CO4930313A1 - Metodo para producir mamiferos transgenicos no humanos que producen oligosacaridos en su leche - Google Patents
Metodo para producir mamiferos transgenicos no humanos que producen oligosacaridos en su lecheInfo
- Publication number
- CO4930313A1 CO4930313A1 CO98050804A CO98050804A CO4930313A1 CO 4930313 A1 CO4930313 A1 CO 4930313A1 CO 98050804 A CO98050804 A CO 98050804A CO 98050804 A CO98050804 A CO 98050804A CO 4930313 A1 CO4930313 A1 CO 4930313A1
- Authority
- CO
- Colombia
- Prior art keywords
- transgene
- milk
- production
- expression
- oligosaccharids
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 4
- 241000124008 Mammalia Species 0.000 title abstract 3
- 239000008267 milk Substances 0.000 title abstract 3
- 210000004080 milk Anatomy 0.000 title abstract 3
- 235000013336 milk Nutrition 0.000 title abstract 3
- 230000009261 transgenic effect Effects 0.000 title abstract 2
- 108700019146 Transgenes Proteins 0.000 abstract 6
- 108090000790 Enzymes Proteins 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 2
- 102000003886 Glycoproteins Human genes 0.000 abstract 2
- 108090000288 Glycoproteins Proteins 0.000 abstract 2
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 2
- 210000001161 mammalian embryo Anatomy 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 229920001542 oligosaccharide Polymers 0.000 abstract 2
- 150000002482 oligosaccharides Chemical class 0.000 abstract 2
- 108010076504 Protein Sorting Signals Proteins 0.000 abstract 1
- 210000004602 germ cell Anatomy 0.000 abstract 1
- 210000004216 mammary stem cell Anatomy 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 230000003248 secreting effect Effects 0.000 abstract 1
- 210000002955 secretory cell Anatomy 0.000 abstract 1
- 210000001082 somatic cell Anatomy 0.000 abstract 1
- 230000000392 somatic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/20—Dietetic milk products not covered by groups A23C9/12 - A23C9/18
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1077—Pentosyltransferases (2.4.2)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/107—Rabbit
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Environmental Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Husbandry (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Cell Biology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Dairy Products (AREA)
- Saccharide Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Peptides Or Proteins (AREA)
- Fodder In General (AREA)
Abstract
Un método para producir mamíferos transgénicos, no humanos,cuyas células somáticas y germinales contienen por lo menos un transgen, donde la expresión de por lo menos un transgen resulta en la producción de oligosacáridos y glicoproteínas en la leche de dicho mamífero, el método comprende las etapas de: (a) preparación de por lo menos un transgen, dicho por lo menos un transgen que contenga en asociación operable 1 ) por lo menos una secuencia de expresión reguladora funcional en las células secretorias mamarias, 2) una secuencia de ADN que codifica una secuencia de señal funcional en las células mamarias secretoras, y 3) una secuencia de ADN que codifica una enzima; (b) introducción de dicho por lo menos un transgen a un embrión mamífero no humano, y transferencia del embrión resultante a un receptor hembra; (c) identificación de por lo menos una cría hembra, en donde la expresión de dicho por lo menos un transgen resulte en la producción de por lo menos una enzima la cual que luego catalice la producción de oligosacáridos y glicoproteínas en la leche de dicho mamífero.