CO4520187A1 - Tienil- y furanil-oxazolidinonas piridocondensadas - Google Patents
Tienil- y furanil-oxazolidinonas piridocondensadasInfo
- Publication number
- CO4520187A1 CO4520187A1 CO97001470A CO97001470A CO4520187A1 CO 4520187 A1 CO4520187 A1 CO 4520187A1 CO 97001470 A CO97001470 A CO 97001470A CO 97001470 A CO97001470 A CO 97001470A CO 4520187 A1 CO4520187 A1 CO 4520187A1
- Authority
- CO
- Colombia
- Prior art keywords
- linear
- mean
- branched
- group
- carbon
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
1. COMPUESTOS DE FORMULA GENERAL (I) FIGURA 1 EN LA CUAL A REPRESENTA UN ATOMO DE OXIGENO O DE AZUFRE O EL GRUPO -SO2 Y D, E, G y L SON IGUALES O DISTINTOS Y UNO, POR LO MENOS, DE ESTOS SUSTITUYENTES REPRESENTA UN ATOMO DE NITROGENO Y LOS OTROS SIGNIFICAN EL RESTO DE FORMULA -CR2, EN DONDE R2 SIGNIFICA HIDROGENO, CIANO, NITRO, CARBOXILO, ALQUILO, ACILO O ALCOXI, LINEAL O RAMIFICADO, CON HASTA 7 ATOMOS DE CARBONO RESPECTIVAMENTE, HALOGE- NO O UN GRUPO DE FORMULA -NR3R4, -CO-NR5R6, -NR7CO -R8 o -S(O)aR9, EN DONDE R3, R4, R5, R6, R7 y R8 SON IGUALES O DISTINTOS Y SIGNIFICAN HIDROGENO, FENILO O ALQUILO LINEAL O RAMIFICADO CON HASTA 6 ATOMOS DE CARBONO, a SIGNIFICA UN NUMERO 0, 1 o 2, R9 SIGNIFICA FENILO O ALQUILO LINEAL O RAMIFICADO CON HASTA 4 ATOMOS DE CARBONO, R1 REPRESENTA AZIDO, HIDROXILO O UN GRUPO DE FOR- MULA -OR10, O-SO2R11 o -NR12R13, EN DONDE R10 SIGNIFICA ACILO LINEAL O RAMIFICADO CON HASTA 8 ATOMOS DE CARBONO O UN GRUPO PROTECTOR DE HIDRO- XILO, R11 SIGNIFICA ALQUILO LINEAL O RAMIFICADO CON HAS- TA 4 ATOMOS DE CARBONO O FENILO QUE, DADO EL CASO, ESTA SUSTITUIDO POR ALQUILO LINEAL O RAMIFICADO CON HASTA 4 ATOMOS DE CARBONO... R12 Y R13 SON IGUALES O DISTINTOS Y SIGNIFICAN CI- CLOALQUILO CON 3 A 6 ATOMOS DE CARBONO, HIDROGENO, FENILO O ALQUILO O ALCOXI, LINEAL O RAMIFICADO, CON HASTA 8 ATOMOS DE CARBONOS RESPECTIVAMENTE O UN GRUPO PROTECTOR DE AMINO, O R12 O R13, SIGNIFI- CAN UN GRUPO DE FORMULA -CO-R14, -CS-R14 P Q OR15 OR16 O -SO2-R17, EN DONDE R14 Y R14- SON IGUALES O DISTINTOS Y SIGNIFICAN CICLOALQUILO CON 3 A 6 ATO- MOS DE CARBONO TRIFLUORMETILO, ALCOXI LINEAL O RA- MIFICADO CON HASTA 8 ATOMOS DE CARBONO, FENILO, BENCILOXI O HIDROGENO, O R14 Y R14-SIGNIFICAN AL- QUILO LINEAL O RAMIFICADO CON HASTA 8 ATOMOS DE CARBONO QUE, DADO EL CASO, ESTA SUSTITUIDO POR CIA NO, HALOGENO O TRIFLUORMETILO, O SIGNIFICAN TIOAL- QUILO O ACILO, LINEAL O REMIFICADO, CON HASTA 6 ATOMOS DE CARBONO RESPECTIVAMENTE, O SIGNIFICAN UN GRUPO DE FORMULA -NR18R19, EN DONDE R18 Y R19 SON IGUALES O DISTINTOS Y SIGNIFICAN HIDROGENO, FENILO O ALQUILO LINEAL O RAMIFICADO CON HASTA 6 ATOMOS DE CARBONO, O SIGNIFICAN UN HETEROCICLO AROMATICO DE 5 ESLABONES CON HASTA 3 HETEROATOMOS DEL GRUPO S, N Y O O...
