CO6220837A2 - Moleculas de transporte que utilizan polpeptidos hiv-tat de secuencia inversa - Google Patents
Moleculas de transporte que utilizan polpeptidos hiv-tat de secuencia inversaInfo
- Publication number
- CO6220837A2 CO6220837A2 CO09079071A CO09079071A CO6220837A2 CO 6220837 A2 CO6220837 A2 CO 6220837A2 CO 09079071 A CO09079071 A CO 09079071A CO 09079071 A CO09079071 A CO 09079071A CO 6220837 A2 CO6220837 A2 CO 6220837A2
- Authority
- CO
- Colombia
- Prior art keywords
- molecule
- transport
- covalently
- transport molecule
- loading
- Prior art date
Links
- 238000003874 inverse correlation nuclear magnetic resonance spectroscopy Methods 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 6
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 6
- 229920001184 polypeptide Polymers 0.000 abstract 5
- 239000003814 drug Substances 0.000 abstract 3
- 229940124597 therapeutic agent Drugs 0.000 abstract 3
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- 239000012528 membrane Substances 0.000 abstract 2
- 230000035515 penetration Effects 0.000 abstract 2
- 108030001720 Bontoxilysin Proteins 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108091034117 Oligonucleotide Proteins 0.000 abstract 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 229940053031 botulinum toxin Drugs 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000003834 intracellular effect Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/14—Peptides, e.g. proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Inorganic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Radiology & Medical Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88263906P | 2006-12-29 | 2006-12-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6220837A2 true CO6220837A2 (es) | 2010-11-19 |
Family
ID=39589169
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO09079071A CO6220837A2 (es) | 2006-12-29 | 2009-07-29 | Moleculas de transporte que utilizan polpeptidos hiv-tat de secuencia inversa |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US20080226551A1 (enExample) |
| EP (1) | EP2109363A4 (enExample) |
| JP (2) | JP2010514779A (enExample) |
| KR (1) | KR20090102833A (enExample) |
| CN (1) | CN101583274A (enExample) |
| AR (1) | AR064707A1 (enExample) |
| AU (1) | AU2007340158A1 (enExample) |
| BR (1) | BRPI0720729A2 (enExample) |
| CA (1) | CA2672886C (enExample) |
| CO (1) | CO6220837A2 (enExample) |
| CR (1) | CR10921A (enExample) |
| MX (1) | MX2009007070A (enExample) |
| NO (1) | NO20092697L (enExample) |
| NZ (1) | NZ598159A (enExample) |
| TW (1) | TW200848080A (enExample) |
| WO (1) | WO2008082885A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101284710B1 (ko) | 2004-03-03 | 2013-07-23 | 레반스 테라퓨틱스, 아이엔씨. | 국소 진단제 및 치료제의 수송을 위한 조성물 및 방법 |
| US9211248B2 (en) | 2004-03-03 | 2015-12-15 | Revance Therapeutics, Inc. | Compositions and methods for topical application and transdermal delivery of botulinum toxins |
| CA2599017C (en) * | 2005-03-03 | 2014-08-12 | Revance Therapeutics, Inc. | Compositions and methods for topical application and transdermal delivery of botulinum toxins |
| ES2805225T3 (es) | 2007-07-26 | 2021-02-11 | Revance Therapeutics Inc | Péptidos antimicrobianos y composiciones de los mismos |
| EP3031825B1 (en) | 2008-03-14 | 2019-07-24 | Allergan, Inc. | Immuno-based botulinum toxin serotype a activity assays |
