CO6331341A2 - Sintesis total de salinosporamida a y sus analogos - Google Patents
Sintesis total de salinosporamida a y sus analogosInfo
- Publication number
- CO6331341A2 CO6331341A2 CO10121512A CO10121512A CO6331341A2 CO 6331341 A2 CO6331341 A2 CO 6331341A2 CO 10121512 A CO10121512 A CO 10121512A CO 10121512 A CO10121512 A CO 10121512A CO 6331341 A2 CO6331341 A2 CO 6331341A2
- Authority
- CO
- Colombia
- Prior art keywords
- unsubstituted
- substituted
- alkyl
- compound
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Epoxy Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
1.- Un método de síntesis química caracterizado porque comprende: (a) oxidar un compuesto de la fórmula (XXII) para formar un compuesto de la fórmula (XXIV) :(b) romper el epóxido del compuesto de la fórmula (XXIV) para formar un compuesto de la fórmula (XV) :en donde: R1 se elige del grupo que consiste de hidrógeno, un C1-6 alquilo sin sustituir o sustituido y un arilo sin sustituir o sustituido; R2 se elige del grupo que consiste de hidrógeno, un C1-6 a alquilo sin sustituir o sustituido, un arilo sin sustituir o sustituido y un arilalquilo sin sustituir o sustituido; y R3 se elige del grupo que consiste de un C1-24 alquilo sin sustituir o sustituido, un C1-24 alquenilo sin sustituir o sustituido, un C1-24 alquinilo sin sustituir o sustituido, un arilo sin sustituir o sustituido, un heteroarilo sin sustituir o sustituido, un C3-24 cicloalquilo sin sustituir o sustituido o un C3-24 cicloalquenilo sin sustituir o sustituido, un C3-24 cicloalquinilo sin sustituir o sustituido, un aril (C1-6 alquilo) sin sustituir o sustituido y un heteroarilo(C1-6 alquilo) sin sustituir o sustituido.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3490008P | 2008-03-07 | 2008-03-07 | |
| US7354508P | 2008-06-18 | 2008-06-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6331341A2 true CO6331341A2 (es) | 2011-10-20 |
Family
ID=41063770
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO10121512A CO6331341A2 (es) | 2008-03-07 | 2010-09-30 | Sintesis total de salinosporamida a y sus analogos |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US8003802B2 (es) |
| EP (1) | EP2262812A2 (es) |
| JP (1) | JP2011514352A (es) |
| KR (1) | KR20100131475A (es) |
| CN (1) | CN102015721A (es) |
| AU (1) | AU2009241635A1 (es) |
| BR (1) | BRPI0909661A2 (es) |
| CA (1) | CA2717715A1 (es) |
| CO (1) | CO6331341A2 (es) |
| IL (1) | IL208035A0 (es) |
| MX (1) | MX2010009860A (es) |
| NZ (1) | NZ587985A (es) |
| WO (1) | WO2009134531A2 (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7176232B2 (en) | 2002-06-24 | 2007-02-13 | The Regents Of The University Of California | Salinosporamides and methods for use thereof |
| KR20060026052A (ko) | 2003-06-20 | 2006-03-22 | 니리어스 파마슈티컬즈, 인코퍼레이션 | 암, 염증 및 감염성 질환의 치료를 위한 [3.2.0]헤테로사이클릭 화합물 및 그 유사체의 사용방법 |
| NZ544858A (en) * | 2003-06-20 | 2009-07-31 | Univ California | Salinosporamides and methods for use thereof |
| CN103230394B (zh) | 2004-12-03 | 2016-04-20 | 达纳-法伯癌症研究公司 | 治疗肿瘤性疾病的化合物及其用途 |
| EP2631237A2 (en) * | 2006-04-06 | 2013-08-28 | Nereus Pharmaceuticals, Inc. | Total synthesis of salinosporamide A and analogs thereof |
| US8394816B2 (en) * | 2007-12-07 | 2013-03-12 | Irene Ghobrial | Methods of using [3.2.0] heterocyclic compounds and analogs thereof in treating Waldenstrom's Macroglobulinemia |
| JP2011514352A (ja) * | 2008-03-07 | 2011-05-06 | ネレアス ファーマシューティカルズ インコーポレイテッド | サリノスポラミドａおよびその類似体の全合成 |