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19601264A DE19601264A1 (de) | 1996-01-16 | 1996-01-16 | Pyrido-annellierte Thienyl- und Furanyl-Oxazolidinone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4520187A1 true CO4520187A1 (es) | 1997-10-15 |
Family
ID=7782815
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO97001470A CO4520187A1 (es) | 1996-01-16 | 1997-01-15 | Tienil- y furanil-oxazolidinonas piridocondensadas |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5827857A (es) |
| EP (1) | EP0785200A3 (es) |
| JP (1) | JPH09194482A (es) |
| KR (1) | KR970059180A (es) |
| AU (1) | AU1009897A (es) |
| BG (1) | BG101132A (es) |
| BR (1) | BR9700702A (es) |
| CA (1) | CA2194938A1 (es) |
| CO (1) | CO4520187A1 (es) |
| CZ (1) | CZ12997A3 (es) |
| DE (1) | DE19601264A1 (es) |
| EE (1) | EE9700031A (es) |
| HR (1) | HRP960615A2 (es) |
| HU (1) | HU9700136D0 (es) |
| IL (1) | IL119995A0 (es) |
| NO (1) | NO970175L (es) |
| PL (1) | PL317929A1 (es) |
| SG (1) | SG50002A1 (es) |
| SK (1) | SK5997A3 (es) |
| SV (1) | SV1997000003A (es) |
| TN (1) | TNSN97008A1 (es) |
| TR (1) | TR199601001A1 (es) |
| ZA (1) | ZA97303B (es) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9601666D0 (en) * | 1996-01-27 | 1996-03-27 | Zeneca Ltd | Chemical compounds |
| US6255304B1 (en) | 1997-05-30 | 2001-07-03 | Pharmacia & Upjohn Company | Oxazolidinone antibacterial agents having a thiocarbonyl functionality |
| JP2002501530A (ja) | 1997-05-30 | 2002-01-15 | ファルマシア・アンド・アップジョン・カンパニー | チオカルボニル官能基を有するオキサゾリジノン抗菌剤 |
| AU764184B2 (en) | 1998-01-23 | 2003-08-14 | Pharmacia & Upjohn Company | Oxazolidinone combinatorial libraries, compositions and methods of preparation |
| EP1060179A1 (en) * | 1998-02-25 | 2000-12-20 | PHARMACIA & UPJOHN COMPANY | Substituted aminomethyl isoxazoline derivatives useful as antimicrobials |
| PL345162A1 (en) | 1998-06-05 | 2001-12-03 | Astrazeneca Ab | Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them |
| US6867203B2 (en) | 1998-12-29 | 2005-03-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds |
| JP2003500397A (ja) * | 1999-05-19 | 2003-01-07 | スミスクライン ビーチャム パブリック リミテッド カンパニー | Ｍｒｓ阻害剤としての２−ｎｈ−ピリドンおよびピリミドン |
| CN1367780A (zh) * | 1999-07-28 | 2002-09-04 | 法玛西雅厄普约翰美国公司 | 噁唑烷酮类化合物、其制备方法及其应用 |
| US6413981B1 (en) | 1999-08-12 | 2002-07-02 | Ortho-Mcneil Pharamceutical, Inc. | Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods |
| US6297242B1 (en) | 1999-08-12 | 2001-10-02 | Ortho-Mcneil Pharmaceutical, Inc. | N-substituted amidine and guanidine oxazolidinone antibacterials and methods of use thereof |
| US6608081B2 (en) | 1999-08-12 | 2003-08-19 | Ortho-Mcneil Pharmaceutical, Inc. | Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods |
| GB9928568D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
