CO6220852A2 - Marcacion radioactiva por fluoracion de aziridinas - Google Patents
Marcacion radioactiva por fluoracion de aziridinasInfo
- Publication number
- CO6220852A2 CO6220852A2 CO09071219A CO09071219A CO6220852A2 CO 6220852 A2 CO6220852 A2 CO 6220852A2 CO 09071219 A CO09071219 A CO 09071219A CO 09071219 A CO09071219 A CO 09071219A CO 6220852 A2 CO6220852 A2 CO 6220852A2
- Authority
- CO
- Colombia
- Prior art keywords
- aryl
- sulfonyl
- substituted
- unsubstituted
- phenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/001—Acyclic or carbocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
- C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D203/08—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
- C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D203/22—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
- C07D203/24—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1.- Un compuesto que comprende un anillo de aziridina apropiadamente activado con fines de marcación, en el cual un radical agente de direccionamiento está unido, ya sea directamente o a través de un conector apropiado, al anillo de aziridina o a un anillo carbocíclico o heterociclico de cinco miembros que está fusionado al anillo de aziridina.2.- El compuesto de acuerdo con la reivindicación 1 que responde a la Fórmula química general Ien el cual R representa Ts, 2,4,6-triisopropil-fenil-sulfonilo, 3,4-dimetoxi-fenil-sulfonilo, fenil-sulfonilo no sustituido, fenil-sulfonilo sustituido con 1 - 5 porciones R2, Ns, Cbz, Bz, Bn, Boc, Fmoc, metoxicarbonilo, etoxi-carbonilo, aliloxicarbonilo, Tr o acilo; en donde R2 representa hidrógeno, alquilo C1-C6 sustituido o no sustituido, lineal o ramificado, ciclo-alquilo, heterocicloalquilo, arilo, heteroarilo, aralquilo o heteroaralquilo, OH, OR3, NH2, NHR3, N(R3)2, SH, SR3, halógeno, NO2, C(=O)R3, C(=O)OR3, C(=O)NHR3 o C(=O)(NR3)2, en donde R3 representa hidrógeno, alquilo C1-C6, arilo, cicloalquilo, heterocicloalquilo, arilo, heteroarilo, aralquilo o heteroaralquilo sustituido o no sustituido, lineal o ramificado;R1 y R4, en forma independiente, se seleccionan entre el grupo que comprende hidrógeno, alquilo C1-C6, cicloalquilo, heterocicloalquilo, arilo, heteroarilo, aralquilo y heteroaralquilo sustituido y no sustituido o lineal o ramificado; L representa un conector adecuado para acoplar con el radical agente de direccionamiento, B representa el radical agente de direccionamiento, y una sal aceptable para uso farmacéutico de un ácido inorgánico u orgánico del mismo, un hidrato, complejo, éster, amida, solvato y prodroga del mismo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07090001A EP1944288A1 (en) | 2007-01-09 | 2007-01-09 | Radiolabelling via fluorination of aziridines |
| EP07090079A EP1985624A3 (en) | 2007-04-23 | 2007-04-23 | Single step method of radiofluorination of biologically active compounds or biomolecules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6220852A2 true CO6220852A2 (es) | 2010-11-19 |
Family
ID=38941926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO09071219A CO6220852A2 (es) | 2007-01-09 | 2009-07-09 | Marcacion radioactiva por fluoracion de aziridinas |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US20090022664A1 (es) |
| EP (1) | EP2099747A1 (es) |
| JP (1) | JP2010522140A (es) |
| KR (1) | KR20090096716A (es) |
| AR (1) | AR062856A1 (es) |
| AU (1) | AU2007343454A1 (es) |
| BR (1) | BRPI0720884A2 (es) |
| CA (1) | CA2674408A1 (es) |
| CL (1) | CL2007002673A1 (es) |
| CO (1) | CO6220852A2 (es) |
| CR (1) | CR10917A (es) |
| DO (1) | DOP2009000173A (es) |
| EC (1) | ECSP099505A (es) |
| MA (1) | MA31175B1 (es) |
| MX (1) | MX2009007395A (es) |
| NO (1) | NO20092813L (es) |
| PA (1) | PA8747801A1 (es) |
| PE (1) | PE20081661A1 (es) |
| RU (1) | RU2009130455A (es) |
| SV (1) | SV2009003328A (es) |
| TN (1) | TN2009000233A1 (es) |
| TW (1) | TW200829275A (es) |
| UY (1) | UY30594A1 (es) |
| WO (1) | WO2008083729A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8784774B2 (en) | 2011-09-16 | 2014-07-22 | General Electric Company | Labeled molecular imaging agents and methods of use |
| US9468692B2 (en) | 2014-01-23 | 2016-10-18 | General Electric Company | Labeled molecular imaging agents and methods of use |
| US9468693B2 (en) | 2014-01-23 | 2016-10-18 | General Electric Company | Labeled molecular imaging agents and methods of use |
