CN220311051U - Automatic sorting hybridization instrument - Google Patents
Automatic sorting hybridization instrument Download PDFInfo
- Publication number
- CN220311051U CN220311051U CN202321822024.6U CN202321822024U CN220311051U CN 220311051 U CN220311051 U CN 220311051U CN 202321822024 U CN202321822024 U CN 202321822024U CN 220311051 U CN220311051 U CN 220311051U
- Authority
- CN
- China
- Prior art keywords
- hybridization
- liquid injection
- moving part
- clamping jaw
- sliding rail
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000009396 hybridization Methods 0.000 title claims abstract description 67
- 239000007788 liquid Substances 0.000 claims abstract description 47
- 238000002347 injection Methods 0.000 claims abstract description 30
- 239000007924 injection Substances 0.000 claims abstract description 30
- 230000007246 mechanism Effects 0.000 claims abstract description 29
- 230000001681 protective effect Effects 0.000 claims description 8
- 239000011550 stock solution Substances 0.000 claims description 6
- 230000009471 action Effects 0.000 claims description 3
- 238000004659 sterilization and disinfection Methods 0.000 claims description 3
- 239000012528 membrane Substances 0.000 abstract description 12
- 238000002474 experimental method Methods 0.000 abstract description 7
- 239000000243 solution Substances 0.000 description 9
- 241000701806 Human papillomavirus Species 0.000 description 8
- 238000001514 detection method Methods 0.000 description 4
- 206010008342 Cervix carcinoma Diseases 0.000 description 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 2
- 201000010881 cervical cancer Diseases 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 206010059313 Anogenital warts Diseases 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000013399 early diagnosis Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 238000003205 genotyping method Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 210000005000 reproductive tract Anatomy 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
Landscapes
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The utility model discloses an automatic sorting hybridization instrument, which comprises: a liquid injection table; a liquid transferring mechanism is arranged on the liquid injecting table, and a clamping jaw is arranged on one side of the liquid transferring mechanism; the clamping jaw is arranged on the pipetting mechanism through a moving mechanism and moves along the setting direction of the moving mechanism; the inner side of the liquid injection table is provided with a volume cavity, a plurality of hybridization boxes are placed on the volume cavity, and the hybridization boxes are taken out through the clamping jaws; the device is equipped with recognition device at the storage port, reads the serial number of membrane strip on the hybridization box, through setting up the clamping jaw, can automatic clamp get letter sorting membrane strip and hybridization box, can avoid the pollution that the manual work brought, save time moreover, shorten the time of experiment, and then shorten the efficiency of reporting.
Description
Technical Field
The utility model relates to the field of detection hybridization instruments, in particular to an automatic sorting hybridization instrument.
Background
Human Papillomaviruses (HPV) can infect the genital tract by a variety of routes, leading to condyloma acuminatum and cervical lesions, possibly even causing cervical cancer to occur. Therefore, the targeted typing detection of HPV is of great importance for early diagnosis of cervical cancer. The HPV detection method adopts the HPV genotyping detection technology combining PCR in vitro amplification and DNA reverse dot hybridization, utilizes the gene characteristics of HPV to design specific primers, can amplify target fragments of 23 HPV genotypes, and then hybridizes the amplified products with typing probes which are fixed on membrane strips and comprise 17 high-risk types and 6 low-risk types, and judges whether the HPV genotypes are infected according to the presence or absence of hybridization signals.
The current full-automatic nucleic acid molecule hybridization instrument does not have the functions of automatically sorting membrane strips and hybridization boxes, manually writing the membrane strips and sorting the hybridization boxes, sequentially placing the hybridization boxes on a storage rack according to the sequence of numbers, placing the hybridization boxes on a liquid injection table, controlling a liquid injection needle to carry out liquid injection hybridization experiments through a control panel, manually writing and placing the hybridization boxes for a large number of membrane strips, and obtaining the results at the later stage, wherein the membrane strips can be polluted by any process when the membrane strips are rewritten, so that analysis of sample results is influenced, wrong auxiliary judgment is given to clinic, and serious people can cross-pollute when hybridization liquid is carried out, so that larger experimental data errors are caused.
Disclosure of Invention
The utility model aims to solve the defects in the prior art and provides an automatic sorting hybridization instrument.
In order to achieve the above purpose, the present utility model adopts the following technical scheme: an automated sorting hybridization apparatus comprising:
a liquid injection table;
a liquid transferring mechanism is arranged on the liquid injecting table, and a clamping jaw is arranged on one side of the liquid transferring mechanism;
the clamping jaw is arranged on the pipetting mechanism through a moving mechanism and moves along the setting direction of the moving mechanism;
the inner side of the liquid injection table is provided with a volume cavity, a plurality of hybridization boxes are placed on the volume cavity, and the hybridization boxes are taken out through the clamping jaws.
