-07-09 Hoffmann-La Roche Inc. Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes
US8513238B2 (en) 2010-05-10 2013-08-20 Hoffmann-La Roche Inc. Heteroaryl-cyclohexyl-tetraazabenzo[E]azulenes

Also Published As

Publication number Publication date
US20110263573A1 (en) 2011-10-27
BR112012027392A2 (pt) 2016-08-09
SI2571879T1 (sl) 2015-12-31
CA2794824A1 (en) 2011-11-03
RS54418B1 (en) 2016-04-28
DK2571879T3 (en) 2015-11-09
ES2553246T3 (es) 2015-12-07
PL2571879T3 (pl) 2016-04-29
MY160977A (en) 2017-03-31
MX2012012517A (es) 2012-11-23
MA34173B1 (fr) 2013-04-03
EA201291109A1 (ru) 2013-04-30
AU2011246553A1 (en) 2012-10-18
KR101506778B1 (ko) 2015-03-27
CN102858778A (zh) 2013-01-02
TWI419891B (zh) 2013-12-21
PT2571879E (pt) 2015-11-30
US8481528B2 (en) 2013-07-09
SG184533A1 (en) 2012-11-29
IL222408A (en) 2014-08-31
HUE028018T2 (en) 2016-11-28
WO2011134877A1 (en) 2011-11-03
AR081182A1 (es) 2012-07-04
CY1117145T1 (el) 2017-04-05
JP5579925B2 (ja) 2014-08-27
HRP20160051T1 (hr) 2016-02-12
EP2571879B1 (en) 2015-10-21
ECSP12012209A (es) 2012-10-30
EA021495B1 (ru) 2015-06-30
NZ602663A (en) 2013-09-27
PE20130189A1 (es) 2013-02-21
TW201141870A (en) 2011-12-01
JP2013525396A (ja) 2013-06-20
EP2571879A1 (en) 2013-03-27
UA110031C2 (xx) 2015-11-10
AU2011246553B2 (en) 2014-02-13
HK1176933A1 (en) 2013-08-09
CN102858778B (zh) 2015-08-26
ZA201207693B (en) 2016-08-31
CL2012002954A1 (es) 2013-04-12
CR20120515A (es) 2012-11-01
KR20130031267A (ko) 2013-03-28

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