CO5590903A2 - Derivados de tetrahidroquinolina - Google Patents

Derivados de tetrahidroquinolina

Info

Publication number
CO5590903A2
CO5590903A2 CO05071364A CO05071364A CO5590903A2 CO 5590903 A2 CO5590903 A2 CO 5590903A2 CO 05071364 A CO05071364 A CO 05071364A CO 05071364 A CO05071364 A CO 05071364A CO 5590903 A2 CO5590903 A2 CO 5590903A2
Authority
CO
Colombia
Prior art keywords
alkoxy
alkylamino
heterocycloalkyl
heteroaryl
aryl
Prior art date
Application number
CO05071364A
Other languages
English (en)
Inventor
Cornelis Marius Timmers
Willem Frederik Johan Karstens
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of CO5590903A2 publication Critical patent/CO5590903A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1.- Un derivado de tetrahidroquinolina de acuerdo con la Fórmula I, O una sal farmacéuticamente aceptable de ésta, en dondeR1 y R2 son H o MeR3 es H, hidroxi, alcoxi(1-4C), (di)alquilamino (1-4C) alcoxi(2-4C) o heterocicloalquilo(2-6)alcoxi(2-4C);R4 es H, OH, alcoxi (1-4C) o R7;R5 es H, OH, alcoxi (1-4C) o R7;Con la condición de que si R4 es H, R5 no es H, OH, o alcoxi (1-4C) y que si R5 es H, R4 no es H, OH, o alcoxi (1-4C);R6 es heteroarilo(2-5C), arilo(6C), cicloalquilo(3-8C), heterocicloalquilo(2-6C) o alquilo(1-6C);R7 es amino, (di)alquilamino(1-4C), arilcarbonilamino(6C), arilcarboniloxi(6C), heteroarilcarbonilamino(2-5C), heteroarilcarboniloxi(2-5C), R8-alquilamino(2-4C), R8-alcoxi(2-4C), R9-metilamino o R9-metoxi;R8 es hidroxi, amino, alcoxi(1-4C), (di)alquilamino(1-4C) heterocicloalquilo(2-6C), heterocicloalquilcarbonilamino(2-6C), (di)alquilaminocarbonilamino(1-4C), alcoxicarbonilamino (1-4C) y R9 es aminocarbonilo, (di)alquilaminocarbonilo(1-4C), heteroarilo(2-5C) o arilo(6C).2.- El derivado de tetrahidroquinolina de la reivindicación 1 en donde R6 es heteroarilo(2-5C), arilo(6C), cicloalquilo(3-8C) o alquilo(1-6C).3.- El derivado de tetrahidroquinolina de las reivindicaciones 1 o 2 en donde R7 es (di)alquilamino(1-4C), heteroarilcarboniloxi(2-5C), R8-alcoxi(2-4C), R9-metilamino o R9-metoxi.
CO05071364A 2002-12-20 2005-07-19 Derivados de tetrahidroquinolina CO5590903A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43504002P 2002-12-20 2002-12-20
EP02102866 2002-12-20

Publications (1)

Publication Number Publication Date
CO5590903A2 true CO5590903A2 (es) 2005-12-30

Family

ID=32683821

Family Applications (1)

Application Number Title Priority Date Filing Date
CO05071364A CO5590903A2 (es) 2002-12-20 2005-07-19 Derivados de tetrahidroquinolina

Country Status (10)

Country Link
KR (1) KR20050084341A (es)
CO (1) CO5590903A2 (es)
DE (1) DE60326390D1 (es)
EC (1) ECSP055871A (es)
EG (1) EG24958A (es)
HK (1) HK1077577A1 (es)
HR (1) HRP20050576A2 (es)
IS (1) IS2647B (es)
MX (1) MXPA05006767A (es)
NO (1) NO330612B1 (es)

Also Published As

Publication number Publication date
NO20052727L (no) 2005-07-13
NO330612B1 (no) 2011-05-30
KR20050084341A (ko) 2005-08-26
IS2647B (is) 2010-08-15
NO20052727D0 (no) 2005-06-07
DE60326390D1 (en) 2009-04-09
HRP20050576A2 (en) 2005-10-31
ECSP055871A (es) 2005-09-20
HK1077577A1 (en) 2006-02-17
IS7871A (is) 2005-05-26
EG24958A (en) 2011-02-28
MXPA05006767A (es) 2005-09-08

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Legal Events

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