CO4340731A1 - Una combinacion farmaceutica de fluoxetina, venlafaxina, milnacipran o duloxetina, y un componente de alprenolol, way 100135, espiperona, pindolol, (s)-uh-301, penbutolol, pro- pranolol, tertatolol, y una ariloxipropanolamina - Google Patents
Una combinacion farmaceutica de fluoxetina, venlafaxina, milnacipran o duloxetina, y un componente de alprenolol, way 100135, espiperona, pindolol, (s)-uh-301, penbutolol, pro- pranolol, tertatolol, y una ariloxipropanolaminaInfo
- Publication number
- CO4340731A1 CO4340731A1 CO94049618A CO94049618A CO4340731A1 CO 4340731 A1 CO4340731 A1 CO 4340731A1 CO 94049618 A CO94049618 A CO 94049618A CO 94049618 A CO94049618 A CO 94049618A CO 4340731 A1 CO4340731 A1 CO 4340731A1
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- group
- component
- independently
- tertatolol
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
REIVINDICACION NUMERO UNA COMPOSICION FARMACEUTICA QUE COMPRENDE UN PRI- MER COMPONENTE ELEGIDO DEL GRUPO CONSISTENTE EN FLUOXETINA, VENLAFAXINA, MILNACIPRAN Y DULOXETINA EN COMBINACION CON UN SEGUNDO COMPONENTE ELEGIDO DEL GRUPO CONSISTENTE EN EL ALPRENOLOL, WAY 100135 ESPIPERONA, PINDOLOL, (S)-UH-301, PENBUTOLOL, PRO- PANOLOL, TERTATOLOL, Y UN COMPUESTO DE LA FORMULA FIGURA 1 EN DONDE Ar ES FIGURA 2 R1 ES UN GRUPO METILO OPCIONAL SUBSTITUIDO EN UNO DE LOS TRES ATOMOS DE CARBONO CONECTORES; R2 ES HIDROGENO, (C1-C4 ALQUILO), TRIFLUORMETIL, HIDROXI, (C1-C4 ALQUILO)-O-, (C1-C4 ALQUILO)-S(O)p -, O HALOGENO; FIGURA 3 R1 ES UN GRUPO METILO OPCIONAL SUBSTITUIDO EN UNO DE LOS TRES ATOMOS DE CARBONO CONECTORES; R2 ES HIDROGENO, (C1-C4 ALQUILO), TRIFLUORMETIL, HIDROXI, (C1-C4 ALQUILO)-O-, (C1-C4 ALQUILO)-S(O)p -, O HALOGENO; R3 ES UN GRUPO C3-C8 CICLOALQUILO O BICICLOALQUILO DE FORMULA FIGURA 4 EN DONDE a Y c SON INDEPENTIENTEMENTE 1-5, b ES 0-5, Y (a+c) ES MAYOR QUE 2; z ES UN GRUPO ALCANO, ALQUENO O ALQUILO LINEAL O RAMIFICADO C4-C10; (C4-C8 CICLOALQUILO) OPCIONAL- MENTE SUBSTITUIDO CON UN ALQUILO C1-C4 O FENILO; UN GRUPO BICICLOALQUILO CON UN ALQUILO C1-C4 O FE- NILO; UN GRUPO BICICLOALQUILO DE FORMULA FIGURA 5 EN DONDE a y c SON INDEPENDIENTEMENTE 1-5, b ES 0-5 Y (a+c) ES MAYOR QUE 2, C2-C10 ALQUILO OPCIO- NALMENTE SUBSTITUIDO CON R2 SEGUN SE DEFINIO PRE- VIAMENTE; O (C1-C4 ALQUILIDENO)-T-(C1-C4 ALQUILO), EN DONDE T ES -0-, -S-, -SO-, o SO2; donde CADA G ES INDEPENDIENTEMENTE UN ENLACE O C1-C4 AL- QUILIDENO; X ES -H, -COY, -CN, O C1-C4 ALQUILO; Y ES -OH, -O-(C1-C4 ALQUILO), O -NH2; Ra Y Ra´ SON INDEPENDIENTEMENTE HIDROGENO O C1-C3 ALQUILO, O CUANDO SE TOMAN JUNTOS CON EL ATOMO DE CARBON AL CUAL ELLOS ESTAN UNIDOS FORMAN UN ANILLO C3-C8 CICLOALQUILO; p ES 0, 1, o 2; A ES -O-, -S-, -NH-, o -NCH3-; Y m ES 0, 1, 2, 03, O UNA SAL FARMACEUTICAMENTE A- CEPTABLE DE LOS ANTERIORES".
