CO4910133A1 - Antagonistas de 5-h[1f] - Google Patents
Antagonistas de 5-h[1f]Info
- Publication number
- CO4910133A1 CO4910133A1 CO97066711A CO97066711A CO4910133A1 CO 4910133 A1 CO4910133 A1 CO 4910133A1 CO 97066711 A CO97066711 A CO 97066711A CO 97066711 A CO97066711 A CO 97066711A CO 4910133 A1 CO4910133 A1 CO 4910133A1
- Authority
- CO
- Colombia
- Prior art keywords
- formula
- compounds
- ht1f
- employing
- antagonists
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title 1
- 102100036311 5-hydroxytryptamine receptor 1F Human genes 0.000 abstract 2
- 101710138086 5-hydroxytryptamine receptor 1F Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000004913 activation Effects 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Electroluminescent Light Sources (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3095096P | 1996-11-15 | 1996-11-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4910133A1 true CO4910133A1 (es) | 2000-04-24 |
Family
ID=21856862
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO97066711A CO4910133A1 (es) | 1996-11-15 | 1997-11-13 | Antagonistas de 5-h[1f] |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US5817671A (enExample) |
| EP (1) | EP0842934B1 (enExample) |
| JP (1) | JP2001503774A (enExample) |
| AT (1) | ATE253063T1 (enExample) |
| AU (1) | AU5435298A (enExample) |
| CA (1) | CA2271272A1 (enExample) |
| CO (1) | CO4910133A1 (enExample) |
| DE (1) | DE69725825T2 (enExample) |
| DK (1) | DK0842934T3 (enExample) |
| ES (1) | ES2210463T3 (enExample) |
| ID (1) | ID18883A (enExample) |
| IL (1) | IL129592A0 (enExample) |
| NO (1) | NO991974L (enExample) |
| PE (1) | PE14199A1 (enExample) |
| PT (1) | PT842934E (enExample) |
| WO (1) | WO1998020875A1 (enExample) |
| ZA (1) | ZA979961B (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA989389B (en) * | 1997-11-14 | 2000-04-14 | Lilly Co Eli | Pyrrolo [3,2-b] pyridine processes and intermediates. |
| US5905084A (en) * | 1997-11-14 | 1999-05-18 | Eli Lilly And Company | 5-HTIF -agonists effective in treating migraine |
| US6133290A (en) * | 1998-07-31 | 2000-10-17 | Eli Lilly And Company | 5-HT1F agonists |
| GB9823845D0 (en) * | 1998-11-02 | 1998-12-23 | Lilly Co Eli | Pharmaceutical compounds |
| AU1937300A (en) * | 1998-12-11 | 2000-06-26 | Eli Lilly And Company | Indole derivatives and their use as 5-HT1F agonists |
| AU2002351412B2 (en) | 2001-12-21 | 2010-05-20 | Exelixis Patent Company Llc | Modulators of LXR |
| US7482366B2 (en) | 2001-12-21 | 2009-01-27 | X-Ceptor Therapeutics, Inc. | Modulators of LXR |
| TWI263497B (en) | 2002-03-29 | 2006-10-11 | Lilly Co Eli | Pyridinoylpiperidines as 5-HT1F agonists |
| ES2201899B1 (es) * | 2002-04-01 | 2005-06-01 | Almirall Prodesfarma, S.A. | Derivados de la azaindolilpiperidina como agentes antihistaminicos y antialergicos. |
| MXPA05011223A (es) | 2003-04-18 | 2006-01-26 | Lilly Co Eli | Compuestos de (piperidiniloxi)fenilo, (piperidiniloxi)piridinilo, (piperidinilsulfanil)fenilo y (piperidinilsulfanil)piridinilo como agonistas 5-htif. |