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/925,834 US6204431B1 (en) | 1994-03-09 | 1997-09-05 | Transgenic non-human mammals expressing heterologous glycosyltransferase DNA sequences produce oligosaccharides and glycoproteins in their milk |
Publications (1)
Publication Number | Publication Date |
---|---|
CO4930313A1 true CO4930313A1 (es) | 2000-06-27 |
Family
ID=25452320
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO98050804A CO4930313A1 (es) | 1997-09-05 | 1998-09-04 | Metodo para producir mamiferos transgenicos no humanos que producen oligosacaridos en su leche |
Country Status (20)
Country | Link |
---|---|
US (1) | US6204431B1 (es) |
EP (1) | EP1007651A1 (es) |
JP (1) | JP2001520001A (es) |
KR (1) | KR20010023645A (es) |
CN (1) | CN1273602A (es) |
AR (1) | AR017515A1 (es) |
AU (1) | AU9220398A (es) |
BG (1) | BG104236A (es) |
BR (1) | BR9811733A (es) |
CA (1) | CA2302777A1 (es) |
CO (1) | CO4930313A1 (es) |
HU (1) | HUP0004709A2 (es) |
IL (1) | IL133992A0 (es) |
MX (1) | MXPA00002266A (es) |
NO (1) | NO20001105L (es) |
PL (1) | PL339132A1 (es) |
SK (1) | SK3042000A3 (es) |
TR (1) | TR200000500T2 (es) |
WO (1) | WO1999011773A1 (es) |
ZA (1) | ZA987504B (es) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030129745A1 (en) | 1999-10-28 | 2003-07-10 | Robl James M. | Gynogenetic or androgenetic production of pluripotent cells and cell lines, and use thereof to produce differentiated cells and tissues |
AU1777301A (en) * | 1999-11-19 | 2001-05-30 | Hematech, Llc | Production of ungulates, preferably bovines that produce human immunoglobulins |
US7074983B2 (en) * | 1999-11-19 | 2006-07-11 | Kirin Beer Kabushiki Kaisha | Transgenic bovine comprising human immunoglobulin loci and producing human immunoglobulin |
US7414170B2 (en) * | 1999-11-19 | 2008-08-19 | Kirin Beer Kabushiki Kaisha | Transgenic bovines capable of human antibody production |
US7820878B2 (en) * | 1999-11-19 | 2010-10-26 | Kyowa Hakko Kirin Co., Ltd. | Production of ungulates, preferably bovines that produce human immunoglobulins |
US8697394B2 (en) * | 2000-06-28 | 2014-04-15 | Glycofi, Inc. | Production of modified glycoproteins having multiple antennary structures |
US7863020B2 (en) | 2000-06-28 | 2011-01-04 | Glycofi, Inc. | Production of sialylated N-glycans in lower eukaryotes |
DE60114830T2 (de) * | 2000-06-28 | 2006-08-03 | Glycofi, Inc. | Verfahren zur herstellung modifizierter glycoproteine |
US7449308B2 (en) | 2000-06-28 | 2008-11-11 | Glycofi, Inc. | Combinatorial DNA library for producing modified N-glycans in lower eukaryotes |
US7598055B2 (en) * | 2000-06-28 | 2009-10-06 | Glycofi, Inc. | N-acetylglucosaminyltransferase III expression in lower eukaryotes |
US7625756B2 (en) | 2000-06-28 | 2009-12-01 | GycoFi, Inc. | Expression of class 2 mannosidase and class III mannosidase in lower eukaryotic cells |
US6576464B2 (en) * | 2000-11-27 | 2003-06-10 | Geron Corporation | Methods for providing differentiated stem cells |
