CO2022013599A2 - Anticuerpos anti-ccr8 para el tratamiento del cáncer - Google Patents
Anticuerpos anti-ccr8 para el tratamiento del cáncerInfo
- Publication number
- CO2022013599A2 CO2022013599A2 CONC2022/0013599A CO2022013599A CO2022013599A2 CO 2022013599 A2 CO2022013599 A2 CO 2022013599A2 CO 2022013599 A CO2022013599 A CO 2022013599A CO 2022013599 A2 CO2022013599 A2 CO 2022013599A2
- Authority
- CO
- Colombia
- Prior art keywords
- ccr8
- antibody
- disclosure provides
- cancer treatment
- antibodies
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Abstract
Esta divulgación proporciona anticuerpos aislados, por ejemplo, anticuerpos monoclonales, que se unen específicamente al receptor de quimiocina 8 del motivo C-C (CCR8) expresado en la superficie de una célula y median el agotamiento de la célula que expresa CCR8 por citotoxicidad celular dependiente de anticuerpos (ADCC). La divulgación proporciona métodos para tratar un sujeto que padece un cáncer que comprenden administrar al sujeto una cantidad terapéuticamente eficaz de un anticuerpo anti-CCR8 como monoterapia o en combinación con un agente anticanceroso tal como un inhibidor del punto de control inmune, por ejemplo, un anticuerpo anti-PD-1 o anti-PD-L1.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202062993570P | 2020-03-23 | 2020-03-23 | |
US202063041992P | 2020-06-21 | 2020-06-21 | |
US202163157618P | 2021-03-05 | 2021-03-05 | |
PCT/US2021/023430 WO2021194942A1 (en) | 2020-03-23 | 2021-03-22 | Anti-ccr8 antibodies for treating cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2022013599A2 true CO2022013599A2 (es) | 2022-10-11 |
Family
ID=75478295
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2022/0013599A CO2022013599A2 (es) | 2020-03-23 | 2022-09-21 | Anticuerpos anti-ccr8 para el tratamiento del cáncer |
Country Status (15)
Country | Link |
---|---|
US (1) | US20230119066A1 (es) |
EP (1) | EP4126950A1 (es) |
JP (1) | JP2023519254A (es) |
KR (1) | KR20220157446A (es) |
CN (1) | CN115768792A (es) |
AU (1) | AU2021244200A1 (es) |
BR (1) | BR112022018636A2 (es) |
CA (1) | CA3172697A1 (es) |
CL (1) | CL2022002555A1 (es) |
CO (1) | CO2022013599A2 (es) |
IL (1) | IL296673A (es) |
MX (1) | MX2022011701A (es) |
PE (1) | PE20230821A1 (es) |
TW (1) | TW202202521A (es) |
WO (1) | WO2021194942A1 (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
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US11692038B2 (en) | 2020-02-14 | 2023-07-04 | Gilead Sciences, Inc. | Antibodies that bind chemokine (C-C motif) receptor 8 (CCR8) |
TW202216771A (zh) | 2020-06-26 | 2022-05-01 | 德商拜耳廠股份有限公司 | 用於治療應用之ccr8抗體 |
CA3198647A1 (en) | 2020-10-16 | 2022-04-21 | LaNova Medicines Limited | Anti-ccr8 monoclonal antibodies and uses thereof |
EP4317439A1 (en) | 2021-03-31 | 2024-02-07 | Shionogi & Co., Ltd | Chimeric antigen receptor that recognizes ccr8 as antigen |
WO2022268192A1 (en) * | 2021-06-25 | 2022-12-29 | Nanjing Immunophage Biotech Co., Ltd | Anti-ccr8 antibodies and uses thereof |
BR112023024837A2 (pt) | 2021-07-27 | 2024-02-20 | Abbvie Inc | Anticorpos anti-ccr8 |
WO2023116880A1 (en) * | 2021-12-23 | 2023-06-29 | Concept To Medicine Biotech Co., Ltd. | Anti-ccr8 antibodies and uses thereof |
TW202400648A (zh) * | 2022-04-29 | 2024-01-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 抗ccr8抗體及其用途 |
WO2023230473A1 (en) | 2022-05-24 | 2023-11-30 | Bristol-Myers Squibb Company | Antibodies that bind to human ccr8 |
WO2023240135A2 (en) | 2022-06-07 | 2023-12-14 | Actinium Pharmaceuticals, Inc. | Bifunctional chelators and conjugates |
CN115058387B (zh) * | 2022-06-11 | 2023-12-01 | 重庆医科大学 | 一种人胚胎干细胞与前列腺癌细胞共培养制备抗前列腺癌药物的方法 |
WO2024026400A2 (en) * | 2022-07-27 | 2024-02-01 | Varian Medical Systems, Inc. | Therapeutic combinations of titr effectors with radiation therapy |
WO2024027823A1 (en) * | 2022-08-04 | 2024-02-08 | Beigene, Ltd. | Anti-ccr8 antibodies and methods of use |
WO2024040216A2 (en) * | 2022-08-19 | 2024-02-22 | Fibrogen, Inc. | Anti-ccr8 antibodies and uses thereof |
WO2024052517A2 (en) | 2022-09-09 | 2024-03-14 | Bayer Aktiengesellschaft | Medical use of ccr8 antibodies and dosing schedule |
WO2024062019A1 (en) | 2022-09-21 | 2024-03-28 | Synabs | Anti-ccr8 antibodies and uses thereof |