| US6518285B2 (en) | 1999-12-21 | 2003-02-11 | Ortho Mcneil Pharmaceutical, Inc. | Piperidinyloxy and pyrrolidinyloxy oxazolidinone antibacterials |
| DE19962924A1 (de) | 1999-12-24 | 2001-07-05 | Bayer Ag | Substituierte Oxazolidinone und ihre Verwendung |
| US6514529B2 (en) | 2000-03-22 | 2003-02-04 | Pharmacia & Upjohn Company | Oxazolidinone tablet formulation |
| MY127336A (en) | 2000-03-22 | 2006-11-30 | Upjohn Co | Container for linezolid iv solution |
| GB0009803D0 (en) * | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
| DK1301207T3 (da) | 2000-06-30 | 2005-10-10 | Pharmacia & Upjohn Co Llc | Sammensætninger til behandling af bakterieinfektioner indeholdende en oxazolidinonforbindelse, sulbactam og ampicillin |
| DE10129725A1 (de) * | 2001-06-20 | 2003-01-02 | Bayer Ag | Kombinationstherapie substituierter Oxazolidinone |
| TW200302095A (en) * | 2002-01-25 | 2003-08-01 | Upjohn Co | Oxazolidinone cotherapy |
| AR038536A1 (es) * | 2002-02-25 | 2005-01-19 | Upjohn Co | N-aril-2-oxazolidinona-5- carboxamidas y sus derivados |
| US7141588B2 (en) * | 2002-02-25 | 2006-11-28 | Pfizer, Inc. | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives |
| IL164195A0 (en) * | 2002-03-29 | 2005-12-18 | Upjohn Co | Parenteral, intravenous, and oral administration of oxazolidinones for treating diabetic foot infections |
| US6868358B2 (en) * | 2002-07-24 | 2005-03-15 | The Goodyear Tire & Rubber Company | Method for processing information in a tire pressure monitoring system |
| US7094900B2 (en) * | 2002-08-12 | 2006-08-22 | Pharmacia & Upjohn Company Llc | N-Aryl-2-oxazolidinones and their derivatives |
| AU2003280143A1 (en) * | 2002-11-21 | 2004-06-15 | Pharmacia & Upjohn Company Llc | N-(4-(piperazin-1-yl)-phenyl-2-oxazolidinone-5-carboxamide derivates and related compounds as antibacterial agents |
| DE10300111A1 (de) * | 2003-01-07 | 2004-07-15 | Bayer Healthcare Ag | Verfahren zur Herstellung von 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid |
| MXPA05007937A (es) * | 2003-02-07 | 2005-09-30 | Warner Lambert Co | Agentes antibacterianos. |
| MXPA05007724A (es) * | 2003-02-07 | 2005-09-30 | Warner Lambert Co | Agentes antibacterianos. |
| US20040204463A1 (en) * | 2003-04-01 | 2004-10-14 | Harris Christina Renee | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives |
| WO2005019214A1 (en) * | 2003-08-25 | 2005-03-03 | Warner-Lambert Company Llc | Novel antimicrobial aryloxazolidinone compounds |
| US7304050B2 (en) * | 2003-09-16 | 2007-12-04 | Pfizer Inc. | Antibacterial agents |
| DE10355461A1 (de) | 2003-11-27 | 2005-06-23 | Bayer Healthcare Ag | Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung |
| DE102004062475A1 (de) * | 2004-12-24 | 2006-07-06 | Bayer Healthcare Ag | Feste, oral applizierbare pharmazeutische Darreichungsformen mit modifizierter Freisetzung |
