CO4750830A1 - Metanosulfonato de (1s, 2s)-1-(4-hidroxifenil)-2-(4-hidroxi- 4-fenilpiperidin-1-il)-1-propanol trihidrato - Google Patents

Metanosulfonato de (1s, 2s)-1-(4-hidroxifenil)-2-(4-hidroxi- 4-fenilpiperidin-1-il)-1-propanol trihidrato

Info

Publication number
CO4750830A1
CO4750830A1 CO96042164A CO96042164A CO4750830A1 CO 4750830 A1 CO4750830 A1 CO 4750830A1 CO 96042164 A CO96042164 A CO 96042164A CO 96042164 A CO96042164 A CO 96042164A CO 4750830 A1 CO4750830 A1 CO 4750830A1
Authority
CO
Colombia
Prior art keywords
phenylpiperidin
hydroxyphenyl
propanol
hydroxy
trihydrate
Prior art date
Application number
CO96042164A
Other languages
English (en)
Inventor
Marta Maria Andino
Terry Gene Sinay
Eugene Fred Fiese
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CO4750830A1 publication Critical patent/CO4750830A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Psychology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Endocrinology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Esta invención se refiere a la sal de mesilato de(1S, 2S)-1-(4-hidroxifenil)-2-(4-hidroxi-4-fenilpiperidin-1-il)-1-propanol trihidrato, a composiciones farmacéuticas que la contengan y a métodos para su utilización en el tratamiento de enfermedades del SNC.
CO96042164A 1995-08-11 1996-08-09 Metanosulfonato de (1s, 2s)-1-(4-hidroxifenil)-2-(4-hidroxi- 4-fenilpiperidin-1-il)-1-propanol trihidrato CO4750830A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US223895P 1995-08-11 1995-08-11

Publications (1)

Publication Number Publication Date
CO4750830A1 true CO4750830A1 (es) 1999-03-31

Family

ID=21699847

Family Applications (1)

Application Number Title Priority Date Filing Date
CO96042164A CO4750830A1 (es) 1995-08-11 1996-08-09 Metanosulfonato de (1s, 2s)-1-(4-hidroxifenil)-2-(4-hidroxi- 4-fenilpiperidin-1-il)-1-propanol trihidrato

Country Status (41)

Country Link
US (1) US6008233A (es)
EP (1) EP0843661B1 (es)
JP (1) JP3099072B2 (es)
KR (1) KR100291882B1 (es)
CN (2) CN1198739A (es)
AP (1) AP755A (es)
AR (1) AR004676A1 (es)
AT (1) ATE215072T1 (es)
AU (1) AU710984B2 (es)
BG (1) BG63678B1 (es)
BR (1) BR9610766A (es)
CA (1) CA2228752C (es)
CO (1) CO4750830A1 (es)
CZ (1) CZ296236B6 (es)
DE (1) DE69620191T2 (es)
DK (1) DK0843661T3 (es)
DZ (1) DZ2083A1 (es)
ES (1) ES2170857T3 (es)
GT (1) GT199600051A (es)
HR (1) HRP960372B1 (es)
HU (1) HUP9802862A3 (es)
IL (1) IL122649A (es)
IS (1) IS1945B (es)
MA (1) MA23957A1 (es)
NO (1) NO310458B1 (es)
NZ (1) NZ309134A (es)
OA (1) OA10664A (es)
PE (1) PE4898A1 (es)
PL (1) PL185603B1 (es)
PT (1) PT843661E (es)
RO (1) RO120134B1 (es)
RS (1) RS49521B (es)
RU (1) RU2140910C1 (es)
SA (1) SA96170171B1 (es)
SK (1) SK284209B6 (es)
TN (1) TNSN96104A1 (es)
TR (1) TR199800208T1 (es)
TW (1) TW495502B (es)
UA (1) UA59341C2 (es)
WO (1) WO1997007098A1 (es)
ZA (1) ZA966760B (es)

