CO6220940A2 - Inhibidores de pirrolotriazina cinasa - Google Patents

Inhibidores de pirrolotriazina cinasa

Info

Publication number
CO6220940A2
CO6220940A2 CO09000765A CO09000765A CO6220940A2 CO 6220940 A2 CO6220940 A2 CO 6220940A2 CO 09000765 A CO09000765 A CO 09000765A CO 09000765 A CO09000765 A CO 09000765A CO 6220940 A2 CO6220940 A2 CO 6220940A2
Authority
CO
Colombia
Prior art keywords
substituted
arylalkyl
alkynyl
alkyl
alkanoyl
Prior art date
Application number
CO09000765A
Other languages
English (en)
Inventor
Harold Mastalerz
Mark D Wittman
Kurt Zimmermann
Mark G Saulnier
Upender Velaparthi
Dolatrai Vyas
Guifen Zhang
Walter Lewis Johnson
David B Frennesson
Xiaopeng Sang
Peiying Liu
David R Langley
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of CO6220940A2 publication Critical patent/CO6220940A2/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

1.- Compuesto de la fórmula Icaracterizado porque: Q1 es arilo, arilo substituido, heteroarilo o heteroarilo substituido; X es C=O, C=S, C=NR9 ó CH2; R1, R2, y R3 son independientemente hidrógeno, aiquilo, alquilo substituido, cicloalquilo, cicloalquilo substituido, hidroxi, alcoxi, alcoxi substituido, halógeno, haloalquilo, haloalcoxi, alcanoilo, alcanoilo substituido, amino, amino substituido, aminoalquilo, aminoalquilo substituido, alquilamino, alquilamino substituido, amida, amida substituida, carbamato, ureido, ciano, sulfonamido, sulfanamido substituido, alquilsulfona, nitro, tio, tioalquilo, alquiltio, diamino substituido, alquilsulfonilo, alquilsulfinilo, carboxi, alcoxicarbonilo, alquilcarboniloxi, carbamoilo, carbamoilo substituido, alquenilo, alquenilo substituido, alquinilo, alquinilo substituido, o alquilcarbonilo; R4 es hidrógeno, alquilo, alquilo substituido, hidroxi, alcoxi, halógeno, haloalquilo, haloalcoxi, oxo, ariloxi, arilalquilo, arilalquiloxi, alcanoilo, alcanoilo substituido, alcanoiloxi, amino, amino substituido, aminoalquilo, aminoalquilo substituido, alquilamino, alquilamino substituido, hidroxialquilo, diamino substituido, amida, amida substituida, carbamato, carbamato substituido, ureido, ciano, sulfonamida, sulfonamida substituida, alquilsulfona, heterocicloalquilo, heterocicloalquilo substituido, cicloalquilo, cicloalquilo substituido, cicloalquenilo, cicloalquenilo substituido, cicloalquilalquilo, cicloalquilalcoxi, nitro, tio, tioalquilo, alquiltio, alquilsulfonilo, alquilsulfinilo, carboxi, alcoxicarbonilo, alquilcarboniloxi, carbamoilo, alquenilo, alquenilo substituido, alquinilo, alquinilo substituido, arilo, arilo substituido, heteroarilo, heteroarilo substituido, heteroariloxi, arilheteroarilo, arilalcoxicarbonilo, heteroarilalquilo, heteroarilalcoxi, ariloxialquilo, ariloxiarilo, heterociclo, heterociclo substituido, alquilcarbonilo, heteroalquilo substituido, heteroalquenilo, heteroalquenilo substituido, heteroalquinilo, heteroalquinilo substituido, arilamino, arilalquilamino, alcanoilamino, aroilamino, arilalcanoilamino, ariltio, arilalquiltio, arilsulfonilo, arilalquilsulfonilo, alquilsulfonilo, arilcarbonilamino, o alquilaminocarbonilo; R5 es hidrógeno, halógeno, ciano, alquilo o alquilo substituido; ...
CO09000765A 2006-07-07 2009-01-06 Inhibidores de pirrolotriazina cinasa CO6220940A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81917106P 2006-07-07 2006-07-07

Publications (1)

Publication Number Publication Date
CO6220940A2 true CO6220940A2 (es) 2010-11-19

Family

ID=38671050

Family Applications (1)

Application Number Title Priority Date Filing Date
CO09000765A CO6220940A2 (es) 2006-07-07 2009-01-06 Inhibidores de pirrolotriazina cinasa

Country Status (26)

Country Link
US (4) US7534792B2 (es)
EP (1) EP2041138B1 (es)
JP (1) JP5185930B2 (es)
KR (1) KR101443400B1 (es)
CN (1) CN101511835B (es)
AR (1) AR061873A1 (es)
AU (1) AU2007269163B2 (es)
BR (1) BRPI0714359A2 (es)
CA (1) CA2657594C (es)
CL (1) CL2007001995A1 (es)
CO (1) CO6220940A2 (es)
DK (1) DK2041138T3 (es)
EA (1) EA018322B1 (es)
ES (1) ES2493566T3 (es)
HR (1) HRP20140688T1 (es)
IL (1) IL196033A0 (es)
MX (1) MX2008016517A (es)
NO (1) NO342385B1 (es)
NZ (1) NZ574189A (es)
PE (1) PE20080677A1 (es)
PL (1) PL2041138T3 (es)
PT (1) PT2041138E (es)
SI (1) SI2041138T1 (es)
TW (1) TWI393722B (es)
WO (1) WO2008005956A2 (es)
ZA (1) ZA200900109B (es)

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Also Published As

Publication number Publication date
US7534792B2 (en) 2009-05-19
US20080009497A1 (en) 2008-01-10
JP2009542814A (ja) 2009-12-03
AR061873A1 (es) 2008-09-24
US8592579B2 (en) 2013-11-26
EP2041138A2 (en) 2009-04-01
US20090239838A1 (en) 2009-09-24
US20120302747A1 (en) 2012-11-29
AU2007269163B2 (en) 2011-07-28
CN101511835A (zh) 2009-08-19
TW200813059A (en) 2008-03-16
CA2657594C (en) 2012-01-17
MX2008016517A (es) 2009-01-19
US8263765B2 (en) 2012-09-11
ES2493566T3 (es) 2014-09-12
HRP20140688T1 (hr) 2014-10-24
ZA200900109B (en) 2010-03-31
EA200900152A1 (ru) 2009-06-30
KR20090027764A (ko) 2009-03-17
AU2007269163A1 (en) 2008-01-10
WO2008005956A2 (en) 2008-01-10
NO20090025L (no) 2009-02-02
WO2008005956A3 (en) 2008-03-06
NZ574189A (en) 2011-03-31
PL2041138T3 (pl) 2014-11-28
SI2041138T1 (sl) 2014-08-29
CL2007001995A1 (es) 2008-01-25
PT2041138E (pt) 2014-10-07
PE20080677A1 (es) 2008-06-26
EA018322B1 (ru) 2013-07-30
CN101511835B (zh) 2013-11-27
BRPI0714359A2 (pt) 2013-02-26
JP5185930B2 (ja) 2013-04-17
US20110124623A1 (en) 2011-05-26
NO342385B1 (no) 2018-05-14
IL196033A0 (en) 2009-09-01
DK2041138T3 (da) 2014-08-11
TWI393722B (zh) 2013-04-21
EP2041138B1 (en) 2014-06-25
CA2657594A1 (en) 2008-01-10
US7879855B2 (en) 2011-02-01
KR101443400B1 (ko) 2014-10-02

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