CO6210702A2 - Derivado de pirazolopirimidina - Google Patents

Derivado de pirazolopirimidina

Info

Publication number
CO6210702A2
CO6210702A2 CO09039060A CO09039060A CO6210702A2 CO 6210702 A2 CO6210702 A2 CO 6210702A2 CO 09039060 A CO09039060 A CO 09039060A CO 09039060 A CO09039060 A CO 09039060A CO 6210702 A2 CO6210702 A2 CO 6210702A2
Authority
CO
Colombia
Prior art keywords
formula
compound represented
hsp90
pirazolopirimidine
derivative
Prior art date
Application number
CO09039060A
Other languages
English (en)
Inventor
Satoru Ohsuki
Atsushi Tengeiji
Masahiro Ikeda
Toshihiro Shibata
Chikahiro Nagata
Takashi Shimada
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Publication of CO6210702A2 publication Critical patent/CO6210702A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/16—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

1.- Un compuesto representado por la fórmula (1), una sal del compuesto, o un hidrato del compuesto o la sal:caracterizado porque en la fórmula (1), R1 representa un grupo metileno, un grupo etileno o n grupo propenileno, el cual puede estar sustituido con 1 o 2 grupos alquilo que tienen 1 a 8 átomos de carbono, R2 representa un grupo arilo, el cual puede tener uno varios sustituyentes o un grupo heterocíclico que puede tener uno o varios sustituyentes, el anillo A representa un anillo de 5 a 8 miembros (en donde los átomos constituyentes del anillo A diferentes del átomo de azufre en la posición 6, son átomos de carbono), y R3 representa un átomo de hidrógeno de 1 a 4 sustituyentes iguales o diferentes con los cuales el anillo A está sustituida,en donde los mismos o diferentes sustituyentes cada uno representa independientemente un sustituyente seleccionado del grupo que consiste de un átomo de halógeno, un grupo hidroxilo, un grupo carboxilo, un grupo alquilo que tiene 1 a 8 átomos de carbono que pueden tener uno o varios sustituyentes, un grupo alquenilo que tiene 2 a 8 átomos de carbono que puede tener uno o varios sustituyentes, un grupo alquinilo que tiene 2 a 8 átomos de carbono que puede. tener un o varios sustituyentes, un grupo alcoxi que tiene 1 a 8 átomos de carbono que puede tener uno o varios sustituyentes, un grupo alcoxicarbonilo que tiene 1 a 8 átomos de carbono que puede tener uno o varios sustituyentes, un grupo alcanoiloxi que tiene 1 a 8 átomos de carbono que puede tener uno o varios sustituyentes, un grupo carbamoilo que puede tener uno o varios sustituyentes, un grupo carbamoiloxi que puede tener uno o varios sustituyentes, un grupo alquilsulfoniloxi que tiene 1 a 8 átomos de carbono que puede tener uno o varios sustituyentes, un grupo amino que puede tener uno o varios sustituyentes, un grupo ciano, un grupo arilo el cual puede tener uno o varios sustituyentes, ...
CO09039060A 2006-09-19 2009-04-17 Derivado de pirazolopirimidina CO6210702A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2006253465 2006-09-19

Publications (1)

Publication Number Publication Date
CO6210702A2 true CO6210702A2 (es) 2010-10-20

Family

ID=39200455

Family Applications (1)

Application Number Title Priority Date Filing Date
CO09039060A CO6210702A2 (es) 2006-09-19 2009-04-17 Derivado de pirazolopirimidina

Country Status (26)