US6921665B2 (en) * | 2000-11-27 | 2005-07-26 | Roslin Institute (Edinburgh) | Selective antibody targeting of undifferentiated stem cells |
AU2002353374A1 (en) * | 2001-12-21 | 2003-07-09 | Nexia Biotechnologies, Inc. | Production of butyrylcholinesterases in transgenic mammals |
US20060253913A1 (en) * | 2001-12-21 | 2006-11-09 | Yue-Jin Huang | Production of hSA-linked butyrylcholinesterases in transgenic mammals |
US7169548B2 (en) * | 2002-09-13 | 2007-01-30 | Xy, Inc. | Sperm cell processing and preservation systems |
CA2502490A1 (en) * | 2002-11-08 | 2004-05-27 | Hematech, Llc | Transgenic ungulates having reduced prion protein activity and uses thereof |
US20040231010A1 (en) * | 2003-01-09 | 2004-11-18 | Murray James D. | Lysozyme transgenic ungulates |
US7332299B2 (en) * | 2003-02-20 | 2008-02-19 | Glycofi, Inc. | Endomannosidases in the modification of glycoproteins in eukaryotes |
US7514593B2 (en) * | 2003-05-30 | 2009-04-07 | The University Of North Carolina At Chapel Hill | Animal model for chronic obstructive pulmonary disease and cystic fibrosis |
US7771978B2 (en) * | 2003-09-22 | 2010-08-10 | Henrik Clausen | β1,4mannosyltransferases |
CA2548140A1 (en) * | 2003-12-05 | 2005-06-23 | University Of Massachusetts | Oligosaccharide compositions and use thereof in the treatment of infection |
WO2005080585A1 (en) * | 2004-02-13 | 2005-09-01 | Glycotope Gmbh | Highly active glycoproteins-process conditions and an efficient method for their production |
JP2007533328A (ja) | 2004-04-22 | 2007-11-22 | キリンホールディングス株式会社 | トランスジェニック動物及びその用途 |
US20060053500A1 (en) * | 2004-05-28 | 2006-03-09 | Univ. of Pittsburgh of the Commonwealth System of Higher Education, Office of Technology Management | Modification of sugar metabolic processes in transgenic cells, tissues and animals |
JP5502328B2 (ja) * | 2006-02-09 | 2014-05-28 | メディカゴ インコーポレイテッド | 植物体中でのシアル酸の合成 |
US7663019B2 (en) * | 2006-05-24 | 2010-02-16 | North Carolina State University | Transgenic snakes and methods of making |
US8124831B2 (en) * | 2006-07-06 | 2012-02-28 | Duke University | Transgenic mice carrying functional single nucleotide polymorphisms in brain-specific tryptophan hydroxylase |
US20090208480A1 (en) * | 2006-08-04 | 2009-08-20 | Yue Huang | Long half-life recombinant butyrylcholinesterase |
EP2631650B1 (en) | 2007-09-07 | 2015-04-22 | Children's Hospital Medical Center | Composition comprising alpha-1,2 fucosyl glycans for treating gastrointestinal disorders |
PT2217246E (pt) * | 2007-11-08 | 2015-02-10 | Nestec Sa | Utilização de oligossacáridos contendo n-acetil-lactosamina para maturação de respostas imunes em recém-nascidos |
CA2757169A1 (en) | 2009-04-13 | 2010-10-21 | Children's Hospital Medical Center | Milk oligosaccharide compositions and use thereof in treating infection in animals |
ES2660698T3 (es) * | 2009-06-08 | 2018-03-23 | Jennewein Biotechnologie Gmbh | Síntesis de HMO |
US9034847B2 (en) | 2009-07-06 | 2015-05-19 | Children's Hospital Medical Center | Inhibiting inflammation with milk oligosaccharides |
MY189329A (en) | 2009-07-15 | 2022-02-04 | Nutricia Nv | Mixture of non-digestible oligosaccharides for stimulating the immune system |
EP2813230A1 (en) | 2009-07-15 | 2014-12-17 | N.V. Nutricia | Fucosyllactose as breast milk identical non-digestible oligosaccharide for treating and/or preventing infections |