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NZ284852A (en) * 1994-08-18 1998-06-26 Pfizer 3-(piperidin-1-yl)-chroman-4,7-diol and 1-(4-hydrophenyl)-2-(piperidin-1-yl) alkanol derivatives; medicaments; used as a neuroprotective agent
ES2170857T3 (es) * 1995-08-11 2002-08-16 Pfizer Metanosulfonato de (1s,2s)-1-(4-hidroxifenil)-2-(4-hidroxi-4-fenilpiperidin-1-il)-1-propanol trihidrato.
GB9820405D0 (en) * 1998-09-18 1998-11-11 Smithkline Beecham Plc Process
AU3676100A (en) * 1999-04-09 2000-11-14 Mochida Pharmaceutical Co., Ltd. Remedies for neuropathic pain
GB9920917D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel process
GB9920919D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel compound
US6620830B2 (en) * 2000-04-21 2003-09-16 Pfizer, Inc. Thyroid receptor ligands
YU27801A (sh) * 2000-04-28 2003-04-30 Pfizer Products Inc. Postupak za dobijanje trihidrata mezilatne soli 1-(4- hidroksifenil)-2-(4-hidroksi-4-fenilpiperidin-1-il)-1-propanola i korisnih intermedijera
YU27701A (sh) * 2000-04-28 2003-04-30 Pfizer Products Inc. Postupak za dobijanje trihidrata mezilatne soli 1-(4- hidroksifenil)-2-(4-hidroksi-4-fenilpiperidin-1-il)1-propanola
AU8339301A (en) 2000-08-16 2002-02-25 Upjohn Co Compounds for the treatment of addictive disorders
EP1186303A3 (en) * 2000-09-06 2003-12-10 Pfizer Products Inc. Pharmaceutical combinations, for the treatment of stroke and traumatic brain injury, containing a neutrophil inhibiting factor and an selective NMDA-NR2B receptor antagonist
EP1674087A1 (en) 2000-10-02 2006-06-28 Pfizer Products Inc. Prophylactic use of n-methyl-d-aspartate (NMDA) antagonists
IL145584A0 (en) 2000-10-02 2002-06-30 Pfizer Prod Inc Nmda nr2b antagonists for treatment
UA73619C2 (en) * 2000-12-13 2005-08-15 Pfizer Prod Inc Stable pharmaceutical compositions of nmda receptor agonist (variants) and method of treatment
BRPI0213393B8 (pt) * 2001-10-19 2021-05-25 Fujifilm Toyama Chemical Co Ltd derivados de éter alquílico, ou um de seus sais, processo para produzir um derivado de éter alquílico, derivado de alquil-amida, ou um de seus sais, e, composição farmacêutica
KR100517638B1 (ko) 2002-04-08 2005-09-28 주식회사 엘지생명과학 게미플록사신 산염의 새로운 제조방법
CN103936690B (zh) 2005-10-25 2016-06-08 盐野义制药株式会社 氨基二氢噻嗪衍生物
EP2147914B1 (en) 2007-04-24 2014-06-04 Shionogi&Co., Ltd. Aminodihydrothiazine derivatives substituted with cyclic groups
JP5383483B2 (ja) 2007-04-24 2014-01-08 塩野義製薬株式会社 アルツハイマー症治療用医薬組成物
ES2738123T3 (es) 2008-06-13 2020-01-20 Shionogi & Co Derivado heterocíclico que contiene azufre que tiene actividad inhibitoria de ß-secretasa
JPWO2010047372A1 (ja) 2008-10-22 2012-03-22 塩野義製薬株式会社 Ｂａｃｅ１阻害活性を有する２−アミノピリミジン−４−オンおよび２−アミノピリジン誘導体
BR112012013854A2 (pt) 2009-12-11 2019-09-24 Shionogi & Co derivados de oxazina.
JP5766198B2 (ja) 2010-10-29 2015-08-19 塩野義製薬株式会社 縮合アミノジヒドロピリミジン誘導体
US8927721B2 (en) 2010-10-29 2015-01-06 Shionogi & Co., Ltd. Naphthyridine derivative
US8883779B2 (en) 2011-04-26 2014-11-11 Shinogi & Co., Ltd. Oxazine derivatives and a pharmaceutical composition for inhibiting BACE1 containing them
WO2014065434A1 (en) 2012-10-24 2014-05-01 Shionogi & Co., Ltd. Dihydrooxazine or oxazepine derivatives having bace1 inhibitory activity
KR102569031B1 (ko) 2014-09-15 2023-08-22 뤼겐 홀딩스 (케이맨) 리미티드 Nr2b nmda 수용체 길항제로서의 피롤로피리미딘 유도체
EP3197440A4 (en) * 2014-09-22 2018-04-18 Rugen Holdings (Cayman) Limited Treatment of anxiety disorders and autism spectrum disorders
US10221182B2 (en) 2015-02-04 2019-03-05 Rugen Holdings (Cayman) Limited 3,3-difluoro-piperidine derivatives as NR2B NMDA receptor antagonists
JP6876625B2 (ja) 2015-06-01 2021-05-26 リューゲン ホールディングス （ケイマン） リミテッド Ｎｒ２ｂｎｍｄａレセプターアンタゴニストとしての３，３−ジフルオロピペリジンカルバメート複素環式化合物
EP3544610A1 (en) 2016-11-22 2019-10-02 Rugen Holdings (Cayman) Limited Treatment of autism spectrum disorders, obsessive-compulsive disorder and anxiety disorders