As a further description of the above technical solution: the liquid injection table is provided with a storage port, the storage port is communicated with the internal volume cavity, and an identification device is arranged above the storage port to identify the conveyed hybridization box.
As a further description of the above technical solution: the pipetting mechanism comprises a first moving part, a second moving part is slidably arranged on the first moving part, and a third moving part is arranged on the second moving part through a sliding block.
As a further description of the above technical solution: the hybridization box output port is arranged below the first moving part, and the ultraviolet disinfection lamp is arranged above the hybridization box output port.
As a further description of the above technical solution: and a pipetting needle is arranged below the third moving part.
As a further description of the above technical solution: the moving mechanism comprises a rotary disc, the rotary disc is arranged on one side of the sliding block, a sliding groove is formed in the end face of one side of the rotary disc, a sliding rail is arranged on the sliding groove, and the rotary disc is rotated to drive the sliding rail to rotate.
As a further description of the above technical solution: the sliding groove is in clearance fit with the sliding rail, a rack is arranged on one side of the sliding rail, a gear is arranged on one side of the sliding groove, and the sliding rail is driven to move on the sliding groove through rotation of the control gear.
As a further description of the above technical solution: and one side of the sliding rail is provided with a clamping jaw which is electrically connected with the control panel to control the action state of the clamping jaw.
As a further description of the above technical solution: and a liquid adding needle and a stock solution bottle are arranged on one side of the liquid injection table.
As a further description of the above technical solution: the liquid injection table is provided with a protective cover, and the control panel is arranged on the outer side of the protective cover.
The technical scheme has the following advantages or beneficial effects:
1. the identification device is arranged at the storage port, the number of the membrane strip on the hybridization box is read, the sorting membrane strip and the hybridization box can be automatically clamped by the clamping jaw, the pollution caused by manpower can be avoided, the time is saved, the time of the experiment is shortened, and the efficiency of reporting is further shortened.
Drawings
FIG. 1 is a perspective view of an automated sorting hybridization apparatus according to the present utility model;
FIG. 2 is an enlarged view of a portion of FIG. 1 at A;
FIG. 3 is a front view of a self-sorting hybridization instrument;
fig. 4 is a schematic structural diagram of a rotary disc and a sliding rail in the present utility model.
Legend description:
1. a liquid injection table; 2. a clamping jaw; 3. a storage port; 4. an identification device; 5. a first moving part; 6. a second moving part; 7. a third moving part; 8. a slide block; 9. a hybridization cassette output port; 10. an ultraviolet sterilizing lamp; 11. a pipetting needle; 12. a rotary plate; 13. a chute; 14. a slide rail; 15. a liquid adding needle; 16. a stock solution bottle; 17. and a protective cover.
Detailed Description
The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.
Referring to fig. 1-4, one embodiment provided by the present utility model is: an automated sorting hybridization apparatus comprising: a liquid injection table 1; a pipetting mechanism is arranged on the pipetting platform 1, and a clamping jaw 2 is arranged on one side of the pipetting mechanism; the clamping jaw 2 is arranged on the pipetting mechanism through a moving mechanism and moves along the setting direction of the moving mechanism; the inner side of the liquid injection table 1 is provided with a volume cavity, a plurality of hybridization boxes are placed, and the hybridization boxes are taken out through the clamping jaw 2.
In this embodiment, the hybridization box is placed in the liquid injection table 1, the inner side of the liquid injection table 1 is provided with an arrangement groove, the hybridization box conveyed in is conveyed out after being arranged through the arrangement groove, the hybridization box is taken out and placed on the liquid injection table 1 through the clamping jaw 2 to be sorted, the hybridization box corresponding to the film strip number is taken out, the hybridization box can be rapidly identified, after the hybridization box is clamped and placed on the liquid injection table 1 through the clamping jaw 2, the position coordinate data of the hybridization box is obtained, after the liquid taking mechanism is controlled to move to take liquid, the liquid moving mechanism moves to the position again, and the liquid injection hybridization experiment is performed.
The liquid injection table 1 is provided with a storage opening 3, the storage opening 3 is communicated with an internal volume cavity, and an identification device 4 is arranged above the storage opening 3 to identify the conveyed hybridization box.