US8729245B2 (en) | 2009-12-21 | 2014-05-20 | Pharmathene, Inc. | Recombinant butyrylcholinesterases and truncates thereof |
SG190260A1 (en) * | 2011-01-06 | 2013-06-28 | Univ Johns Hopkins | Method of production of recombinant glycoproteins with increased circulatory half-life in mammalian cells |
WO2012168495A1 (es) | 2011-06-07 | 2012-12-13 | Hero Ag | Obtención de oligosacaridos mediante un procedimiento biotecnológico |
NL2007268C2 (en) | 2011-08-16 | 2013-02-19 | Friesland Brands Bv | Nutritional compositions comprising human milk oligosaccharides and uses thereof. |
CN102839157A (zh) * | 2012-07-12 | 2012-12-26 | 扬州大学 | 稳定共表达hST3GalIV和β1-4GalT1的MDCK细胞系及构建方法和应用 |
US20140115728A1 (en) | 2012-10-24 | 2014-04-24 | A. Joseph Tector | Double knockout (gt/cmah-ko) pigs, organs and tissues |
US10034921B2 (en) * | 2013-02-13 | 2018-07-31 | Laboratoire Français Du Fractionnement Et Des Biotechnologies | Proteins with modified glycosylation and methods of production thereof |
EP3594231A1 (en) | 2013-02-13 | 2020-01-15 | Laboratoire Français du Fractionnement et des Biotechnologies | Highly galactosylated anti-tnf-alpha antibodies and uses thereof |
US10626460B2 (en) | 2013-02-21 | 2020-04-21 | Children's Hospital Medical Center | Use of glycans and glycosyltransferases for diagnosing/monitoring inflammatory bowel disease |
CN103196725B (zh) * | 2013-03-26 | 2015-07-08 | 上海交通大学 | 制备与富集单个微纳米珠携带单根多聚物分子的方法 |
EP3288389A4 (en) | 2015-04-28 | 2018-10-10 | Children's Hospital Medical Center | Use of oligosaccharide compositions to enhance weight gain |
WO2019031961A1 (en) | 2017-08-11 | 2019-02-14 | N.V. Nutricia | OLIGOSACCHARIDE OF HUMAN MILK TO IMPROVE PHYSICAL IMMUNE CONDITION |
CA3105470A1 (en) | 2018-07-11 | 2020-01-16 | Ohio University | Peptide-based inhibitors of growth hormone action and methods of use thereof |
US11266129B2 (en) | 2019-11-05 | 2022-03-08 | Versiti Blood Research Institute Foundation, Inc. | Murine model of fetal/neonatal alloimmune thrombocytopenia |
CA3162639A1 (en) | 2019-11-05 | 2021-05-14 | Versiti Blood Research Institute Foundation, Inc. | A murine model of fetal/neonatal alloimmune thrombocytopenia |
AU2021395887B9 (en) * | 2020-12-11 | 2023-11-02 | Ausnutria B.V. | Increased 2'-fl production by goats |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4435363A (en) | 1981-07-02 | 1984-03-06 | Exxon Nuclear Company, Inc. | Continuous countercurrent liquid-solids contactor |
DE3334167A1 (de) | 1983-09-21 | 1985-04-04 | Siemens AG, 1000 Berlin und 8000 München | Halbleiterdiode |
GB8615942D0 (en) | 1986-06-30 | 1986-08-06 | Animal & Food Research Council | Peptide production |
US5322775A (en) | 1986-06-30 | 1994-06-21 | Pharmaceutical Proteins Ltd. | Peptide production |
AU7879987A (en) | 1986-08-28 | 1988-03-24 | Immunex Corp. | Expression of heterologous proteins by transgenic lactating mammals |
EP0279582A3 (en) | 1987-02-17 | 1989-10-18 | Pharming B.V. | Dna sequences to target proteins to the mammary gland for efficient secretion |
GB8826446D0 (en) | 1988-11-11 | 1988-12-14 | Agricultural & Food Res | Peptide production |