| UA82711C2 (en) | 2003-09-12 | 2008-05-12 | Эли Лилли Энд Компани | Substituted 2-carbonylamino-6-piperidinaminopyridines and substituted 1-carbonylamino-3-piperidinaminobenzenes as 5-ht1f agonists |
| US20050130954A1 (en) * | 2003-11-21 | 2005-06-16 | Mitchell Ian S. | AKT protein kinase inhibitors |
| ATE370116T1 (de) | 2003-12-17 | 2007-09-15 | Lilly Co Eli | Substituierte (4-aminocyclohexen-1-yl) phenyl and (4-aminocyclohexen-1-yl) pyridinyl verbindungen als 5-ht1f agonisten |
| WO2008006032A1 (en) * | 2006-07-06 | 2008-01-10 | Array Biopharma Inc. | Cyclopenta [d] pyrimidines as akt protein kinase inhibitors |
| ATE532789T1 (de) | 2006-07-06 | 2011-11-15 | Array Biopharma Inc | Dihydrothienopyrimidine als akt-proteinkinase- inhibitoren |
| CN101511842B (zh) | 2006-07-06 | 2012-10-31 | 阵列生物制药公司 | 作为akt蛋白激酶抑制剂的二氢呋喃并嘧啶 |
| US8063050B2 (en) * | 2006-07-06 | 2011-11-22 | Array Biopharma Inc. | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
| US8846683B2 (en) | 2007-07-05 | 2014-09-30 | Array Biopharma, Inc. | Pyrimidyl cyclopentanes as Akt protein kinase inhibitors |
| SI2173723T1 (sl) * | 2007-07-05 | 2011-12-30 | Array Biopharma Inc | Pirimidil ciklopentani kot inhibitorji AKT-protein-kinaze |
| US8618097B2 (en) | 2007-07-05 | 2013-12-31 | Array Biopharma, Inc. | Pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
| US9409886B2 (en) | 2007-07-05 | 2016-08-09 | Array Biopharma Inc. | Pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
| JP5346345B2 (ja) * | 2008-01-09 | 2013-11-20 | アレイ バイオファーマ、インコーポレイテッド | Ａｋｔタンパク質キナーゼ阻害剤としての水酸化されたピリミジルシクロペンタン類 |
| EP2240455B1 (en) * | 2008-01-09 | 2012-12-26 | Array Biopharma, Inc. | Hydroxylated pyrimidyl cyclopentane as akt protein kinase inhibitor |
| NZ596161A (en) * | 2009-04-02 | 2013-11-29 | Colucid Pharmaceuticals Inc | Composition of 2,4,6-trifluoro-n-[6-(1-methyl-piperidin-4-carbonyl)-pyridin-2-yl]-benzamide |
| WO2011123654A1 (en) | 2010-04-02 | 2011-10-06 | Colucid Pharmaceuticals, Inc. | Compositions and methods of synthesis of pyridinoylpiperidine 5-ht1f agonists |
| KR20140022053A (ko) | 2011-04-01 | 2014-02-21 | 제넨테크, 인크. | Akt 및 mek 억제제 화합물의 조합물, 및 사용 방법 |
| ES2620644T3 (es) | 2011-04-01 | 2017-06-29 | Genentech, Inc. | Combinaciones de compuestos inhibidores de AKT y agentes quimioterapéuticos, y métodos de uso |
| BG111544A (bg) | 2013-07-29 | 2015-01-30 | Николай Цветков | Субституирани бензамидни производни като in vitro mao-b инхибитори |
| GEP20186876B (en) * | 2013-08-02 | 2018-07-10 | Pfizer | Heterobicycloaryl rorc2 inhibitors and methods of use thereof |
| MA40759A (fr) * | 2014-09-26 | 2017-08-01 | Pfizer | Modulateurs de rorc2 de type pyrrolopyridine substitué par un méthyle et trifluorométhyle et leurs procédés d'utilisation |
| JP6912486B2 (ja) * | 2016-02-19 | 2021-08-04 | フェニックス モレキュラー デザインズ | Ｒｓｋ阻害剤として有用なカルボキサミド誘導体 |
| EP3841096A4 (en) | 2018-08-24 | 2022-05-18 | Sunshine Lake Pharma Co., Ltd. | PYRIDINYLMETHYLENEPIPERIDEINDIVATES AND THEIR USES |
| TWI826514B (zh) | 2018-09-04 | 2023-12-21 | 美商美國禮來大藥廠 | 用於預防偏頭痛之拉米迪坦(lasmiditan)長期夜間投藥 |
| KR20210126077A (ko) | 2019-02-11 | 2021-10-19 | 피닉스 몰레큘라 디자인스 | Rsk 억제제의 결정형 |
