CO5611194A2 - Inhibidores novedosos de la farnesil proteina transferasa como agentes antitumorales - Google Patents
Inhibidores novedosos de la farnesil proteina transferasa como agentes antitumoralesInfo
- Publication number
- CO5611194A2 CO5611194A2 CO04079404A CO04079404A CO5611194A2 CO 5611194 A2 CO5611194 A2 CO 5611194A2 CO 04079404 A CO04079404 A CO 04079404A CO 04079404 A CO04079404 A CO 04079404A CO 5611194 A2 CO5611194 A2 CO 5611194A2
- Authority
- CO
- Colombia
- Prior art keywords
- carbon
- substituents
- substituent
- antitumural
- transferasa
- Prior art date
Links
- NVKAWKQGWWIWPM-ABEVXSGRSA-N 17-β-hydroxy-5-α-Androstan-3-one Chemical compound C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC[C@H]21 NVKAWKQGWWIWPM-ABEVXSGRSA-N 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 title 1
- 229950008696 farnesil Drugs 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 229910052799 carbon Inorganic materials 0.000 abstract 10
- 125000001424 substituent group Chemical group 0.000 abstract 10
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 6
- 150000001721 carbon Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/085,896 US20030229099A1 (en) | 2000-08-30 | 2002-02-27 | Novel farnesyl protein transferase inhibitors as antitumor agents |
| US10/325,896 US7342016B2 (en) | 2000-08-30 | 2002-12-19 | Farnesyl protein transferase inhibitors as antitumor agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5611194A2 true CO5611194A2 (es) | 2006-02-28 |
Family
ID=27767345
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO04079404A CO5611194A2 (es) | 2002-02-27 | 2004-08-13 | Inhibidores novedosos de la farnesil proteina transferasa como agentes antitumorales |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7342016B2 (enExample) |
| EP (1) | EP1492772A1 (enExample) |
| JP (1) | JP2005525356A (enExample) |
| KR (1) | KR20040098004A (enExample) |
| CN (1) | CN100537542C (enExample) |
| AR (1) | AR039557A1 (enExample) |
| AU (1) | AU2003215389B2 (enExample) |
| BR (1) | BR0308071A (enExample) |
| CA (1) | CA2477328A1 (enExample) |
| CO (1) | CO5611194A2 (enExample) |
| IL (1) | IL163673A0 (enExample) |
| MX (1) | MXPA04008303A (enExample) |
| NO (1) | NO20044053L (enExample) |
| NZ (1) | NZ534809A (enExample) |
| PE (1) | PE20031038A1 (enExample) |
| PL (1) | PL372335A1 (enExample) |
| RU (1) | RU2004128465A (enExample) |
| TW (1) | TW200303867A (enExample) |
| WO (1) | WO2003072549A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS20160203A1 (sr) | 2003-05-30 | 2016-10-31 | Genentech Inc | Tretman sa anti-vegf antitelima |
| RU2006106768A (ru) * | 2003-08-07 | 2007-09-20 | Шеринг Корпорейшн (US) | Новые ингибиторы фарнезилпротеинтрансферазы как противоопухолевые агенты |
| JP2008501031A (ja) * | 2004-05-28 | 2008-01-17 | バーテックス ファーマシューティカルズ インコーポレイテッド | ムスカリン受容体のモジュレーター |
| ATE412651T1 (de) | 2004-06-09 | 2008-11-15 | Glaxo Group Ltd | Pyrrolopyridinderivate |
| CA2591123A1 (en) * | 2004-12-14 | 2006-06-22 | Schering Corporation | Farnesyl protein transferase inhibitors and methods for treating proliferative diseases |
| US20060205755A1 (en) * | 2004-12-21 | 2006-09-14 | Schering Corporation | Novel farnesyl protein transferase inhibitors as antitumor agents |
| EP1973882A1 (en) * | 2006-01-19 | 2008-10-01 | Schering Corporation | Piperazine derivatives as farnesyl protein transferase inhibitors |
| WO2008054598A2 (en) * | 2006-09-29 | 2008-05-08 | Schering Corporation | Panel of biomarkers for prediction of fti efficacy |
| KR20140148491A (ko) * | 2006-12-19 | 2014-12-31 | 제넨테크, 인크. | 조기 종양의 치료 및 아주반트 및 네오아주반트 요법을 위한 ｖｅｇｆ－특이적 길항제 |
