CO2021001742A2 - Anticuerpos anti–sortilina y métodos para su uso - Google Patents

Anticuerpos anti–sortilina y métodos para su uso

Info

Publication number
CO2021001742A2
CO2021001742A2 CONC2021/0001742A CO2021001742A CO2021001742A2 CO 2021001742 A2 CO2021001742 A2 CO 2021001742A2 CO 2021001742 A CO2021001742 A CO 2021001742A CO 2021001742 A2 CO2021001742 A2 CO 2021001742A2
Authority
CO
Colombia
Prior art keywords
sortilin
methods
compositions
sortilin antibodies
antibodies
Prior art date
Application number
CONC2021/0001742A
Other languages
English (en)
Inventor
Arnon Rosenthal
Robert Pejchal
Tina Schwabe
Michael Kurnellas
Anthony B Cooper
Original Assignee
Alector Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alector Llc filed Critical Alector Llc
Publication of CO2021001742A2 publication Critical patent/CO2021001742A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/286—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against neuromediator receptors, e.g. serotonin receptor, dopamine receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente descripción hace referencia, en términos generales, a composiciones que incluyen anticuerpos, por ejemplo, monoclonales, quiméricos, madurados por afinidad, anticuerpos humanizados, fragmentos de anticuerpos, etc., que se unen específicamente a la proteína sortilina, por ejemplo, sortilina humana o sortilina de mamífero, y que tienen características funcionales mejoradas y/o potenciadas, y al uso de tales composiciones en la prevención, disminución del riesgo o tratamiento de un individuo que lo necesite.
CONC2021/0001742A 2018-07-13 2021-02-12 Anticuerpos anti–sortilina y métodos para su uso CO2021001742A2 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862698007P 2018-07-13 2018-07-13
US201962860184P 2019-06-11 2019-06-11
US201962868849P 2019-06-28 2019-06-28
PCT/US2019/041614 WO2020014617A1 (en) 2018-07-13 2019-07-12 Anti-sortilin antibodies and methods of use thereof

Publications (1)

Publication Number Publication Date
CO2021001742A2 true CO2021001742A2 (es) 2021-03-08

Family

ID=67480375

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2021/0001742A CO2021001742A2 (es) 2018-07-13 2021-02-12 Anticuerpos anti–sortilina y métodos para su uso

Country Status (29)

Country Link
US (3) US11396546B2 (es)
EP (2) EP4212210A1 (es)
JP (2) JP7208157B2 (es)
KR (2) KR102530517B1 (es)
CN (1) CN111372655A (es)
AU (1) AU2019246837B2 (es)
BR (1) BR112019022666A2 (es)
CA (1) CA3060547A1 (es)
CL (2) CL2021000089A1 (es)
CO (1) CO2021001742A2 (es)
CR (1) CR20210057A (es)
DK (1) DK3618928T3 (es)
EC (1) ECSP21010450A (es)
ES (1) ES2940311T3 (es)
FI (1) FI3618928T3 (es)
HR (1) HRP20230344T1 (es)
HU (1) HUE061841T2 (es)
IL (1) IL270214B1 (es)
LT (1) LT3618928T (es)
MX (1) MX2019012869A (es)
PE (1) PE20210186A1 (es)
PH (1) PH12021550041A1 (es)
PL (1) PL3618928T3 (es)
PT (1) PT3618928T (es)
RS (1) RS64034B1 (es)
SI (1) SI3618928T1 (es)
TW (1) TWI809147B (es)
WO (1) WO2020014617A1 (es)
ZA (1) ZA201906731B (es)

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MX2017012802A (es) 2015-04-07 2018-04-11 Alector Llc Anticuerpos antisortilina y métodos para su uso.
GB201512215D0 (en) 2015-07-13 2015-08-19 Lundbeck & Co As H Agents,uses and methods
US10894833B2 (en) * 2017-07-20 2021-01-19 H. Lundbeck A/S Agents, uses and methods for treatment
TW202112817A (zh) * 2019-06-11 2021-04-01 美商阿列克特有限責任公司 抗揀選蛋白抗體之使用方法
AU2021362487A1 (en) 2020-10-14 2023-06-08 Denali Therapeutics Inc. Methods for treating and monitoring frontotemporal dementia
WO2022120352A1 (en) * 2020-12-02 2022-06-09 Alector Llc Methods of use of anti-sortilin antibodies
CN112920264B (zh) * 2021-02-08 2022-07-05 武汉大学 Tdp-43蛋白的o-糖基化突变体及其应用
WO2023247754A1 (en) 2022-06-23 2023-12-28 Draupnir Bio Aps Bifunctional molecules that selectively induce degradation of extracellular targets in lysosomes
CN115281146B (zh) * 2022-07-08 2023-06-16 山东省农业科学院家禽研究所（山东省无特定病原鸡研究中心） 一种鸡湿热下利证模型的构建方法
CN116731169B (zh) * 2023-08-09 2023-11-03 瑞诺元(苏州)生物科技有限公司 一种分拣蛋白1特异性的纳米抗体及其应用

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