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26085794A | 1994-06-16 | 1994-06-16 | |
US27746094A | 1994-07-19 | 1994-07-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO4340731A1 true CO4340731A1 (es) | 1996-07-30 |
Family
ID=26948222
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO94049618A CO4340731A1 (es) | 1994-06-16 | 1994-10-31 | Una combinacion farmaceutica de fluoxetina, venlafaxina, milnacipran o duloxetina, y un componente de alprenolol, way 100135, espiperona, pindolol, (s)-uh-301, penbutolol, pro- pranolol, tertatolol, y una ariloxipropanolamina |
Country Status (15)
Country | Link |
---|---|
US (6) | US5532268A (es) |
EP (1) | EP0687472A3 (es) |
JP (1) | JPH083035A (es) |
CN (1) | CN1113436A (es) |
AU (1) | AU685510B2 (es) |
CA (1) | CA2134038C (es) |
CO (1) | CO4340731A1 (es) |
CZ (1) | CZ262494A3 (es) |
HU (1) | HUT71582A (es) |
IL (1) | IL111380A0 (es) |
NO (1) | NO944046L (es) |
NZ (1) | NZ264774A (es) |
PE (1) | PE28695A1 (es) |
PL (1) | PL305701A1 (es) |
SG (1) | SG70562A1 (es) |
Families Citing this family (92)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0714663A3 (en) * | 1994-11-28 | 1997-01-15 | Lilly Co Eli | Potentiation of drug responses by serotonin 1A receptor antagonists |
EA000856B1 (ru) * | 1995-07-24 | 2000-06-26 | Эли Лилли Энд Компани | Способ лечения синдрома дефицита внимания/гиперактивности |
DE69607904T2 (de) * | 1995-08-16 | 2000-10-05 | Eli Lilly And Co., Indianapolis | Potenzierung von Serotonin-Wirkstoffresponz |
ZA967892B (en) * | 1995-09-21 | 1998-03-18 | Lilly Co Eli | Selective β3 adrenergic agonists. |
US6075040A (en) | 1996-09-05 | 2000-06-13 | Eli Lilly And Company | Selective β3 adrenergic agonists |
EP0792649A1 (en) * | 1996-02-29 | 1997-09-03 | Eli Lilly And Company | Treatment of sleep disorders |
US20060068001A1 (en) * | 1996-03-25 | 2006-03-30 | Wyeth | Extended release formulation |
US20030215507A1 (en) * | 1996-03-25 | 2003-11-20 | Wyeth | Extended release formulation |
US6274171B1 (en) * | 1996-03-25 | 2001-08-14 | American Home Products Corporation | Extended release formulation of venlafaxine hydrochloride |
FR2746314B1 (fr) * | 1996-03-25 | 1998-06-12 | Pf Medicament | Produit contenant du milnacipran et de l'idazoxan comme preparation pharmaceutique combinee |
EP0818198A1 (en) * | 1996-07-09 | 1998-01-14 | Lilly S.A. | Potentiation of drug response by increasing serotonin availability |
US5958429A (en) * | 1996-08-16 | 1999-09-28 | Eli Lilly And Company | Potentiation of serotonin response |
US5958965A (en) * | 1996-08-27 | 1999-09-28 | American Home Products Corporation | 4-aminoethoxy indoles |
FR2752732B1 (fr) * | 1996-08-28 | 1998-11-20 | Pf Medicament | Forme galenique a liberation prolongee de milnacipran |
EP0827746B1 (en) | 1996-09-05 | 2002-04-03 | Eli Lilly And Company | Carbazole analogues as selective beta3 adrenergic agonists |
