NO20001105L - Transgene pattedyr som danner oligosakkarider i melken - Google Patents

Transgene pattedyr som danner oligosakkarider i melken

Info

Publication number
NO20001105L
NO20001105L NO20001105A NO20001105A NO20001105L NO 20001105 L NO20001105 L NO 20001105L NO 20001105 A NO20001105 A NO 20001105A NO 20001105 A NO20001105 A NO 20001105A NO 20001105 L NO20001105 L NO 20001105L
Authority
NO
Norway
Prior art keywords
milk
transgenic mammals
oligosaccharides
form oligosaccharides
mammals
Prior art date
Application number
NO20001105A
Other languages
English (en)
Other versions
NO20001105D0 (no
Inventor
Pedro A Prieto
John J Kopchick
Richard D Cummings
James M Pierce
David F Smith
Kelley W Moremen
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of NO20001105D0 publication Critical patent/NO20001105D0/no
Publication of NO20001105L publication Critical patent/NO20001105L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/20—Dietetic milk products not covered by groups A23C9/12 - A23C9/18
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1077—Pentosyltransferases (2.4.2)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/107—Rabbit
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Environmental Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Husbandry (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Plant Pathology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Cell Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Dairy Products (AREA)
  • Peptides Or Proteins (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Fodder In General (AREA)
  • Saccharide Compounds (AREA)

Abstract

Det er beskrevet fremgangsmåter for fremstilling av ikke- humane transgene pattedyr som danner forskjellige oligosa- karider og glykokonjugater i melken. I tillegg er det be- skrevet pattedyrene i seg selv, melken som de produserer, sammensetninger omfattende melken, fraksjoner av melken og -de renséde^oligosakaridér så vel som glykokonjugater som er tilstede i melken.
NO20001105A 1997-09-05 2000-03-03 Transgene pattedyr som danner oligosakkarider i melken NO20001105L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/925,834 US6204431B1 (en) 1994-03-09 1997-09-05 Transgenic non-human mammals expressing heterologous glycosyltransferase DNA sequences produce oligosaccharides and glycoproteins in their milk
PCT/US1998/018383 WO1999011773A1 (en) 1997-09-05 1998-09-04 Transgenic mammals which produce oligosaccharides in their milk

Publications (2)

Publication Number Publication Date
NO20001105D0 NO20001105D0 (no) 2000-03-03
NO20001105L true NO20001105L (no) 2000-05-05

Family

ID=25452320

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20001105A NO20001105L (no) 1997-09-05 2000-03-03 Transgene pattedyr som danner oligosakkarider i melken

Country Status (20)