| EP2313091A4 (en) * | 2008-07-14 | 2012-04-04 | Univ Kingston | PHARMACEUTICAL COMPOSITIONS WITH RET-HEMMERN AND METHOD FOR THE TREATMENT OF CANCER |
| WO2010107739A2 (en) | 2009-03-18 | 2010-09-23 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions of treating a flaviviridae family viral infection |
| US9227962B2 (en) | 2013-03-13 | 2016-01-05 | Boston Biomedical, Inc. | Heterocyclic substituted-3-heteroarylidenyl-2-indolinone derivative |
| US9187454B2 (en) * | 2013-03-13 | 2015-11-17 | Boston Biomedical, Inc. | Inhibitors of kinases and cancer stem cells, and methods of preparation and use thereof |
| CN105777646A (zh) * | 2016-04-08 | 2016-07-20 | 西南科技大学 | 一种新的5-碘-2-苯基-1-甲基咪唑的制备方法 |
| CN111454329A (zh) * | 2020-04-07 | 2020-07-28 | 哈尔滨师范大学 | 一种具有抗癌活性的异茚哚酮桥连环九肽及其制备方法 |
| CN115385892A (zh) * | 2021-10-28 | 2022-11-25 | 天津市昕晨投资发展有限公司 | 地氯雷他定衍生物、其制备方法及其用途 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4826853A (en) | 1986-10-31 | 1989-05-02 | Schering Corporation | 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use |
| US5089496A (en) * | 1986-10-31 | 1992-02-18 | Schering Corporation | Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies |
| US5393890A (en) * | 1988-06-02 | 1995-02-28 | Ajinomoto Co., Inc. | Piperidine derivatives and hypotensives containing the same |
| AU8854091A (en) * | 1990-10-10 | 1992-05-20 | Schering Corporation | Bis-benzo cyclohepta piperidylidene, piperidine and piperazine compounds, compositions and methods of use |
| GB9513371D0 (en) | 1995-06-30 | 1995-09-06 | Biocine Spa | Immunogenic detoxified mutant toxins |
| US5643909A (en) | 1993-04-19 | 1997-07-01 | Syntex (U.S.A.) Inc. | 10,11-Methanodibenzosuberane derivatives |
| IL111235A (en) * | 1993-10-15 | 2001-03-19 | Schering Plough Corp | Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them |
| US6075025A (en) * | 1993-10-15 | 2000-06-13 | Schering Corporation | Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
| US5721236A (en) * | 1993-10-15 | 1998-02-24 | Schering Corporation | Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
| US5719148A (en) | 1993-10-15 | 1998-02-17 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
| DE69635424T2 (de) * | 1995-12-22 | 2006-08-03 | Schering Corp. | Zur hemming der g-protein-funktion und zur behandlung proliferativer krankheiten geeignete tricyclische amide |
| US5874442A (en) * | 1995-12-22 | 1999-02-23 | Schering-Plough Corporation | Tricyclic amides useful for inhibition of G-protein function and for treatment of proliferative disease |
| CN1237176A (zh) * | 1996-09-13 | 1999-12-01 | 先灵公司 | 用作fpt抑制剂的三环化合物 |
| US5861395A (en) * | 1996-09-13 | 1999-01-19 | Schering Corporation | Compounds useful for inhibition of farnesyl proteins transferase |
| US6071907A (en) * | 1996-09-13 | 2000-06-06 | Schering Corporation | Tricyclic compounds useful as FPT inhibitors |
| KR20000036111A (ko) | 1996-09-13 | 2000-06-26 | 둘락 노먼 씨. | 파네실 단백질 트랜스페라제 억제제인 트리사이클릭 항종양성화합물 |
| GB9801231D0 (en) * | 1997-06-05 | 1998-03-18 | Merck & Co Inc | A method of treating cancer |
| HUP0004627A2 (hu) | 1997-06-17 | 2001-10-28 | Schering Corp. | Farnezil-protein transzferáz inhibitor hatású új triciklusos szulfonamidszármazékok és a vegyületeket tartalmazó gyógyszerkészítmények |
| NZ501571A (en) | 1997-06-17 | 2002-02-01 | Schering Corp | Novel n-substituted urea inhibitors of farnesyl-protein transferase |
| AU753863B2 (en) | 1997-06-17 | 2002-10-31 | Schering Corporation | Benzo(5,6)cyclohepta(1,2-B)pyridine derivatives for the inhibition of farnesyl protein transferase |
| AU753658B2 (en) | 1997-06-17 | 2002-10-24 | Pharmacopeia, Inc. | Benzpyrido cycloheptane compounds useful for inhibition of farnesyl protein transferase |