WO2024062076A1 (en) | 2022-09-21 | 2024-03-28 | Domain Therapeutics | Anti-ccr8 monoclonal antibodies and their therapeutic use |
WO2024062082A1 (en) | 2022-09-21 | 2024-03-28 | Domain Therapeutics | Anti-ccr8 monoclonal antibodies and their therapeutic use |
WO2024062072A2 (en) | 2022-09-21 | 2024-03-28 | Domain Therapeutics | Anti-ccr8 monoclonal antibodies and their therapeutic use |
WO2024077239A1 (en) * | 2022-10-07 | 2024-04-11 | Genentech, Inc. | Methods of treating cancer with anti-c-c motif chemokine receptor 8 (ccr8) antibodies |
WO2024088346A1 (en) * | 2022-10-28 | 2024-05-02 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Anti-ccr8 antibodies and uses thereof |
CN117186202B (zh) * | 2023-11-08 | 2024-02-02 | 北京大学第三医院(北京大学第三临床医学院) | 一种新细胞因子csbf及其在干眼治疗中的应用 |
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ES2420835T3 (es) | 1999-04-09 | 2013-08-27 | Kyowa Hakko Kirin Co., Ltd. | Procedimiento para controlar la actividad de las moléculas inmunofuncionales |
WO2001014557A1 (en) | 1999-08-23 | 2001-03-01 | Dana-Farber Cancer Institute, Inc. | Pd-1, a receptor for b7-4, and uses therefor |
EA200401325A1 (ru) | 2002-04-09 | 2005-04-28 | Киова Хакко Когио Ко., Лтд. | Клетки с модифицированным геномом |
MXPA05006828A (es) | 2002-12-23 | 2005-09-08 | Wyeth Corp | Anticuerpos contra pd-1, y sus usos. |
DE602004024041D1 (de) | 2003-03-05 | 2009-12-24 | Halozyme Inc | Lösliches hyaluronidase-glycoprotein (shasegp), verfahren zu seiner herstellung, verwendungen und dieses enthaltende pharmazeutische zusammensetzungen |
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BRPI0613361A2 (pt) | 2005-07-01 | 2011-01-04 | Medarex Inc | anticorpo monoclonal humano isolado, composição, imunoconjugado, molécula biespecìfica, molécula de ácido nucleico isolada, vetor de expressão, célula hospedeira, camundongo transgênico, método para modular uma resposta imune num indivìduo, método para inibir crescimento de células tumorais num indivìduo, método para tratar uma doença infecciosa num indivìduo, método para aumentar uma resposta imune a um antìgeno num indivìduo, método para tratar ou prevenir uma doença inflamatória num indivìduo e método para preparar o anticorpo anti-pd-l1 |
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DK2992017T3 (da) | 2013-05-02 | 2021-01-25 | Anaptysbio Inc | Antistoffer rettet mod programmeret død-1 (pd-1) |
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CN107011441B (zh) | 2013-09-13 | 2020-12-01 | 百济神州(广州)生物科技有限公司 | 抗pd1抗体及其作为治疗剂与诊断剂的用途 |
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AR105654A1 (es) | 2015-08-24 | 2017-10-25 | Lilly Co Eli | Anticuerpos pd-l1 (ligando 1 de muerte celular programada) |
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-
2021
- 2021-03-22 US US17/914,257 patent/US20230119066A1/en active Pending
- 2021-03-22 CN CN202180024063.9A patent/CN115768792A/zh active Pending
- 2021-03-22 JP JP2022557776A patent/JP2023519254A/ja active Pending
- 2021-03-22 WO PCT/US2021/023430 patent/WO2021194942A1/en active Application Filing
- 2021-03-22 TW TW110110284A patent/TW202202521A/zh unknown
- 2021-03-22 CA CA3172697A patent/CA3172697A1/en active Pending
- 2021-03-22 IL IL296673A patent/IL296673A/en unknown
- 2021-03-22 KR KR1020227036358A patent/KR20220157446A/ko unknown
- 2021-03-22 BR BR112022018636A patent/BR112022018636A2/pt unknown
- 2021-03-22 PE PE2022002058A patent/PE20230821A1/es unknown
- 2021-03-22 MX MX2022011701A patent/MX2022011701A/es unknown
- 2021-03-22 AU AU2021244200A patent/AU2021244200A1/en active Pending
- 2021-03-22 EP EP21718409.2A patent/EP4126950A1/en active Pending
-
2022
- 2022-09-20 CL CL2022002555A patent/CL2022002555A1/es unknown
- 2022-09-21 CO CONC2022/0013599A patent/CO2022013599A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
JP2023519254A (ja) | 2023-05-10 |
PE20230821A1 (es) | 2023-05-19 |
MX2022011701A (es) | 2022-10-07 |
CL2022002555A1 (es) | 2023-03-17 |
KR20220157446A (ko) | 2022-11-29 |
IL296673A (en) | 2022-11-01 |
CA3172697A1 (en) | 2021-09-30 |
EP4126950A1 (en) | 2023-02-08 |
BR112022018636A2 (pt) | 2023-01-31 |
US20230119066A1 (en) | 2023-04-20 |
AU2021244200A1 (en) | 2022-11-24 |
WO2021194942A1 (en) | 2021-09-30 |
TW202202521A (zh) | 2022-01-16 |
CN115768792A (zh) | 2023-03-07 |
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