CO5080789A1 - Compuestos monociclicos con accion antagonista nk2 y composicion que los contiene - Google Patents
Compuestos monociclicos con accion antagonista nk2 y composicion que los contieneInfo
- Publication number
- CO5080789A1 CO5080789A1 CO99049466A CO99049466A CO5080789A1 CO 5080789 A1 CO5080789 A1 CO 5080789A1 CO 99049466 A CO99049466 A CO 99049466A CO 99049466 A CO99049466 A CO 99049466A CO 5080789 A1 CO5080789 A1 CO 5080789A1
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- different
- group selected
- methanesulfonyl
- furan
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/22—Tachykinins, e.g. Eledoisins, Substance P; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Compuestos monocíclicos de la fórmula general (I)<EMI FILE="99049466_1" ID="1" IMF=JPEG >Donde:X1, X2, X3, X4, ya sean iguales o diferentes, forman un grupo seleccionado entre:-CONR-, -CH2 -NR-, -NR- CH2- donde H es R, C1-3 alquilo, bencilo;f, m, ya sean iguales o diferentes, son un número seleccionado entre 0, 1 y 2;R1 y R2, ya sean iguales o diterentes, forman un grupo: (CH2)r -Ar donde r= 0, 1, 2 y Ar es un grupo aromático seleccionado entre benceno, naftalina, tiofeno, benzotiofeno, piridina, quinolina, indol, furano, benzofuran, tiazol, benzotiazol, imidazol, benzoimidazol, con posibilidad de sustitución por medio de hasta 2 sustitutos seleccionados entre C1-3 alquilo, haloalquilo, C1-3, alquiloxy,C2-4 amino a!quiloxy, halógenos, OH, NH2, CN, NR6 R7, donde R6 y R7 , ya sean iguales o diferentes, son H o C1-3 alquilo, R3 es un grupo seleccionado entre los siguientes grupos: ? (CH2)r -Ar1 donde r = 0, 1, 2 y Ar1 es un grupo aromático seleccionado entre benceno, naftalina, tiofeno, benzotiofeno, piridina, quinolina, indol, furano, benzofuran, tiazol, benzotiazol, imidazol, benzoimidazol, con posibilidad de sustitución por medio de hasta 2 sustitutos seleccionados entre C1-3 alquilo, haloalquilo, C1-3 alquiloxy y amino alquiloxi, halógenos, OH, NH2, CN, NR6, R7, donde R6 y R7 , ya sean iguales o diferentes, son H o C1-3 alquilo, R5 es H R4 es un grupo seleccionado entre:-NR8 R9 , donde R8 es H o C1-3 alquilo y R9 es un metanosulfonilo, tosilo, tetrahidropiranilo, tetrahidrotiopiranilo, posiblemente mono o bisustituido por oxígeno en el átomo S, piperidilo posiblemente sustituido en el átomo N por un C1-3 alquilo, C1-3 acilo, amino sulfonilo, metanosulfonilo; o un grupo , (CH2)g- R10 donde g es 1, 2, 3 y R10 se selecciona entre morfolino, furano, CN, o, R8 y R9 junto con el átomo N al que están vinculados forman piperacina posiblemente sustituida en uno de sus nitrógenos por C1-3 alquilo, C1-3 acilo o metanosulfonilo; N(R11 ) CO(CH2 )h-R12 donde R11 es H, C1-3 alquilo, h es 0, 1, 2, 3; y R12 se selecciona entre morfolino, ...
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1998FI000186A IT1304888B1 (it) | 1998-08-05 | 1998-08-05 | Composti monociclici ad azione nk-2 antagonista e formulazioni che licontengono |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5080789A1 true CO5080789A1 (es) | 2001-09-25 |
Family
ID=11352646
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO99049466A CO5080789A1 (es) | 1998-08-05 | 1999-08-05 | Compuestos monociclicos con accion antagonista nk2 y composicion que los contiene |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1102789A1 (es) |
| JP (1) | JP2002522450A (es) |
| AR (1) | AR021751A1 (es) |
| AU (1) | AU5507999A (es) |
| CA (1) | CA2339638A1 (es) |
| CO (1) | CO5080789A1 (es) |
| IT (1) | IT1304888B1 (es) |
| PE (1) | PE20001002A1 (es) |
| TR (1) | TR200100354T2 (es) |
| TW (1) | TW491857B (es) |
| WO (1) | WO2000008046A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1307809B1 (it) * | 1999-10-21 | 2001-11-19 | Menarini Ricerche Spa | Composti monociclici basici ad azione nk-2 antagonista, processi difabbricazione e formulazioni che li contengono. |
| AU2004233863B2 (en) | 2003-04-24 | 2010-06-17 | Incyte Holdings Corporation | Aza spiro alkane derivatives as inhibitors of metalloproteases |
| UY38485A (es) | 2018-11-27 | 2020-06-30 | Novartis Ag | Compuestos tetrámeros cíclicos como inhibidores de proproteína convertasa subtilisina/kexina tipo 9 (pcsk9), método de tratamiento, uso y su preparación |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4703034A (en) * | 1986-04-28 | 1987-10-27 | Merck & Co., Inc. | Novel cyclic tetrapeptide |
| JPH06509571A (ja) * | 1991-08-08 | 1994-10-27 | エイ・メナリニ・インダストリー・ファーマシューティケ・リウニテ・エスアールエル | タキキニン拮抗薬としての環状ヘキサペプチドの製法およびその薬学的化合物 |
| DK0528312T3 (da) * | 1991-08-13 | 1997-12-29 | Takeda Chemical Industries Ltd | Cykliske peptider og anvendelse deraf |
| IT1277835B1 (it) * | 1995-03-13 | 1997-11-12 | Menarini Farma Ind | Composti biciclici, loro preparazione ed uso in composizioni farmaceutiche |
| IT1291776B1 (it) * | 1997-02-07 | 1999-01-21 | Menarini Ricerche Spa | Composti monociclici a quattro residui bifunzionali, aventi azione nk-2 antagonista |
-
1998
- 1998-08-05 IT IT1998FI000186A patent/IT1304888B1/it active
-
1999
- 1999-07-27 TW TW088112671A patent/TW491857B/zh active
- 1999-07-30 TR TR2001/00354T patent/TR200100354T2/xx unknown
- 1999-07-30 CA CA002339638A patent/CA2339638A1/en not_active Abandoned
- 1999-07-30 AU AU55079/99A patent/AU5507999A/en not_active Abandoned
- 1999-07-30 EP EP99941479A patent/EP1102789A1/en not_active Withdrawn
- 1999-07-30 WO PCT/EP1999/005459 patent/WO2000008046A1/en not_active Application Discontinuation
- 1999-07-30 JP JP2000563679A patent/JP2002522450A/ja active Pending
- 1999-08-04 PE PE1999000784A patent/PE20001002A1/es not_active Application Discontinuation
- 1999-08-05 CO CO99049466A patent/CO5080789A1/es unknown
- 1999-08-05 AR ARP990103922A patent/AR021751A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000008046A1 (en) | 2000-02-17 |
| TR200100354T2 (tr) | 2001-05-21 |
| CA2339638A1 (en) | 2000-02-17 |
| AR021751A1 (es) | 2002-08-07 |
| ITFI980186A1 (it) | 2000-02-05 |
| PE20001002A1 (es) | 2000-10-16 |
| IT1304888B1 (it) | 2001-04-05 |
| EP1102789A1 (en) | 2001-05-30 |
| JP2002522450A (ja) | 2002-07-23 |
| TW491857B (en) | 2002-06-21 |
| AU5507999A (en) | 2000-02-28 |
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