CO5261503A1 - Derivados de piperazina y piperidina - Google Patents
Derivados de piperazina y piperidinaInfo
- Publication number
- CO5261503A1 CO5261503A1 CO01009891A CO01009891A CO5261503A1 CO 5261503 A1 CO5261503 A1 CO 5261503A1 CO 01009891 A CO01009891 A CO 01009891A CO 01009891 A CO01009891 A CO 01009891A CO 5261503 A1 CO5261503 A1 CO 5261503A1
- Authority
- CO
- Colombia
- Prior art keywords
- branched
- straight
- alkenyl
- alkyl
- ring
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
Un compuesto de la fórmula:<EMI FILE="01009891_1" ID="1" IMF=JPEG >en donde:cada Q es un sistema de anillo monocíclico, bicíclico o tricíclico, en donde en dicho sistema de anillo:cada anillo es independientemente insaturado de manera parcial o completamente saturado;cada anillo comprende 3 a 7 átomos de anillo independientemente seleccionado de C, N, O o S;no más de cuatro átomos del anillo en Q son seleccionados de N, O o S;cualquier S es opcionalmente reemplazado con S (O) o S(O)2;al menos un anillo comprende un átomo de anillo N que es sustituido con R1;f. De uno a cinco átomos de hidrógeno en Q son opcional e independientemente reemplazados con halo-OH, =O, =N-OR1, alquilo recto o ramificado (C1-C6), alquilo Ar- sustituido-(C1-C6)-recto o ramificado, alquenilo o alquinilo recto o ramificado (C2-C6), alquenilo o alquinilo Ar-sustituido-g. (C2C6)-recto o ramificado, alquilo O-C1-C6)-recto o ramificado, O-[alquilo (C1-C6)-recto o ramificado]-Ar, alquenilo o alquinilo O-(C2-C6)-recto o ramificado, O-[alquenilo o alquinilo (C2-C6)-recto o ramificado]-Ar, o O-Ar; y - 2 -h. Q no es un indol o una porción piroglutámica, en dondeCada R1 es independientemente seleccionado de alquilo (C1-C6)-recto o ramificado, alquilo Ar-sustituido-(C1-C6)-recto o ramificado, alquilo cicloalquilo (C1-C6)-recto o ramificado, o alquenilo o alquinilo (C2-C6)-recto o ramificado, o alquenilo alquinilo Ar-sustituido-(C2-C6)-recto o ramificado; en dondeUno a dos grupos CH2 de dichas cadenas de alquilo, alquenilo, o alquinilo, en R1 son opcional e independientemente reemplazadas con O, S, S(O), S(O)2, C(O) o N(R2), en donde cuando R1 está unido al nitrógeno, el grupo CH2 del R1 unido directamente a dicho nitrógeno no puede ser reemplazado con C(O);Ar se selecciona de fenilo, 1-naftilo, 2-naftilo, indenilo, azulenilo, 2-furilo, 3-furilo, 2-tienilo, 3-tienilo, 2-piridilo, 3-piridilo, 4-piridilo, pirrolilo, oxazolilo, tiazolilo, imidazolilo, piraxolilo, pirazolinilo, piraolidinilo, isoxazolilo, isotiazolilo, 1,2,3-oxadiazolilo, 1,2,3-triazolilo, 1,3,4-tiadiazolilo, 1,2,4-triazolilo, 1,2,4-oxadiazolilo, 1,2,4-tiadiazolilo, 1,2,3-tiadiazolilo, benoxazolilo, piridazinilo, 2-pirimidinilo, 4- pirimidinilo, 5- pirimidinilo, pirazinilo, 1,3,5-triazinilo, 1,3,5-tritianilo, indolisinilo, indolilo, isoindolilo, 3H-indolilo, indolinilo, benzo[b]furanilo, benzo[b]tiofenilo, 1H-indazolilo, benzimidiazolilo, benztiazolilo, purinilo, 4H-quinolisinilo, quinolinilo, 1,2,3,4-tetrahidroisoquinolinilo, isoquinolinilo, 1,2,3,4-tetrahidroquinolinilo, cinolinilo, eftalasinilo, quinazolinilo, quinoxalinilo, 1,8-naftiridinilo, o cualquier otro sistema de anillo monocíclico o bicíclico químicamente factible, en donde cada anillo consiste de 5 a 7 átomos de anillo en donde cada anillo comprende 0 a 3 héteroátomos independientemente seleccionados de N, O, o S, en dondeCada Ar es opcionalmente e independientemente sustituido con uno a tres sustituyentes seleccionados de halo, hidroxi, nitro, =O, -SO3H, trifluorometilo, trifluorometoxi, alquilo (C1-C6)-recto o ramificado, alquenilo (C1-C6)-recto o ramificado, O-[alquilo (C1-C6)-recto o