AR017798A1 - Agonistas de receptores adrenergicos beta 3, selectivos, utiles para el tratamiento de la diabetes ii y la obesidad - Google Patents

Agonistas de receptores adrenergicos beta 3, selectivos, utiles para el tratamiento de la diabetes ii y la obesidad

Info

Publication number
AR017798A1
AR017798A1 ARP980106149A ARP980106149A AR017798A1 AR 017798 A1 AR017798 A1 AR 017798A1 AR P980106149 A ARP980106149 A AR P980106149A AR P980106149 A ARP980106149 A AR P980106149A AR 017798 A1 AR017798 A1 AR 017798A1
Authority
AR
Argentina
Prior art keywords
alkyl
aryl
hydrogen
optionally substituted
heterocycle
Prior art date
Application number
ARP980106149A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of AR017798A1 publication Critical patent/AR017798A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Se trata de agonistas de los receptores beta 3, selectivos, utiles en el tratamiento de diabetes Tipo II y obesidad, de formula:(I) donde X1 es -OCH2-,SCH2- o un enlace; R1 es un heterociclo de formula II; R3 es hidrogeno, alquilo C1-4 o arilo, R4 esun heterociclo opcionalmente sustituido o un gruposeleccionado entre el grupo de formulas III, donde X2 es un enlace, o un grupo alquileno recto o ramificado de 1 a 5 átomos de carbono; R5 es hidrogeno oalquilo C1-4; R6 es hidrogeno o alquilo C1-4;o R5 y R6 en combinacion con el átomo de carbono al que están ligados para formar un grupo cicloalquilo C3-6; oR6 en combinacion con X2 y con el átomo de carbono al cual se encuentra unido para formar un grupo cicloalquilo C3-8; o R6 en combinacion con X2, R4 y elcarbono al cual se encuentra unido para formar la formula IV donde cuando R5 es hidrogeno; R7 es hidrogeno, hidroxi, ciano, oxo, CONR2, CONHR2, alquilo C1-4,alcoxi C1-4, haloalquilo C1-4, alquilo opcionalmente sustituido C1-4, arilo (CH2)n, (CH2)n heterociclo, arilo opcionalmente sustituido (CH2)n o heterocicloopcionalmente sustituido (CH2)n, R8 es independientemente hidrogeno, halo o alquilo C1-4; R9 es halo, CN, OR10, alquilo C1-4, haloalquilo C1-4, CO2R2, NONR11R12, CONH(alquiloC1-4), SR2, CSNHR2, CSNR11R12, SO2R2, SOR2, NR11R12, arilo opcionalmente sustituido, heterociclo opcionalmente sustituido, o alquinilo C2-4sustituido con CN, CO2R2, CONR11R12; R10 es alquilo C1-4, haloalquilo C1-4 (CH2)n cicloalquilo C3-8, (CH2)n arilo, (CH2)n heterociclo, (CH2)n cicloalquilo C3-8opcionalmente sustituido, arilo opcionalmente sustituido (CH2)n, o heterociclo opcionalmente sustituido (CH2)n; R11 y R12 son independientemente hidrogeno,alquilo C1-4, arilo (CH2)narilo, o en combinacion con el átomo de nitrogeno al que está ligado cada uno, unido para formar un grupo elegido entre morfolinilo,piperidilo, pirrolidinilo o piperazinilo; R13 es hidrogeno, halo arilo o alquilo C1-4; m es 0 o 1; n es 0,1, 2 o 3; o sales farmacéuticamente aceptables de losmismos.
ARP980106149A 1997-12-05 1998-12-03 Agonistas de receptores adrenergicos beta 3, selectivos, utiles para el tratamiento de la diabetes ii y la obesidad AR017798A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6759997P 1997-12-05 1997-12-05

Publications (1)

Publication Number Publication Date
AR017798A1 true AR017798A1 (es) 2001-10-24

Family

ID=22077113

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980106149A AR017798A1 (es) 1997-12-05 1998-12-03 Agonistas de receptores adrenergicos beta 3, selectivos, utiles para el tratamiento de la diabetes ii y la obesidad

Country Status (11)

Country Link
US (2) US6046227A (es)
EP (1) EP0921120A1 (es)
JP (1) JP2001525399A (es)
AR (1) AR017798A1 (es)
AU (1) AU1628199A (es)
CA (1) CA2312987A1 (es)
CO (1) CO5011072A1 (es)
PE (1) PE132699A1 (es)
SV (1) SV1998000142A (es)
WO (1) WO1999029673A1 (es)
ZA (1) ZA9811026B (es)

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CO5011072A1 (es) * 1997-12-05 2001-02-28 Lilly Co Eli Etanolaminas pirazinil substituidas como agfonistas de los receptores
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US6841563B1 (en) 1999-11-15 2005-01-11 Eli Lilly And Company Aryloxy propanolamines for improving livestock production
KR100816527B1 (ko) * 2001-09-12 2008-04-10 한국화학연구원 페닐테트라졸 유도체로 치환된 β-아미노알코올 화합물
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CN105837500A (zh) * 2016-03-31 2016-08-10 常州大学 一种n-(2-(3-(三氟甲基)苯氧基)-4-吡啶基)甲亚胺的合成方法
KR102614814B1 (ko) 2017-05-15 2023-12-20 카그니션 테라퓨틱스, 인코퍼레이티드 신경변성 질환 치료용 조성물
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WO1999029673A1 (en) 1999-06-17
JP2001525399A (ja) 2001-12-11
ZA9811026B (en) 2000-06-02
CO5011072A1 (es) 2001-02-28
AU1628199A (en) 1999-06-28
EP0921120A1 (en) 1999-06-09
US6617347B1 (en) 2003-09-09
CA2312987A1 (en) 1999-06-17
US6046227A (en) 2000-04-04
SV1998000142A (es) 1999-10-06
PE132699A1 (es) 1999-12-21

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