US6087376A (en) * | 1997-02-05 | 2000-07-11 | University Of Kentucky Research Foundation | Use of lobeline compounds in the treatment of central nervous system diseases and pathologies |
US5830904A (en) * | 1997-02-05 | 1998-11-03 | University Of Kentucky Research Foundation | Lobeline compounds as a treatment for psychostimulant abuse and withdrawal, and for eating disorders |
FR2759290B1 (fr) * | 1997-02-13 | 2004-06-18 | Pf Medicament | Minalcipran pour le traitement de l'incontinence urinaire |
FR2759906B1 (fr) * | 1997-02-21 | 2004-06-04 | Pf Medicament | Utilisation de milnacipran et de ses derives pour la preparation d'un medicament destine au traitement de certaines maladies psychiatriques |
US5776969A (en) * | 1997-02-27 | 1998-07-07 | Eli Lilly And Company | Treatment of sleep disorders |
US5910319A (en) * | 1997-05-29 | 1999-06-08 | Eli Lilly And Company | Fluoxetine enteric pellets and methods for their preparation and use |
GB9714675D0 (en) * | 1997-07-11 | 1997-09-17 | Smithkline Beecham Plc | Novel composition |
AU736596B2 (en) * | 1997-07-25 | 2001-08-02 | H. Lundbeck A/S | Indole and 2,3-dihydroindole derivatives, their preparation and use |
UA56257C2 (uk) * | 1997-09-23 | 2003-05-15 | Елі Ліллі Енд Компані | Спосіб лікування неадекватної визивної поведінки |
JP2001517628A (ja) * | 1997-09-23 | 2001-10-09 | イーライ・リリー・アンド・カンパニー | 注意欠陥/多動障害の治療法 |
UA57107C2 (uk) * | 1997-09-23 | 2003-06-16 | Елі Ліллі Енд Компані | Спосіб лікування розладу поведінки |
AU9692898A (en) * | 1997-10-17 | 1999-05-10 | Eli Lilly And Company | Potentiation of pharmaceuticals |
US6228864B1 (en) | 1997-10-28 | 2001-05-08 | Vivus, Inc. | Administration of 5-HT receptor agonists and antagonists, to treat premature ejaculation |
US6037360A (en) * | 1997-10-28 | 2000-03-14 | Vivus, Incorporated | Administration of 5-HT3 receptor antagonists to treat premature ejaculation |
CO5011072A1 (es) | 1997-12-05 | 2001-02-28 | Lilly Co Eli | Etanolaminas pirazinil substituidas como agfonistas de los receptores |
US20030013740A1 (en) * | 1998-03-27 | 2003-01-16 | Martin P. Redmon | Stable dosage forms of fluoxetine and its enantiomers |
US6500827B2 (en) * | 1998-05-08 | 2002-12-31 | Pharmacia & Upjohn Company | Drug combinations |
AU764579B2 (en) * | 1998-05-08 | 2003-08-21 | Pharmacia & Upjohn Company | New drug combinations of a N.A.R.I., preferably reboxetine, and pindolol |
AU4100699A (en) * | 1998-05-28 | 1999-12-13 | Sepracor, Inc. | Compositions and methods employing r(-) fluoxetine and other active ingredients |
FR2781671A1 (fr) * | 1998-07-28 | 2000-02-04 | Synthelabo | Compositions pharmaceutiques contenant un inhibiteur de la recapture de la serotonine et leur application en therapeutique |
US6339106B1 (en) | 1999-08-11 | 2002-01-15 | Sepracor, Inc. | Methods and compositions for the treatment and prevention of sexual dysfunction |
US6331571B1 (en) * | 1998-08-24 | 2001-12-18 | Sepracor, Inc. | Methods of treating and preventing attention deficit disorders |