ramificado], O-[alquenilo (C1-C6)-recto o ramificado], O-benzilo, O-fenilo, 1,2-metilenedioxi, -N(R3)(R4), carboxilo, N-(alquilo (C1-C6)-recto o ramificado o alquenilo (C2-C6)-recto o ramificado) carboxamidas, N,N-di-(alquilo C1-C6-recto o ramificado o alquenilo C2-C6-recto o ramificado) carboxamidas, N-(alquilo C1-C6-recto o ramificado o alquenilo C2-C6-recto o ramificado) sulfonamidas, o N,N-di-(alquilo C1-C6-recto o ramificado o alquenilo C2-C6-recto o ramificado) sulfonamidas;Cada uno de los R3 y R4 son independientemente seleccionados de alquilo (C1-C6)-recto o ramificado, alquenilo o alquinilo (C2-C6)-recto o ramificado, hidrógeno, fenilo o benzilo, o en donde R3 y R4 son tomados juntos con el átomo de nitrógeno al cual ellos están unidos para formar un anillo héterocíclico de 5 a 7 miembros;Cada R2 es independientemente seleccionado de hidrógeno, alquilo (C1-C6)-recto o ramificado, o alquenilo o alquinilo (C2-C6)-recto o ramificado;X se selecciona de C(R2)2, N(R2), N, O, S, S(O), o S(O)2;Y se selecciona de un enlace, -O-, alquilo (C1-C6)-recto o ramificado, o alquenilo o alquinilo (C2-C6)-recto o ramificado; en donde Y está unido al anillo descrito vía un enlace simple o un enlace doble; y en donde uno a dos de los grupos CH2 de dicho alquilo, alquenilo o alquinilo está opcional e independientemente reemplazado con O, As, S(O), S(O)2, C(O) o N(R2);Z es -C(O)- o -CH2-P es 0, 1 o 2;Cada uno de A y B es independientemente seleccionado de hidrógeno o Ar; o uno de A o B está ausente; yEn donde dos átomos del anillo de carbono en la estructura del anillo descrita están opcionalmente unidos uno al otro por vía de un alquilo C1-C4 recto o un alquenilo C2-C4 recto para crear una porción bicíclica.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18194400P | 2000-02-11 | 2000-02-11 | |
US24733000P | 2000-11-10 | 2000-11-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO5261503A1 true CO5261503A1 (es) | 2003-03-31 |
Family
ID=26877657
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO01009891A CO5261503A1 (es) | 2000-02-11 | 2001-02-09 | Derivados de piperazina y piperidina |
Country Status (23)
Country | Link |
---|---|
EP (1) | EP1257544B1 (es) |
JP (1) | JP2003522767A (es) |
KR (1) | KR20020073586A (es) |
CN (1) | CN1210274C (es) |
AP (1) | AP2002002596A0 (es) |
AU (1) | AU4146401A (es) |
BR (1) | BR0108175A (es) |
CA (1) | CA2398822A1 (es) |
CO (1) | CO5261503A1 (es) |
CZ (1) | CZ20022720A3 (es) |
EA (1) | EA200200847A1 (es) |
EE (1) | EE200200442A (es) |
HR (1) | HRP20020737A2 (es) |
HU (1) | HUP0301391A3 (es) |
IL (1) | IL150849A0 (es) |
IS (1) | IS6477A (es) |
MX (1) | MXPA02007790A (es) |
NO (1) | NO20023787L (es) |
NZ (1) | NZ520638A (es) |
PE (1) | PE20011081A1 (es) |
PL (1) | PL357177A1 (es) |
SK (1) | SK11452002A3 (es) |
WO (1) | WO2001058891A2 (es) |
Families Citing this family (30)
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CA2439149C (en) | 2001-02-28 | 2012-04-24 | Merck & Co., Inc. | Acylated piperidine derivatives as melanocortin-4 receptor agonists |
WO2002067869A2 (en) | 2001-02-28 | 2002-09-06 | Merck & Co., Inc. | Acylated piperidine derivatives as melanocortin-4 receptor agonists |
JP4336196B2 (ja) | 2001-07-18 | 2009-09-30 | メルク エンド カムパニー インコーポレーテッド | メラノコルチン受容体作動薬としての架橋ピペリジン誘導体 |
WO2003022835A1 (en) | 2001-09-06 | 2003-03-20 | Schering Corporation | 17beta-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases |
EP1441728A2 (en) * | 2001-11-01 | 2004-08-04 | Vertex Pharmaceuticals Incorporated | Modulators of the cholesterol biosynthetic pathway |
AU2003268493A1 (en) | 2002-09-11 | 2004-04-30 | Merck & Co., Inc. | Piperazine urea derivatives as melanocortin-4 receptor agonists |