| US5925648A (en) * | 1997-07-29 | 1999-07-20 | Schering Corporation | Tricyclic N-cyanoimines useful as inhibitors of a farnesyl-protein transferase |
| TR200101755T2 (tr) | 1998-12-18 | 2001-09-21 | Schering Corporation | Trisiklik farnezil protein transferaz inhibitörleri. |
| SK7582001A3 (en) | 1998-12-18 | 2002-03-05 | Schering Corp | Compound, method of therapy and pharmaceutical composition comprising the same, and its use for farnesyl protein transferase inhibition |
| AU2292801A (en) * | 1999-12-22 | 2001-07-03 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Compositions and methods for treatment of breast cancer |
| EP1255537B1 (en) | 2000-02-04 | 2006-04-19 | Janssen Pharmaceutica N.V. | Farnesyl protein transferase inhibitors for treating breast cancer |
| AR033680A1 (es) * | 2000-08-30 | 2004-01-07 | Schering Corp | Compuestos triciclicos utiles como inhibidores de la farnesil proteino transferasa y su uso para la manufactura de medicamentos como agentes antitumorales |
| CA2468996A1 (en) * | 2001-12-03 | 2003-06-12 | Schering Corporation | Use of fpt inhibitors and at least two antineoplastic agents in the treatment of cancer |
| RU2006106768A (ru) * | 2003-08-07 | 2007-09-20 | Шеринг Корпорейшн (US) | Новые ингибиторы фарнезилпротеинтрансферазы как противоопухолевые агенты |
-
2002
- 2002-12-19 US US10/325,896 patent/US7342016B2/en not_active Expired - Fee Related
-
2003
- 2003-02-25 PL PL03372335A patent/PL372335A1/xx not_active Application Discontinuation
- 2003-02-25 CA CA002477328A patent/CA2477328A1/en not_active Abandoned
- 2003-02-25 AU AU2003215389A patent/AU2003215389B2/en not_active Ceased
- 2003-02-25 NZ NZ534809A patent/NZ534809A/en not_active IP Right Cessation
- 2003-02-25 RU RU2004128465/04A patent/RU2004128465A/ru not_active Application Discontinuation
- 2003-02-25 AR ARP030100602A patent/AR039557A1/es unknown
- 2003-02-25 BR BR0308071-4A patent/BR0308071A/pt not_active IP Right Cessation
- 2003-02-25 MX MXPA04008303A patent/MXPA04008303A/es unknown
- 2003-02-25 EP EP03711214A patent/EP1492772A1/en not_active Withdrawn
- 2003-02-25 WO PCT/US2003/005479 patent/WO2003072549A1/en not_active Ceased
- 2003-02-25 KR KR10-2004-7013310A patent/KR20040098004A/ko not_active Abandoned
- 2003-02-25 CN CNB038047209A patent/CN100537542C/zh not_active Expired - Fee Related
- 2003-02-25 IL IL16367303A patent/IL163673A0/xx unknown
- 2003-02-25 JP JP2003571255A patent/JP2005525356A/ja active Pending
- 2003-02-26 PE PE2003000190A patent/PE20031038A1/es not_active Application Discontinuation
- 2003-02-26 TW TW092104046A patent/TW200303867A/zh unknown
-
2004
- 2004-08-13 CO CO04079404A patent/CO5611194A2/es not_active Application Discontinuation
- 2004-09-24 NO NO20044053A patent/NO20044053L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003215389B2 (en) | 2007-10-18 |
| AU2003215389A1 (en) | 2003-09-09 |
| EP1492772A1 (en) | 2005-01-05 |
| CN100537542C (zh) | 2009-09-09 |
| TW200303867A (en) | 2003-09-16 |
| AR039557A1 (es) | 2005-02-23 |
| JP2005525356A (ja) | 2005-08-25 |
| BR0308071A (pt) | 2004-12-21 |
| KR20040098004A (ko) | 2004-11-18 |
| PE20031038A1 (es) | 2004-01-10 |
| US20040122018A1 (en) | 2004-06-24 |
| RU2004128465A (ru) | 2005-09-27 |
| MXPA04008303A (es) | 2005-11-23 |
| WO2003072549A1 (en) | 2003-09-04 |
| NZ534809A (en) | 2007-12-21 |
| CN1630641A (zh) | 2005-06-22 |
| US7342016B2 (en) | 2008-03-11 |
| IL163673A0 (en) | 2005-12-18 |
| CA2477328A1 (en) | 2003-09-04 |
| PL372335A1 (en) | 2005-07-11 |
| NO20044053L (no) | 2004-11-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Application granted | ||
| FD | Application lapsed |