CO4900059A1 - 3- ureido-piridofuranos y- piridotiofenos - Google Patents

3- ureido-piridofuranos y- piridotiofenos

Info

Publication number
CO4900059A1
CO4900059A1 CO97039173A CO97039173A CO4900059A1 CO 4900059 A1 CO4900059 A1 CO 4900059A1 CO 97039173 A CO97039173 A CO 97039173A CO 97039173 A CO97039173 A CO 97039173A CO 4900059 A1 CO4900059 A1 CO 4900059A1
Authority
CO
Colombia
Prior art keywords
carbon atoms
straight
branched chain
same
halogen
Prior art date
Application number
CO97039173A
Other languages
English (en)
Inventor
Gabriele Braunlich
Es-Sayed Mazen
Rudiger Fischer
Rolf Henning
Burkhard Fugmann
Stephan Schneider
Michael Sperzel
Graham Sturton
Barbara Briggs
Concepcion Arnel
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of CO4900059A1 publication Critical patent/CO4900059A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Abstract

3-ureido-piridofuranos y -piridotiofenos de fórmula general (I)en la que E, G, L y M son iguales o distintos yrepresentan un átomo de nitrógeno o un resto de fórmula -C-A, en la que al C-A, en la que al menos uno de los sustituyentes E, G, L o M debe representar un átomo de nitrógeno y, en la que A representa hidrógeno, acilo o alcoxicarbonilo de cadena lineal ramificada, cada uno con hasta 6 átomos de carbono, o alquilo de cadena lineal o ramificada, cada uno con hasta 6 átomos de carbono, o alquilo de cadena lineal o ramificada con hasta 6 átomos de carbono que está opcionalmente sustituido por carboxilo, halógeno, hidroxilo alcoxicarbonilo de cadena lineal o ramificada, o alcoxi, cada uno con hasta 6 átomos de carbono, fenoxi, benzoílo o por un grupo de fórmula -O-CO-CH3 , o representa halógeno, carboxilo, ciano, nitro, trifluorometilo, trifluorometoxi o un grupo de fórmula -OR5 , -S(O)a R6 , -(O-CH2 CO)b -NR7 R8 , -CONR9 R10 , -SONR11 R12 o NH-SO2 R13 ,en el que R6 , R8 , R10 y R12 son iguales o distintos y representan hidrógeno, cicloalquilo de 3 a 6 átomos de carbono, bencilo o un heterociclo saturado o insaturado de 5 a 7 eslabones que tiene hasta 3 heteroátomos de la serie formada por N, S y O, y con el cual puede estar condensado un anillo de fenilo y que está opcionalmente sustituido por sustituyentes iguales o distintos de la serie formada por halógeno, ciano, nitro o por un alquilo de cadena lineal o ramificada con hasta 6 átomos de carbono o representa alquenilo o acilo de cadena lineal o ramificada, cada uno con hasta 8 átomos de carbono, o representa fenilo, que está opcionalmente monosustituido o disustituido por sustituyentes iguales o distintos de la serie formada por nitro, halógeno, carboxi o alcoxicarbonilo de cadena lineal o ramificada con hasta 6 átomos de carbono, R7 , R9 y R11 son iguales o distintos y representan hidrógeno o un alquilo de cadena lineal o ramificada con hasta 4 átomos de carbono, o R7 y R8 juntos al átomo de nitrógeno forman un heterociclo de 5 a 6 eslabones,...
CO97039173A 1996-07-12 1997-07-11 3- ureido-piridofuranos y- piridotiofenos CO4900059A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9614718.6A GB9614718D0 (en) 1996-07-12 1996-07-12 3-ureido-pyridofurans and -pyridothiophenes

Publications (1)

Publication Number Publication Date
CO4900059A1 true CO4900059A1 (es) 2000-03-27

Family

ID=10796835

Family Applications (1)

Application Number Title Priority Date Filing Date
CO97039173A CO4900059A1 (es) 1996-07-12 1997-07-11 3- ureido-piridofuranos y- piridotiofenos

Country Status (9)

Country Link
US (1) US6169092B1 (es)
EP (1) EP0912578A1 (es)
JP (1) JP2000514804A (es)
AR (1) AR007827A1 (es)
AU (1) AU3441197A (es)
CO (1) CO4900059A1 (es)
GB (1) GB9614718D0 (es)
WO (1) WO1998002440A1 (es)
ZA (1) ZA976168B (es)

Families Citing this family (37)