| TWI829107B (zh) | 2019-07-09 | 2024-01-11 | 美商美國禮來大藥廠 | 大規模製備2,4,6-三氟-n-[6-(1-甲基-哌啶-4-羰基)-吡啶-2-基]-苯甲醯胺半琥珀酸鹽的方法及中間體，以及2,4,6-三氟-n-[6-(1-甲基-哌啶-4-羰基)-吡啶-2-基]-苯甲醯胺醋酸鹽之製備 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3080374A (en) * | 1962-02-08 | 1963-03-05 | Abbott Lab | 2-guanidino-3-nitropyridine and derivatives thereof |
| MX19185A (es) * | 1989-01-20 | 1993-12-01 | Pfizer | Procedimiento para preparar 3-(1,2,5,6-tretrahidropiridil)-pirrolopiridinas. |
| US5521196A (en) * | 1994-10-05 | 1996-05-28 | Eli Lilly And Company | 5-HT1F agonists for the treatment of migraine |
| GB9423460D0 (en) * | 1994-11-21 | 1995-01-11 | Merck Sharp & Dohme | Therapeutic agents |
| US5521197A (en) * | 1994-12-01 | 1996-05-28 | Eli Lilly And Company | 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists |
| AU702322B2 (en) * | 1995-03-20 | 1999-02-18 | Eli Lilly And Company | 5-substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)- and 3-(piperidin-4-yl)-1h-indoles: new 5-ht1f agonists |
-
1997
- 1997-11-05 ZA ZA979961A patent/ZA979961B/xx unknown
- 1997-11-12 ES ES97309106T patent/ES2210463T3/es not_active Expired - Lifetime
- 1997-11-12 DE DE69725825T patent/DE69725825T2/de not_active Expired - Fee Related
- 1997-11-12 DK DK97309106T patent/DK0842934T3/da active
- 1997-11-12 PT PT97309106T patent/PT842934E/pt unknown
- 1997-11-12 AT AT97309106T patent/ATE253063T1/de not_active IP Right Cessation
- 1997-11-12 EP EP97309106A patent/EP0842934B1/en not_active Expired - Lifetime
- 1997-11-13 CO CO97066711A patent/CO4910133A1/es unknown
- 1997-11-13 CA CA002271272A patent/CA2271272A1/en not_active Abandoned
- 1997-11-13 IL IL12959297A patent/IL129592A0/xx unknown
- 1997-11-13 PE PE1997001023A patent/PE14199A1/es not_active Application Discontinuation
- 1997-11-13 WO PCT/US1997/020630 patent/WO1998020875A1/en not_active Ceased
- 1997-11-13 ID IDP973668A patent/ID18883A/id unknown
- 1997-11-13 AU AU54352/98A patent/AU5435298A/en not_active Abandoned
- 1997-11-13 JP JP52277798A patent/JP2001503774A/ja not_active Ceased
- 1997-11-14 US US08/969,851 patent/US5817671A/en not_active Expired - Fee Related
-
1998
- 1998-07-09 US US09/112,562 patent/US5998622A/en not_active Expired - Fee Related
- 1998-07-09 US US09/112,560 patent/US5919936A/en not_active Expired - Fee Related
-
1999
- 1999-04-26 NO NO991974A patent/NO991974L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001503774A (ja) | 2001-03-21 |
| US5817671A (en) | 1998-10-06 |
| NO991974D0 (no) | 1999-04-26 |
| WO1998020875A1 (en) | 1998-05-22 |
| DK0842934T3 (da) | 2004-03-08 |
| NO991974L (no) | 1999-04-26 |
| US5919936A (en) | 1999-07-06 |
| AU5435298A (en) | 1998-06-03 |
| ZA979961B (en) | 1999-05-05 |
| PT842934E (pt) | 2004-03-31 |
| IL129592A0 (en) | 2000-02-29 |
| DE69725825D1 (de) | 2003-12-04 |
| US5998622A (en) | 1999-12-07 |
| CA2271272A1 (en) | 1998-05-22 |
| ATE253063T1 (de) | 2003-11-15 |
| DE69725825T2 (de) | 2004-08-12 |
| ES2210463T3 (es) | 2004-07-01 |
| PE14199A1 (es) | 1999-02-12 |
| EP0842934A1 (en) | 1998-05-20 |
| EP0842934B1 (en) | 2003-10-29 |
| ID18883A (id) | 1998-05-20 |
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