In this embodiment, a storage port 3 is formed on one side of the liquid injection table 1, the hybridization box and the inner membrane strip are transported into the volume cavity of the liquid injection table 1 through the storage port 3, and when entering the storage port 3, the membrane strip numbers are read by an identification device 4 above to obtain the arrangement sequence of the hybridization box number transportation, and the identification device 4 is specifically an infrared scanner or a CCD identification camera.
The pipetting mechanism comprises a first moving part 5, a second moving part 6 is slidably arranged on the first moving part 5, and a third moving part 7 is arranged on the second moving part 6 through a sliding block 8.
In this embodiment, the first moving portion 5 is provided with a chute, one side of the second moving portion 6 is disposed in the chute of the first moving portion 5, the second moving portion 6 is driven to move by a motor, a sliding block 8 is mounted on the second moving portion 6, two through openings are provided on the sliding block 8, the two through openings are provided in directions perpendicular to each other, one through opening is matched with the second moving portion 6, the other through opening is matched with the third moving portion 7, a sprocket (not shown in the figure) is disposed on one side of the second moving portion 6, and is connected with the sliding block 8 for accommodating wires, and the positions of the sliding block 8 on the second moving portion 6 and the positions of the third moving portion 7 in the vertical direction are controlled under the driving of the motor.
A pipetting needle 11 is arranged below the third moving part 7, and the position of the pipetting needle 11 is positioned by a moving mechanism so as to be convenient for injecting stock solution into the hybridization box when hybridization experiments are carried out.
The hybridization box output port 9 is arranged below the first moving part 5, the ultraviolet disinfection lamp 10 is arranged above the first moving part, so that the hybridization box taken out of the clamping jaw 2 can be primarily disinfected, and the irradiation power can be increased to disinfect the surface of the liquid injection table 1 after the hybridization experiment is finished.
The moving mechanism comprises a rotary disc 12, the rotary disc 12 is arranged on one side of the sliding block 8, a sliding groove 13 is formed in the end face of one side of the rotary disc 12, a sliding rail 14 is arranged on the sliding groove 13, and the rotary disc 12 is rotated to drive the sliding rail 14 to rotate; the sliding groove 13 is in clearance fit with the sliding rail 14, a rack is arranged on one side of the sliding rail 14, a gear is arranged on one side of the sliding groove 13, and the sliding rail 14 is driven to move on the sliding groove 13 through rotation of the control gear.
In this embodiment, the rotary disc 12 is driven by a micro stepping motor, an output shaft is connected with the inner side of the rotary disc 8, the rotation angle of the rotary disc 12 is controlled, a sliding groove 13 is formed in the other side of the rotary disc 12, the sliding groove 13 is in clearance fit with a sliding rail 14, a notch is formed in the inner wall of the sliding groove 13, one side of a gear extends outwards through the notch to be in contact with a rack on one side of the sliding rail 14, and the gear is driven to rotate by the motor to drive the sliding rail 14 to move on the sliding groove 13.
One side of the slide rail 14 is provided with a clamping jaw 2 which is electrically connected with the control panel to control the action state of the clamping jaw 2; the liquid injection table 1 is provided with a protective cover 17, and the control panel is arranged outside the protective cover 17.
In this embodiment, the control panel may be a PLC controller or a processor, and is controlled by a touch screen, and the liquid injection table 1 is closed by the protective cover 17, so that external contamination is prevented from entering the hybridization box when the hybridization experiment is performed.
A liquid adding needle 15 and a stock solution bottle 16 are arranged on one side of the liquid injection table 1, and liquid is injected into the stock solution bottle 16 through the liquid adding needle to supplement the liquid to be tested.
Finally, it should be noted that: the foregoing description is only illustrative of the preferred embodiments of the present utility model, and although the present utility model has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments described, or equivalents may be substituted for elements thereof, and any modifications, equivalents, improvements or changes may be made without departing from the spirit and principles of the present utility model.
Claims (10)
1. An automated sorting hybridization apparatus, comprising:
a liquid injection table (1);
a pipetting mechanism is arranged on the pipetting platform (1), and a clamping jaw (2) is arranged on one side of the pipetting mechanism;
the clamping jaw (2) is arranged on the pipetting mechanism through a moving mechanism and moves along the arrangement direction of the moving mechanism;
the inner side of the liquid injection table (1) is provided with a volume cavity, a plurality of hybridization boxes are placed on the volume cavity, and the hybridization boxes are taken out through the clamping jaws (2).