ES2324293T3 (es) * | 2002-10-03 | 2009-08-04 | Vertex Pharmaceuticals Incorporated | Derivados de piperacina y piperidina para el tratamiento de enfermedades neurologicas. |
AR043434A1 (es) | 2003-03-03 | 2005-07-27 | Merck & Co Inc | Derivados de piperizacina acilados como agonistas del receptor de melanocortina-4. composiciones farmaceuticas y usos |
CA2523426C (en) | 2003-04-24 | 2013-02-26 | Incyte Corporation | Aza spiro alkane derivatives as inhibitors of metalloproteases |
EP1524265A1 (en) * | 2003-10-15 | 2005-04-20 | Newron Pharmaceuticals S.p.A. | Prolinamide derivatives as sodium and/or calcium channel blockers or selective MAO-B inhibitors |
EP1773338B1 (en) | 2004-07-19 | 2010-01-06 | Merck & Co., Inc. | Acylated piperidine derivatives as melanocortin-4 receptor agonists |
GB0508319D0 (en) | 2005-04-25 | 2005-06-01 | Novartis Ag | Organic compounds |
ATE450525T1 (de) * | 2005-06-20 | 2009-12-15 | Schering Corp | Kohlenstoffgebundene substituierte piperidine und derivate daraus als histamin-h3-antagonisten |
ES2337727T3 (es) | 2005-06-20 | 2010-04-28 | Schering Corporation | Derivados de piperidina utiles como antagonistas de histamina h3. |
GB0514018D0 (en) * | 2005-07-07 | 2005-08-17 | Ionix Pharmaceuticals Ltd | Chemical compounds |
CA2637707A1 (en) | 2006-02-02 | 2007-08-09 | Rinat Neuroscience Corporation | Methods for treating obesity by administering a trkb antagonist |
PT2076508E (pt) | 2006-10-18 | 2011-03-07 | Pfizer Prod Inc | Compostos de ureia de éter biarílico |
US8759539B2 (en) | 2008-11-17 | 2014-06-24 | Merck Sharp & Dohme Corp. | Substituted bicyclic amines for the treatment of diabetes |
WO2011011506A1 (en) | 2009-07-23 | 2011-01-27 | Schering Corporation | Spirocyclic oxazepine compounds as stearoyl-coenzyme a delta-9 desaturase inhibitors |
WO2011011508A1 (en) | 2009-07-23 | 2011-01-27 | Schering Corporation | Benzo-fused oxazepine compounds as stearoyl-coenzyme a delta-9 desaturase inhibitors |
WO2011137024A1 (en) | 2010-04-26 | 2011-11-03 | Merck Sharp & Dohme Corp. | Novel spiropiperidine prolylcarboxypeptidase inhibitors |
EP2568812B1 (en) | 2010-05-11 | 2016-10-26 | Merck Sharp & Dohme Corp. | Novel prolylcarboxypeptidase inhibitors |
US9006268B2 (en) | 2010-06-11 | 2015-04-14 | Merck Sharp & Dohme Corp. | Prolylcarboxypeptidase inhibitors |
MY174339A (en) | 2012-08-13 | 2020-04-09 | Novartis Ag | 1,4-disubstituted pyridazine analogs and methods for treating smn-deficiency-related conditions |
MX2020011652A (es) * | 2013-07-31 | 2022-09-27 | Novartis Ag | Derivados de piridazina 1,4-disustituida, y su uso para el tratamiento de afecciones relacionadas con la deficiencia de smn. |
JP6985179B2 (ja) * | 2018-02-27 | 2021-12-22 | 田辺三菱製薬株式会社 | プロリンアミド化合物の製造方法 |
KR20220030222A (ko) | 2019-05-31 | 2022-03-10 | 이케나 온콜로지, 인코포레이티드 | Tead 억제제 및 이의 용도 |
WO2020243423A1 (en) | 2019-05-31 | 2020-12-03 | Ikena Oncology, Inc. | Tead inhibitors and uses thereof |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE791501A (fr) * | 1971-11-19 | 1973-05-17 | Albert Ag Chem Werke | Diamines cycliques n,n'-disubstituees et leur procede de preparation |
US3862937A (en) * | 1972-02-23 | 1975-01-28 | Univ Mississippi | 6-Phenethyl-3-piperidinecarboxamides |
FR2597100A1 (fr) * | 1986-01-21 | 1987-10-16 | Nippon Shinyaku Co Ltd | Derives du pyroglutamide |
US4745123A (en) * | 1986-02-18 | 1988-05-17 | Warner-Lambert Company | Substituted tetrahydro-3-pyridine-carboxylic acid, ester, and amide cholinergic agents |
US5232923A (en) * | 1988-03-18 | 1993-08-03 | Mitsui Toatsu Chemicals, Incorporated | Catechol derivatives and pharmaceutical preparations containing same |
