CO5080789A1 - Compuestos monociclicos con accion antagonista nk2 y composicion que los contiene - Google Patents
Compuestos monociclicos con accion antagonista nk2 y composicion que los contieneInfo
- Publication number
- CO5080789A1 CO5080789A1 CO99049466A CO99049466A CO5080789A1 CO 5080789 A1 CO5080789 A1 CO 5080789A1 CO 99049466 A CO99049466 A CO 99049466A CO 99049466 A CO99049466 A CO 99049466A CO 5080789 A1 CO5080789 A1 CO 5080789A1
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- different
- group selected
- methanesulfonyl
- furan
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/22—Tachykinins, e.g. Eledoisins, Substance P; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Compuestos monocíclicos de la fórmula general (I)<EMI FILE="99049466_1" ID="1" IMF=JPEG >Donde:X1, X2, X3, X4, ya sean iguales o diferentes, forman un grupo seleccionado entre:-CONR-, -CH2 -NR-, -NR- CH2- donde H es R, C1-3 alquilo, bencilo;f, m, ya sean iguales o diferentes, son un número seleccionado entre 0, 1 y 2;R1 y R2, ya sean iguales o diterentes, forman un grupo: (CH2)r -Ar donde r= 0, 1, 2 y Ar es un grupo aromático seleccionado entre benceno, naftalina, tiofeno, benzotiofeno, piridina, quinolina, indol, furano, benzofuran, tiazol, benzotiazol, imidazol, benzoimidazol, con posibilidad de sustitución por medio de hasta 2 sustitutos seleccionados entre C1-3 alquilo, haloalquilo, C1-3, alquiloxy,C2-4 amino a!quiloxy, halógenos, OH, NH2, CN, NR6 R7, donde R6 y R7 , ya sean iguales o diferentes, son H o C1-3 alquilo, R3 es un grupo seleccionado entre los siguientes grupos: ? (CH2)r -Ar1 donde r = 0, 1, 2 y Ar1 es un grupo aromático seleccionado entre benceno, naftalina, tiofeno, benzotiofeno, piridina, quinolina, indol, furano, benzofuran, tiazol, benzotiazol, imidazol, benzoimidazol, con posibilidad de sustitución por medio de hasta 2 sustitutos seleccionados entre C1-3 alquilo, haloalquilo, C1-3 alquiloxy y amino alquiloxi, halógenos, OH, NH2, CN, NR6, R7, donde R6 y R7 , ya sean iguales o diferentes, son H o C1-3 alquilo, R5 es H R4 es un grupo seleccionado entre:-NR8 R9 , donde R8 es H o C1-3 alquilo y R9 es un metanosulfonilo, tosilo, tetrahidropiranilo, tetrahidrotiopiranilo, posiblemente mono o bisustituido por oxígeno en el átomo S, piperidilo posiblemente sustituido en el átomo N por un C1-3 alquilo, C1-3 acilo, amino sulfonilo, metanosulfonilo; o un grupo , (CH2)g- R10 donde g es 1, 2, 3 y R10 se selecciona entre morfolino, furano, CN, o, R8 y R9 junto con el átomo N al que están vinculados forman piperacina posiblemente sustituida en uno de sus nitrógenos por C1-3 alquilo, C1-3 acilo o metanosulfonilo; N(R11 ) CO(CH2 )h-R12 donde R11 es H, C1-3 alquilo, h es 0, 1, 2, 3; y R12 se selecciona entre morfolino, ...
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1998FI000186A IT1304888B1 (it) | 1998-08-05 | 1998-08-05 | Composti monociclici ad azione nk-2 antagonista e formulazioni che licontengono |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5080789A1 true CO5080789A1 (es) | 2001-09-25 |
Family
ID=11352646
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO99049466A CO5080789A1 (es) | 1998-08-05 | 1999-08-05 | Compuestos monociclicos con accion antagonista nk2 y composicion que los contiene |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1102789A1 (es) |
| JP (1) | JP2002522450A (es) |
| AR (1) | AR021751A1 (es) |
| AU (1) | AU5507999A (es) |
| CA (1) | CA2339638A1 (es) |
| CO (1) | CO5080789A1 (es) |
| IT (1) | IT1304888B1 (es) |
| PE (1) | PE20001002A1 (es) |
| TR (1) | TR200100354T2 (es) |
| TW (1) | TW491857B (es) |
| WO (1) | WO2000008046A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1307809B1 (it) | 1999-10-21 | 2001-11-19 | Menarini Ricerche Spa | Composti monociclici basici ad azione nk-2 antagonista, processi difabbricazione e formulazioni che li contengono. |
| HUP0501182A3 (en) | 2003-04-24 | 2011-08-29 | Incyte Corp | Aza spiro alkane derivatives as inhibitors of metallproteases and pharmaceutical compositions containing them |
| UY38485A (es) | 2018-11-27 | 2020-06-30 | Novartis Ag | Compuestos tetrámeros cíclicos como inhibidores de proproteína convertasa subtilisina/kexina tipo 9 (pcsk9), método de tratamiento, uso y su preparación |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4703034A (en) * | 1986-04-28 | 1987-10-27 | Merck & Co., Inc. | Novel cyclic tetrapeptide |
| WO1993003059A1 (en) * | 1991-08-08 | 1993-02-18 | A. Menarini Industrie Farmaceutiche Riunite S.R.L. | Cyclic hexapeptides as tachyquinin antagonists, their preparation and pharmaceutical compositions thereof |
| ATE155486T1 (de) * | 1991-08-13 | 1997-08-15 | Takeda Chemical Industries Ltd | Zyklische peptide und ihre verwendung |
| IT1277835B1 (it) * | 1995-03-13 | 1997-11-12 | Menarini Farma Ind | Composti biciclici, loro preparazione ed uso in composizioni farmaceutiche |
| IT1291776B1 (it) * | 1997-02-07 | 1999-01-21 | Menarini Ricerche Spa | Composti monociclici a quattro residui bifunzionali, aventi azione nk-2 antagonista |
-
1998
- 1998-08-05 IT IT1998FI000186A patent/IT1304888B1/it active
-
1999
- 1999-07-27 TW TW088112671A patent/TW491857B/zh active
- 1999-07-30 CA CA002339638A patent/CA2339638A1/en not_active Abandoned
- 1999-07-30 WO PCT/EP1999/005459 patent/WO2000008046A1/en not_active Application Discontinuation
- 1999-07-30 TR TR2001/00354T patent/TR200100354T2/xx unknown
- 1999-07-30 EP EP99941479A patent/EP1102789A1/en not_active Withdrawn
- 1999-07-30 AU AU55079/99A patent/AU5507999A/en not_active Abandoned
- 1999-07-30 JP JP2000563679A patent/JP2002522450A/ja active Pending
- 1999-08-04 PE PE1999000784A patent/PE20001002A1/es not_active Application Discontinuation
- 1999-08-05 CO CO99049466A patent/CO5080789A1/es unknown
- 1999-08-05 AR ARP990103922A patent/AR021751A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002522450A (ja) | 2002-07-23 |
| AR021751A1 (es) | 2002-08-07 |
| PE20001002A1 (es) | 2000-10-16 |
| ITFI980186A1 (it) | 2000-02-05 |
| TR200100354T2 (tr) | 2001-05-21 |
| CA2339638A1 (en) | 2000-02-17 |
| EP1102789A1 (en) | 2001-05-30 |
| WO2000008046A1 (en) | 2000-02-17 |
| TW491857B (en) | 2002-06-21 |
| IT1304888B1 (it) | 2001-04-05 |
| AU5507999A (en) | 2000-02-28 |
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