| NL2014828B1 (en) * | 2015-05-20 | 2017-01-31 | Out And Out Chemistry S P R L | Method of performing a plurality of synthesis processes of preparing a radiopharmaceutical in series, a device and cassette for performing this method. |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3954994A (en) * | 1968-10-03 | 1976-05-04 | Pfizer Inc. | Intermediates for preparing hipolipemic agents and method of lowering the blood lipid level in mammals with said agents |
| JPS5810380B2 (ja) * | 1975-01-31 | 1983-02-25 | 三共株式会社 | ペプチドノ セイホウ |
| US6015790A (en) * | 1997-10-06 | 2000-01-18 | Basf Aktiengesellschaft | Methods and compositions for treating rheumatoid arthritis |
| ATE453627T1 (de) * | 1999-07-21 | 2010-01-15 | Univ Pennsylvania | Herstellung von verbindungen zur bestimmung der hypoxie |
| SE9903998D0 (sv) * | 1999-11-03 | 1999-11-03 | Astra Ab | New compounds |
| US6894057B2 (en) * | 2002-03-08 | 2005-05-17 | Warner-Lambert Company | Oxo-azabicyclic compounds |
| AU2003249532A1 (en) * | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | 4-hydroxyquinoline derivatives as matrix metalloproteinase inhibitors |
| GB0222909D0 (en) * | 2002-10-03 | 2002-11-13 | Astrazeneca Ab | Novel process and intermediates |
| US6875784B2 (en) * | 2002-10-09 | 2005-04-05 | Pharmacia & Upjohn Company | Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives |
| CN1212307C (zh) * | 2003-07-23 | 2005-07-27 | 中国科学院上海有机化学研究所 | 一种合成β－氟胺化合物的方法 |
| EP1799637A1 (en) * | 2004-09-23 | 2007-06-27 | Amgen, Inc | Substituted sulfonamidopropionamides and methods of use |
| JP2008535839A (ja) * | 2005-04-07 | 2008-09-04 | メルク エンド カムパニー インコーポレーテッド | 有糸分裂キネシン阻害剤 |
-
2007
- 2007-09-07 BR BRPI0720884-7A patent/BRPI0720884A2/pt not_active IP Right Cessation
- 2007-09-07 EP EP07802294A patent/EP2099747A1/en not_active Withdrawn
- 2007-09-07 RU RU2009130455/04A patent/RU2009130455A/ru not_active Application Discontinuation
- 2007-09-07 CA CA002674408A patent/CA2674408A1/en not_active Abandoned
- 2007-09-07 JP JP2009545069A patent/JP2010522140A/ja active Pending
- 2007-09-07 MX MX2009007395A patent/MX2009007395A/es unknown
- 2007-09-07 KR KR1020097014304A patent/KR20090096716A/ko not_active Application Discontinuation
- 2007-09-07 AU AU2007343454A patent/AU2007343454A1/en not_active Abandoned
- 2007-09-07 WO PCT/EP2007/007968 patent/WO2008083729A1/en active Application Filing
- 2007-09-07 US US11/851,786 patent/US20090022664A1/en not_active Abandoned
- 2007-09-10 TW TW096133836A patent/TW200829275A/zh unknown
- 2007-09-14 UY UY30594A patent/UY30594A1/es not_active Application Discontinuation
- 2007-09-14 PA PA20078747801A patent/PA8747801A1/es unknown
- 2007-09-14 PE PE2007001247A patent/PE20081661A1/es not_active Application Discontinuation
- 2007-09-14 CL CL200702673A patent/CL2007002673A1/es unknown
- 2007-09-14 AR ARP070104087A patent/AR062856A1/es unknown
-
2009
- 2009-06-08 TN TNP2009000233A patent/TN2009000233A1/fr unknown
- 2009-07-08 DO DO2009000173A patent/DOP2009000173A/es unknown
- 2009-07-09 SV SV2009003328A patent/SV2009003328A/es not_active Application Discontinuation
- 2009-07-09 CR CR10917A patent/CR10917A/es unknown
- 2009-07-09 EC EC2009009505A patent/ECSP099505A/es unknown
- 2009-07-09 CO CO09071219A patent/CO6220852A2/es not_active Application Discontinuation
- 2009-08-06 MA MA32154A patent/MA31175B1/fr unknown
- 2009-08-07 NO NO20092813A patent/NO20092813L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PA8747801A1 (es) | 2009-08-26 |
| TN2009000233A1 (en) | 2010-10-18 |
| NO20092813L (no) | 2009-09-22 |
| CA2674408A1 (en) | 2008-07-17 |
| WO2008083729A1 (en) | 2008-07-17 |
| CR10917A (es) | 2009-08-27 |
| EP2099747A1 (en) | 2009-09-16 |
| MX2009007395A (es) | 2009-07-17 |
| JP2010522140A (ja) | 2010-07-01 |
| TW200829275A (en) | 2008-07-16 |
| AU2007343454A1 (en) | 2008-07-17 |
| DOP2009000173A (es) | 2010-10-31 |
| PE20081661A1 (es) | 2009-01-18 |
| AR062856A1 (es) | 2008-12-10 |
| US20090022664A1 (en) | 2009-01-22 |
| KR20090096716A (ko) | 2009-09-14 |
| BRPI0720884A2 (pt) | 2014-03-25 |
| RU2009130455A (ru) | 2011-02-20 |
| MA31175B1 (fr) | 2010-02-01 |
| ECSP099505A (es) | 2009-08-28 |
| UY30594A1 (es) | 2008-09-02 |
| CL2007002673A1 (es) | 2008-07-18 |
| SV2009003328A (es) | 2009-12-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Application refused |