| EP1685841A1 (en) | 2005-01-31 | 2006-08-02 | Bayer Health Care Aktiengesellschaft | Prevention and treatment of thromboembolic disorders |
| US20070155738A1 (en) | 2005-05-20 | 2007-07-05 | Alantos Pharmaceuticals, Inc. | Heterobicyclic metalloprotease inhibitors |
| DE102005045518A1 (de) | 2005-09-23 | 2007-03-29 | Bayer Healthcare Ag | 2-Aminoethoxyessigsäure-Derivate und ihre Verwendung |
| DE102005047561A1 (de) | 2005-10-04 | 2007-04-05 | Bayer Healthcare Ag | Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung |
| CA2624310C (en) | 2005-10-04 | 2014-01-07 | Bayer Healthcare Ag | Polymorphic form of 5-chloro-n-({5s)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophenecarboxamide |
| DE102005047558A1 (de) * | 2005-10-04 | 2008-02-07 | Bayer Healthcare Ag | Kombinationstherapie substituierter Oxazolidinone zur Prophylaxe und Behandlung von cerebralen Durchblutungsstörungen |
| TW200815428A (en) * | 2006-08-15 | 2008-04-01 | Wyeth Corp | Oxazolidone derivatives as PR modulators |
| US7649007B2 (en) * | 2006-08-15 | 2010-01-19 | Wyeth Llc | Oxazolidine derivatives as PR modulators |
| US7652018B2 (en) * | 2006-08-15 | 2010-01-26 | Wyeth Llc | Imidazolidin-2-one derivatives useful as PR modulators |
| WO2008021337A1 (en) | 2006-08-15 | 2008-02-21 | Wyeth | Oxazinan-2-one derivatives useful as pr modulators |
| DE102006051625A1 (de) * | 2006-11-02 | 2008-05-08 | Bayer Materialscience Ag | Kombinationstherapie substituierter Oxazolidinone |
| US7998992B2 (en) * | 2007-03-30 | 2011-08-16 | Institute Of Medicinal Molecular Design, Inc. | Oxazolidinone derivative having inhibitory activity on 11β-hydroxysteroid dehydrogenase type 1 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH614711A5 (es) * | 1975-04-08 | 1979-12-14 | Sandoz Ag | |
| US4705799A (en) | 1983-06-07 | 1987-11-10 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents |
| US4965268A (en) * | 1987-10-09 | 1990-10-23 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents |
| US5032605A (en) * | 1987-10-09 | 1991-07-16 | Du Pont Merck Pharmaceutical Company | Aminomethyl oxooxazolidinyl oxa or thia cycloalkylbenzene derivatives useful as antibacterial agents |
| US4801600A (en) * | 1987-10-09 | 1989-01-31 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents |
| US4921869A (en) * | 1987-10-09 | 1990-05-01 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents |
| US5254577A (en) * | 1988-07-29 | 1993-10-19 | The Du Pont Merck Pharmaceutical Company | Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents |
| US5164510A (en) * | 1988-09-15 | 1992-11-17 | The Upjohn Company | 5'Indolinyl-5β-amidomethyloxazolidin-2-ones |
| DE68918792T2 (de) | 1988-09-15 | 1995-03-30 | Upjohn Co | 5-Indolinyl-5-beta-amidomethyloxazolidin-2-one, 3-(substituierte kondensierte)phenyl-5-beta amidomethyloxazolidin-2-one und 3-(Nitrogen-substituierte)phenyl-5-beta-amidomethyloxazolidin-2-one. |
