TW200621778A - 1β-methyl carbapenem derivatives - Google Patents

1β-methyl carbapenem derivatives

Info

Publication number
TW200621778A
TW200621778A TW094138190A TW94138190A TW200621778A TW 200621778 A TW200621778 A TW 200621778A TW 094138190 A TW094138190 A TW 094138190A TW 94138190 A TW94138190 A TW 94138190A TW 200621778 A TW200621778 A TW 200621778A
Authority
TW
Taiwan
Prior art keywords
group
optionally substituted
carbapenern
infectious disease
carbapenem derivatives
Prior art date
Application number
TW094138190A
Other languages
Chinese (zh)
Inventor
Takuya Uchida
Shigeo Yamanoi
Tetsufumi Koga
Takahiro Shibayama
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of TW200621778A publication Critical patent/TW200621778A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring

Abstract

The present invention provides a carbapenern derivative having the prophylactic or therapeutic effect for the bacterial infectious disease, especially for infectious disease of the respiratory system. A carbapenern comound of the following formula (I), ?wherein, A represents an optionally substituted C1-6 alkyl group, an optionally substituted C2-4alkenyl group, a C3-6 cycloalkyl group, an optionally substituted 4-6 membered heterocylic group, a mono-substituted amino group or di-substituted amino group, n represents 1 or 2, X represents an oxygen atom or an sulfur atom?, the pharmaceutically acceptable salt or ester derivative thereof.
TW094138190A 2004-11-02 2005-11-01 1β-methyl carbapenem derivatives TW200621778A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2004319228 2004-11-02

Publications (1)

Publication Number Publication Date
TW200621778A true TW200621778A (en) 2006-07-01

Family

ID=36319154

Family Applications (1)

Application Number Title Priority Date Filing Date
TW094138190A TW200621778A (en) 2004-11-02 2005-11-01 1β-methyl carbapenem derivatives

Country Status (2)

Country Link
TW (1) TW200621778A (en)
WO (1) WO2006049148A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112513043A (en) * 2018-05-30 2021-03-16 维纳拓尔斯制药公司 Broad spectrum carbapenems

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH023687A (en) * 1988-06-22 1990-01-09 Sankyo Co Ltd 1-methylcarbapenem derivative
JP3242677B2 (en) * 1990-08-10 2001-12-25 住友製薬株式会社 Novel β-lactam compound and method for producing the same
JP2004043438A (en) * 2002-05-15 2004-02-12 Sankyo Co Ltd Medicine containing 1-methylcarbapenem derivative

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112513043A (en) * 2018-05-30 2021-03-16 维纳拓尔斯制药公司 Broad spectrum carbapenems

Also Published As

Publication number Publication date
WO2006049148A1 (en) 2006-05-11

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