AR016131A1 - -oxazolidinonas triciclicamente substituidas, procedimientos para su preparacion, uso de dichos compuestos y medicamentos. - Google Patents
-oxazolidinonas triciclicamente substituidas, procedimientos para su preparacion, uso de dichos compuestos y medicamentos.Info
- Publication number
- AR016131A1 AR016131A1 ARP980103515A ARP980103515A AR016131A1 AR 016131 A1 AR016131 A1 AR 016131A1 AR P980103515 A ARP980103515 A AR P980103515A AR P980103515 A ARP980103515 A AR P980103515A AR 016131 A1 AR016131 A1 AR 016131A1
- Authority
- AR
- Argentina
- Prior art keywords
- atoms
- straight
- branched chain
- chain alkyl
- group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Abstract
Oxazolidinonas tricíclicamente substituidas que comprenden la formula general I en la que R1 representa azido, hidroxi, o un grupo de formula -OR2, OSO2R3,-(CO)aNR4R5, D-R6 o -CO-R7, en las que R2 significa acilo de cadena lineal o ramificado con hasta 8 átomos de carbono o un grupo protector de hidroxi, R3significa alquilo de cadena lineal o ramificado con hasta 4 átomos de carbono o fenilo, que dado el caso está sustituido con alquilo de cadena lineal oramificado con hasta 4 átomos de carbono,a significa un numero 0, o 1, R4 y R5 son iguales o distintos y significan cicloalquilo con 3 a 6 átomos de carbono,hidrogeno, fenilo o alquilo o alcoxi de cadena lineal o ramificados con hasta 8 átomos de carbono cada uno o un grupo protector de amino, o R4 o R5 significaun grupo de formula -CO-R8, P(O)(OR9)(OR10) o -SO2-R11,en las que R8 significa cicloalquilo C3-6, que dado el caso está sustituido con halogeno, o significatrifluorometilo, alcoxi de cadena lineal o ramificado con hasta 8 átomos de C, fenilo o H, o significa alquilo de cadena lineal o ramificado con hasta 8 átomosde C, que dado el caso está sustituido con ciano, halogeno o trifluorometilo, o significa tioalquilo o acilo de cadena lineal o ramificados con hasta 6 átomosdeC cada uno, o significa un grupo de formula -NR12R13, en la que R12 y R13 son iguales o distintos y significan H, fenilo o alquilo de cadena lineal oramificado con hasta 6 átomos de C o R8 significa un hetrociclo aromático de 5 o 6 eslabones con asta3 heteroátomos de la serie de S, N y/u O, R9 y R10 soniguales o distintos y significan H o alquilo de cadena lineal o ramificado con hasta 4 átomos de C, R11 significa alquilo de cadena lineal o ramificado conhasta 4 átomos de C o fenilo; D significa el grupo -COO o -SO2; R6 significa fenilo o alquilo de cadena lineal o ramificada de hasta 7 átomos de C, R7significa trifluorometilo o alquilo de cadena lineal o ramificada de hasta 5 átomos de C, que está sustituido con halogeno o trifluorometilo, A representa unresto de formulas (II), en las que E significa un átomo de oxígeno o azufre, o significa el grupo CO, CH2, SO, SO2, o significa un grupo de formula -NR14
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19730847A DE19730847A1 (de) | 1997-07-18 | 1997-07-18 | Tricyclisch substituierte Oxazolidinone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR016131A1 true AR016131A1 (es) | 2001-06-20 |
Family
ID=7836119
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980103515A AR016131A1 (es) | 1997-07-18 | 1998-07-17 | -oxazolidinonas triciclicamente substituidas, procedimientos para su preparacion, uso de dichos compuestos y medicamentos. |
Country Status (5)
| Country | Link |
|---|---|
| AR (1) | AR016131A1 (es) |
| AU (1) | AU8441798A (es) |
| DE (1) | DE19730847A1 (es) |
| WO (1) | WO1999003846A1 (es) |
| ZA (1) | ZA986360B (es) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0103082A3 (en) | 1998-06-05 | 2002-12-28 | Astrazeneca Ab | Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them |
| DE19905278A1 (de) * | 1999-02-09 | 2000-08-10 | Bayer Ag | Oxazolidinone und ihre Verwendung als antibakterielle Mittel |
| MXPA02000985A (es) * | 1999-07-28 | 2002-07-30 | Upjohn Co | Oxazolidinonas y su uso como antiinfecciosos. |
| DE19962924A1 (de) | 1999-12-24 | 2001-07-05 | Bayer Ag | Substituierte Oxazolidinone und ihre Verwendung |
| GB0010757D0 (en) | 2000-05-05 | 2000-06-28 | Astrazeneca Ab | Chemical compounds |
| CA2423599A1 (en) | 2000-10-17 | 2002-04-25 | Pharmacia & Upjohn Company | Methods of producing oxazolidinone compounds |
