CO2019009480A2 - Composición farmacéutica de bajo ph que comprende construcciones de anticuerpos que activan linfocitos t - Google Patents
Composición farmacéutica de bajo ph que comprende construcciones de anticuerpos que activan linfocitos tInfo
- Publication number
- CO2019009480A2 CO2019009480A2 CONC2019/0009480A CO2019009480A CO2019009480A2 CO 2019009480 A2 CO2019009480 A2 CO 2019009480A2 CO 2019009480 A CO2019009480 A CO 2019009480A CO 2019009480 A2 CO2019009480 A2 CO 2019009480A2
- Authority
- CO
- Colombia
- Prior art keywords
- pharmaceutical composition
- low
- antibody constructs
- lymphocytes
- activate
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 210000001744 T-lymphocyte Anatomy 0.000 title 1
- 101710160107 Outer membrane protein A Proteins 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 239000006172 buffering agent Substances 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente invención proporciona una composición farmacéutica de bajo pH que comprende (a) construcciones de anticuerpos que comprenden un primer dominio que se une a un antígeno de superficie celular diana, un segundo dominio que se une a un segundo antígeno y preferentemente un tercer dominio, que es una modalidad de Fc específica, (b) al menos un agente amortiguador, (c) al menos un sacárido, y (d) al menos un tensioactivo; y en donde el pH de la composición farmacéutica está en el intervalo de 3.5 a 6.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762453952P | 2017-02-02 | 2017-02-02 | |
PCT/EP2018/052665 WO2018141910A1 (en) | 2017-02-02 | 2018-02-02 | Low ph pharmaceutical composition comprising t cell engaging antibody constructs |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2019009480A2 true CO2019009480A2 (es) | 2019-09-18 |
Family
ID=61274222
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2019/0009480A CO2019009480A2 (es) | 2017-02-02 | 2019-08-30 | Composición farmacéutica de bajo ph que comprende construcciones de anticuerpos que activan linfocitos t |
Country Status (24)
Country | Link |
---|---|
US (1) | US20200332000A1 (es) |
EP (1) | EP3576788A1 (es) |
JP (2) | JP7189141B2 (es) |
KR (2) | KR102658637B1 (es) |
CN (1) | CN110582297A (es) |
AR (1) | AR110955A1 (es) |
AU (1) | AU2018214223A1 (es) |
BR (1) | BR112019016104A2 (es) |
CA (1) | CA3052098A1 (es) |
CL (1) | CL2019002178A1 (es) |
CO (1) | CO2019009480A2 (es) |
CR (1) | CR20190408A (es) |
EA (1) | EA201991769A1 (es) |
IL (1) | IL268351A (es) |
JO (1) | JOP20190189A1 (es) |
MA (1) | MA47425A (es) |
MX (1) | MX2019009133A (es) |
NZ (1) | NZ756016A (es) |
PE (1) | PE20200153A1 (es) |
PH (1) | PH12019501796A1 (es) |
SG (1) | SG11201907048UA (es) |
TN (1) | TN2019000225A1 (es) |
WO (1) | WO2018141910A1 (es) |
ZA (1) | ZA201905674B (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
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JP7412409B2 (ja) * | 2018-07-31 | 2024-01-12 | アムジェン インコーポレイテッド | マスクされた抗体の医薬製剤 |
AU2019356564A1 (en) * | 2018-10-11 | 2021-04-29 | Amgen Inc. | Downstream processing of bispecific antibody constructs |
EP4054590A1 (en) | 2019-11-04 | 2022-09-14 | Amgen Inc. | Methods for treating leukemia |
CN115461080A (zh) | 2020-04-29 | 2022-12-09 | 安进公司 | 药物配制品 |
JP2023524444A (ja) | 2020-04-29 | 2023-06-12 | アムジェン インコーポレイテッド | 医薬製剤 |
CA3184351A1 (en) * | 2020-06-04 | 2021-12-09 | Amgen Inc. | Bispecific binding constructs |
WO2022046651A1 (en) * | 2020-08-24 | 2022-03-03 | Amgen Inc. | Pharmaceutical formulation comprising a bite, bispecific antibody, and methionine |
AU2021345124A1 (en) | 2020-09-16 | 2023-03-30 | Amgen Inc. | Methods for administering therapeutic doses of bispecific T-cell engaging molecules for the treatment of cancer |
WO2022060878A1 (en) | 2020-09-16 | 2022-03-24 | Amgen Inc. | Methods for treating prostate cancer |
EP4247850A1 (en) | 2020-11-20 | 2023-09-27 | Simcere Innovation, Inc. | Armed dual car-t compositions and methods for cancer immunotherapy |
WO2023183231A1 (en) | 2022-03-21 | 2023-09-28 | Amgen Inc. | Combination therapy methods with t-cell engaging molecules for treatment of prostate cancer |
WO2024077044A1 (en) | 2022-10-05 | 2024-04-11 | Amgen Inc. | Combination therapies comprising t-cell redirecting therapies and agonistic anti-il-2r antibodies or fragments thereof |
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2018
- 2018-02-02 CN CN201880023948.5A patent/CN110582297A/zh active Pending
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PE20200153A1 (es) | 2020-01-17 |
EP3576788A1 (en) | 2019-12-11 |
AR110955A1 (es) | 2019-05-22 |
WO2018141910A1 (en) | 2018-08-09 |
PH12019501796A1 (en) | 2019-09-16 |
JP2023022235A (ja) | 2023-02-14 |
KR20190137077A (ko) | 2019-12-10 |
ZA201905674B (en) | 2020-10-28 |
KR20240055865A (ko) | 2024-04-29 |
MX2019009133A (es) | 2019-12-19 |
MA47425A (fr) | 2019-12-11 |
CR20190408A (es) | 2020-01-31 |
TN2019000225A1 (en) | 2021-01-07 |
JOP20190189A1 (ar) | 2019-08-01 |
EA201991769A1 (ru) | 2020-07-29 |
JP2020506924A (ja) | 2020-03-05 |
IL268351A (en) | 2019-09-26 |
BR112019016104A2 (pt) | 2020-04-14 |
JP7189141B2 (ja) | 2022-12-13 |
CN110582297A (zh) | 2019-12-17 |
CL2019002178A1 (es) | 2020-09-21 |
KR102658637B1 (ko) | 2024-04-19 |
SG11201907048UA (en) | 2019-08-27 |
NZ756016A (en) | 2022-07-01 |
CA3052098A1 (en) | 2018-08-09 |
AU2018214223A1 (en) | 2019-08-15 |
US20200332000A1 (en) | 2020-10-22 |
TW201900209A (zh) | 2019-01-01 |
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