US5032519A (en) | 1989-10-24 | 1991-07-16 | The Regents Of The Univ. Of California | Method for producing secretable glycosyltransferases and other Golgi processing enzymes |
AU656720B2 (en) | 1989-12-01 | 1995-02-16 | Gene Pharming Europe Bv | Production of recombinant polypeptides by bovine species and transgenic methods |
EP0481038B1 (en) | 1990-04-16 | 2002-10-02 | The Trustees Of The University Of Pennsylvania | Saccharide compositions, methods and apparatus for their synthesis |
WO1992003917A1 (en) | 1990-08-29 | 1992-03-19 | Genpharm International | Homologous recombination in mammalian cells |
US5198466A (en) | 1990-11-09 | 1993-03-30 | Warner-Lambert Company | Oxysulfonyl urea acat inhibitors |
US5362480A (en) | 1991-12-31 | 1994-11-08 | Lever Brothers Company, Division Of Conopco, Inc. | Oral hygiene compositions containing amino sugars as antiplaque agents |
DK8892D0 (da) | 1992-01-23 | 1992-01-23 | Symbicom Ab | Humant proteingen |
US5401723A (en) | 1992-12-02 | 1995-03-28 | Colgate-Palmolive Company | Glycoconjugate inhibition of Streptococcus pyrogenes adhesion |
JPH08509467A (ja) | 1993-02-26 | 1996-10-08 | ノルマーク,ヤーン・スタツフアン | 細菌接着のインヒビターとしてのオリゴ糖グリコシドの使用 |
DK76193D0 (da) | 1993-06-25 | 1993-06-25 | Astra Ab | Kulhydratderivater |
US5750176A (en) | 1994-03-09 | 1998-05-12 | Abbott Laboratories | Transgenic non-human mammal milk comprising 2'-fucosyl-lactose |
EP0750671A1 (en) | 1994-03-09 | 1997-01-02 | Abbott Laboratories | Transgenic animals producing oligosaccharides and glycoconjugates |
CA2184687A1 (en) * | 1994-03-09 | 1995-09-14 | Pedro Antonio Prieto | Humanized milk |
US5625124A (en) | 1994-07-11 | 1997-04-29 | Washington University | Animal model for helicobacter pylori infection |
SK39498A3 (en) | 1995-09-29 | 1999-01-11 | Glycim Oy | Synthetic multivalent slex containing polylactosamines and methods for use |
US5874411A (en) | 1995-11-13 | 1999-02-23 | Glycomed Incorporated | Oligosaccharide glycosides having mammalian immunosuppresive and tolerogenic properties |
AU1122697A (en) | 1995-11-22 | 1997-06-11 | Research And Development Institute, Inc. | Therapeutic and diagnostic agents for the treatment of microbial infections |
-
1997
- 1997-09-05 US US08/925,834 patent/US6204431B1/en not_active Expired - Fee Related
-
1998
- 1998-08-19 ZA ZA987504A patent/ZA987504B/xx unknown
- 1998-09-04 TR TR2000/00500T patent/TR200000500T2/xx unknown
- 1998-09-04 CN CN98808662A patent/CN1273602A/zh active Pending
- 1998-09-04 HU HU0004709A patent/HUP0004709A2/hu unknown
- 1998-09-04 WO PCT/US1998/018383 patent/WO1999011773A1/en not_active Application Discontinuation
- 1998-09-04 BR BR9811733-5A patent/BR9811733A/pt not_active IP Right Cessation
- 1998-09-04 JP JP2000508784A patent/JP2001520001A/ja active Pending
- 1998-09-04 PL PL98339132A patent/PL339132A1/xx unknown
- 1998-09-04 AU AU92203/98A patent/AU9220398A/en not_active Abandoned
- 1998-09-04 CO CO98050804A patent/CO4930313A1/es unknown
- 1998-09-04 AR ARP980104420A patent/AR017515A1/es unknown
- 1998-09-04 KR KR1020007002297A patent/KR20010023645A/ko not_active Application Discontinuation
- 1998-09-04 SK SK304-2000A patent/SK3042000A3/sk unknown
- 1998-09-04 EP EP98944736A patent/EP1007651A1/en not_active Withdrawn
- 1998-09-04 CA CA002302777A patent/CA2302777A1/en not_active Abandoned
- 1998-09-04 IL IL13399298A patent/IL133992A0/xx unknown