US6974838B2 (en) * | 1998-08-24 | 2005-12-13 | Sepracor Inc. | Methods of treating or preventing pain using sibutramine metabolites |
US6476078B2 (en) * | 1999-08-11 | 2002-11-05 | Sepracor, Inc. | Methods of using sibutramine metabolites in combination with a phosphodiesterase inhibitor to treat sexual dysfunction |
SI1113797T1 (sl) * | 1998-09-15 | 2010-02-26 | Lilly Co Eli | Uporaba duloksetina pri zdravljenju fibromialgije |
ATE305307T1 (de) * | 1999-07-01 | 2005-10-15 | Pharmacia & Upjohn Co Llc | Reboxetin zur behandlung von migränekopfschmerzen |
US6399826B1 (en) | 1999-08-11 | 2002-06-04 | Sepracor Inc. | Salts of sibutramine metabolites, methods of making sibutramine metabolites and intermediates useful in the same, and methods of treating pain |
BR0014166A (pt) * | 1999-09-03 | 2002-05-14 | Lilly Co Eli | Método de utilização de inibidores de reabsorção de serotonina seletivo de rápido ataque para tratamento de disfunção sexual |
US7163949B1 (en) | 1999-11-03 | 2007-01-16 | Amr Technology, Inc. | 4-phenyl substituted tetrahydroisoquinolines and use thereof |
RU2309953C2 (ru) | 1999-11-03 | 2007-11-10 | Эймр Текнолоджи, Инк. | Арил- и гетероарилзамещенные тетрагидроизохинолины, фармацевтическая композиция и способ лечения на их основе |
UA77650C2 (en) | 1999-12-06 | 2007-01-15 | Lundbeck & Co As H | Use of serotonin reuptake inhibitor in combination with deramcyclane |
GB0004003D0 (en) * | 2000-02-22 | 2000-04-12 | Knoll Ag | Therapeutic agents |
US6683114B2 (en) * | 2000-03-07 | 2004-01-27 | Eli Lilly And Company | Treatment of psoriasis |
GB2362826A (en) * | 2000-06-02 | 2001-12-05 | Lilly Co Eli | A pharmaceutical composition comprising a serotonin transport inhibitor and a serotonin recptor antagonist |
CA2415532C (en) * | 2000-07-11 | 2010-05-11 | Albany Molecular Research, Inc. | Novel 4-phenyl substituted tetrahydroisoquinolines therapeutic use thereof |
DE10042412B4 (de) * | 2000-08-30 | 2005-12-22 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System zur Abgabe von Venlafaxin, und seine Verwendung |
US20040030131A1 (en) * | 2000-10-04 | 2004-02-12 | Martine Keenan | Pharmaceutical compounds |
US20060223824A1 (en) * | 2000-11-28 | 2006-10-05 | Wyeth | Serotonergic agents |
US20060287335A1 (en) | 2000-11-28 | 2006-12-21 | Wyeth | Serotonergic agents for treating sexual dysfunction |
FR2817257B1 (fr) * | 2000-11-30 | 2009-03-20 | Sanofi Synthelabo | Cyclohexyl(alkyl)-propanolamines, leur preparation et compositions pharmaceutiques en contenant |
US20050192220A1 (en) * | 2001-02-05 | 2005-09-01 | Gevys Pharmaceuticas Ltd. | Composition and method for potentiating drugs |
US6833377B2 (en) | 2001-02-05 | 2004-12-21 | Gevys Pharmaceuticals Ltd. | Composition and method for potentiating drugs |
US6855729B2 (en) * | 2001-02-20 | 2005-02-15 | Timothy G. Dinan | Treatment of fibromyalgia and related fatigue syndromes using antagonists or partial agonists of 5HT1a receptors |