NZ228329A (en) * | 1988-03-18 | 1991-12-23 | Mitsui Toatsu Chemicals | Catechol derivatives and pharmaceutical compositions thereof |
US5290793A (en) * | 1989-09-12 | 1994-03-01 | Mitsui Toatsu Chemicals, Incorporated | Dihydrocaffeic acid derivatives and pharmaceutical preparation containing same |
FR2705095B1 (fr) | 1993-05-12 | 1995-06-23 | Adir | Nouveaux indoles substitués, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
US5614547A (en) | 1995-06-07 | 1997-03-25 | Guilford Pharmaceuticals Inc. | Small molecule inhibitors of rotamase enzyme |
US5811434A (en) * | 1996-11-13 | 1998-09-22 | Vertex Pharmacueticals Incorporated | Methods and compositions for stimulating neurite growth |
PA8442401A1 (es) * | 1996-12-09 | 2000-05-24 | Guilford Pharm Inc | Inhibidores polipropilos de ciclofilina |
JPH11106375A (ja) * | 1997-08-18 | 1999-04-20 | Pfizer Pharmaceut Inc | ブラジキニンアンタゴニストとしての光学的に活性な1,4−ジヒドロピリジン化合物 |
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2001
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- 2001-02-09 AP APAP/P/2002/002596A patent/AP2002002596A0/en unknown
- 2001-02-09 EE EEP200200442A patent/EE200200442A/xx unknown
- 2001-02-09 PE PE2001000144A patent/PE20011081A1/es not_active Application Discontinuation
- 2001-02-09 HU HU0301391A patent/HUP0301391A3/hu unknown
- 2001-02-09 EA EA200200847A patent/EA200200847A1/ru unknown
- 2001-02-09 BR BR0108175-6A patent/BR0108175A/pt not_active IP Right Cessation
- 2001-02-09 JP JP2001558441A patent/JP2003522767A/ja active Pending
- 2001-02-09 CA CA002398822A patent/CA2398822A1/en not_active Abandoned
- 2001-02-09 SK SK1145-2002A patent/SK11452002A3/sk not_active Application Discontinuation
- 2001-02-09 CZ CZ20022720A patent/CZ20022720A3/cs unknown
- 2001-02-09 KR KR1020027010367A patent/KR20020073586A/ko not_active Application Discontinuation
- 2001-02-09 IL IL15084901A patent/IL150849A0/xx unknown
- 2001-02-09 PL PL01357177A patent/PL357177A1/xx not_active Application Discontinuation
- 2001-02-09 WO PCT/US2001/004210 patent/WO2001058891A2/en active IP Right Grant
- 2001-02-09 EP EP01912714A patent/EP1257544B1/en not_active Expired - Lifetime
- 2001-02-09 CN CNB018048021A patent/CN1210274C/zh not_active Expired - Fee Related
- 2001-02-09 AU AU41464/01A patent/AU4146401A/en not_active Abandoned
- 2001-02-09 MX MXPA02007790A patent/MXPA02007790A/es unknown
- 2001-02-09 NZ NZ520638A patent/NZ520638A/en unknown
-
2002
- 2002-07-19 IS IS6477A patent/IS6477A/is unknown
- 2002-08-09 NO NO20023787A patent/NO20023787L/no unknown
- 2002-09-09 HR HR20020737A patent/HRP20020737A2/hr not_active Application Discontinuation
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CN1404477A (zh) | 2003-03-19 |
HRP20020737A2 (en) | 2005-10-31 |
AU4146401A (en) | 2001-08-20 |
WO2001058891A3 (en) | 2002-04-25 |
NO20023787D0 (no) | 2002-08-09 |
AP2002002596A0 (en) | 2002-09-30 |
CA2398822A1 (en) | 2001-08-16 |
NZ520638A (en) | 2004-05-28 |
CN1210274C (zh) | 2005-07-13 |
EE200200442A (et) | 2003-12-15 |
BR0108175A (pt) | 2003-01-28 |
KR20020073586A (ko) | 2002-09-27 |
NO20023787L (no) | 2002-10-11 |
MXPA02007790A (es) | 2002-10-17 |
JP2003522767A (ja) | 2003-07-29 |
HUP0301391A3 (en) | 2010-03-29 |
HUP0301391A2 (hu) | 2003-08-28 |
EA200200847A1 (ru) | 2003-02-27 |
IL150849A0 (en) | 2003-02-12 |
IS6477A (is) | 2002-07-19 |
WO2001058891A2 (en) | 2001-08-16 |
EP1257544A2 (en) | 2002-11-20 |
CZ20022720A3 (cs) | 2002-11-13 |
PL357177A1 (en) | 2004-07-26 |
PE20011081A1 (es) | 2001-10-22 |
SK11452002A3 (sk) | 2003-03-04 |
EP1257544B1 (en) | 2012-07-25 |
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