Country Link
US (1) US6204431B1 (no)
EP (1) EP1007651A1 (no)
JP (1) JP2001520001A (no)
KR (1) KR20010023645A (no)
CN (1) CN1273602A (no)
AR (1) AR017515A1 (no)
AU (1) AU9220398A (no)
BG (1) BG104236A (no)
BR (1) BR9811733A (no)
CA (1) CA2302777A1 (no)
CO (1) CO4930313A1 (no)
HU (1) HUP0004709A2 (no)
IL (1) IL133992A0 (no)
MX (1) MXPA00002266A (no)
NO (1) NO20001105L (no)
PL (1) PL339132A1 (no)
SK (1) SK3042000A3 (no)
TR (1) TR200000500T2 (no)
WO (1) WO1999011773A1 (no)
ZA (1) ZA987504B (no)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030129745A1 (en) * 1999-10-28 2003-07-10 Robl James M. Gynogenetic or androgenetic production of pluripotent cells and cell lines, and use thereof to produce differentiated cells and tissues
US7414170B2 (en) * 1999-11-19 2008-08-19 Kirin Beer Kabushiki Kaisha Transgenic bovines capable of human antibody production
US7820878B2 (en) * 1999-11-19 2010-10-26 Kyowa Hakko Kirin Co., Ltd. Production of ungulates, preferably bovines that produce human immunoglobulins
AU1777301A (en) * 1999-11-19 2001-05-30 Hematech, Llc Production of ungulates, preferably bovines that produce human immunoglobulins
US7074983B2 (en) * 1999-11-19 2006-07-11 Kirin Beer Kabushiki Kaisha Transgenic bovine comprising human immunoglobulin loci and producing human immunoglobulin
US7863020B2 (en) 2000-06-28 2011-01-04 Glycofi, Inc. Production of sialylated N-glycans in lower eukaryotes
MXPA03000105A (es) * 2000-06-28 2004-09-13 Glycofi Inc Metodo para producir glicoproteinas modificadas.
US7449308B2 (en) * 2000-06-28 2008-11-11 Glycofi, Inc. Combinatorial DNA library for producing modified N-glycans in lower eukaryotes
US7598055B2 (en) * 2000-06-28 2009-10-06 Glycofi, Inc. N-acetylglucosaminyltransferase III expression in lower eukaryotes
US7625756B2 (en) * 2000-06-28 2009-12-01 GycoFi, Inc. Expression of class 2 mannosidase and class III mannosidase in lower eukaryotic cells
US8697394B2 (en) * 2000-06-28 2014-04-15 Glycofi, Inc. Production of modified glycoproteins having multiple antennary structures
US6921665B2 (en) * 2000-11-27 2005-07-26 Roslin Institute (Edinburgh) Selective antibody targeting of undifferentiated stem cells
US6576464B2 (en) 2000-11-27 2003-06-10 Geron Corporation Methods for providing differentiated stem cells
US20060253913A1 (en) * 2001-12-21 2006-11-09 Yue-Jin Huang Production of hSA-linked butyrylcholinesterases in transgenic mammals
WO2003054182A2 (en) * 2001-12-21 2003-07-03 Nexia Biotechnologies, Inc. Production of butyrylcholinesterases in transgenic mammals
US7169548B2 (en) * 2002-09-13 2007-01-30 Xy, Inc. Sperm cell processing and preservation systems
NZ539459A (en) * 2002-11-08 2009-02-28 Kirin Pharma Kk Transgenic ungulates having reduced prion protein activity and uses thereof
US20040231010A1 (en) * 2003-01-09 2004-11-18 Murray James D. Lysozyme transgenic ungulates
US7332299B2 (en) * 2003-02-20 2008-02-19 Glycofi, Inc. Endomannosidases in the modification of glycoproteins in eukaryotes
US7514593B2 (en) * 2003-05-30 2009-04-07 The University Of North Carolina At Chapel Hill Animal model for chronic obstructive pulmonary disease and cystic fibrosis
US7771978B2 (en) * 2003-09-22 2010-08-10 Henrik Clausen β1,4mannosyltransferases
US7893041B2 (en) 2003-12-05 2011-02-22 Children's Hospital Medical Center Oligosaccharide compositions and use thereof in the treatment of infection
JP4913604B2 (ja) * 2004-02-13 2012-04-11 グリコトープ ゲーエムベーハー 高活性糖タンパク質−製造条件、及びその効率的製造方法
CN101014715A (zh) 2004-04-22 2007-08-08 麒麟麦酒株式会社 转基因动物及其用途
US20060053500A1 (en) * 2004-05-28 2006-03-09 Univ. of Pittsburgh of the Commonwealth System of Higher Education, Office of Technology Management Modification of sugar metabolic processes in transgenic cells, tissues and animals
DK2224009T3 (da) * 2006-02-09 2013-02-11 Medicago Inc Syntese af sialinsyre i planter
US7663019B2 (en) * 2006-05-24 2010-02-16 North Carolina State University Transgenic snakes and methods of making
US8124831B2 (en) * 2006-07-06 2012-02-28 Duke University Transgenic mice carrying functional single nucleotide polymorphisms in brain-specific tryptophan hydroxylase
EP2049661A4 (en) * 2006-08-04 2012-07-04 Pharmathene Inc RECOMBINANT BUTYRYLCHOLINESTERASE WITH LONG HALF-LIFE
MX2010002562A (es) 2007-09-07 2011-04-11 Inst Nac De Ciencias Medicas Y Nutricion Uso de los niveles de antigeno secretor, de lewis y de sialilo como predictores para enfermedad.
US20100233198A1 (en) * 2007-11-08 2010-09-16 Nestec S.A. Use of oligosaccharides containing n-acetyllactosamine for maturation of immune responses in neonates
CA2757169A1 (en) 2009-04-13 2010-10-21 Children's Hospital Medical Center Milk oligosaccharide compositions and use thereof in treating infection in animals
RU2517602C2 (ru) * 2009-06-08 2014-05-27 Йенневайн Биотехнологи Гмбх Синтез нмо
ES2651067T3 (es) 2009-07-06 2018-01-24 Children's Hospital Medical Center Inhibición de la inflamación con oligosacáridos de la leche
CN106890329A (zh) * 2009-07-15 2017-06-27 N·V·努特里奇亚 用于刺激免疫系统的不可消化低聚糖的混合物
MY164674A (en) 2009-07-15 2018-01-30 Nutricia Nv Fucosyllactose as breast milk identical non-digestible oligosaccharide with new functional benefit
JP2013526840A (ja) 2009-12-21 2013-06-27 ファーマシーネ，インコーポレイテッド 組み換えブチリルコリンエステラーゼおよびその切断型
CA2817765A1 (en) * 2011-01-06 2012-07-12 The Johns Hopkins University Method of production of recombinant glycoproteins with increased circulatory half-life in mammalian cells
CN103764835B (zh) * 2011-06-07 2016-08-17 海罗公司 通过生物技术方法获取低聚糖
NL2007268C2 (en) 2011-08-16 2013-02-19 Friesland Brands Bv Nutritional compositions comprising human milk oligosaccharides and uses thereof.
CN102839157A (zh) * 2012-07-12 2012-12-26 扬州大学 稳定共表达hST3GalIV和β1-4GalT1的MDCK细胞系及构建方法和应用
US20140115728A1 (en) 2012-10-24 2014-04-24 A. Joseph Tector Double knockout (gt/cmah-ko) pigs, organs and tissues
AR094778A1 (es) * 2013-02-13 2015-08-26 Laboratoire Français Du Fractionnement Et Des Biotechnologies Proteínas con glicosilación modificada y métodos para producirlas
CA2900909A1 (en) 2013-02-13 2014-08-21 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Highly galactosylated anti-tnf-.alpha. antibodies and uses thereof
WO2014130789A1 (en) 2013-02-21 2014-08-28 Children's Hospital Medical Center Use of glycans and glycosyltransferases for diagnosing/monitoring inflammatory bowel disease
CN103196725B (zh) * 2013-03-26 2015-07-08 上海交通大学 制备与富集单个微纳米珠携带单根多聚物分子的方法
US10857167B2 (en) 2015-04-28 2020-12-08 Children's Hospital Medical Center Use of oligosaccharide compositions to enhance weight gain
WO2019031961A1 (en) 2017-08-11 2019-02-14 N.V. Nutricia OLIGOSACCHARIDE OF HUMAN MILK TO IMPROVE PHYSICAL IMMUNE CONDITION
CN112399851A (zh) 2018-07-11 2021-02-23 俄亥俄大学 基于肽的生长激素作用抑制剂及其使用方法
WO2021091539A1 (en) 2019-11-05 2021-05-14 Versiti Blood Research Institute Foundation, Inc. A murine model of fetal/neonatal alloimmune thrombocytopenia
US11266129B2 (en) 2019-11-05 2022-03-08 Versiti Blood Research Institute Foundation, Inc. Murine model of fetal/neonatal alloimmune thrombocytopenia
AU2021395887B9 (en) * 2020-12-11 2023-11-02 Ausnutria B.V. Increased 2'-fl production by goats

