CO4900059A1 - 3- ureido-piridofuranos y- piridotiofenos - Google Patents
3- ureido-piridofuranos y- piridotiofenosInfo
- Publication number
- CO4900059A1 CO4900059A1 CO97039173A CO97039173A CO4900059A1 CO 4900059 A1 CO4900059 A1 CO 4900059A1 CO 97039173 A CO97039173 A CO 97039173A CO 97039173 A CO97039173 A CO 97039173A CO 4900059 A1 CO4900059 A1 CO 4900059A1
- Authority
- CO
- Colombia
- Prior art keywords
- carbon atoms
- straight
- branched chain
- same
- halogen
- Prior art date
Links
- 125000004432 carbon atom Chemical group C* 0.000 abstract 9
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 229910052757 nitrogen Inorganic materials 0.000 abstract 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 3
- 150000002367 halogens Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 3
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- SBQXVXAKRGIPSL-UHFFFAOYSA-N furo[3,2-b]pyridin-3-ylurea Chemical class C1=CN=C2C(NC(=O)N)=COC2=C1 SBQXVXAKRGIPSL-UHFFFAOYSA-N 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- -1 phenoxy, benzoyl Chemical group 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000006296 sulfonyl amino group Chemical group [H]N(*)S(*)(=O)=O 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
3-ureido-piridofuranos y -piridotiofenos de fórmula general (I)en la que E, G, L y M son iguales o distintos yrepresentan un átomo de nitrógeno o un resto de fórmula -C-A, en la que al C-A, en la que al menos uno de los sustituyentes E, G, L o M debe representar un átomo de nitrógeno y, en la que A representa hidrógeno, acilo o alcoxicarbonilo de cadena lineal ramificada, cada uno con hasta 6 átomos de carbono, o alquilo de cadena lineal o ramificada, cada uno con hasta 6 átomos de carbono, o alquilo de cadena lineal o ramificada con hasta 6 átomos de carbono que está opcionalmente sustituido por carboxilo, halógeno, hidroxilo alcoxicarbonilo de cadena lineal o ramificada, o alcoxi, cada uno con hasta 6 átomos de carbono, fenoxi, benzoílo o por un grupo de fórmula -O-CO-CH3 , o representa halógeno, carboxilo, ciano, nitro, trifluorometilo, trifluorometoxi o un grupo de fórmula -OR5 , -S(O)a R6 , -(O-CH2 CO)b -NR7 R8 , -CONR9 R10 , -SONR11 R12 o NH-SO2 R13 ,en el que R6 , R8 , R10 y R12 son iguales o distintos y representan hidrógeno, cicloalquilo de 3 a 6 átomos de carbono, bencilo o un heterociclo saturado o insaturado de 5 a 7 eslabones que tiene hasta 3 heteroátomos de la serie formada por N, S y O, y con el cual puede estar condensado un anillo de fenilo y que está opcionalmente sustituido por sustituyentes iguales o distintos de la serie formada por halógeno, ciano, nitro o por un alquilo de cadena lineal o ramificada con hasta 6 átomos de carbono o representa alquenilo o acilo de cadena lineal o ramificada, cada uno con hasta 8 átomos de carbono, o representa fenilo, que está opcionalmente monosustituido o disustituido por sustituyentes iguales o distintos de la serie formada por nitro, halógeno, carboxi o alcoxicarbonilo de cadena lineal o ramificada con hasta 6 átomos de carbono, R7 , R9 y R11 son iguales o distintos y representan hidrógeno o un alquilo de cadena lineal o ramificada con hasta 4 átomos de carbono, o R7 y R8 juntos al átomo de nitrógeno forman un heterociclo de 5 a 6 eslabones,...
