CN85105193A - 制备苯并噻吩止腹泻剂方法 - Google Patents

制备苯并噻吩止腹泻剂方法 Download PDF

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Publication number
CN85105193A
CN85105193A CN198585105193A CN85105193A CN85105193A CN 85105193 A CN85105193 A CN 85105193A CN 198585105193 A CN198585105193 A CN 198585105193A CN 85105193 A CN85105193 A CN 85105193A CN 85105193 A CN85105193 A CN 85105193A
Authority
CN
China
Prior art keywords
formula
compound
phenyl
thiophene
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN198585105193A
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English (en)
Chinese (zh)
Inventor
斯蒂芬·詹姆斯·雷
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp SRL
Original Assignee
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp SRL filed Critical Pfizer Corp SRL
Publication of CN85105193A publication Critical patent/CN85105193A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Insulating Materials (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
CN198585105193A 1984-07-10 1985-07-08 制备苯并噻吩止腹泻剂方法 Pending CN85105193A (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848417559A GB8417559D0 (en) 1984-07-10 1984-07-10 Anti-diarrhoeal agents

Publications (1)

Publication Number Publication Date
CN85105193A true CN85105193A (zh) 1987-01-28

Family

ID=10563672

Family Applications (1)

Application Number Title Priority Date Filing Date
CN198585105193A Pending CN85105193A (zh) 1984-07-10 1985-07-08 制备苯并噻吩止腹泻剂方法

Country Status (20)

Country Link
US (1) US4654352A (https=)
EP (1) EP0169012A1 (https=)
JP (1) JPS6136281A (https=)
KR (1) KR860001094A (https=)
CN (1) CN85105193A (https=)
AU (1) AU556058B2 (https=)
CS (1) CS249545B2 (https=)
DD (1) DD238792A5 (https=)
DK (1) DK312485A (https=)
ES (1) ES8604557A1 (https=)
FI (1) FI852691A7 (https=)
GB (1) GB8417559D0 (https=)
GR (1) GR851688B (https=)
HU (1) HUT38330A (https=)
IL (1) IL75740A0 (https=)
NO (1) NO852760L (https=)
PL (1) PL254445A1 (https=)
PT (1) PT80786B (https=)
YU (1) YU113985A (https=)
ZA (1) ZA855153B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9091170B2 (en) 2008-12-24 2015-07-28 Mitsubishi Hitachi Power Systems, Ltd. One-stage stator vane cooling structure and gas turbine

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4128690A1 (de) * 1991-08-29 1993-03-04 Boehringer Mannheim Gmbh Bicyclische sulfone, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
ES2173182T3 (es) * 1994-04-11 2002-10-16 Chugai Pharmaceutical Co Ltd Derivado de 4,6-dl-butil-2,3-dihidrobenzotiofenos como antioxidantes de ldl.
CA2207141A1 (en) * 1996-07-15 1998-01-15 David Thompson Berg Benzothiophene compounds, and uses and formulations thereof
CA2207083A1 (en) * 1996-07-15 1998-01-15 Brian William Grinnell Benzothiophene compounds, and uses and formulations thereof
US5792798A (en) * 1996-07-29 1998-08-11 Eli Lilly And Company Method for inhibiting plasminogen activator inhibitor 1
WO1998037070A1 (en) * 1997-02-21 1998-08-27 Takeda Chemical Industries, Ltd. Fused ring compounds, process for producing the same and use thereof
US6251936B1 (en) 1998-05-12 2001-06-26 American Home Products Corporation Benzothiophenes, benzofurans, and indoles useful in the treatment of insulin resistance and hyperglycemia
HRP20000767A2 (en) * 1998-05-12 2001-10-31 American Home Prod Benzothiophenes, benzofurans and indoles useful in the treatment of insulin resistance and hyperglycemia
KR100545430B1 (ko) * 2000-11-02 2006-01-24 에프. 호프만-라 로슈 아게 콜레스테롤 저하성 벤조[ｂ]티오펜 및 벤조[ｄ]이소티아졸
US6969730B2 (en) 2001-03-16 2005-11-29 Abbott Laboratories Amines as histamine-3 receptor ligands and their therapeutic applications
WO2006019497A2 (en) * 2004-06-17 2006-02-23 Neurocrine Biosciences, Inc. Sleep-inducing compounds and methods related thereto

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1174411A (en) * 1966-03-02 1969-12-17 Aspro Nicholas Ltd Novel Benzothiophen Compounds, Compositions containing them and processes for their manufacture
US3598839A (en) * 1969-06-30 1971-08-10 Parke Davis & Co Phenylbenzothiophene compounds
US3944672A (en) * 1972-12-13 1976-03-16 Schering Corporation Method for treating microbial infections
DE2522669A1 (de) * 1974-05-28 1975-12-11 Scherico Ltd Antimikrobielle verbindungen und sie enthaltende zusammensetzungen
US4018893A (en) * 1974-05-28 1977-04-19 Schering Corporation Methods for treating microbial infections
US4137414A (en) * 1977-09-26 1979-01-30 G. D. Searle & Co. 5-Substituted-2-phenylbenzo[b]thiophene-3-alkylamines and related compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9091170B2 (en) 2008-12-24 2015-07-28 Mitsubishi Hitachi Power Systems, Ltd. One-stage stator vane cooling structure and gas turbine

Also Published As

Publication number Publication date
PT80786A (en) 1985-08-01
ZA855153B (en) 1987-02-25
EP0169012A1 (en) 1986-01-22
FI852691L (fi) 1986-01-11
HUT38330A (en) 1986-05-28
KR860001094A (ko) 1986-02-22
ES8604557A1 (es) 1986-02-01
AU556058B2 (en) 1986-10-23
GB8417559D0 (en) 1984-08-15
PL254445A1 (en) 1986-07-15
DK312485D0 (da) 1985-07-09
JPS6136281A (ja) 1986-02-20
YU113985A (en) 1987-08-31
US4654352A (en) 1987-03-31
FI852691A0 (fi) 1985-07-08
PT80786B (en) 1987-03-26
DK312485A (da) 1986-01-11
AU4471385A (en) 1986-01-16
ES544970A0 (es) 1986-02-01
FI852691A7 (fi) 1986-01-11
GR851688B (https=) 1985-11-26
DD238792A5 (de) 1986-09-03
IL75740A0 (en) 1985-11-29
CS249545B2 (en) 1987-03-12
NO852760L (no) 1986-01-13

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