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US5272160A (en) * 1989-05-17 1993-12-21 Pfizer Inc 2-piperidino-1-alkanol derivatives as antiischemic agents
WO1990014087A1 (en) * 1989-05-17 1990-11-29 Pfizer Inc. 2-piperidino-1-alkanol derivatives as antiischemic agents
NZ284852A (en) * 1994-08-18 1998-06-26 Pfizer 3-(piperidin-1-yl)-chroman-4,7-diol and 1-(4-hydrophenyl)-2-(piperidin-1-yl) alkanol derivatives; medicaments; used as a neuroprotective agent
ES2170857T3 (es) * 1995-08-11 2002-08-16 Pfizer Metanosulfonato de (1s,2s)-1-(4-hidroxifenil)-2-(4-hidroxi-4-fenilpiperidin-1-il)-1-propanol trihidrato.

Also Published As

Publication number Publication date
AU5908496A (en) 1997-03-12
TW495502B (en) 2002-07-21
NZ309134A (en) 1999-09-29
BR9610766A (pt) 1999-07-13
AU710984B2 (en) 1999-10-07
IL122649A0 (en) 1998-08-16
GT199600051A (es) 1997-12-26
CA2228752A1 (en) 1997-02-27
CN1615861A (zh) 2005-05-18
HRP960372B1 (en) 2003-04-30
WO1997007098A1 (en) 1997-02-27
SK16698A3 (en) 1999-06-11
EP0843661A1 (en) 1998-05-27
RU2140910C1 (ru) 1999-11-10
RS49521B (sr) 2006-10-27
DE69620191T2 (de) 2002-07-18
IS1945B (is) 2004-08-13
DE69620191D1 (de) 2002-05-02
HRP960372A2 (en) 1998-04-30
CA2228752C (en) 2002-12-10
PT843661E (pt) 2002-07-31
CN1198739A (zh) 1998-11-11
PL325050A1 (en) 1998-07-06
MX9801149A (es) 1998-05-31
MA23957A1 (fr) 1997-04-01
NO980574L (no) 1998-02-10
NO310458B1 (no) 2001-07-09
EP0843661B1 (en) 2002-03-27
RO120134B1 (ro) 2005-09-30
JP3099072B2 (ja) 2000-10-16
BG102289A (en) 1998-09-30
AR004676A1 (es) 1999-03-10
AP9600856A0 (en) 1996-10-31
JPH10510552A (ja) 1998-10-13
CZ296236B6 (cs) 2006-02-15
US6008233A (en) 1999-12-28
OA10664A (en) 2000-11-06
TNSN96104A1 (fr) 2005-03-15
PE4898A1 (es) 1998-03-16
SA96170171B1 (ar) 2006-05-20
CZ39098A3 (cs) 1999-02-17
IL122649A (en) 2001-08-26
BG63678B1 (bg) 2002-09-30
DK0843661T3 (da) 2002-07-22
UA59341C2 (uk) 2003-09-15
NO980574D0 (no) 1998-02-10
PL185603B1 (pl) 2003-06-30
HUP9802862A3 (en) 1999-05-28
HUP9802862A2 (hu) 1999-04-28
SK284209B6 (en) 2004-11-03
ES2170857T3 (es) 2002-08-16
KR19990036321A (ko) 1999-05-25
IS4643A (is) 1997-12-30
ZA966760B (en) 1998-02-09
ATE215072T1 (de) 2002-04-15
YU46196A (sh) 1999-07-28
AP755A (en) 1999-08-02
DZ2083A1 (fr) 2002-10-23
TR199800208T1 (es) 1998-05-21
KR100291882B1 (ko) 2001-10-26

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