WO2002083631A1 (en) * | 2001-04-13 | 2002-10-24 | Sepracor Inc. | Methods of preparing didesmethylsibutramine and other sibutramine derivatives |
US7034059B2 (en) | 2001-07-02 | 2006-04-25 | Sepracor Inc. | Methods of using norfluoxetine |
US20030087963A1 (en) | 2001-09-13 | 2003-05-08 | Senanayake Chris H. | Methods of preparing and using 2-hydroxy derivatives of sibutramine and its metabolites |
US6602911B2 (en) | 2001-11-05 | 2003-08-05 | Cypress Bioscience, Inc. | Methods of treating fibromyalgia |
US20040034101A1 (en) * | 2001-11-05 | 2004-02-19 | Cypress Bioscience, Inc. | Treatment and prevention of depression secondary to pain (DSP) |
EP1482921A1 (en) * | 2002-02-12 | 2004-12-08 | Cypress Bioscience, Inc. | Methods of treating attention deficit/hyperactivity disorder (adhd) |
CA2382419A1 (en) * | 2002-04-24 | 2003-10-24 | Le Groupe Lysac Inc. | Synergistic blends of polysaccharides as biodegradable absorbent materials or superabsorbents |
MXPA05000566A (es) * | 2002-07-24 | 2005-08-29 | Cypress Bioscience Inc | Tratamiento de depresion secundaria al dolor (dsp). |
EP1558231A4 (en) * | 2002-10-03 | 2010-09-08 | Cypress Bioscience Inc | DOSAGE CLIMBING AND FRICTIONAL DAILY DOSE OF ANTIDEPRESSANTS TO TREAT NEUROLOGICAL DISORDERS |
US7704527B2 (en) * | 2002-10-25 | 2010-04-27 | Collegium Pharmaceutical, Inc. | Modified release compositions of milnacipran |
ES2310715T3 (es) * | 2003-02-14 | 2009-01-16 | Pierre Fabre Medicament | Uso del enantiomero (1s,2r) del milnacipran para la preparacion de un medicamento. |
FR2851163B1 (fr) * | 2003-02-14 | 2007-04-27 | Utilisation de l'enantiomere dextrogyre du milnacipran pour la preparation d'un medicament | |
GB0309440D0 (en) * | 2003-04-25 | 2003-06-04 | Lilly Co Eli | Quinolone derivatives |
US20040265373A1 (en) * | 2003-06-27 | 2004-12-30 | David Wynn | Soft tablet containing high molecular weight cellulosics |
US20040265372A1 (en) * | 2003-06-27 | 2004-12-30 | David Wynn | Soft tablet containing high molecular weight cellulosics |
AR047553A1 (es) | 2003-07-04 | 2006-01-25 | Lundbeck & Co As H | La combinacion de un inhibidor de reabsorcion de serotonina y agomelatina |
US20050226923A1 (en) * | 2004-04-07 | 2005-10-13 | Gassert Chad M | Venlafaxine compositions in the form of microtablets |
KR101412339B1 (ko) * | 2004-07-15 | 2014-06-25 | 알바니 몰레큘라 리써치, 인크. | 아릴- 및 헤테로아릴-치환된 테트라히드로이소퀴놀린, 및이것의 노르에피네프린, 도파민 및 세로토닌의 재흡수를차단하기 위한 용도 |
US20060111393A1 (en) * | 2004-11-22 | 2006-05-25 | Molino Bruce F | 4-Phenyl substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin |
US20060111394A1 (en) * | 2004-11-22 | 2006-05-25 | Molino Bruce F | Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin |
US20060111385A1 (en) * | 2004-11-22 | 2006-05-25 | Molino Bruce F | Novel 4-phenyl substituted tetrahydroisoquinolines and therapeutic use thereof |
US20070027162A1 (en) * | 2005-03-01 | 2007-02-01 | Wyeth | Crystalline and amorphous 4-cyano-N-{(2R)-2-[4-(2,3-dihydro-benzo[1,4]dioxin-5-yl)-piperazin -1-yl]-propyl}-N-pyridin-2-yl-benzamide hydrochloride |
