NO20052727L - Tetrahydrokinolinderivater - Google Patents

Tetrahydrokinolinderivater

Info

Publication number
NO20052727L
NO20052727L NO20052727A NO20052727A NO20052727L NO 20052727 L NO20052727 L NO 20052727L NO 20052727 A NO20052727 A NO 20052727A NO 20052727 A NO20052727 A NO 20052727A NO 20052727 L NO20052727 L NO 20052727L
Authority
NO
Norway
Prior art keywords
alkoxy
alkylamino
heterocycloalkyl
derivatives
heteroaryl
Prior art date
Application number
NO20052727A
Other languages
English (en)
Other versions
NO330612B1 (no
NO20052727D0 (no
Inventor
Cornelis Marius Timmers
Willem Frederik Johan Karstens
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2003/051025 external-priority patent/WO2004056780A2/en
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of NO20052727D0 publication Critical patent/NO20052727D0/no
Publication of NO20052727L publication Critical patent/NO20052727L/no
Publication of NO330612B1 publication Critical patent/NO330612B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Foreliggende oppfinnelse omhandler telrahydrokinolinderivater sonn har generell R3 fornnel (I) Formel I eller et farmasøytisk akseptabelt salt derav, hvor R^ og R^ er H eller Me; R' er H, hydroksy, (1-4C)alkoksy, (di)(1-4C)alkylamino(2-4C)alkoksy eller (2- 6)heterocykloalkyl(2-4C)alkoksy; R'' er H, OH, (1-4C)alkoksy eller R^; R^ er H, OH, (1 -4C)alkoksy eller R^med det forbehold at hvis R" er H, er R^ ikke H, OH eller (1- 4C)alkoksy og at hvis R^ er H, er R"* ikke H, OH eller (1-4C)alkoksy; R^ er (2- 5C)heteroaryl, (6C)aryl, (3-8C)cykloalkyl, (2-6C)heterocykloalkyl eller (1-6C)alkyl; r'^ er amino, (di)(1-4C)alkylamino, (6C)arylkarbonylamino, (6C)arylkarbonyloksy, (2-5C)heteroarylkarbonylamino, (2-5C)heteroarylkarbonyloksy, R^-(2- 4C)alkylamino, R°-(2-4C)alkoksy, R^-metylamino eller R^-metoksy; R^ er hydroksy, amino, (1-4C)alkoksy, (di)(1-4C)alkylamino, (2-6C)heterocykloalkyl, (2- 6C)heterocykloalkylkarbonylamino, (di)(1-4C)alkylaminokarbonylannino, (1- 4C)alkoksykarbonylamino og R^ er aminokarbonyl, (di)(1-4C)alkylaminokarbonyl, (2-5C)heteroaryl eller (6C)aryl. Foreliggende oppfinnelse omhandler også famna- søytiske preparater som omfatter nevnte derivater og anvendelsen av disse deri- vatene for å regulere fertilitet.
NO20052727A 2002-12-20 2005-06-07 Tetrahydrokinolinderivater, farmasoytisk preparat omfattende slike, slike forbindelser for anvendelse i terapi samt anvendelse av slike for fremstilling av medikament for fruktbarhetsregulering NO330612B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US43504002P 2002-12-20 2002-12-20
EP02102866 2002-12-20
PCT/EP2003/051025 WO2004056780A2 (en) 2002-12-20 2003-12-16 Tetrahydroquinoline derivatives

Publications (3)

Publication Number Publication Date
NO20052727D0 NO20052727D0 (no) 2005-06-07
NO20052727L true NO20052727L (no) 2005-07-13
NO330612B1 NO330612B1 (no) 2011-05-30

Family

ID=32683821

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20052727A NO330612B1 (no) 2002-12-20 2005-06-07 Tetrahydrokinolinderivater, farmasoytisk preparat omfattende slike, slike forbindelser for anvendelse i terapi samt anvendelse av slike for fremstilling av medikament for fruktbarhetsregulering

Country Status (10)

Country Link
KR (1) KR20050084341A (no)
CO (1) CO5590903A2 (no)
DE (1) DE60326390D1 (no)
EC (1) ECSP055871A (no)
EG (1) EG24958A (no)
HK (1) HK1077577A1 (no)
HR (1) HRP20050576A2 (no)
IS (1) IS2647B (no)
MX (1) MXPA05006767A (no)
NO (1) NO330612B1 (no)

Also Published As

Publication number Publication date
NO330612B1 (no) 2011-05-30
CO5590903A2 (es) 2005-12-30
IS2647B (is) 2010-08-15
KR20050084341A (ko) 2005-08-26
HRP20050576A2 (en) 2005-10-31
DE60326390D1 (en) 2009-04-09
NO20052727D0 (no) 2005-06-07
IS7871A (is) 2005-05-26
EG24958A (en) 2011-02-28
HK1077577A1 (en) 2006-02-17
ECSP055871A (es) 2005-09-20
MXPA05006767A (es) 2005-09-08

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