| JP2011519975A (ja) * | 2008-05-12 | 2011-07-14 | ネレアス ファーマシューティカルズ インコーポレイテッド | プロテアソーム阻害剤としてのサリノスポラミド誘導体 |
| WO2012135528A2 (en) * | 2011-03-29 | 2012-10-04 | Texas Tech University System | Galectin-3c combination therapy for human cancer |
| WO2017210463A1 (en) | 2016-06-01 | 2017-12-07 | Celgene Tri A Holdings Ltd. | Use of marizomib for the treatment of central nervous system (cns) cancers |
| EP3500576A1 (en) | 2016-08-19 | 2019-06-26 | Celgene International II Sàrl | Morphic forms of marizomib and uses thereof |
| CN107383033A (zh) * | 2017-06-29 | 2017-11-24 | 上海药明康德新药开发有限公司 | 顺式5‑叔丁氧羰基‑四氢呋喃并[3,4‑c]吡咯‑3A‑羧酸甲酯的合成方法 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6335358B1 (en) | 1995-04-12 | 2002-01-01 | President And Fellows Of Harvard College | Lactacystin analogs |
| WO1999009006A1 (en) | 1997-08-15 | 1999-02-25 | Soucy Francois | SYNTHESIS OF CLASTO-LACTACYSTIN β-LACTONE AND ANALOGS THEREOF |
| AU9580098A (en) | 1997-09-25 | 1999-04-12 | Millennium Pharmaceuticals, Inc. | Proteasome inhibitors, ubiquitin pathway inhibitors or agents that interfere with the activation of nf-(k)b via the ubiquitin proteasome pathway to treat inflammatory and autoimmune diseases |
| JP4395549B2 (ja) | 2000-11-16 | 2010-01-13 | ザ レジェンツ オブ ザ ユニヴァースティ オブ カリフォルニア | 薬物及び発酵生成物の発見のための海洋放線菌分類群 |
| US7176232B2 (en) | 2002-06-24 | 2007-02-13 | The Regents Of The University Of California | Salinosporamides and methods for use thereof |
| US7179834B2 (en) | 2002-06-24 | 2007-02-20 | The Regents Of The University Of California | Salinosporamides and methods for use thereof |
| AU2004212296B2 (en) | 2003-02-14 | 2010-06-17 | Intermed Discovery Gmbh | Substituted heterocycles |
| NZ544858A (en) | 2003-06-20 | 2009-07-31 | Univ California | Salinosporamides and methods for use thereof |
| KR20060026052A (ko) | 2003-06-20 | 2006-03-22 | 니리어스 파마슈티컬즈, 인코퍼레이션 | 암, 염증 및 감염성 질환의 치료를 위한 [3.2.0]헤테로사이클릭 화합물 및 그 유사체의 사용방법 |
| US7371875B2 (en) | 2004-03-12 | 2008-05-13 | Miikana Therapeutics, Inc. | Cytotoxic agents and methods of use |
| WO2005099687A2 (en) | 2004-04-09 | 2005-10-27 | President And Fellows Of Harvard College | Analogs of salinosporamide a |
| US7183417B2 (en) | 2004-04-09 | 2007-02-27 | President And Fellows Of Harvard College | Simple stereocontrolled synthesis of salinosporamide A |
| US20060264495A1 (en) | 2004-04-30 | 2006-11-23 | Michael Palladino | Methods of using [3.2.0] heterocyclic compounds and analogs thereof |
| US7579371B2 (en) | 2004-04-30 | 2009-08-25 | Nereus Pharmaceuticals, Inc. | Methods of using [3.2.0] heterocyclic compounds and analogs thereof |
| NZ550910A (en) | 2004-04-30 | 2011-06-30 | Nereus Pharmaceuticals Inc | [3.2.0] Heterocyclic compounds and methods of using the same |
| WO2006005551A1 (en) | 2004-07-12 | 2006-01-19 | Bayer Cropscience Ag | Substituted 2-pyrrolidone derivatives as fungicides and insecticides |
| CN103230394B (zh) | 2004-12-03 | 2016-04-20 | 达纳-法伯癌症研究公司 | 治疗肿瘤性疾病的化合物及其用途 |
| EP1835910A2 (en) | 2004-12-03 | 2007-09-26 | Nereus Pharmaceuticals, Inc. | Methods of using [3.2.0] heterocyclic compounds and analogs thereof |
| WO2006118973A2 (en) | 2005-04-29 | 2006-11-09 | Nereus Pharmaceuticals, Inc. | Methods of using heterobyclic compounds for treatment of rectal cancer |
| US20060287520A1 (en) | 2005-05-16 | 2006-12-21 | Danishefsky Samuel J | Synthesis of salinosporamide A and analogues thereof |