CN101495184A (zh) * | 2005-07-15 | 2009-07-29 | Amr科技公司 | 芳基和杂芳基取代的四氢苯并氮杂及其在阻断去甲肾上腺素多巴胺和血清素的重摄取中的应用 |
US7994220B2 (en) * | 2005-09-28 | 2011-08-09 | Cypress Bioscience, Inc. | Milnacipran for the long-term treatment of fibromyalgia syndrome |
BRPI0720958A2 (pt) * | 2006-12-27 | 2014-03-18 | Lek Pharmaceuticals | Omposição de duloxetina |
AR071997A1 (es) * | 2008-06-04 | 2010-07-28 | Bristol Myers Squibb Co | Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina |
US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
US8815894B2 (en) * | 2009-05-12 | 2014-08-26 | Bristol-Myers Squibb Company | Crystalline forms of (S)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline and use thereof |
CA2760837C (en) | 2009-05-12 | 2018-04-03 | Albany Molecular Research, Inc. | 7-([1,2,4]triazolo[1,5-.alpha.]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline and use thereof |
US9034899B2 (en) | 2009-05-12 | 2015-05-19 | Albany Molecular Research, Inc. | Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof |
US8865937B2 (en) * | 2009-11-06 | 2014-10-21 | Mahendra G. Dedhiya | Crystalline forms of (1S,2R)-2-(amino methyl)-N,N-diethyl-1-phenyl cyclopropane carboxamide |
US9045468B2 (en) | 2010-08-17 | 2015-06-02 | Albany Molecular Research, Inc. | 2,5-methano- and 2,5-ethano-tetrahydrobenzazepine derivatives and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
EP2959904A1 (en) | 2014-06-27 | 2015-12-30 | Institut De Recerca Contra La Leucemia Josep Carreras | Methods for treating, diagnosing and prognosing a haematological malignancy |
EP3348266A1 (en) | 2017-01-16 | 2018-07-18 | Leukos Biotech, S.L. | Combination therapy for treating cancer |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3155669A (en) * | 1962-06-22 | 1964-11-03 | Res Lab Dr C Janssen N V | 2, 4, 8-triaza-spiro (4, 5) dec-2-enes |
US3155670A (en) * | 1962-06-22 | 1964-11-03 | Res Lab Dr C Janssen N V | 1-oxo-2, 4, 8, triaza-spiro (4, 5) decanes |
NL300886A (es) * | 1962-11-23 | |||
US3471515A (en) * | 1965-02-01 | 1969-10-07 | Sandoz Ag | (2-hydroxy-3-substituted aminopropoxy)indoles |
US3466325A (en) * | 1965-04-30 | 1969-09-09 | Haessle Ab | 1-(ortho-alkenyl phenoxy) - 2-hydroxy-3-isopropylaminopropanes and the salts thereof |
DE1668055B2 (de) * | 1967-03-10 | 1973-09-06 | Farbwerke Hoechst AG, vormals Mei ster Lucius & Bruning, 6000 Frankfurt | Basisch substituierte cyclopentylphenolaether, deren salze mit physiologisch vertraeglichen saeuren und verfahren zu deren herstellung |
GB1308191A (en) * | 1970-04-06 | 1973-02-21 | Science Union & Cie | Thiochroman derivatives and a process for preparing them |
US4314081A (en) * | 1974-01-10 | 1982-02-02 | Eli Lilly And Company | Arloxyphenylpropylamines |
FR2508035A1 (fr) * | 1981-06-23 | 1982-12-24 | Fabre Sa Pierre | Derives d'aryl-1-aminomethyl-2 cyclopropanes carboxamides (z), leur preparation et leur application en tant que medicaments utiles dans le traitement des troubles du systeme nerveux central |