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GB2350109A (en) * 1999-05-17 2000-11-22 Bayer Ag Pharmaceutically active benzofuranyl sulfonates
GB2350112A (en) * 1999-05-17 2000-11-22 Bayer Ag Pharmaceutically active cycloalkyl ketones
GB2350110A (en) * 1999-05-17 2000-11-22 Bayer Ag Pharmaceutically active benzofurans
GB2350111A (en) * 1999-05-17 2000-11-22 Bayer Ag Oligohydroxyl substituted 3-urea-benzofuran and pyridofuran derivatives
US6953774B2 (en) 2000-08-11 2005-10-11 Applied Research Systems Ars Holding N.V. Methods of inducing ovulation
KR20040007583A (ko) 2001-05-23 2004-01-24 다나베 세이야꾸 가부시키가이샤 연골 질환의 재생치료용 조성물
TWI221838B (en) 2001-08-09 2004-10-11 Tanabe Seiyaku Co Pyrazinoisoquinoline compound or naphthalene compound
ATE526013T1 (de) 2001-12-14 2011-10-15 Merck Serono Sa Verfahren zur herbeiführung einer ovulation über einen nicht-polypeptid-camp-spiegel-modulator
US7144885B2 (en) 2002-02-22 2006-12-05 Bayer Pharmaceuticals Corporation Fused tricyclic heterocycles useful for treating hyper-proliferative disorders
BR0307905A (pt) 2002-02-22 2006-04-04 Bayer Pharmaceuticals Corp derivados de benzotiofeno e benzofurano úteis no tratamento de distúrbios hiperproliferativos
GB0214268D0 (en) * 2002-06-20 2002-07-31 Celltech R&D Ltd Chemical compounds
GB0218800D0 (en) * 2002-08-13 2002-09-18 Celltech R&D Ltd Chemical compounds
CA2506415A1 (en) 2002-11-19 2004-06-03 Achillion Pharmaceuticals, Inc. Substituted aryl thioureas and releated compounds; inhibitors of viral replication
CA2528927A1 (en) * 2003-06-20 2004-12-29 Celltech R & D Limited Process for preparing 3-aminothienopyridone derivatives
CA2528603A1 (en) * 2003-06-20 2004-12-29 Celltech R & D Limited Thienopyridone derivatives as kinase inhibitors
JP2007509164A (ja) * 2003-10-23 2007-04-12 カイロン コーポレイション 安定化組成物
US7795256B2 (en) 2003-10-24 2010-09-14 Ucb Pharma S.A. Thieno-pyridinone derivatives as kinase inhibitors
TW200600492A (en) * 2004-05-18 2006-01-01 Achillion Pharmaceuticals Inc Substituted aryl acylthioureas and related compounds; inhibitors of viral replication
EP1753512B1 (en) 2004-05-28 2008-07-09 Nycomed GmbH Tetrahydropyridothiophenes
ES2308504T3 (es) 2004-06-04 2008-12-01 4Sc Ag Tetrahidropiridotiofenos para su utilizacion en el tratamiento del cancer.
CA2569623A1 (en) 2004-06-11 2005-12-22 Altana Pharma Ag Novel compounds and use of tetrahydropyridothiophenes
EP1851229A1 (en) 2005-02-09 2007-11-07 Nycomed GmbH Tetrahydropyridothiophenes for the treatment of proliferative diseases such as cancer
US7741488B2 (en) 2005-02-11 2010-06-22 4Sc Ag Tetrahydropyridothiophenes as antiproliferative agents for the treatment of cancer
US7714136B2 (en) 2005-05-25 2010-05-11 4Sc Ag Tetrahydropyridothiophenes
US7763728B2 (en) 2005-05-25 2010-07-27 4Sc Ag Tetrahydropyridothiophenes
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
RU2008112313A (ru) * 2005-09-01 2009-10-10 Эррэй Биофарма Инк. (Us) Соединения ингибиторы raf и способы их применения
AU2006304787A1 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
CA2625210A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
EP2377531A2 (en) 2006-05-09 2011-10-19 Braincells, Inc. Neurogenesis by modulating angiotensin
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
EP2804603A1 (en) 2012-01-10 2014-11-26 President and Fellows of Harvard College Beta-cell replication promoting compounds and methods of their use
US8883857B2 (en) 2012-12-07 2014-11-11 Baylor College Of Medicine Small molecule xanthine oxidase inhibitors and methods of use
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US4455427A (en) 1981-07-01 1984-06-19 The Upjohn Company Pyridyl-substituted-benzofurans
AU559687B2 (en) 1981-07-01 1987-03-19 Upjohn Company, The Pyridinyl-and imidazolyl-benzofurane and benzothiophenes
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GB9309324D0 (en) * 1993-05-06 1993-06-16 Bayer Ag Venzofuranyl-and-thiophenyl-alkanecarboxyclic acids derivatives
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GB9410877D0 (en) * 1994-05-31 1994-07-20 Bayer Ag Heterocyclycarbonyl substituted benzoduranyl-and-thiophenyl-alkanecarboxyclic acid derivatives
HRP950288A2 (en) 1994-05-31 1997-08-31 Bayer Ag Oxalylamino-benzofuran- and benzothienyl-derivatives
ES2127966T3 (es) * 1994-05-31 1999-05-01 Bayer Ag Derivados de amino-benzofurilo y -benzotienilo.
GB9504460D0 (en) * 1995-03-06 1995-04-26 Bayer Ag N-(3-Benzofuranyl)urea-derivatives
GB9525262D0 (en) 1995-12-11 1996-02-07 Bayer Ag Heterocyclylcarbonyl substituted benzofuranyl-ureas

Also Published As

Publication number Publication date
JP2000514804A (ja) 2000-11-07
AR007827A1 (es) 1999-11-24
AU3441197A (en) 1998-02-09
US6169092B1 (en) 2001-01-02
GB9614718D0 (en) 1996-09-04
ZA976168B (en) 1998-02-02
EP0912578A1 (en) 1999-05-06
WO1998002440A1 (en) 1998-01-22

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