| JP4936343B6 (ja) | 2008-10-23 | 2018-06-27 | 国立大学法人 東京大学 | ｍｉｃｒｏＲＮＡの機能阻害法 |
| US20120148562A1 (en) | 2009-04-01 | 2012-06-14 | Revance Therapeutics, Inc. | Methods and compositions for treating skin conditions associated with vascular hyper-reactivity |
| US9623117B2 (en) * | 2011-04-04 | 2017-04-18 | Wisconsin Alumni Research Foundation | Method for selective targeting and entry of bacterial toxins to cells |
| MX370929B (es) | 2012-10-28 | 2020-01-08 | Revance Therapeutics Inc | Composiciones y usos de las mismas para el tratamiento seguro de la rinitis. |
| US11484580B2 (en) | 2014-07-18 | 2022-11-01 | Revance Therapeutics, Inc. | Topical ocular preparation of botulinum toxin for use in ocular surface disease |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| NZ756012A (en) | 2017-01-17 | 2025-10-31 | Michael David Forrest | Therapeutic inhibitors of the reverse mode of atp synthase |
| IL271845B2 (en) | 2017-07-13 | 2024-06-01 | Michael David Forrest | Therapeutic modulators of the reverse mode of atp synthase |
| IL303969A (en) | 2021-01-24 | 2023-08-01 | David Forrest Michael | ugh |
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-
2007
- 2007-12-12 NZ NZ598159A patent/NZ598159A/xx not_active IP Right Cessation
- 2007-12-12 MX MX2009007070A patent/MX2009007070A/es not_active Application Discontinuation
- 2007-12-12 US US11/954,885 patent/US20080226551A1/en not_active Abandoned
- 2007-12-12 WO PCT/US2007/087241 patent/WO2008082885A2/en not_active Ceased
- 2007-12-12 EP EP07869157.3A patent/EP2109363A4/en not_active Withdrawn
- 2007-12-12 AU AU2007340158A patent/AU2007340158A1/en not_active Abandoned
- 2007-12-12 CN CNA2007800483630A patent/CN101583274A/zh active Pending
- 2007-12-12 BR BRPI0720729-8A patent/BRPI0720729A2/pt not_active IP Right Cessation
- 2007-12-12 JP JP2009544158A patent/JP2010514779A/ja not_active Ceased
- 2007-12-12 US US12/520,964 patent/US20100093639A1/en not_active Abandoned
- 2007-12-12 KR KR1020097015649A patent/KR20090102833A/ko not_active Ceased
- 2007-12-12 CA CA2672886A patent/CA2672886C/en not_active Expired - Fee Related
- 2007-12-21 TW TW096149556A patent/TW200848080A/zh unknown
- 2007-12-28 AR ARP070105982A patent/AR064707A1/es unknown
-
2009
- 2009-07-13 CR CR10921A patent/CR10921A/es unknown
- 2009-07-17 NO NO20092697A patent/NO20092697L/no not_active Application Discontinuation
- 2009-07-29 CO CO09079071A patent/CO6220837A2/es not_active Application Discontinuation
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2013
- 2013-08-06 JP JP2013163127A patent/JP2014012680A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20080226551A1 (en) | 2008-09-18 |
| EP2109363A2 (en) | 2009-10-21 |
| WO2008082885A2 (en) | 2008-07-10 |
| CN101583274A (zh) | 2009-11-18 |
| BRPI0720729A2 (pt) | 2014-04-08 |
| JP2010514779A (ja) | 2010-05-06 |
| AR064707A1 (es) | 2009-04-22 |
| NO20092697L (no) | 2009-09-28 |
| TW200848080A (en) | 2008-12-16 |
| MX2009007070A (es) | 2009-07-10 |
| NZ598159A (en) | 2013-08-30 |
| KR20090102833A (ko) | 2009-09-30 |
| EP2109363A4 (en) | 2014-07-09 |
| US20100093639A1 (en) | 2010-04-15 |
| CA2672886A1 (en) | 2008-07-10 |
| CA2672886C (en) | 2015-02-10 |
| CR10921A (es) | 2009-09-14 |
| WO2008082885A3 (en) | 2008-11-20 |
| JP2014012680A (ja) | 2014-01-23 |
| AU2007340158A1 (en) | 2008-07-10 |
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