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9614718.6A GB9614718D0 (en) | 1996-07-12 | 1996-07-12 | 3-ureido-pyridofurans and -pyridothiophenes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4900059A1 true CO4900059A1 (es) | 2000-03-27 |
Family
ID=10796835
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO97039173A CO4900059A1 (es) | 1996-07-12 | 1997-07-11 | 3- ureido-piridofuranos y- piridotiofenos |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6169092B1 (es) |
| EP (1) | EP0912578A1 (es) |
| JP (1) | JP2000514804A (es) |
| AR (1) | AR007827A1 (es) |
| AU (1) | AU3441197A (es) |
| CO (1) | CO4900059A1 (es) |
| GB (1) | GB9614718D0 (es) |
| WO (1) | WO1998002440A1 (es) |
| ZA (1) | ZA976168B (es) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2350112A (en) * | 1999-05-17 | 2000-11-22 | Bayer Ag | Pharmaceutically active cycloalkyl ketones |
| GB2350111A (en) * | 1999-05-17 | 2000-11-22 | Bayer Ag | Oligohydroxyl substituted 3-urea-benzofuran and pyridofuran derivatives |
| GB2350110A (en) * | 1999-05-17 | 2000-11-22 | Bayer Ag | Pharmaceutically active benzofurans |
| GB2350109A (en) | 1999-05-17 | 2000-11-22 | Bayer Ag | Pharmaceutically active benzofuranyl sulfonates |
| US6953774B2 (en) | 2000-08-11 | 2005-10-11 | Applied Research Systems Ars Holding N.V. | Methods of inducing ovulation |
| MXPA03010672A (es) | 2001-05-23 | 2004-03-02 | Tanabe Seiyaku Co | Composicion para el tratamiento regenerativo de enfermedades del cartilago. |
| TWI221838B (en) | 2001-08-09 | 2004-10-11 | Tanabe Seiyaku Co | Pyrazinoisoquinoline compound or naphthalene compound |
| DK1908463T3 (da) | 2001-12-14 | 2011-11-28 | Merck Serono Sa | Fremgangsmåder til at inducere ægløsning ved anvendelse af en ikke polypeptid-CAMP-niveaumodulator |
| NZ534255A (en) | 2002-02-22 | 2007-06-29 | Bayer Pharmaceuticals Corp | Benzofuran and benzothiophene derivatives useful in the treatment of hyper-proliferative disorders |
| US7144885B2 (en) | 2002-02-22 | 2006-12-05 | Bayer Pharmaceuticals Corporation | Fused tricyclic heterocycles useful for treating hyper-proliferative disorders |
| GB0214268D0 (en) * | 2002-06-20 | 2002-07-31 | Celltech R&D Ltd | Chemical compounds |
| GB0218800D0 (en) * | 2002-08-13 | 2002-09-18 | Celltech R&D Ltd | Chemical compounds |
| WO2004046095A1 (en) * | 2002-11-19 | 2004-06-03 | Achillion Pharmaceuticals, Inc. | Substituted aryl thioureas and related compounds; inhibitors of viral replication |
| JP2007516162A (ja) * | 2003-06-20 | 2007-06-21 | セルテック アール アンド ディ リミテッド | キナーゼ阻害剤としてのチエノピリドン誘導体 |
| US7482452B2 (en) * | 2003-06-20 | 2009-01-27 | Celltech R&D Limited | Process for preparing 3-aminothienopyridone derivatives |
| US7883709B2 (en) * | 2003-10-23 | 2011-02-08 | Novartis Ag | Stabilised compositions |
| JP2007509123A (ja) | 2003-10-24 | 2007-04-12 | セルテック アール アンド ディ リミテッド | キナーゼ阻害剤としてのチエノ−ピリジノン誘導体 |
| TW200600492A (en) * | 2004-05-18 | 2006-01-01 | Achillion Pharmaceuticals Inc | Substituted aryl acylthioureas and related compounds; inhibitors of viral replication |
| CN1988934B (zh) | 2004-05-28 | 2011-01-05 | 奥坦纳医药公司 | 四氢吡啶并噻吩化合物 |
| ES2308504T3 (es) | 2004-06-04 | 2008-12-01 | 4Sc Ag | Tetrahidropiridotiofenos para su utilizacion en el tratamiento del cancer. |
| EP1758655A2 (en) * | 2004-06-11 | 2007-03-07 | Altana Pharma AG | Tetrahydropyridothiophenes for treating hyperproliferative disorders |
| JP2008529989A (ja) | 2005-02-09 | 2008-08-07 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 癌のような増殖性の疾病の治療用のテトラヒドロピリドチオフェン |
| EP1851230A1 (en) | 2005-02-11 | 2007-11-07 | Nycomed GmbH | Tetrahydropyridothiophenes as antripoliferative agents for the treatment of cancer |
| AU2006251169A1 (en) | 2005-05-25 | 2006-11-30 | 4Sc Ag | Tetrahydropyridothiophenes for use in the treatment of cancer |
| US7714136B2 (en) | 2005-05-25 | 2010-05-11 | 4Sc Ag | Tetrahydropyridothiophenes |
| EP2258358A3 (en) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
| WO2007025177A2 (en) | 2005-08-26 | 2007-03-01 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
| AU2006284751A1 (en) * | 2005-09-01 | 2007-03-08 | Array Biopharma Inc. | Raf inhibitor compounds and methods of use thereof |
| EP2377530A3 (en) | 2005-10-21 | 2012-06-20 | Braincells, Inc. | Modulation of neurogenesis by PDE inhibition |
| US20070112017A1 (en) | 2005-10-31 | 2007-05-17 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| EP2377531A2 (en) | 2006-05-09 | 2011-10-19 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| EP2804603A1 (en) | 2012-01-10 | 2014-11-26 | President and Fellows of Harvard College | Beta-cell replication promoting compounds and methods of their use |
| US8883857B2 (en) | 2012-12-07 | 2014-11-11 | Baylor College Of Medicine | Small molecule xanthine oxidase inhibitors and methods of use |
| WO2015191636A2 (en) * | 2014-06-09 | 2015-12-17 | Baylor College Of Medicine | Xanthine oxidase inhibitors and methods of use |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU559687B2 (en) | 1981-07-01 | 1987-03-19 | Upjohn Company, The | Pyridinyl-and imidazolyl-benzofurane and benzothiophenes |
| US4455427A (en) | 1981-07-01 | 1984-06-19 | The Upjohn Company | Pyridyl-substituted-benzofurans |
| EP0146243A1 (en) * | 1983-10-31 | 1985-06-26 | Merck Frosst Canada Inc. | Lipoxygenase inhibitors |
| US4663347A (en) | 1983-10-31 | 1987-05-05 | Merck Frosst Canada, Inc. | Benzofuran 2-carboxylic acid esters useful as inhibitors of leukotriene biosynthesis |
| GB9200623D0 (en) | 1992-01-13 | 1992-03-11 | Bayer Ag | Benzofuranyl and thiophenyl-methylthio-alkanecarboxylic acid derivatives |
| GB9309324D0 (en) * | 1993-05-06 | 1993-06-16 | Bayer Ag | Venzofuranyl-and-thiophenyl-alkanecarboxyclic acids derivatives |
| US5377477A (en) | 1993-12-09 | 1995-01-03 | Signode Corporation | Method and apparatus for a power strapping machine |
| HRP950288A2 (en) | 1994-05-31 | 1997-08-31 | Bayer Ag | Oxalylamino-benzofuran- and benzothienyl-derivatives |
| GB9410877D0 (en) * | 1994-05-31 | 1994-07-20 | Bayer Ag | Heterocyclycarbonyl substituted benzoduranyl-and-thiophenyl-alkanecarboxyclic acid derivatives |
| EP0685475B1 (en) * | 1994-05-31 | 1999-01-13 | Bayer Ag | Amino-benzofuryl-and thienyl-derivatives |
| GB9504460D0 (en) | 1995-03-06 | 1995-04-26 | Bayer Ag | N-(3-Benzofuranyl)urea-derivatives |
| GB9525262D0 (en) * | 1995-12-11 | 1996-02-07 | Bayer Ag | Heterocyclylcarbonyl substituted benzofuranyl-ureas |
-
1996
- 1996-07-12 GB GBGB9614718.6A patent/GB9614718D0/en active Pending
-
1997
- 1997-07-01 US US09/214,370 patent/US6169092B1/en not_active Expired - Fee Related
- 1997-07-01 EP EP97930468A patent/EP0912578A1/en not_active Withdrawn
- 1997-07-01 JP JP10505555A patent/JP2000514804A/ja active Pending
- 1997-07-01 WO PCT/EP1997/003432 patent/WO1998002440A1/en not_active Application Discontinuation
- 1997-07-01 AU AU34411/97A patent/AU3441197A/en not_active Abandoned
- 1997-07-08 AR ARP970103040A patent/AR007827A1/es unknown
- 1997-07-11 CO CO97039173A patent/CO4900059A1/es unknown
- 1997-07-11 ZA ZA9706168A patent/ZA976168B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0912578A1 (en) | 1999-05-06 |
| AR007827A1 (es) | 1999-11-24 |
| AU3441197A (en) | 1998-02-09 |
| ZA976168B (en) | 1998-02-02 |
| JP2000514804A (ja) | 2000-11-07 |
| GB9614718D0 (en) | 1996-09-04 |
| WO1998002440A1 (en) | 1998-01-22 |
| US6169092B1 (en) | 2001-01-02 |
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