2. An automated sorting hybridization apparatus according to claim 1, wherein: the liquid injection table (1) is provided with a storage opening (3), the storage opening (3) is communicated with the internal volume cavity, and an identification device (4) is arranged above the storage opening (3) to identify the conveyed hybridization box.
3. An automated sorting hybridization apparatus according to claim 1, wherein: the pipetting mechanism comprises a first moving part (5), a second moving part (6) is slidably arranged on the first moving part (5), and a third moving part (7) is arranged on the second moving part (6) through a sliding block (8).
4. An automated sorting hybridization apparatus according to claim 3, wherein: the hybridization box output port (9) is arranged below the first moving part (5), and the ultraviolet disinfection lamp (10) is arranged above the hybridization box output port.
5. An automated sorting hybridization apparatus according to claim 3, wherein: a pipetting needle (11) is arranged below the third moving part (7).
6. An automated sorting hybridization apparatus according to claim 3, wherein: the moving mechanism comprises a rotary disc (12), the rotary disc (12) is arranged on one side of the sliding block (8), a sliding groove (13) is formed in the end face of one side of the rotary disc (12), a sliding rail (14) is arranged on the sliding groove (13), and the rotary disc (12) is rotated to drive the sliding rail (14) to rotate.
7. The automated sortation hybridization apparatus as claimed in claim 6 wherein: the sliding groove (13) is in clearance fit with the sliding rail (14), a rack is arranged on one side of the sliding rail (14), a gear is arranged on one side of the sliding groove (13), and the sliding rail (14) is driven to move on the sliding groove (13) through rotation of the control gear.
8. The automated sortation hybridization apparatus as claimed in claim 6 wherein: one side of the sliding rail (14) is provided with a clamping jaw (2) which is electrically connected with the control panel to control the action state of the clamping jaw (2).
9. An automated sorting hybridization apparatus according to claim 1, wherein: one side of the liquid injection table (1) is provided with a liquid adding needle (15) and a stock solution bottle (16).
10. The automated sortation hybridization apparatus as claimed in claim 8 wherein: the liquid injection table (1) is provided with a protective cover (17), and the control panel is arranged on the outer side of the protective cover (17).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321822024.6U CN220311051U (en) | 2023-07-12 | 2023-07-12 | Automatic sorting hybridization instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321822024.6U CN220311051U (en) | 2023-07-12 | 2023-07-12 | Automatic sorting hybridization instrument |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220311051U true CN220311051U (en) | 2024-01-09 |
Family
ID=89416522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202321822024.6U Active CN220311051U (en) | 2023-07-12 | 2023-07-12 | Automatic sorting hybridization instrument |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220311051U (en) |
-
2023
- 2023-07-12 CN CN202321822024.6U patent/CN220311051U/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO2022237181A1 (en) | Dna and rna nucleic acid co-extraction and detection system | |
| CN108048302B (en) | Full-automatic nucleic acid extractor | |
| TWI391492B (en) | Automated system and method for processing genetic material | |
| EP2392929A1 (en) | Analyzer, and control method for rotation of disc | |
| CN220311051U (en) | Automatic sorting hybridization instrument | |
| CN114134032A (en) | Gene sequencing pretreatment device | |
| CN113249208B (en) | Blood sample culture detection workstation | |
| CN111575172A (en) | Gene detection system | |
| US20240053370A1 (en) | Device for sample pretreatment | |
| CN115505526B (en) | Full-automatic nucleic acid detection assembly line and use method | |
| CN216082592U (en) | Pretreatment device for microbial mass spectrometry detection | |
| CN108315243B (en) | Automatic sample adding system | |
| WO2024021222A1 (en) | Exosome extractor | |
| CN217377902U (en) | Full-automatic nucleic acid extraction amplification analyzer | |
| CN215592565U (en) | Divide cup processing system | |
| CN113295856B (en) | High-flux virus detection device and application thereof in detection of novel coronavirus | |
| CN212610645U (en) | Gene detection system | |
| CN216688084U (en) | Nucleic acid extraction detection device | |
| JPH09187270A (en) | Analysis of bacteria and device for analyzing the same | |
| CN214060493U (en) | Integrated nucleic acid detection workstation | |
| CN115873704A (en) | Salmonella drug resistance detection device | |
| CN114806849A (en) | Microbial purification appearance | |
| CN113249197A (en) | System for preparing microorganism mass spectrum identification sample | |
| TW201827586A (en) | Apparatus of primary cell isolation and use method therefor aiming at saving manpower, unifying tissue slicing degree, and reducing contamination | |
| CN220867423U (en) | Full-automatic molecular diagnosis all-in-one equipment |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant |