CO5690614A2 - Uso de peptidos ciclicos tipo anabaenopeptina para el tratamiento de una enfermedad en donde es benefica la inhibicion de carboxipeptidasa u derivados novedosos de anabaenopeptina y sus intermedios - Google Patents
Uso de peptidos ciclicos tipo anabaenopeptina para el tratamiento de una enfermedad en donde es benefica la inhibicion de carboxipeptidasa u derivados novedosos de anabaenopeptina y sus intermediosInfo
- Publication number
- CO5690614A2 CO5690614A2 CO06049388A CO06049388A CO5690614A2 CO 5690614 A2 CO5690614 A2 CO 5690614A2 CO 06049388 A CO06049388 A CO 06049388A CO 06049388 A CO06049388 A CO 06049388A CO 5690614 A2 CO5690614 A2 CO 5690614A2
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- anabaenopeptine
- nhcnh
- cnh
- ocf3
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Psychology (AREA)
- Vascular Medicine (AREA)
- Surgery (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
Abstract
1.- El uso de un compuesto de fórmula (I):en donde:X es (CH2)m y (CH2)n;m y n son, independientemente, 1, 2, 3, 4, 5 ó 6; con la salvedad que m + n no sea superior a 6;Y es un enlace, O, S (O)p, o S-S;R1 es CO2R15 o un isóstero de ácido carboxílico tal como S(O)2OH, S(O)2NHR15, PO(OR15)OH, PO(OR15)NH2, B(OR15)2, PO(R15)OH, PO(R15)NH2 o tetrazol; R2, R3, R4, R5 y R6 son, independientemente, hidrógeno, C1-6 alquilo (sustituido opcionalmente por halógeno, hidroxi, ciano, SH, S(O)3H, S(O)q(C1-6 alquilo), OC(O)(C1-4alquilo), CF3, C1-4 alcoxi, OCF3, COOH, CONH2, CONH (C1-6 alquilo), NH2, CNH(NH2), o NHCNH(NH2)), C3-6 cicloalquil(C1-4)alquilo (en donde el anillo cicloalquilo se sustituye opcionalmente por halógeno, hidroxi, ciano, C1-4 alquilo, CF3, C1-4 alcoxi, OCF3, NH2, CNH(NH2) o NHCNH(NH2)), heterociclil(C1-4)alquilo (en donde el anillo heterociclilo se sustituye opcionalmente por halógeno, hidroxi, ciano, C1-4 alquilo, CF3, C1-4 alcoxi, OCF3, NH2, CNH(NH2) o NHCNH(NH2)), fenil(C1-4)alquilo (en donde el anillo fenilo se sustituye opcionalmente por halógeno, hidroxi, ciano, C1-4 alquilo, CF3, C1-4 alcoxi, OCF3, NH2, CNH(NH2) ó NHCNH(NH2)) o heteroaril(C1-4)alquilo (en donde el anillo heteroarilo se sustituye opcionalmente por halógeno, hidroxi, ciano, C1-4 alquilo, CF3, C1-4 alcoxi, OCF3, NH2, CNH(NH2) o NHCNH(NH2));p y q son, independientemente, 0, 1 ó 2;R7, R8, R9, R10, R11, R12 y R13 son, independientemente, H o C1-4 alquilo;R14 es H o C1-4 alquilo; y, R15 es H o C1-4 alquilo;o su sal farmacéuticamente aceptable o solvato, o un solvato de tal sal; en un método de fabricar un medicamento para el tratamiento o profilaxis de una enfermedad es donde la inhibición de carboxipeptidasa U es benéfica.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0302853A SE0302853D0 (sv) | 2003-10-29 | 2003-10-29 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5690614A2 true CO5690614A2 (es) | 2006-10-31 |
Family
ID=29580155
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO06049388A CO5690614A2 (es) | 2003-10-29 | 2006-05-23 | Uso de peptidos ciclicos tipo anabaenopeptina para el tratamiento de una enfermedad en donde es benefica la inhibicion de carboxipeptidasa u derivados novedosos de anabaenopeptina y sus intermedios |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20080039376A1 (es) |
| EP (1) | EP1689424A1 (es) |
| JP (1) | JP2008501622A (es) |
| KR (1) | KR20060132596A (es) |
| CN (1) | CN1897963A (es) |
| AR (1) | AR046612A1 (es) |
| AU (1) | AU2004283643B2 (es) |
| BR (1) | BRPI0415964A (es) |
| CA (1) | CA2543630A1 (es) |
| CO (1) | CO5690614A2 (es) |
| IL (1) | IL175198A0 (es) |
| IS (1) | IS8471A (es) |
| MY (1) | MY143363A (es) |
| NO (1) | NO20061999L (es) |
| RU (1) | RU2365594C2 (es) |
| SA (1) | SA05250463B1 (es) |
| SE (1) | SE0302853D0 (es) |
| TW (1) | TW200524576A (es) |
| UA (1) | UA85199C2 (es) |
| UY (1) | UY28585A1 (es) |
| WO (1) | WO2005039617A1 (es) |
| ZA (1) | ZA200603355B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016053901A1 (en) | 2014-09-30 | 2016-04-07 | Apple Inc | Configurable force-sensitive input structures for electronic devices |
| TWI628569B (zh) | 2015-09-30 | 2018-07-01 | 蘋果公司 | 具有適應性輸入列之鍵盤 |
| RS63143B1 (sr) | 2016-06-01 | 2022-05-31 | Athira Pharma Inc | Jedinjenja |
| US10732743B2 (en) | 2017-07-18 | 2020-08-04 | Apple Inc. | Concealable input region for an electronic device having microperforations |
| US20210130409A1 (en) * | 2017-09-01 | 2021-05-06 | Alsonex Pty Ltd | Method for the Solid-Phase Synthesis of Cyclic Pentapeptides |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9524630D0 (en) * | 1994-12-24 | 1996-01-31 | Zeneca Ltd | Chemical compounds |
| BR0113289A (pt) * | 2000-08-17 | 2003-06-17 | Pfizer | Imidazóis substituìdos como inibidores de tafia |
-
2003
- 2003-10-29 SE SE0302853A patent/SE0302853D0/xx unknown
-
2004
- 2004-10-27 MY MYPI20044426A patent/MY143363A/en unknown
- 2004-10-28 RU RU2006117821/04A patent/RU2365594C2/ru not_active IP Right Cessation
- 2004-10-28 KR KR1020067010392A patent/KR20060132596A/ko not_active Application Discontinuation
- 2004-10-28 AU AU2004283643A patent/AU2004283643B2/en not_active Ceased
- 2004-10-28 UY UY28585A patent/UY28585A1/es not_active Application Discontinuation
- 2004-10-28 UA UAA200604776A patent/UA85199C2/ru unknown
- 2004-10-28 CN CNA2004800390596A patent/CN1897963A/zh active Pending
- 2004-10-28 WO PCT/SE2004/001568 patent/WO2005039617A1/en active Application Filing
- 2004-10-28 US US10/578,022 patent/US20080039376A1/en not_active Abandoned
- 2004-10-28 BR BRPI0415964-0A patent/BRPI0415964A/pt not_active IP Right Cessation
- 2004-10-28 CA CA002543630A patent/CA2543630A1/en not_active Abandoned
- 2004-10-28 EP EP04793868A patent/EP1689424A1/en not_active Withdrawn
- 2004-10-28 JP JP2006537936A patent/JP2008501622A/ja not_active Withdrawn
- 2004-10-29 TW TW093132865A patent/TW200524576A/zh unknown
- 2004-11-01 AR ARP040104004A patent/AR046612A1/es unknown
-
2005
- 2005-01-29 SA SA05250463A patent/SA05250463B1/ar unknown
-
2006
- 2006-04-25 IL IL175198A patent/IL175198A0/en unknown
- 2006-04-26 ZA ZA200603355A patent/ZA200603355B/en unknown
- 2006-05-04 NO NO20061999A patent/NO20061999L/no not_active Application Discontinuation
- 2006-05-16 IS IS8471A patent/IS8471A/is unknown
- 2006-05-23 CO CO06049388A patent/CO5690614A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IS8471A (is) | 2006-05-16 |
| IL175198A0 (en) | 2006-09-05 |
| RU2006117821A (ru) | 2007-12-10 |
| SA05250463B1 (ar) | 2009-02-07 |
| CN1897963A (zh) | 2007-01-17 |
| KR20060132596A (ko) | 2006-12-21 |
| NO20061999L (no) | 2006-07-27 |
| CA2543630A1 (en) | 2005-05-06 |
| JP2008501622A (ja) | 2008-01-24 |
| US20080039376A1 (en) | 2008-02-14 |
| WO2005039617A1 (en) | 2005-05-06 |
| AU2004283643B2 (en) | 2008-07-10 |
| EP1689424A1 (en) | 2006-08-16 |
| ZA200603355B (en) | 2007-07-25 |
| SE0302853D0 (sv) | 2003-10-29 |
| AR046612A1 (es) | 2005-12-14 |
| MY143363A (en) | 2011-04-29 |
| BRPI0415964A (pt) | 2007-01-23 |
| UA85199C2 (ru) | 2009-01-12 |
| RU2365594C2 (ru) | 2009-08-27 |
| SA05250463A (ar) | 2005-12-03 |
| AU2004283643A1 (en) | 2005-05-06 |
| TW200524576A (en) | 2005-08-01 |
| UY28585A1 (es) | 2005-05-31 |
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Legal Events
| Date | Code | Title | Description |
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| FC | Application refused |