Country Link
US (1) US8158638B2 (es)
EP (1) EP2065388B1 (es)
JP (1) JP5252636B2 (es)
KR (2) KR20140127367A (es)
CN (1) CN101541811B (es)
AT (1) ATE523513T1 (es)
AU (1) AU2007298286B2 (es)
BR (1) BRPI0717176A2 (es)
CA (1) CA2663965C (es)
CO (1) CO6210702A2 (es)
CY (1) CY1112191T1 (es)
DK (1) DK2065388T3 (es)
ES (1) ES2373160T3 (es)
HK (1) HK1127476A1 (es)
IL (1) IL197513A (es)
MX (1) MX2009002998A (es)
MY (1) MY145041A (es)
NO (1) NO20091495L (es)
NZ (1) NZ575564A (es)
PL (1) PL2065388T3 (es)
PT (1) PT2065388E (es)
RU (1) RU2420530C2 (es)
SI (1) SI2065388T1 (es)
TW (1) TWI388563B (es)
WO (1) WO2008035629A1 (es)
ZA (1) ZA200901921B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010098344A1 (ja) * 2009-02-25 2010-09-02 第一三共株式会社 三環性ピラゾロピリミジン誘導体
WO2010114905A1 (en) * 2009-03-31 2010-10-07 Arqule, Inc. Peri-fused pyrazolo-pyrimidine compounds
AR077405A1 (es) 2009-07-10 2011-08-24 Sanofi Aventis Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer
FR2949467B1 (fr) 2009-09-03 2011-11-25 Sanofi Aventis Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation
EP2810945A1 (en) * 2010-08-23 2014-12-10 Daiichi Sankyo Company, Limited Dihydrochloride salt of a tricyclic pyrazolopyrimidine derivative
CA2809388A1 (en) 2010-08-23 2012-03-01 Daiichi Sankyo Company, Limited Crystal of a free tricyclic pyrazolopyrimidine derivative
KR20160099081A (ko) 2013-07-26 2016-08-19 업데이트 파마 인코포레이트 비산트렌의 치료 효과 개선용 조합 방법
CN114380738A (zh) * 2021-09-28 2022-04-22 都创(重庆)医药科技有限公司 一种3-溴-4-氯-2-甲基吡啶的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9615934D0 (en) 1996-07-30 1996-09-11 Netlon Ltd Integral tube
WO1998043991A1 (en) 1997-04-02 1998-10-08 Amersham Pharmacia Biotech Uk Limited Tricyclic base analogues
JP2001526639A (ja) * 1997-04-02 2001-12-18 アマーシャム・ファルマシア・バイオテック・ユーケイ・リミテッド 三環式塩基類似体
MXPA05005425A (es) 2002-11-22 2005-11-23 Japan Tobacco Inc Heterociclos que contienen nitrogeno, biciclicos, fusionados.
JP2007504152A (ja) * 2003-08-27 2007-03-01 ビオタ， インコーポレイテッド 治療剤としての新規三環ヌクレオシドまたはヌクレオチド
NZ546611A (en) * 2003-09-18 2010-02-26 Conforma Therapeutics Corp Novel heterocyclic compounds as HSP90-inhibitors
TW200612918A (en) 2004-07-29 2006-05-01 Threshold Pharmaceuticals Inc Lonidamine analogs

Also Published As

Publication number Publication date
PL2065388T3 (pl) 2012-02-29
AU2007298286A1 (en) 2008-03-27
ZA200901921B (en) 2009-12-30
CN101541811A (zh) 2009-09-23
JP5252636B2 (ja) 2013-07-31
KR20090066274A (ko) 2009-06-23
US20100113410A1 (en) 2010-05-06
ES2373160T3 (es) 2012-02-01
TWI388563B (zh) 2013-03-11
US8158638B2 (en) 2012-04-17
HK1127476A1 (en) 2009-09-25
CN101541811B (zh) 2014-07-09
IL197513A0 (en) 2009-12-24
RU2009114731A (ru) 2010-10-27
NO20091495L (no) 2009-06-18
CA2663965A1 (en) 2008-03-27
NZ575564A (en) 2011-02-25
IL197513A (en) 2014-01-30
JPWO2008035629A1 (ja) 2010-01-28
KR20140127367A (ko) 2014-11-03
CA2663965C (en) 2012-06-12
PT2065388E (pt) 2011-11-10
MY145041A (en) 2011-12-15
ATE523513T1 (de) 2011-09-15
WO2008035629A1 (fr) 2008-03-27
CY1112191T1 (el) 2015-12-09
EP2065388B1 (en) 2011-09-07
SI2065388T1 (sl) 2012-03-30
KR101485199B1 (ko) 2015-01-22
DK2065388T3 (da) 2012-01-09
RU2420530C2 (ru) 2011-06-10
EP2065388A1 (en) 2009-06-03
MX2009002998A (es) 2009-04-02
AU2007298286B2 (en) 2011-02-03
BRPI0717176A2 (pt) 2013-10-15
TW200823223A (en) 2008-06-01
EP2065388A4 (en) 2009-11-18

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