CO5680494A2 - Interferencia de arn doble que tiene extremos romos y modificaciones 3 - Google Patents

Interferencia de arn doble que tiene extremos romos y modificaciones 3

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Publication number
CO5680494A2
CO5680494A2 CO06027688A CO06027688A CO5680494A2 CO 5680494 A2 CO5680494 A2 CO 5680494A2 CO 06027688 A CO06027688 A CO 06027688A CO 06027688 A CO06027688 A CO 06027688A CO 5680494 A2 CO5680494 A2 CO 5680494A2
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Colombia
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aryl
alkyl
rna interference
romes
extreme
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CO06027688A
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English (en)
Inventor
Jan Weiler
Jonathan Hall
Jean Charles Bologna
Francois Jean-Charles Natt
Robert Haner
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Novartis Ag
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Publication of CO5680494A2 publication Critical patent/CO5680494A2/es

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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    • C12N2310/00—Structure or type of the nucleic acid
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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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Abstract

1.- ARN de estructura de cadena doble con por lo menos un extremo romo que comprende por lo menos un extremo 3AND#39 de la fórmula: en donde X es O o S R1 y R2 son independientemente OH, NH2, SH, alquilo, arilo, alquilarilo, aril-alquilo, en donde el alquilo, arilo, alquil-arilo, aril-alquilo pueden estar substituidos por átomos heterogéneos adicionales y grupos funcionales, preferiblemente un átomo heterogéneo seleccionado del grupo que consiste de N, O, o S o un grupo funcional seleccionado del grupo OH, NH2, SH, ácido o éster carboxílico;o, R1 y R2 pueden ser de la fórmula Y-Z en donde Y es O, N, S y Z es H, alquilo, arilo, alquil-arilo, aril- alquilo, en donde eI alquilo, arilo, alquilariIo, aril-aIquiIo pueden estar substituidos por átomos heterogéneos adicionales, preferiblemente un átomo heterogéneo seleccionado del grupo de N, O, o S;y en donde dicho ARN de estructura de cadena doble media la interferencia de ARN.
CO06027688A 2003-08-28 2006-03-21 Interferencia de arn doble que tiene extremos romos y modificaciones 3 CO5680494A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49851403P 2003-08-28 2003-08-28

Publications (1)

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CO5680494A2 true CO5680494A2 (es) 2006-09-29

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US (2) US20070203084A1 (es)
EP (3) EP2338995A3 (es)
JP (2) JP2007503803A (es)
KR (3) KR20060087531A (es)
CN (2) CN101914533B (es)
AU (1) AU2004269150C1 (es)
BR (1) BRPI0413146A (es)
CA (1) CA2536333C (es)
CO (1) CO5680494A2 (es)
EC (1) ECSP066388A (es)
IL (1) IL173565A (es)
IS (1) IS8358A (es)
MA (1) MA28029A1 (es)
MX (1) MXPA06002216A (es)
NO (1) NO20061345L (es)
NZ (1) NZ545360A (es)
RU (2) RU2399671C2 (es)
SG (1) SG152279A1 (es)
TN (1) TNSN06065A1 (es)
WO (1) WO2005021749A1 (es)
ZA (1) ZA200601003B (es)

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MA28029A1 (fr) 2006-07-03
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EP1660657A1 (en) 2006-05-31
BRPI0413146A (pt) 2006-10-03
IL173565A (en) 2012-07-31
TNSN06065A1 (en) 2007-10-03
KR20080034046A (ko) 2008-04-17
NZ545360A (en) 2009-06-26
IL173565A0 (en) 2006-07-05
AU2004269150C1 (en) 2010-11-18
JP2007503803A (ja) 2007-03-01
US20090192113A1 (en) 2009-07-30
KR20110007263A (ko) 2011-01-21
ECSP066388A (es) 2006-08-30
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AU2004269150B2 (en) 2009-06-04
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CN101914533B (zh) 2013-06-19
US20070203084A1 (en) 2007-08-30
KR101059315B1 (ko) 2011-08-24
RU2010119292A (ru) 2011-12-10
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EP2338995A2 (en) 2011-06-29
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