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4435363A (en) 1981-07-02 1984-03-06 Exxon Nuclear Company, Inc. Continuous countercurrent liquid-solids contactor
DE3334167A1 (de) 1983-09-21 1985-04-04 Siemens AG, 1000 Berlin und 8000 München Halbleiterdiode
US5322775A (en) 1986-06-30 1994-06-21 Pharmaceutical Proteins Ltd. Peptide production
GB8615942D0 (en) 1986-06-30 1986-08-06 Animal & Food Research Council Peptide production
AU7879987A (en) 1986-08-28 1988-03-24 Immunex Corp. Expression of heterologous proteins by transgenic lactating mammals
EP0279582A3 (en) 1987-02-17 1989-10-18 Pharming B.V. Dna sequences to target proteins to the mammary gland for efficient secretion
GB8826446D0 (en) 1988-11-11 1988-12-14 Agricultural & Food Res Peptide production
US5032519A (en) 1989-10-24 1991-07-16 The Regents Of The Univ. Of California Method for producing secretable glycosyltransferases and other Golgi processing enzymes
DK0502976T3 (da) 1989-12-01 1996-11-11 Pharming Bv Produktion af rekombinante polypeptider ved bovine arter og transgene fremgangsmåder
US5180674A (en) 1990-04-16 1993-01-19 The Trustees Of The University Of Pennsylvania Saccharide compositions, methods and apparatus for their synthesis
CA2090473A1 (en) 1990-08-29 1992-03-01 Robert M. Kay Homologous recombinatin in mammalian cells
US5198466A (en) 1990-11-09 1993-03-30 Warner-Lambert Company Oxysulfonyl urea acat inhibitors
US5362480A (en) 1991-12-31 1994-11-08 Lever Brothers Company, Division Of Conopco, Inc. Oral hygiene compositions containing amino sugars as antiplaque agents
DK8892D0 (da) 1992-01-23 1992-01-23 Symbicom Ab Humant proteingen
US5401723A (en) 1992-12-02 1995-03-28 Colgate-Palmolive Company Glycoconjugate inhibition of Streptococcus pyrogenes adhesion
CN1121311A (zh) 1993-02-26 1996-04-24 扬·施塔芬·诺马克 应用低聚糖苷作为细菌粘连的抑制剂
DK76193D0 (da) 1993-06-25 1993-06-25 Astra Ab Kulhydratderivater
CA2184687A1 (en) * 1994-03-09 1995-09-14 Pedro Antonio Prieto Humanized milk
US5750176A (en) 1994-03-09 1998-05-12 Abbott Laboratories Transgenic non-human mammal milk comprising 2'-fucosyl-lactose
WO1995024488A1 (en) * 1994-03-09 1995-09-14 Abbott Laboratories Transgenic animals producing oligosaccharides and glycoconjugates
US5625124A (en) 1994-07-11 1997-04-29 Washington University Animal model for helicobacter pylori infection
CZ89098A3 (cs) 1995-09-29 1998-09-16 Glycim Oy Syntetické polylaktosaminy obsahující až multivalentní sLEX a metody pro jejich použití
US5874411A (en) 1995-11-13 1999-02-23 Glycomed Incorporated Oligosaccharide glycosides having mammalian immunosuppresive and tolerogenic properties
JP2000503630A (ja) 1995-11-22 2000-03-28 ザ リサーチ アンド ディベロップメント インスティチュート，インコーポレイテッド 微生物感染症の治療用治療剤及び診断剤