| WO2007021897A1 (en) | 2005-08-10 | 2007-02-22 | President And Fellows Of Harvard College | Analogs of salinosporamide a |
| US7691896B2 (en) | 2005-08-10 | 2010-04-06 | President And Fellows Of Harvard College | Analogs of salinosporamide A |
| US7465720B2 (en) | 2005-09-12 | 2008-12-16 | President And Fellows Of Harvard College | Proteasome inhibiting β-lactam compounds |
| CA2628110A1 (en) | 2005-11-04 | 2007-05-18 | The Regents Of The University Of California | Methods of sensitizing cancer to therapy-induced cytotoxicity |
| WO2007068090A1 (en) * | 2005-12-12 | 2007-06-21 | Audiokinetic Inc. | System and method for authoring media content |
| US7759327B2 (en) | 2006-01-06 | 2010-07-20 | The Trustees Of Columbia University In The City Of New York | Compositions containing zinc salts for coating medical articles |
| EP2631237A2 (en) | 2006-04-06 | 2013-08-28 | Nereus Pharmaceuticals, Inc. | Total synthesis of salinosporamide A and analogs thereof |
| US20080280968A1 (en) | 2007-05-04 | 2008-11-13 | Nereus Pharmaceuticals, Inc. | Methods of using [3.2.0] heterocyclic compounds and analogs thereof for treating infectious diseases |
| US8394816B2 (en) | 2007-12-07 | 2013-03-12 | Irene Ghobrial | Methods of using [3.2.0] heterocyclic compounds and analogs thereof in treating Waldenstrom's Macroglobulinemia |
| JP2011514352A (ja) * | 2008-03-07 | 2011-05-06 | ネレアス ファーマシューティカルズ インコーポレイテッド | サリノスポラミドａおよびその類似体の全合成 |
| JP2011519975A (ja) | 2008-05-12 | 2011-07-14 | ネレアス ファーマシューティカルズ インコーポレイテッド | プロテアソーム阻害剤としてのサリノスポラミド誘導体 |
-
2009
- 2009-03-06 JP JP2010549919A patent/JP2011514352A/ja active Pending
- 2009-03-06 US US12/399,382 patent/US8003802B2/en active Active
- 2009-03-06 MX MX2010009860A patent/MX2010009860A/es not_active Application Discontinuation
- 2009-03-06 KR KR1020107022279A patent/KR20100131475A/ko not_active Application Discontinuation
- 2009-03-06 WO PCT/US2009/036376 patent/WO2009134531A2/en active Application Filing
- 2009-03-06 AU AU2009241635A patent/AU2009241635A1/en not_active Abandoned
- 2009-03-06 CA CA2717715A patent/CA2717715A1/en not_active Abandoned
- 2009-03-06 BR BRPI0909661-2A patent/BRPI0909661A2/pt not_active IP Right Cessation
- 2009-03-06 NZ NZ587985A patent/NZ587985A/en not_active IP Right Cessation
- 2009-03-06 CN CN2009801162354A patent/CN102015721A/zh active Pending
- 2009-03-06 EP EP09739333A patent/EP2262812A2/en not_active Withdrawn
-
2010
- 2010-09-07 IL IL208035A patent/IL208035A0/en unknown
- 2010-09-30 CO CO10121512A patent/CO6331341A2/es not_active Application Discontinuation
-
2011
- 2011-07-15 US US13/184,356 patent/US8314251B2/en not_active Expired - Fee Related
-
2012
- 2012-09-14 US US13/619,568 patent/US20130012720A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR20100131475A (ko) | 2010-12-15 |
| US20130012720A1 (en) | 2013-01-10 |
| JP2011514352A (ja) | 2011-05-06 |
| EP2262812A2 (en) | 2010-12-22 |
| US20110269969A1 (en) | 2011-11-03 |
| US8003802B2 (en) | 2011-08-23 |
| WO2009134531A2 (en) | 2009-11-05 |
| CN102015721A (zh) | 2011-04-13 |
| IL208035A0 (en) | 2010-12-30 |
| US20090234137A1 (en) | 2009-09-17 |
| WO2009134531A3 (en) | 2010-11-18 |
| AU2009241635A1 (en) | 2009-11-05 |
| MX2010009860A (es) | 2010-09-30 |
| NZ587985A (en) | 2012-07-27 |
| BRPI0909661A2 (pt) | 2015-08-11 |
| US8314251B2 (en) | 2012-11-20 |
| CA2717715A1 (en) | 2009-11-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Application refused |