-
2000
- 2000-03-03 NO NO20001105A patent/NO20001105L/no not_active Application Discontinuation
- 2000-03-03 MX MXPA00002266 patent/MXPA00002266A/es unknown
- 2000-03-13 BG BG104236A patent/BG104236A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
NO20001105L (no) | 2000-05-05 |
BG104236A (en) | 2000-12-29 |
SK3042000A3 (en) | 2000-09-12 |
JP2001520001A (ja) | 2001-10-30 |
KR20010023645A (ko) | 2001-03-26 |
CN1273602A (zh) | 2000-11-15 |
IL133992A0 (en) | 2001-04-30 |
NO20001105D0 (no) | 2000-03-03 |
WO1999011773A1 (en) | 1999-03-11 |
EP1007651A1 (en) | 2000-06-14 |
AR017515A1 (es) | 2001-09-12 |
AU9220398A (en) | 1999-03-22 |
HUP0004709A2 (hu) | 2001-04-28 |
US6204431B1 (en) | 2001-03-20 |
PL339132A1 (en) | 2000-12-04 |
TR200000500T2 (tr) | 2000-12-21 |
CA2302777A1 (en) | 1999-03-11 |
ZA987504B (en) | 1999-03-15 |
BR9811733A (pt) | 2000-09-05 |
MXPA00002266A (es) | 2000-10-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CO4930313A1 (es) | Metodo para producir mamiferos transgenicos no humanos que producen oligosacaridos en su leche | |
IL126416A0 (en) | Cultured inner cell mass cell lines derived from ungulate embryos | |
CA2075206A1 (en) | Production of recombinant polypeptides by bovine species and transgenic methods | |
BR9806872A (pt) | Transferência nuclear com células diferenciadas doadoras fetais e adultas | |
MXPA01001389A (es) | Transgenesis de mamifero por inyeccion de esperma intracitoplasmica. | |
GB2350619B (en) | Sex-specific insemination of mammals with low number of sperm cells | |
CA2427322A1 (en) | Methods for cloning mammals using reprogrammed donor chromatin or donor cells | |
AU2002361327A1 (en) | Exogenous protein expression system in an avian system | |
ATE281516T1 (de) | Verfahren zur herstellung von säugetieren mit definierten genetischen eigenschaften | |
AR007731A1 (es) | Un metodo para producir una planta transformada de adn extrano dentro del cigote o embrion de un saco embrionario aislado. | |
ATE332077T1 (de) | Transgene mäuse die ein menschliche antikörper exprimieren | |
EP0652889A4 (en) | PRODUCTION OF RECOMBINANT POLYPEPTIDES BY BOVINE SPECIES AND TRANSGENIC PROCESSES. | |
Latham | Cloning: questions answered and unsolved | |
Ono et al. | Nuclear transfer preserves the nuclear genome of freeze-dried mouse cells | |
WO2000026357A3 (en) | Transgenic and cloned mammals | |
Jitong et al. | Cloned goats (Capra hircus) from adult ear cells | |
EP1375654A3 (en) | Transgenic and cloned mammals | |
WO2000069257A3 (en) | Genetic modification of male germ cells for generation of transgenic species and genetic therapies | |
GB2369828A (en) | Nuclear transfer with selected donor cells | |
Hirabayashi et al. | Factors influencing chromosome condensation and development of cloned rat embryos | |
NZ511808A (en) | Transgenic bovine that produce the heterologous protein in milk | |
ATE364693T1 (de) | Verfahren zur herstellung von nicht-humanen geklonten und transgenen säugetieren | |
Kato et al. | Nuclear transplantation of mouse fetal germ cells into enucleated two-cell embryos | |
Tsunoda et al. | Viability of blastocysts and morulae cultured from 1-cell stage and transferred to recipients in the mouse | |
BR0010588A (pt) | Oócitos enucleados de telofase para transferência nuclear |