Also Published As

Publication number Publication date
SK3042000A3 (en) 2000-09-12
JP2001520001A (ja) 2001-10-30
AR017515A1 (es) 2001-09-12
WO1999011773A1 (en) 1999-03-11
US6204431B1 (en) 2001-03-20
ZA987504B (en) 1999-03-15
TR200000500T2 (tr) 2000-12-21
CO4930313A1 (es) 2000-06-27
PL339132A1 (en) 2000-12-04
BR9811733A (pt) 2000-09-05
CA2302777A1 (en) 1999-03-11
IL133992A0 (en) 2001-04-30
NO20001105D0 (no) 2000-03-03
MXPA00002266A (es) 2000-10-01
CN1273602A (zh) 2000-11-15
AU9220398A (en) 1999-03-22
BG104236A (en) 2000-12-29
EP1007651A1 (en) 2000-06-14
HUP0004709A2 (hu) 2001-04-28
KR20010023645A (ko) 2001-03-26

Similar Documents

Publication Publication Date Title
NO20001105L (no) Transgene pattedyr som danner oligosakkarider i melken
DK0975235T3 (da) Ernæringssammensætninger indeholdende oligosaccharider
NO20012979D0 (no) Fiberblanding for enterale sammensetninger
HUP0101564A2 (hu) Epotilon készítmények
HRP20020888A2 (en) Glycopeptide phosphonate derivatives
DK2301541T3 (da) Antibiotiske sammensætninger til behandling af øjet
GT199900102A (es) Fenoxipropanolaminas, procedimiento para su preparacìon y composiciones farmacèuticasque las contienen.
FI972945A (fi) Antigeenien antamiseen soveltuvia koostumuksia
BG103914A (en) Maintained separation of delayed gels
BG101892A (en) Sugar-modified cytostatics
ATE229340T1 (de) Relaxinartiger faktor und damit zusammenhängende verfahren und verwendungen
DE68914742T2 (de) Kalorienarme Fettersatzzusammensetzungen, die die laxierenden Nebeneffekte ausschliessen.
DE69001295D1 (de) In zufuhranlage niederschlaege kontrollierende zusammensetzungen.
IL139832A0 (en) Therapeutic compositions that produce an immune response by altering the antigen
HK1016432A1 (en) The lactose-containing food compositions for infants
DK1217898T3 (da) Hårde karameller med forbedret lagerstabilitet
EP0297594A3 (en) Novel 3',4'-dinitrogen substituted epipodophyllotoxin glucoside derivatives
EA200000736A1 (ru) Фармацевтические композиции
WO1999012945A3 (en) Hydrophobic glycosylamine derivatives, compositions, and methods for use
EP0908107A3 (en) Sweetening compositions containing neohesteridin dihydrochalcone and at least another high-intensity sweetener
ITRM920178A1 (it) Scatola, in particolare per prodotti dolciari tipo cioccolatini.
TR28369A (tr) Ikili cam elyafinin üretimine yönelik cam kompozisyonlari.
MX9300890A (es) Nuevos pirazolilpirazoles substituidos, su elaboracion asi como productos intermedios para su elaboracion y, su empleo como agentes con efecto herbicida.
ES1028211Y (es) Juguete transformable por composicion.
ES1025952U (es) Elementos para mueble modular.

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application