HK1176933A1 - Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes --[e] - Google Patents
Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes --[e]Info
- Publication number
- HK1176933A1 HK1176933A1 HK13104455.5A HK13104455A HK1176933A1 HK 1176933 A1 HK1176933 A1 HK 1176933A1 HK 13104455 A HK13104455 A HK 13104455A HK 1176933 A1 HK1176933 A1 HK 1176933A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- tetraazabenzo
- heterobiaryl
- azulenes
- cyclohexyl
- Prior art date
Links
- 150000001545 azulenes Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10161043 | 2010-04-26 | ||
| PCT/EP2011/056391 WO2011134877A1 (en) | 2010-04-26 | 2011-04-21 | Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1176933A1 true HK1176933A1 (en) | 2013-08-09 |
Family
ID=43991411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK13104455.5A HK1176933A1 (en) | 2010-04-26 | 2013-04-12 | Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes --[e] |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US8481528B2 (xx) |
| EP (1) | EP2571879B1 (xx) |
| JP (1) | JP5579925B2 (xx) |
| KR (1) | KR101506778B1 (xx) |
| CN (1) | CN102858778B (xx) |
| AR (1) | AR081182A1 (xx) |
| AU (1) | AU2011246553B2 (xx) |
| BR (1) | BR112012027392A2 (xx) |
| CA (1) | CA2794824A1 (xx) |
| CL (1) | CL2012002954A1 (xx) |
| CO (1) | CO6612268A2 (xx) |
| CR (1) | CR20120515A (xx) |
| CY (1) | CY1117145T1 (xx) |
| DK (1) | DK2571879T3 (xx) |
| EA (1) | EA021495B1 (xx) |
| EC (1) | ECSP12012209A (xx) |
| ES (1) | ES2553246T3 (xx) |
| HK (1) | HK1176933A1 (xx) |
| HR (1) | HRP20160051T1 (xx) |
| HU (1) | HUE028018T2 (xx) |
| IL (1) | IL222408A (xx) |
| MA (1) | MA34173B1 (xx) |
| MX (1) | MX2012012517A (xx) |
| MY (1) | MY160977A (xx) |
| NZ (1) | NZ602663A (xx) |
| PE (1) | PE20130189A1 (xx) |
| PL (1) | PL2571879T3 (xx) |
| PT (1) | PT2571879E (xx) |
| RS (1) | RS54418B1 (xx) |
| SG (1) | SG184533A1 (xx) |
| SI (1) | SI2571879T1 (xx) |
| TW (1) | TWI419891B (xx) |
| UA (1) | UA110031C2 (xx) |
| WO (1) | WO2011134877A1 (xx) |
| ZA (1) | ZA201207693B (xx) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0921110A2 (pt) * | 2008-11-13 | 2016-02-16 | Hoffmann La Roche | espiro-5,6-di-hidro-4h-2,3,5,10b-tetraaza-benzo[e]azulenos |
| WO2010057795A1 (en) * | 2008-11-18 | 2010-05-27 | F. Hoffmann-La Roche Ag | Alkylcyclohexylethers of dihydrotetraazabenzoazulenes |
| ES2431279T3 (es) | 2008-11-28 | 2013-11-25 | F. Hoffmann-La Roche Ag | Arilciclohexiléteres de dihidro-tetraazabenzoazulenos para uso como antagonistas del receptor V1A de la vasopresina |
| US8420633B2 (en) | 2010-03-31 | 2013-04-16 | Hoffmann-La Roche Inc. | Aryl-cyclohexyl-tetraazabenzo[e]azulenes |
| US8461151B2 (en) | 2010-04-13 | 2013-06-11 | Hoffmann-La Roche Inc. | Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes |
| US8481528B2 (en) | 2010-04-26 | 2013-07-09 | Hoffmann-La Roche Inc. | Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes |
| US8513238B2 (en) * | 2010-05-10 | 2013-08-20 | Hoffmann-La Roche Inc. | Heteroaryl-cyclohexyl-tetraazabenzo[E]azulenes |
| CN115246781B (zh) * | 2021-04-28 | 2024-03-29 | 南京正大天晴制药有限公司 | 一种沙芬酰胺的制备方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5516774A (en) * | 1993-07-29 | 1996-05-14 | American Cyanamid Company | Tricyclic diazepine vasopressin antagonists and oxytocin antagonists |
| US5521173A (en) | 1995-01-17 | 1996-05-28 | American Home Products Corporation | Tricyclic benzazepine vasopressin antagonists |
| NZ502449A (en) * | 1997-07-30 | 2002-08-28 | Wyeth Corp | Tricyclic vasopressin agonists and their pharmaceutical use |
| EP1147115B3 (en) | 1999-01-19 | 2008-12-24 | Ortho-McNeil Pharmaceutical, Inc. | Tricyclic benzodiazepines as vasopressin receptor antagonists |
| US7022699B2 (en) | 2001-04-12 | 2006-04-04 | Wyeth | Cyclohexenyl phenyl diazepines vasopressin and oxytocin receptor modulators |
| US7109193B2 (en) * | 2001-04-12 | 2006-09-19 | Wyeth | Tricyclic diazepines tocolytic oxytocin receptor antagonists |
| GB0303852D0 (en) * | 2003-02-19 | 2003-03-26 | Pfizer Ltd | Triazole compounds useful in therapy |