US4761501A (en) * | 1983-10-26 | 1988-08-02 | American Home Products Corporation | Substituted phenylacetamides |
US4956388A (en) * | 1986-12-22 | 1990-09-11 | Eli Lilly And Company | 3-aryloxy-3-substituted propanamines |
US5013761A (en) * | 1988-06-03 | 1991-05-07 | Eli Lilly And Company | Serotonin antagonists |
GB8909209D0 (en) * | 1989-04-22 | 1989-06-07 | Wyeth John & Brother Ltd | Piperazine derivatives |
-
1994
- 1994-10-21 CA CA002134038A patent/CA2134038C/en not_active Expired - Fee Related
- 1994-10-24 AU AU77421/94A patent/AU685510B2/en not_active Ceased
- 1994-10-24 HU HU9403071A patent/HUT71582A/hu unknown
- 1994-10-24 NO NO944046A patent/NO944046L/no unknown
- 1994-10-24 IL IL11138094A patent/IL111380A0/xx unknown
- 1994-10-24 CZ CZ942624A patent/CZ262494A3/cs unknown
- 1994-10-25 NZ NZ264774A patent/NZ264774A/en unknown
- 1994-10-26 SG SG1996008007A patent/SG70562A1/en unknown
- 1994-10-26 EP EP94307876A patent/EP0687472A3/en not_active Ceased
- 1994-10-27 CN CN94119338A patent/CN1113436A/zh active Pending
- 1994-10-31 CO CO94049618A patent/CO4340731A1/es unknown
- 1994-11-02 PE PE1994253991A patent/PE28695A1/es not_active Application Discontinuation
- 1994-11-04 PL PL94305701A patent/PL305701A1/xx unknown
- 1994-11-18 JP JP6284933A patent/JPH083035A/ja not_active Withdrawn
-
1995
- 1995-05-17 US US08/442,735 patent/US5532268A/en not_active Expired - Fee Related
- 1995-05-17 US US08/442,734 patent/US5538992A/en not_active Expired - Fee Related
- 1995-05-17 US US08/442,737 patent/US5532244A/en not_active Expired - Fee Related
- 1995-05-17 US US08/442,609 patent/US5532250A/en not_active Expired - Fee Related
- 1995-05-17 US US08/442,736 patent/US5532264A/en not_active Expired - Fee Related
- 1995-05-17 US US08/442,733 patent/US5552429A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
IL111380A0 (en) | 1994-12-29 |
CZ262494A3 (en) | 1996-01-17 |
US5532250A (en) | 1996-07-02 |
US5538992A (en) | 1996-07-23 |
US5552429A (en) | 1996-09-03 |
NO944046D0 (no) | 1994-10-24 |
HUT71582A (en) | 1995-12-28 |
US5532244A (en) | 1996-07-02 |
EP0687472A2 (en) | 1995-12-20 |
CA2134038A1 (en) | 1995-12-17 |
US5532264A (en) | 1996-07-02 |
PL305701A1 (en) | 1995-12-27 |
HU9403071D0 (en) | 1994-12-28 |
US5532268A (en) | 1996-07-02 |
NZ264774A (en) | 1997-07-27 |
CA2134038C (en) | 1997-06-03 |
SG70562A1 (en) | 2000-02-22 |
NO944046L (no) | 1995-12-18 |
EP0687472A3 (en) | 1997-01-15 |
AU7742194A (en) | 1996-01-04 |
AU685510B2 (en) | 1998-01-22 |
JPH083035A (ja) | 1996-01-09 |
PE28695A1 (es) | 1995-10-04 |
CN1113436A (zh) | 1995-12-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CO4340731A1 (es) | Una combinacion farmaceutica de fluoxetina, venlafaxina, milnacipran o duloxetina, y un componente de alprenolol, way 100135, espiperona, pindolol, (s)-uh-301, penbutolol, pro- pranolol, tertatolol, y una ariloxipropanolamina | |
