CO2017007123A2 - Anticuerpos biespecíficos contra calicreína y factor xii del plasma - Google Patents

Anticuerpos biespecíficos contra calicreína y factor xii del plasma

Info

Publication number
CO2017007123A2
CO2017007123A2 CONC2017/0007123A CO2017007123A CO2017007123A2 CO 2017007123 A2 CO2017007123 A2 CO 2017007123A2 CO 2017007123 A CO2017007123 A CO 2017007123A CO 2017007123 A2 CO2017007123 A2 CO 2017007123A2
Authority
CO
Colombia
Prior art keywords
light chain
factor xii
heavy chain
bispecific antibodies
kallikrein
Prior art date
Application number
CONC2017/0007123A
Other languages
English (en)
Spanish (es)
Inventor
Burt Adelman
Andrew Nixon
Niksa Kastrapeli
Shauna Mason
Kristopher Kopacz
Gregory P Conley
Stephen R Comeau
Jon A Kenniston
Allison P Lindberg
Original Assignee
Dyax Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dyax Corp filed Critical Dyax Corp
Publication of CO2017007123A2 publication Critical patent/CO2017007123A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CONC2017/0007123A 2015-01-02 2017-07-17 Anticuerpos biespecíficos contra calicreína y factor xii del plasma CO2017007123A2 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562099236P 2015-01-02 2015-01-02
US201562200363P 2015-08-03 2015-08-03
US201562261609P 2015-12-01 2015-12-01
PCT/US2015/068238 WO2016109774A1 (en) 2015-01-02 2015-12-31 Bispecific antibodies against plasma kallikrein and factor xii

Publications (1)

Publication Number Publication Date
CO2017007123A2 true CO2017007123A2 (es) 2017-12-15

Family

ID=56285069

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2017/0007123A CO2017007123A2 (es) 2015-01-02 2017-07-17 Anticuerpos biespecíficos contra calicreína y factor xii del plasma

Country Status (13)

Country Link
US (2) US11390687B2 (OSRAM)
EP (2) EP3240570B1 (OSRAM)
JP (4) JP6744313B2 (OSRAM)
KR (2) KR20240091031A (OSRAM)
CN (2) CN107405399B (OSRAM)
AU (2) AU2015373910B2 (OSRAM)
CA (1) CA2972800A1 (OSRAM)
CO (1) CO2017007123A2 (OSRAM)
EA (1) EA201791527A1 (OSRAM)
IL (2) IL298086B2 (OSRAM)
MX (2) MX2017008541A (OSRAM)
NZ (1) NZ771568A (OSRAM)
WO (1) WO2016109774A1 (OSRAM)

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Also Published As

Publication number Publication date
CA2972800A1 (en) 2016-07-07
EP3240570A4 (en) 2018-08-08
AU2022201076A1 (en) 2022-03-10
NZ733580A (en) 2024-02-23
CN114316061A (zh) 2022-04-12
EP3240570C0 (en) 2025-09-24
IL298086A (en) 2023-01-01
EA201791527A1 (ru) 2017-12-29
JP7635285B2 (ja) 2025-02-25
AU2015373910A1 (en) 2017-07-27
EP4670785A2 (en) 2025-12-31
KR20240091031A (ko) 2024-06-21
US11390687B2 (en) 2022-07-19
MX2024000317A (es) 2024-01-25
IL298086B1 (en) 2024-07-01
MX2017008541A (es) 2017-12-04
JP6744313B2 (ja) 2020-08-26
JP2020186248A (ja) 2020-11-19
WO2016109774A1 (en) 2016-07-07
KR20170118058A (ko) 2017-10-24
JP2022023038A (ja) 2022-02-07
CN107405399B (zh) 2022-02-08
BR112017014308A2 (pt) 2018-03-06
US20180118851A1 (en) 2018-05-03
CN107405399A (zh) 2017-11-28
KR102670705B1 (ko) 2024-05-31
US20230117565A1 (en) 2023-04-20
US12240918B2 (en) 2025-03-04
JP2018502572A (ja) 2018-02-01
IL253180B2 (en) 2023-04-01
CN114316061B (zh) 2024-11-01
EP3240570A1 (en) 2017-11-08
EP3240570B1 (en) 2025-09-24
JP2023065659A (ja) 2023-05-12
IL253180A0 (en) 2017-08-31
IL253180B (en) 2022-12-01
AU2022201076B2 (en) 2025-05-15
JP7241827B2 (ja) 2023-03-17
AU2015373910B2 (en) 2021-11-18
NZ771568A (en) 2024-11-29
JP7003347B2 (ja) 2022-02-04
IL298086B2 (en) 2024-11-01

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