| KR100750028B1 (ko) * | 2003-02-19 | 2007-08-16 | 화이자 인코포레이티드 | 치료에 유용한 트리아졸 화합물 |
| GB0400700D0 (en) * | 2004-01-13 | 2004-02-18 | Pfizer Ltd | Compounds useful in therapy |
| KR100840852B1 (ko) | 2004-05-25 | 2008-06-23 | 화이자 프로덕츠 인크. | 테트라아자벤조[ｅ]아줄렌 유도체 및 이의 유사체 |
| CA2568056A1 (en) | 2004-05-25 | 2005-12-08 | Pfizer Products Inc. | Tetraazabenzo[e]azulene derivatives and analogs thereof |
| GB0412874D0 (en) * | 2004-06-09 | 2004-07-14 | Pfizer Ltd | Novel pharmaceuticals |
| EP1632494A1 (en) | 2004-08-24 | 2006-03-08 | Ferring B.V. | Vasopressin v1a antagonists |
| JP2008510789A (ja) * | 2004-08-25 | 2008-04-10 | ファイザー・インク | トリアゾロベンゾジアゼピン及びバゾプレシンアンタゴニストとしてのそれらの使用 |
| US20080188478A1 (en) | 2005-04-26 | 2008-08-07 | Pfizer Inc. | Compounds Useful In Therapy |
| US20080234252A1 (en) | 2005-05-18 | 2008-09-25 | Pfizer Inc | Compounds Useful in Therapy |
| ES2376378T3 (es) | 2007-01-12 | 2012-03-13 | F. Hoffmann-La Roche Ag | Derivados de espiropiperidina-glicinamida. |
| WO2010057795A1 (en) | 2008-11-18 | 2010-05-27 | F. Hoffmann-La Roche Ag | Alkylcyclohexylethers of dihydrotetraazabenzoazulenes |
| US8420633B2 (en) | 2010-03-31 | 2013-04-16 | Hoffmann-La Roche Inc. | Aryl-cyclohexyl-tetraazabenzo[e]azulenes |
| US8461151B2 (en) | 2010-04-13 | 2013-06-11 | Hoffmann-La Roche Inc. | Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes |
| US8481528B2 (en) | 2010-04-26 | 2013-07-09 | Hoffmann-La Roche Inc. | Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes |
| US8513238B2 (en) | 2010-05-10 | 2013-08-20 | Hoffmann-La Roche Inc. | Heteroaryl-cyclohexyl-tetraazabenzo[E]azulenes |
-
2011
- 2011-04-19 US US13/089,354 patent/US8481528B2/en active Active
- 2011-04-21 BR BR112012027392A patent/BR112012027392A2/pt not_active IP Right Cessation
- 2011-04-21 EP EP11715545.7A patent/EP2571879B1/en not_active Not-in-force
- 2011-04-21 MX MX2012012517A patent/MX2012012517A/es active IP Right Grant
- 2011-04-21 DK DK11715545.7T patent/DK2571879T3/en active
- 2011-04-21 HU HUE11715545A patent/HUE028018T2/en unknown
- 2011-04-21 EA EA201291109A patent/EA021495B1/ru not_active IP Right Cessation
- 2011-04-21 PL PL11715545T patent/PL2571879T3/pl unknown
- 2011-04-21 CA CA2794824A patent/CA2794824A1/en not_active Abandoned
- 2011-04-21 AU AU2011246553A patent/AU2011246553B2/en not_active Ceased
- 2011-04-21 JP JP2013506597A patent/JP5579925B2/ja not_active Expired - Fee Related
- 2011-04-21 PE PE2012002067A patent/PE20130189A1/es not_active Application Discontinuation
- 2011-04-21 MY MYPI2012004626A patent/MY160977A/en unknown
- 2011-04-21 PT PT117155457T patent/PT2571879E/pt unknown
- 2011-04-21 RS RS20150763A patent/RS54418B1/en unknown
- 2011-04-21 CN CN201180021078.6A patent/CN102858778B/zh not_active Expired - Fee Related
- 2011-04-21 SI SI201130662T patent/SI2571879T1/sl unknown
- 2011-04-21 SG SG2012075149A patent/SG184533A1/en unknown
- 2011-04-21 ES ES11715545.7T patent/ES2553246T3/es active Active
- 2011-04-21 NZ NZ602663A patent/NZ602663A/xx not_active IP Right Cessation
- 2011-04-21 MA MA35327A patent/MA34173B1/fr unknown
- 2011-04-21 WO PCT/EP2011/056391 patent/WO2011134877A1/en active Application Filing
- 2011-04-21 UA UAA201213289A patent/UA110031C2/uk unknown
- 2011-04-21 KR KR1020127030686A patent/KR101506778B1/ko not_active IP Right Cessation
- 2011-04-25 AR ARP110101400A patent/AR081182A1/es unknown
- 2011-04-25 TW TW100114337A patent/TWI419891B/zh not_active IP Right Cessation
-
2012
- 2012-09-28 CO CO12170756A patent/CO6612268A2/es not_active Application Discontinuation
- 2012-10-02 EC ECSP12012209 patent/ECSP12012209A/es unknown
- 2012-10-11 CR CR20120515A patent/CR20120515A/es unknown
- 2012-10-11 IL IL222408A patent/IL222408A/en active IP Right Grant
- 2012-10-12 ZA ZA2012/07693A patent/ZA201207693B/en unknown
- 2012-10-23 CL CL2012002954A patent/CL2012002954A1/es unknown
-
2013
- 2013-04-12 HK HK13104455.5A patent/HK1176933A1/xx not_active IP Right Cessation
-
2016
- 2016-01-15 HR HRP20160051TT patent/HRP20160051T1/hr unknown
- 2016-01-19 CY CY20161100048T patent/CY1117145T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20230426 |