| JP2669579B2 (ja) | 1991-10-23 | 1997-10-29 | エーザイ株式会社 | オキサゾリドン誘導体 |
| DE4332384A1 (de) * | 1993-09-23 | 1995-03-30 | Merck Patent Gmbh | Adhäsionsrezeptor-Antagonisten III |
| TW286317B (es) * | 1993-12-13 | 1996-09-21 | Hoffmann La Roche | |
| DE4425613A1 (de) * | 1994-07-20 | 1996-01-25 | Bayer Ag | 5-gliedrige Heteroaryl-oxazolidinone |
-
1996
- 1996-01-16 DE DE19601264A patent/DE19601264A1/de not_active Withdrawn
- 1996-12-12 TR TR96/01001A patent/TR199601001A1/xx unknown
- 1996-12-23 HR HR19601264.3A patent/HRP960615A2/hr not_active Application Discontinuation
-
1997
- 1997-01-03 EP EP97100025A patent/EP0785200A3/de not_active Withdrawn
- 1997-01-09 AU AU10098/97A patent/AU1009897A/en not_active Abandoned
- 1997-01-09 US US08/781,001 patent/US5827857A/en not_active Expired - Fee Related
- 1997-01-13 CA CA002194938A patent/CA2194938A1/en not_active Abandoned
- 1997-01-13 IL IL11999597A patent/IL119995A0/xx unknown
- 1997-01-14 JP JP9017559A patent/JPH09194482A/ja active Pending
- 1997-01-14 PL PL97317929A patent/PL317929A1/xx unknown
- 1997-01-14 BG BG101132A patent/BG101132A/xx unknown
- 1997-01-15 EE EE9700031A patent/EE9700031A/xx unknown
- 1997-01-15 NO NO970175A patent/NO970175L/no unknown
- 1997-01-15 CO CO97001470A patent/CO4520187A1/es unknown
- 1997-01-15 TN TNTNSN97008A patent/TNSN97008A1/fr unknown
- 1997-01-15 KR KR1019970001028A patent/KR970059180A/ko not_active Application Discontinuation
- 1997-01-15 SG SG1997000092A patent/SG50002A1/en unknown
- 1997-01-15 CZ CZ97129A patent/CZ12997A3/cs unknown
- 1997-01-15 SK SK59-97A patent/SK5997A3/sk unknown
- 1997-01-15 ZA ZA97303A patent/ZA97303B/xx unknown
- 1997-01-16 SV SV1997000003A patent/SV1997000003A/es unknown
- 1997-01-16 BR BR9700702A patent/BR9700702A/pt unknown
- 1997-01-16 HU HU9700136A patent/HU9700136D0/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO970175D0 (no) | 1997-01-15 |
| PL317929A1 (en) | 1997-07-21 |
| HU9700136D0 (en) | 1997-03-28 |
| BR9700702A (pt) | 1998-09-01 |
| SV1997000003A (es) | 1997-08-19 |
| EP0785200A3 (de) | 1999-02-10 |
| TNSN97008A1 (fr) | 2005-03-15 |
| IL119995A0 (en) | 1997-04-15 |
| US5827857A (en) | 1998-10-27 |
| AU1009897A (en) | 1997-07-24 |
| ZA97303B (en) | 1997-07-17 |
| DE19601264A1 (de) | 1997-07-17 |
| SG50002A1 (en) | 1998-06-15 |
| HRP960615A2 (en) | 1998-02-28 |
| SK5997A3 (en) | 1997-09-10 |
| CZ12997A3 (en) | 1997-08-13 |
| EE9700031A (et) | 1997-08-15 |
| EP0785200A2 (de) | 1997-07-23 |
| NO970175L (no) | 1997-07-17 |
| CA2194938A1 (en) | 1997-07-17 |
| BG101132A (en) | 1998-04-30 |
| KR970059180A (ko) | 1997-08-12 |
| MX9700421A (es) | 1997-07-31 |
| JPH09194482A (ja) | 1997-07-29 |
| TR199601001A1 (tr) | 1997-08-21 |
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