CO4480108A1 (es) | Compuestos dipeptidos que son secretagogos de la hormona del crecimiento | |
ES2233479T3 (es) | Derivados de triazaespiro (5,5) undecano y composiciones farmaceuticas que los comprenden, como ingrediente activo. | |
PT97710A (pt) | Processo para a preparacao de novos derivados da amino-piperidina,da amino-pirrolidina e de amino-per-hidroazepina | |
ES2093753T3 (es) | Derivados de estireno. | |
ECSP034660A (es) | Derivados del novedoso carbamato de quinuclidina y las composiciones medicinales que los contienen | |
AR010376A1 (es) | Compuestos con efecto analgesico, su uso para la fabricacion de medicamentos, agentes de diagnostico, composicion farmaceutica, procedimiento para la preparacion de dichos compuestos y compuestos intermediarios | |
BR0012646A (pt) | Composto, análogo de oligonucleotìdeo ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso de um análogo de oligonucleotìdeo | |
AR017796A1 (es) | DERIVADOS DE 2-ARIL-8-OXODIHIDROPURINA, PROCEDIMIENTOS PARA PREPARARLOS, COMPUESTOS INTERMEDIARIOS DE APLICACIoN EN DICHOS PROCEDIMIENTOS, COMPOSICIONES FARMACEUTICAS, Y SU USO PARA LA PREPARACIoN DE UN MEDICAMENTO PARA EL TRATAMIENTO DE ESTADOS DE ANSIEDAD. | |
AR011093A1 (es) | Compuestos derivados de sulfonil urea, composicion farmaceutica que los contiene y procedimiento para su uso. | |
CO5540391A2 (es) | Nuevas quinazolinonas espirocondensadas y su uso como inhibi dores de la fosfodiesterasa | |
HUP0000343A2 (hu) | 1,3-Propándiol-származékok alkalmazása szervátültetés után fellépő kilökődés megakadályozására | |
AR060405A1 (es) | Compuestos organicos y sus usos en tratamientos de infeccion por el virus de hepatitis c | |
AR020016A2 (es) | Compuestos derivados de la eritromicina, composiciones que los contienen, uso de los mismos para preparar un medicamento | |
ES556417A0 (es) | Procedimiento para preparar un conjugado de substancia activa de anclaje a membrana. | |
ATE225782T1 (de) | Benzopyranderivate | |
KR900002777A (ko) | 정신분열증 및 정신병 치료 또는 예방제 | |
KR890014098A (ko) | 카테콜 아민 유도체를 함유하여 이루어지는 중추성 신경퇴행성 질환의 진행방지 및 치료제 | |
ES2142773B1 (es) | Derivados de mononitrato de isosorbida y su empleo como agentes vasodilatadores con tolerancia desminuida. | |
AR031857A1 (es) | Pirroloquinolonas, composiciones farmaceuticas, uso de las mismas para preparar un medicamento antiviral y un metodo para producir un intermediario | |
AR048745A1 (es) | Derivados de (indol-3-il)-heterociclicos | |
AR006301A1 (es) | Derivados de oxazolidin-2-ona, procedimiento para prepararlos, medicamento constituido por dicho derivado y composicion farmaceutica que comprende a dicho derivado | |
ES2069249T3 (es) | Derivados de imidazol, su procedimiento de preparacion y los compuestos farmaceuticos que los contienen. | |
AR021509A1 (es) | Derivados de benzofurano, su preparacion y uso | |
AR049275A1 (es) | Derivados de camptotecina conjugada en posicion 20 con antagonistas de la integrina |