| US6903109B2 (en) | 2001-04-18 | 2005-06-07 | Ortho-Muniel Pharmaceutical, Inc. | Arylindenopyridines and related therapeutic and prophylactic methods |
| US6958328B2 (en) | 2001-04-18 | 2005-10-25 | Ortho-Mcneil Pharmaceutical, Inc | Arylindenopyridines and related therapeutic and prophylactic methods |
| DE10129725A1 (de) | 2001-06-20 | 2003-01-02 | Bayer Ag | Kombinationstherapie substituierter Oxazolidinone |
| GB0121941D0 (en) | 2001-09-11 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
| US7141588B2 (en) | 2002-02-25 | 2006-11-28 | Pfizer, Inc. | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives |
| AR038536A1 (es) | 2002-02-25 | 2005-01-19 | Upjohn Co | N-aril-2-oxazolidinona-5- carboxamidas y sus derivados |
| US20040127510A1 (en) | 2002-04-16 | 2004-07-01 | Heintzelman Geoffrey R. | Arylindenopyridines and arylindenopyrimidines and related therapeutic and prophylactic methods |
| DE60304360T2 (de) | 2002-08-12 | 2006-11-16 | Pharmacia & Upjohn Co. Llc, Kalamazoo | N-aryl-2-oxazolidinone und deren derivate |
| ES2271660T3 (es) | 2002-11-21 | 2007-04-16 | PHARMACIA & UPJOHN COMPANY LLC | Derivados de n-(4-piperazin-1-il)-fenil-2-oxazolidinona-5-carboxamida y compuestos relacionados como agentes antibacterianos. |
| GB0229521D0 (en) * | 2002-12-19 | 2003-01-22 | Astrazeneca Ab | Chemical compounds |
| DE10300111A1 (de) | 2003-01-07 | 2004-07-15 | Bayer Healthcare Ag | Verfahren zur Herstellung von 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid |
| US7304050B2 (en) | 2003-09-16 | 2007-12-04 | Pfizer Inc. | Antibacterial agents |
| DE10355461A1 (de) | 2003-11-27 | 2005-06-23 | Bayer Healthcare Ag | Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung |
| EP1685841A1 (en) | 2005-01-31 | 2006-08-02 | Bayer Health Care Aktiengesellschaft | Prevention and treatment of thromboembolic disorders |
| DE102005045518A1 (de) | 2005-09-23 | 2007-03-29 | Bayer Healthcare Ag | 2-Aminoethoxyessigsäure-Derivate und ihre Verwendung |
| EP1934208B1 (de) | 2005-10-04 | 2011-03-23 | Bayer Schering Pharma Aktiengesellschaft | Neue polymorphe form von 5-chlor-n-({ ( 5s )-2-0x0-3-[4-( 3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl} -methyl)-2-thiophencarboxamid |
| DE102005047561A1 (de) | 2005-10-04 | 2007-04-05 | Bayer Healthcare Ag | Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung |
| US8062442B1 (en) | 2006-04-05 | 2011-11-22 | University Of Central Florida Research Foundation, Inc. | Safe, in situ methodologies for the destruction of triacetone triperoxide and other explosive peroxides |
| EP2141154A4 (en) * | 2007-03-30 | 2011-06-01 | Inst Med Molecular Design Inc | OXAZOLIDINONE DERIVATIVE HAVING INHIBITORY ACTIVITY ON 11-HYDROXYSTEOID DEHYDROGENASE TYPE I |
| ES2935615T3 (es) * | 2017-12-15 | 2023-03-08 | Union Therapeutics As | Azetidina dihidrotienopiridinas sustituidas y su uso como inhibidores de la fosfodiesterasa |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5254577A (en) * | 1988-07-29 | 1993-10-19 | The Du Pont Merck Pharmaceutical Company | Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents |
| DE68929303T2 (de) * | 1988-09-15 | 2002-05-02 | Upjohn Co | 3-(Stickstoff substituierte)phenyl-5-beta-amidomethyloxazoliden-2-one |
| US5182296A (en) * | 1989-10-26 | 1993-01-26 | Tanabe Seiyaky Co., Ltd. | Naphthyloxazolidone derivatives |
| AU667198B2 (en) * | 1991-11-01 | 1996-03-14 | Pharmacia & Upjohn Company | Substituted aryl- and heteroarylphenyloxazolidinones useful as antibacterial agents |
| DE4425609A1 (de) * | 1994-07-20 | 1996-01-25 | Bayer Ag | Benzofuranyl- und Benzothienyloxazolidinone |
| FR2741071B1 (fr) * | 1995-11-09 | 1997-12-12 | Synthelabo | Derives de 3-(benzofuran-5-yl)oxazolidin-2-one, leur preparation et leur application en therapeutique |
-
1997
- 1997-07-18 DE DE19730847A patent/DE19730847A1/de not_active Withdrawn
-
1998
- 1998-07-08 AU AU84417/98A patent/AU8441798A/en not_active Withdrawn
- 1998-07-08 WO PCT/EP1998/004252 patent/WO1999003846A1/de not_active Application Discontinuation
- 1998-07-17 ZA ZA986360A patent/ZA986360B/xx unknown
- 1998-07-17 AR ARP980103515A patent/AR016131A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU8441798A (en) | 1999-02-10 |
| ZA986360B (en) | 1999-01-27 |
| WO1999003846A1 (de) | 1999-01-28 |
| DE19730847A1 (de) | 1999-01-28 |
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